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Protein

Acyl-CoA-binding protein

Gene

DBI

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14Acyl-CoACombined sources2 Publications1
Binding sitei51Acyl-CoACombined sources2 Publications1
Binding sitei55Acyl-CoACombined sources2 Publications1
Binding sitei74Acyl-CoACombined sources2 Publications1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-BTA-77289 Mitochondrial Fatty Acid Beta-Oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding protein
Short name:
ACBP
Alternative name(s):
Diazepam-binding inhibitor
Short name:
DBI
Endozepine
Short name:
EP
Gene namesi
Name:DBI
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Organism-specific databases

VGNCiVGNC:27889 DBI

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved3 Publications
ChainiPRO_00002140012 – 87Acyl-CoA-binding proteinAdd BLAST86

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei8N6-acetyllysine; alternateBy similarity1
Modified residuei8N6-succinyllysine; alternateBy similarity1
Modified residuei17N6-succinyllysineBy similarity1
Modified residuei19N6-acetyllysineBy similarity1
Modified residuei29PhosphotyrosineBy similarity1
Modified residuei51N6-acetyllysineBy similarity1
Modified residuei55N6-acetyllysine; alternateBy similarity1
Modified residuei55N6-malonyllysine; alternateBy similarity1
Modified residuei55N6-succinyllysine; alternateBy similarity1
Modified residuei77N6-acetyllysine; alternateBy similarity1
Modified residuei77N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP07107
PeptideAtlasiP07107
PRIDEiP07107

PTM databases

iPTMnetiP07107

Expressioni

Gene expression databases

BgeeiENSBTAG00000009517

Interactioni

Subunit structurei

Monomer.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012523

Structurei

Secondary structure

187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 12Combined sources10
Helixi13 – 15Combined sources3
Beta strandi16 – 18Combined sources3
Helixi22 – 36Combined sources15
Helixi50 – 61Combined sources12
Turni62 – 64Combined sources3
Helixi67 – 85Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ACANMR-A2-87[»]
1HB6X-ray2.00A2-87[»]
1HB8X-ray2.00A/B/C2-87[»]
1NTINMR-A2-87[»]
1NVLNMR-A2-87[»]
2ABDNMR-A2-87[»]
ProteinModelPortaliP07107
SMRiP07107
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07107

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 87ACBPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 33Acyl-CoA bindingCombined sources2 Publications5

Sequence similaritiesi

Belongs to the ACBP family.Curated

Phylogenomic databases

eggNOGiKOG0817 Eukaryota
COG4281 LUCA
GeneTreeiENSGT00840000129776
HOGENOMiHOG000261845
HOVERGENiHBG000398
InParanoidiP07107
KOiK08762
OMAiRYKFEAW
OrthoDBiEOG091G0NXJ
TreeFamiTF335802

Family and domain databases

Gene3Di1.20.80.101 hit
InterProiView protein in InterPro
IPR022408 Acyl-CoA-binding_prot_CS
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf
PfamiView protein in Pfam
PF00887 ACBP, 1 hit
PRINTSiPR00689 ACOABINDINGP
SUPFAMiSSF47027 SSF47027, 1 hit
PROSITEiView protein in PROSITE
PS00880 ACB_1, 1 hit
PS51228 ACB_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07107-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAEFDKAA EEVKHLKTKP ADEEMLFIYS HYKQATVGDI NTERPGMLDF
60 70 80
KGKAKWDAWN ELKGTSKEDA MKAYIDKVEE LKKKYGI
Length:87
Mass (Da):10,044
Last modified:January 23, 2007 - v2
Checksum:iB2922635F18CA0D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15886 mRNA Translation: AAA30495.1
BC114181 mRNA Translation: AAI14182.1
PIRiA26448 NZBO
RefSeqiNP_001106792.1, NM_001113321.1
UniGeneiBt.46917

Genome annotation databases

EnsembliENSBTAT00000012523; ENSBTAP00000012523; ENSBTAG00000009517
GeneIDi768330
KEGGibta:768330

Similar proteinsi

Entry informationi

Entry nameiACBP_BOVIN
AccessioniPrimary (citable) accession number: P07107
Secondary accession number(s): Q29RG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome