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P07098 (LIPG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 153. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gastric triacylglycerol lipase

Short name=GL
Short name=Gastric lipase
EC=3.1.1.3
Gene names
Name:LIPF
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Subcellular location

Secreted.

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Sequence caution

The sequence CAA29414.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P07098-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P07098-2)

The sequence of this isoform differs from the canonical sequence as follows:
     75-107: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: P07098-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MFSNANSRSKM
Note: No experimental confirmation available.
Isoform 4 (identifier: P07098-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MFSNANSRSKM
     75-107: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.8
Chain20 – 398379Gastric triacylglycerol lipase
PRO_0000017766

Sites

Active site1721Nucleophile
Active site3431Charge relay system
Active site3721Charge relay system

Amino acid modifications

Glycosylation341N-linked (GlcNAc...)
Glycosylation991N-linked (GlcNAc...)
Glycosylation2711N-linked (GlcNAc...)
Glycosylation3271N-linked (GlcNAc...)
Disulfide bond246 ↔ 255

Natural variations

Alternative sequence11M → MFSNANSRSKM in isoform 3 and isoform 4.
VSP_047295
Alternative sequence75 – 10733Missing in isoform 2 and isoform 4.
VSP_047296
Natural variant1611T → A. Ref.4 Ref.7
Corresponds to variant rs814628 [ dbSNP | Ensembl ].
VAR_011947
Natural variant2241F → I. Ref.4
Corresponds to variant rs6586145 [ dbSNP | Ensembl ].
VAR_020565
Natural variant3481P → T. Ref.4
Corresponds to variant rs17333991 [ dbSNP | Ensembl ].
VAR_020566

Experimental info

Sequence conflict3501D → N in BAH13459. Ref.2

Secondary structure

........................................................................ 398
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: CD3EE1621C014F0F

FASTA39845,238
        10         20         30         40         50         60 
MWLLLTMASL ISVLGTTHGL FGKLHPGSPE VTMNISQMIT YWGYPNEEYE VVTEDGYILE 

        70         80         90        100        110        120 
VNRIPYGKKN SGNTGQRPVV FLQHGLLASA TNWISNLPNN SLAFILADAG YDVWLGNSRG 

       130        140        150        160        170        180 
NTWARRNLYY SPDSVEFWAF SFDEMAKYDL PATIDFIVKK TGQKQLHYVG HSQGTTIGFI 

       190        200        210        220        230        240 
AFSTNPSLAK RIKTFYALAP VATVKYTKSL INKLRFVPQS LFKFIFGDKI FYPHNFFDQF 

       250        260        270        280        290        300 
LATEVCSREM LNLLCSNALF IICGFDSKNF NTSRLDVYLS HNPAGTSVQN MFHWTQAVKS 

       310        320        330        340        350        360 
GKFQAYDWGS PVQNRMHYDQ SQPPYYNVTA MNVPIAVWNG GKDLLADPQD VGLLLPKLPN 

       370        380        390 
LIYHKEIPFY NHLDFIWAMD APQEVYNDIV SMISEDKK 

« Hide

Isoform 2 [UniParc].

Checksum: 31199D27DA2A3863
Show »

FASTA36541,693
Isoform 3 [UniParc].

Checksum: 96E2AFF12E20DF86
Show »

FASTA40846,361
Isoform 4 [UniParc].

Checksum: 17FA3CD30823DDCF
Show »

FASTA37542,816

References

« Hide 'large scale' references
[1]"Molecular cloning of a human gastric lipase and expression of the enzyme in yeast."
Bodmer M.W., Angal S., Yarranton G.T., Harris T.J.R., Lyons A., King D.J., Pieroni G., Riviere C., Verger R., Lowe P.A.
Biochim. Biophys. Acta 909:237-244(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Stomach.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Stomach.
[4]NIEHS SNPs program
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-161; ILE-224 AND THR-348.
[5]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-161.
[8]"Human gastric lipase. The N-terminal tetrapeptide is essential for lipid binding and lipase activity."
Bernbaeck S., Blaeckberg L.
Eur. J. Biochem. 182:495-499(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-45.
[9]"Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest."
Roussel A., Canaan S., Egloff M.P., Riviere M., Dupuis L., Verger R., Cambillau C.
J. Biol. Chem. 274:16995-17002(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X05997 mRNA. Translation: CAA29413.1.
X05997 mRNA. Translation: CAA29414.1. Different initiation.
AK301310 mRNA. Translation: BAH13457.1.
AK301320 mRNA. Translation: BAH13459.1.
AK312940 mRNA. Translation: BAG35782.1.
AL833751 mRNA. Translation: CAH56244.1.
AY631869 Genomic DNA. Translation: AAT38115.1.
AL358532 Genomic DNA. Translation: CAH71057.1.
CH471066 Genomic DNA. Translation: EAW50162.1.
BC112272 mRNA. Translation: AAI12273.1.
BC113711 mRNA. Translation: AAI13712.1.
CCDSCCDS55718.1. [P07098-3]
CCDS55719.1. [P07098-2]
CCDS7389.1. [P07098-1]
PIRS07145.
RefSeqNP_001185757.1. NM_001198828.1. [P07098-2]
NP_001185758.1. NM_001198829.1. [P07098-3]
NP_001185759.1. NM_001198830.1. [P07098-4]
NP_004181.1. NM_004190.3. [P07098-1]
UniGeneHs.523130.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1HLGX-ray3.00A/B28-398[»]
ProteinModelPortalP07098.
SMRP07098. Positions 28-398.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114085. 2 interactions.
IntActP07098. 1 interaction.
STRING9606.ENSP00000238983.

Chemistry

ChEMBLCHEMBL1796.

PTM databases

PhosphoSiteP07098.

Polymorphism databases

DMDM126306.

Proteomic databases

PaxDbP07098.
PRIDEP07098.

Protocols and materials databases

DNASU8513.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000238983; ENSP00000238983; ENSG00000182333. [P07098-1]
ENST00000394375; ENSP00000377900; ENSG00000182333. [P07098-3]
ENST00000608620; ENSP00000477140; ENSG00000182333. [P07098-2]
GeneID8513.
KEGGhsa:8513.
UCSCuc001kfg.2. human. [P07098-1]

Organism-specific databases

CTD8513.
GeneCardsGC10P090415.
HGNCHGNC:6622. LIPF.
HPAHPA045930.
MIM601980. gene.
neXtProtNX_P07098.
PharmGKBPA30394.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0596.
HOGENOMHOG000240694.
HOVERGENHBG006265.
InParanoidP07098.
KOK14452.
OMAWARRNLY.
OrthoDBEOG71RXJN.
PhylomeDBP07098.
TreeFamTF315485.

Gene expression databases

ArrayExpressP07098.
BgeeP07098.
CleanExHS_LIPF.
GenevestigatorP07098.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR006693. AB_hydrolase_lipase.
IPR025483. Lipase_euk.
[Graphical view]
PfamPF04083. Abhydro_lipase. 1 hit.
PF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLIPF. human.
EvolutionaryTraceP07098.
GenomeRNAi8513.
NextBio31864.
PMAP-CutDBP07098.
PROP07098.
SOURCESearch...

Entry information

Entry nameLIPG_HUMAN
AccessionPrimary (citable) accession number: P07098
Secondary accession number(s): B7Z723 expand/collapse secondary AC list , F5H1P4, Q2M1P6, Q5VXI7, Q5VXI8, Q658L8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: July 9, 2014
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM