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Protein

Gastric triacylglycerol lipase

Gene

LIPF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei172Nucleophile1 Publication1
Active sitei343Charge relay system1 Publication1
Active sitei372Charge relay system1 Publication1

GO - Molecular functioni

  • lipid binding Source: UniProtKB
  • malate dehydrogenase activity Source: Ensembl
  • triglyceride lipase activity Source: UniProtKB

GO - Biological processi

  • lipid catabolic process Source: UniProtKB-KW
  • malate metabolic process Source: Ensembl
  • triglyceride metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciZFISH:HS04351-MONOMER.
ReactomeiR-HSA-192456. Digestion of dietary lipid.

Protein family/group databases

ESTHERihuman-LIPF. Acidic_Lipase.

Chemistry databases

SwissLipidsiSLP:000000524.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric triacylglycerol lipase (EC:3.1.1.3)
Short name:
GL
Short name:
Gastric lipase
Gene namesi
Name:LIPF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:6622. LIPF.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi8513.
OpenTargetsiENSG00000182333.
PharmGKBiPA30394.

Chemistry databases

ChEMBLiCHEMBL1796.
DrugBankiDB01083. Orlistat.

Polymorphism and mutation databases

BioMutaiLIPF.
DMDMi126306.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001776620 – 398Gastric triacylglycerol lipaseAdd BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...)1 Publication1
Glycosylationi99N-linked (GlcNAc...)1 Publication1
Disulfide bondi246 ↔ 2551 Publication
Glycosylationi271N-linked (GlcNAc...)1 Publication1
Glycosylationi327N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP07098.
PeptideAtlasiP07098.
PRIDEiP07098.

PTM databases

iPTMnetiP07098.
PhosphoSitePlusiP07098.

Miscellaneous databases

PMAP-CutDBP07098.

Expressioni

Gene expression databases

BgeeiENSG00000182333.
CleanExiHS_LIPF.
GenevisibleiP07098. HS.

Organism-specific databases

HPAiHPA045930.

Interactioni

Protein-protein interaction databases

BioGridi114085. 9 interactors.
IntActiP07098. 2 interactors.
STRINGi9606.ENSP00000377900.

Structurei

Secondary structure

1398
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 32Combined sources4
Helixi35 – 41Combined sources7
Beta strandi47 – 52Combined sources6
Beta strandi56 – 64Combined sources9
Beta strandi79 – 83Combined sources5
Helixi90 – 94Combined sources5
Helixi102 – 108Combined sources7
Beta strandi112 – 115Combined sources4
Beta strandi127 – 130Combined sources4
Helixi136 – 138Combined sources3
Helixi142 – 147Combined sources6
Helixi149 – 161Combined sources13
Beta strandi166 – 171Combined sources6
Helixi173 – 184Combined sources12
Helixi186 – 189Combined sources4
Beta strandi192 – 199Combined sources8
Helixi210 – 216Combined sources7
Helixi219 – 226Combined sources8
Beta strandi228 – 230Combined sources3
Turni234 – 239Combined sources6
Helixi241 – 249Combined sources9
Helixi252 – 255Combined sources4
Helixi258 – 263Combined sources6
Helixi272 – 274Combined sources3
Helixi275 – 279Combined sources5
Helixi288 – 300Combined sources13
Helixi311 – 318Combined sources8
Beta strandi319 – 322Combined sources4
Helixi328 – 330Combined sources3
Beta strandi335 – 340Combined sources6
Beta strandi344 – 346Combined sources3
Helixi348 – 357Combined sources10
Beta strandi361 – 367Combined sources7
Helixi374 – 377Combined sources4
Helixi381 – 384Combined sources4
Helixi386 – 393Combined sources8
Turni394 – 397Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HLGX-ray3.00A/B28-398[»]
ProteinModelPortaliP07098.
SMRiP07098.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07098.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 377AB hydrolase-1Sequence analysisAdd BLAST300

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2624. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00550000074328.
HOGENOMiHOG000240694.
HOVERGENiHBG006265.
InParanoidiP07098.
KOiK14452.
OMAiCSRETLN.
OrthoDBiEOG091G09AX.
PhylomeDBiP07098.
TreeFamiTF315485.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P07098-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWLLLTMASL ISVLGTTHGL FGKLHPGSPE VTMNISQMIT YWGYPNEEYE
60 70 80 90 100
VVTEDGYILE VNRIPYGKKN SGNTGQRPVV FLQHGLLASA TNWISNLPNN
110 120 130 140 150
SLAFILADAG YDVWLGNSRG NTWARRNLYY SPDSVEFWAF SFDEMAKYDL
160 170 180 190 200
PATIDFIVKK TGQKQLHYVG HSQGTTIGFI AFSTNPSLAK RIKTFYALAP
210 220 230 240 250
VATVKYTKSL INKLRFVPQS LFKFIFGDKI FYPHNFFDQF LATEVCSREM
260 270 280 290 300
LNLLCSNALF IICGFDSKNF NTSRLDVYLS HNPAGTSVQN MFHWTQAVKS
310 320 330 340 350
GKFQAYDWGS PVQNRMHYDQ SQPPYYNVTA MNVPIAVWNG GKDLLADPQD
360 370 380 390
VGLLLPKLPN LIYHKEIPFY NHLDFIWAMD APQEVYNDIV SMISEDKK
Length:398
Mass (Da):45,238
Last modified:April 1, 1988 - v1
Checksum:iCD3EE1621C014F0F
GO
Isoform 2 (identifier: P07098-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-107: Missing.

Note: No experimental confirmation available.
Show »
Length:365
Mass (Da):41,693
Checksum:i31199D27DA2A3863
GO
Isoform 3 (identifier: P07098-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MFSNANSRSKM

Note: No experimental confirmation available.
Show »
Length:408
Mass (Da):46,361
Checksum:i96E2AFF12E20DF86
GO
Isoform 4 (identifier: P07098-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MFSNANSRSKM
     75-107: Missing.

Note: No experimental confirmation available.
Show »
Length:375
Mass (Da):42,816
Checksum:i17FA3CD30823DDCF
GO

Sequence cautioni

The sequence CAA29414 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti350D → N in BAH13459 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011947161T → A.2 PublicationsCorresponds to variant rs814628dbSNPEnsembl.1
Natural variantiVAR_020565224F → I.1 PublicationCorresponds to variant rs6586145dbSNPEnsembl.1
Natural variantiVAR_020566348P → T.1 PublicationCorresponds to variant rs17333991dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0472951M → MFSNANSRSKM in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_04729675 – 107Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05997 mRNA. Translation: CAA29413.1.
X05997 mRNA. Translation: CAA29414.1. Different initiation.
AK301310 mRNA. Translation: BAH13457.1.
AK301320 mRNA. Translation: BAH13459.1.
AK312940 mRNA. Translation: BAG35782.1.
AL833751 mRNA. Translation: CAH56244.1.
AY631869 Genomic DNA. Translation: AAT38115.1.
AL358532 Genomic DNA. Translation: CAH71057.1.
CH471066 Genomic DNA. Translation: EAW50162.1.
BC112272 mRNA. Translation: AAI12273.1.
BC113711 mRNA. Translation: AAI13712.1.
CCDSiCCDS55718.1. [P07098-3]
CCDS55719.1. [P07098-2]
CCDS65896.1. [P07098-4]
CCDS7389.1. [P07098-1]
PIRiS07145.
RefSeqiNP_001185757.1. NM_001198828.1. [P07098-2]
NP_001185758.1. NM_001198829.1. [P07098-3]
NP_001185759.1. NM_001198830.1. [P07098-4]
NP_004181.1. NM_004190.3. [P07098-1]
XP_011538613.1. XM_011540311.1. [P07098-1]
UniGeneiHs.523130.

Genome annotation databases

EnsembliENST00000238983; ENSP00000238983; ENSG00000182333. [P07098-1]
ENST00000355843; ENSP00000348101; ENSG00000182333. [P07098-4]
ENST00000394375; ENSP00000377900; ENSG00000182333. [P07098-3]
ENST00000608620; ENSP00000477140; ENSG00000182333. [P07098-2]
GeneIDi8513.
KEGGihsa:8513.
UCSCiuc001kfg.3. human. [P07098-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05997 mRNA. Translation: CAA29413.1.
X05997 mRNA. Translation: CAA29414.1. Different initiation.
AK301310 mRNA. Translation: BAH13457.1.
AK301320 mRNA. Translation: BAH13459.1.
AK312940 mRNA. Translation: BAG35782.1.
AL833751 mRNA. Translation: CAH56244.1.
AY631869 Genomic DNA. Translation: AAT38115.1.
AL358532 Genomic DNA. Translation: CAH71057.1.
CH471066 Genomic DNA. Translation: EAW50162.1.
BC112272 mRNA. Translation: AAI12273.1.
BC113711 mRNA. Translation: AAI13712.1.
CCDSiCCDS55718.1. [P07098-3]
CCDS55719.1. [P07098-2]
CCDS65896.1. [P07098-4]
CCDS7389.1. [P07098-1]
PIRiS07145.
RefSeqiNP_001185757.1. NM_001198828.1. [P07098-2]
NP_001185758.1. NM_001198829.1. [P07098-3]
NP_001185759.1. NM_001198830.1. [P07098-4]
NP_004181.1. NM_004190.3. [P07098-1]
XP_011538613.1. XM_011540311.1. [P07098-1]
UniGeneiHs.523130.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HLGX-ray3.00A/B28-398[»]
ProteinModelPortaliP07098.
SMRiP07098.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114085. 9 interactors.
IntActiP07098. 2 interactors.
STRINGi9606.ENSP00000377900.

Chemistry databases

ChEMBLiCHEMBL1796.
DrugBankiDB01083. Orlistat.
SwissLipidsiSLP:000000524.

Protein family/group databases

ESTHERihuman-LIPF. Acidic_Lipase.

PTM databases

iPTMnetiP07098.
PhosphoSitePlusiP07098.

Polymorphism and mutation databases

BioMutaiLIPF.
DMDMi126306.

Proteomic databases

PaxDbiP07098.
PeptideAtlasiP07098.
PRIDEiP07098.

Protocols and materials databases

DNASUi8513.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238983; ENSP00000238983; ENSG00000182333. [P07098-1]
ENST00000355843; ENSP00000348101; ENSG00000182333. [P07098-4]
ENST00000394375; ENSP00000377900; ENSG00000182333. [P07098-3]
ENST00000608620; ENSP00000477140; ENSG00000182333. [P07098-2]
GeneIDi8513.
KEGGihsa:8513.
UCSCiuc001kfg.3. human. [P07098-1]

Organism-specific databases

CTDi8513.
DisGeNETi8513.
GeneCardsiLIPF.
HGNCiHGNC:6622. LIPF.
HPAiHPA045930.
MIMi601980. gene.
neXtProtiNX_P07098.
OpenTargetsiENSG00000182333.
PharmGKBiPA30394.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2624. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00550000074328.
HOGENOMiHOG000240694.
HOVERGENiHBG006265.
InParanoidiP07098.
KOiK14452.
OMAiCSRETLN.
OrthoDBiEOG091G09AX.
PhylomeDBiP07098.
TreeFamiTF315485.

Enzyme and pathway databases

BioCyciZFISH:HS04351-MONOMER.
ReactomeiR-HSA-192456. Digestion of dietary lipid.

Miscellaneous databases

ChiTaRSiLIPF. human.
EvolutionaryTraceiP07098.
GenomeRNAii8513.
PMAP-CutDBP07098.
PROiP07098.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182333.
CleanExiHS_LIPF.
GenevisibleiP07098. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIPG_HUMAN
AccessioniPrimary (citable) accession number: P07098
Secondary accession number(s): B7Z723
, F5H1P4, Q2M1P6, Q5VXI7, Q5VXI8, Q658L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 30, 2016
This is version 173 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.