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P07106 (ACBD5_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acyl-CoA-binding domain-containing protein 5
Alternative name(s):
Endozepine-related protein
Membrane-associated diazepam-binding inhibitor
Short name=MA-DBI
Gene names
Name:ACBD5
Synonyms:DBI
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length533 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds medium- and long-chain acyl-CoA esters By similarity.

Subcellular location

Peroxisome membrane; Single-pass membrane protein By similarity.

Tissue specificity

Highly expressed in brain and liver. Lower levels of expression in spleen and heart. Ref.2

Sequence similarities

Contains 1 ACB (acyl-CoA-binding) domain.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
Peroxisome
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Transmembrane
Transmembrane helix
   LigandLipid-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

peroxisomal membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfatty-acyl-CoA binding

Inferred from electronic annotation. Source: InterPro

lipid binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P07106-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P07106-2)

The sequence of this isoform differs from the canonical sequence as follows:
     163-173: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 533533Acyl-CoA-binding domain-containing protein 5
PRO_0000000290

Regions

Transmembrane503 – 52523Helical; Potential
Domain42 – 13190ACB
Region53 – 6210Acyl-CoA binding By similarity
Region73 – 775Acyl-CoA binding By similarity
Coiled coil448 – 47831 Potential
Compositional bias13 – 175Poly-Cys
Compositional bias527 – 5304Poly-Arg

Sites

Binding site991Acyl-CoA By similarity
Binding site1181Acyl-CoA By similarity

Amino acid modifications

Modified residue1611Phosphothreonine By similarity
Modified residue1941Phosphoserine By similarity
Modified residue1951Phosphoserine By similarity
Modified residue1971Phosphoserine By similarity
Modified residue2011Phosphoserine By similarity
Modified residue4291Phosphoserine By similarity
Modified residue4421Phosphoserine By similarity

Natural variations

Alternative sequence163 – 17311Missing in isoform 2.
VSP_025445

Experimental info

Sequence conflict36 – 372AD → RH in AAA30496. Ref.1
Sequence conflict36 – 372AD → RH in AAB21311. Ref.2
Sequence conflict2191D → E in AAI02374. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 15, 2007. Version 2.
Checksum: 510839B3F8BE1A44

FASTA53359,653
        10         20         30         40         50         60 
MFQFHAGSWE SWCCCCCLIP GDRPWDRGRR WRLEMADTRS VHETRFEAAV KVIQSLPKNG 

        70         80         90        100        110        120 
SFQPTNEMML KFYSFYKQAT EGPCKLSKPG FWDPVGRYKW DAWSSLGDMT KEEAMIAYVE 

       130        140        150        160        170        180 
EMKKILETMP MTEKVEELLH VIGPFYEIVE DKKSGRSSDL TSVRLEKISK CLEDLGNVLA 

       190        200        210        220        230        240 
STPNAKTVNG KAESSDSGAE SEEEAAQEDP KRPEPRDSDK KMMKKSADHK NLEIIVTNGY 

       250        260        270        280        290        300 
DKDSFVQGVQ NSIHTSPSLN GRCTEEVKSV DENLEQTGKT VVFVHQDVNS DHVEDISGIQ 

       310        320        330        340        350        360 
HLTSDSDSEV YCDSMEQFGQ EESLDGFISN NGPFSYYLGG NPSQPLESSG FPEAVQGLPG 

       370        380        390        400        410        420 
NGSPEDMQGA VVEGKGEVKR GGEDGGSNSG APHREKRAGE SEEFSNIRRG RGHRMQHLSE 

       430        440        450        460        470        480 
GSKGRQVGSG GDGERWGSDR GSRGSLNEQI ALVLMRLQED MQNVLQRLHK LEMLAASQAK 

       490        500        510        520        530 
SSALQTSNQP TSPRPSWWPF EMSPGALTFA IIWPFIAQWL VHLYYQRRRR KLN

« Hide

Isoform 2 [UniParc].

Checksum: D2CDC2F4FD578669
Show »

FASTA52258,353

References

« Hide 'large scale' references
[1]"Bovine and human cDNA sequences encoding a putative benzodiazepine receptor ligand."
Webb N.R., Rose T.M., Malik N., Marquardt H., Shoyab M., Todaro G.J., Lee D.C.
DNA 6:71-79(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"Human DBI (endozepine): relationship to a homologous membrane associated protein (MA-DBI)."
Todaro G.J., Rose T.M., Shoyab M.
Neuropharmacology 30:1373-1380(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Tissue: Brain.
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-220 (ISOFORM 2).
Strain: Crossbred X Angus.
Tissue: Ileum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M15888 mRNA. Translation: AAA30496.1.
S80107 mRNA. Translation: AAB21311.2.
BC102373 mRNA. Translation: AAI02374.1. Different termination.
IPIIPI00711675.
IPI00841629.
PIRNZBOR. C26448.
RefSeqNP_851381.1. NM_181038.3.
UniGeneBt.87957.

3D structure databases

ProteinModelPortalP07106.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000022964.

Proteomic databases

PaxDbP07106.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID353160.
KEGGbta:353160.

Organism-specific databases

CTD91452.

Phylogenomic databases

eggNOGCOG4281.
HOGENOMHOG000231479.
HOVERGENHBG106445.
InParanoidP07106.

Family and domain databases

Gene3D1.20.80.10. 1 hit.
InterProIPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR016347. M-assoc_diazepam-bd-inh.
[Graphical view]
PfamPF00887. ACBP. 1 hit.
[Graphical view]
PIRSFPIRSF002412. MA_DBI. 1 hit.
PRINTSPR00689. ACOABINDINGP.
SUPFAMSSF47027. ACBP. 1 hit.
PROSITEPS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20812708.

Entry information

Entry nameACBD5_BOVIN
AccessionPrimary (citable) accession number: P07106
Secondary accession number(s): Q3T0I9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: May 15, 2007
Last modified: April 3, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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