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Protein

Glia-derived nexin

Gene

SERPINE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei365 – 366Reactive bondSequence analysis2

GO - Molecular functioni

  • glycosaminoglycan binding Source: BHF-UCL
  • heparin binding Source: BHF-UCL
  • serine-type endopeptidase inhibitor activity Source: BHF-UCL
  • signaling receptor binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Heparin-binding, Protease inhibitor, Serine protease inhibitor
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-140875 Common Pathway of Fibrin Clot Formation
R-HSA-75205 Dissolution of Fibrin Clot

Protein family/group databases

MEROPSiI04.021

Names & Taxonomyi

Protein namesi
Recommended name:
Glia-derived nexin
Short name:
GDN
Alternative name(s):
Peptidase inhibitor 7
Short name:
PI-7
Protease nexin 1
Short name:
PN-1
Protease nexin I
Serpin E2
Gene namesi
Name:SERPINE2
Synonyms:PI7, PN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000135919.12
HGNCiHGNC:8951 SERPINE2
MIMi177010 gene
neXtProtiNX_P07093

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5270
OpenTargetsiENSG00000135919
PharmGKBiPA269

Polymorphism and mutation databases

BioMutaiSERPINE2
DMDMi121110

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 192 PublicationsAdd BLAST19
ChainiPRO_000003250420 – 398Glia-derived nexinAdd BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP07093
MaxQBiP07093
PaxDbiP07093
PeptideAtlasiP07093
PRIDEiP07093
ProteomicsDBi51945
51946 [P07093-2]
51947 [P07093-3]

PTM databases

CarbonylDBiP07093
iPTMnetiP07093
PhosphoSitePlusiP07093

Miscellaneous databases

PMAP-CutDBiP07093

Expressioni

Gene expression databases

BgeeiENSG00000135919
CleanExiHS_SERPINE2
ExpressionAtlasiP07093 baseline and differential
GenevisibleiP07093 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-10195168,EBI-10175124

GO - Molecular functioni

  • signaling receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi111288, 26 interactors
IntActiP07093, 8 interactors
MINTiP07093
STRINGi9606.ENSP00000415786

Structurei

Secondary structure

1398
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 45Combined sources22
Beta strandi51 – 53Combined sources3
Helixi55 – 66Combined sources12
Helixi71 – 81Combined sources11
Turni86 – 88Combined sources3
Helixi89 – 100Combined sources12
Helixi102 – 104Combined sources3
Beta strandi109 – 117Combined sources9
Helixi124 – 134Combined sources11
Beta strandi136 – 140Combined sources5
Helixi146 – 160Combined sources15
Turni161 – 163Combined sources3
Helixi171 – 173Combined sources3
Turni176 – 178Combined sources3
Beta strandi181 – 189Combined sources9
Beta strandi193 – 195Combined sources3
Helixi199 – 201Combined sources3
Beta strandi203 – 208Combined sources6
Beta strandi210 – 212Combined sources3
Beta strandi214 – 232Combined sources19
Beta strandi238 – 246Combined sources9
Beta strandi249 – 260Combined sources12
Helixi265 – 267Combined sources3
Helixi269 – 271Combined sources3
Helixi274 – 281Combined sources8
Beta strandi285 – 294Combined sources10
Beta strandi296 – 303Combined sources8
Helixi305 – 310Combined sources6
Helixi315 – 317Combined sources3
Turni319 – 321Combined sources3
Turni325 – 327Combined sources3
Beta strandi328 – 330Combined sources3
Beta strandi338 – 347Combined sources10
Beta strandi354 – 356Combined sources3
Helixi357 – 360Combined sources4
Beta strandi370 – 372Combined sources3
Beta strandi377 – 383Combined sources7
Turni384 – 387Combined sources4
Beta strandi388 – 396Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DY0X-ray2.35A/B20-398[»]
4DY7X-ray2.80C/F20-398[»]
ProteinModelPortaliP07093
SMRiP07093
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00900000140788
HOGENOMiHOG000238519
HOVERGENiHBG106493
InParanoidiP07093
KOiK16643
OMAiTGIQVFN
OrthoDBiEOG091G0ION
PhylomeDBiP07093
TreeFamiTF352620

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P07093-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNWHLPLFLL ASVTLPSICS HFNPLSLEEL GSNTGIQVFN QIVKSRPHDN
60 70 80 90 100
IVISPHGIAS VLGMLQLGAD GRTKKQLAMV MRYGVNGVGK ILKKINKAIV
110 120 130 140 150
SKKNKDIVTV ANAVFVKNAS EIEVPFVTRN KDVFQCEVRN VNFEDPASAC
160 170 180 190 200
DSINAWVKNE TRDMIDNLLS PDLIDGVLTR LVLVNAVYFK GLWKSRFQPE
210 220 230 240 250
NTKKRTFVAA DGKSYQVPML AQLSVFRCGS TSAPNDLWYN FIELPYHGES
260 270 280 290 300
ISMLIALPTE SSTPLSAIIP HISTKTIDSW MSIMVPKRVQ VILPKFTAVA
310 320 330 340 350
QTDLKEPLKV LGITDMFDSS KANFAKITTG SENLHVSHIL QKAKIEVSED
360 370 380 390
GTKASAATTA ILIARSSPPW FIVDRPFLFF IRHNPTGAVL FMGQINKP
Length:398
Mass (Da):44,002
Last modified:April 1, 1988 - v1
Checksum:i2A165604E2CBE6B8
GO
Isoform 2 (identifier: P07093-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     329-330: TG → R

Show »
Length:397
Mass (Da):44,000
Checksum:i45A9C934A800D7EB
GO
Isoform 3 (identifier: P07093-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSDCRSSLVEGTM
     329-330: TG → R

Note: No experimental confirmation available.
Show »
Length:409
Mass (Da):45,267
Checksum:i6315691891B53A7B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159N → D in BAG35401 (PubMed:14702039).Curated1
Sequence conflicti261S → E (PubMed:2877744).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05195551I → M. Corresponds to variant dbSNP:rs3795875Ensembl.1
Natural variantiVAR_036027204K → N in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0436681M → MSDCRSSLVEGTM in isoform 3. 1 Publication1
Alternative sequenceiVSP_038367329 – 330TG → R in isoform 2 and isoform 3. 3 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17783 mRNA Translation: AAA35883.1
AK295564 mRNA Translation: BAG58464.1
AK312499 mRNA Translation: BAG35401.1
AC073641 Genomic DNA Translation: AAY14926.1
CH471063 Genomic DNA Translation: EAW70821.1
CH471063 Genomic DNA Translation: EAW70823.1
BC015663 mRNA Translation: AAH15663.1
BC042628 mRNA Translation: AAH42628.1
CCDSiCCDS2460.1 [P07093-1]
CCDS46525.1 [P07093-3]
CCDS46526.1 [P07093-2]
PIRiA37274
RefSeqiNP_001130000.1, NM_001136528.1 [P07093-2]
NP_001130002.1, NM_001136530.1 [P07093-3]
NP_006207.1, NM_006216.3 [P07093-1]
XP_016859818.1, XM_017004329.1 [P07093-1]
XP_016859819.1, XM_017004330.1 [P07093-1]
XP_016859820.1, XM_017004331.1 [P07093-2]
XP_016859821.1, XM_017004332.1 [P07093-2]
UniGeneiHs.38449
Hs.708453

Genome annotation databases

EnsembliENST00000258405; ENSP00000258405; ENSG00000135919 [P07093-1]
ENST00000409304; ENSP00000386412; ENSG00000135919 [P07093-2]
ENST00000409840; ENSP00000386969; ENSG00000135919 [P07093-2]
ENST00000447280; ENSP00000415786; ENSG00000135919 [P07093-3]
GeneIDi5270
KEGGihsa:5270
UCSCiuc002vnu.3 human [P07093-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGDN_HUMAN
AccessioniPrimary (citable) accession number: P07093
Secondary accession number(s): B2R6A4
, B4DIF2, Q53S15, Q5D0C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: June 20, 2018
This is version 184 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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