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P07093

- GDN_HUMAN

UniProt

P07093 - GDN_HUMAN

Protein

Glia-derived nexin

Gene

SERPINE2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 1 (01 Apr 1988)
      Previous versions | rss
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    Functioni

    Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei365 – 3662Reactive bondSequence Analysis

    GO - Molecular functioni

    1. glycosaminoglycan binding Source: BHF-UCL
    2. heparin binding Source: BHF-UCL
    3. protein binding Source: UniProtKB
    4. receptor binding Source: BHF-UCL
    5. serine-type endopeptidase inhibitor activity Source: BHF-UCL

    GO - Biological processi

    1. blood coagulation Source: Ensembl
    2. cerebellar granular layer morphogenesis Source: Ensembl
    3. detection of mechanical stimulus involved in sensory perception Source: Ensembl
    4. innervation Source: Ensembl
    5. long-term synaptic potentiation Source: Ensembl
    6. mating plug formation Source: Ensembl
    7. negative regulation of blood coagulation Source: BHF-UCL
    8. negative regulation of cell growth Source: Ensembl
    9. negative regulation of cell proliferation Source: Ensembl
    10. negative regulation of endopeptidase activity Source: RefGenome
    11. negative regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
    12. negative regulation of plasminogen activation Source: BHF-UCL
    13. negative regulation of platelet activation Source: Ensembl
    14. negative regulation of platelet aggregation Source: BHF-UCL
    15. negative regulation of protein catabolic process Source: Ensembl
    16. negative regulation of protein processing Source: BHF-UCL
    17. negative regulation of proteolysis Source: BHF-UCL
    18. negative regulation of smoothened signaling pathway Source: Ensembl
    19. negative regulation of sodium ion transport Source: Ensembl
    20. positive regulation of astrocyte differentiation Source: BHF-UCL
    21. regulation of cell migration Source: UniProtKB
    22. regulation of synaptic transmission, glutamatergic Source: Ensembl
    23. regulation of timing of cell differentiation Source: Ensembl
    24. secretion by cell Source: Ensembl
    25. secretory granule organization Source: Ensembl
    26. seminal vesicle epithelium development Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Protease inhibitor, Serine protease inhibitor

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    ReactomeiREACT_641. Dissolution of Fibrin Clot.

    Protein family/group databases

    MEROPSiI04.021.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glia-derived nexin
    Short name:
    GDN
    Alternative name(s):
    Peptidase inhibitor 7
    Short name:
    PI-7
    Protease nexin 1
    Short name:
    PN-1
    Protease nexin I
    Serpin E2
    Gene namesi
    Name:SERPINE2
    Synonyms:PI7, PN1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:8951. SERPINE2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: BHF-UCL
    2. extracellular matrix Source: BHF-UCL
    3. extracellular region Source: BHF-UCL
    4. extracellular space Source: RefGenome
    5. extrinsic component of external side of plasma membrane Source: BHF-UCL
    6. neuromuscular junction Source: BHF-UCL
    7. platelet alpha granule Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA269.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19192 PublicationsAdd
    BLAST
    Chaini20 – 398379Glia-derived nexinPRO_0000032504Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP07093.
    PaxDbiP07093.
    PeptideAtlasiP07093.
    PRIDEiP07093.

    PTM databases

    PhosphoSiteiP07093.

    Miscellaneous databases

    PMAP-CutDBP07093.

    Expressioni

    Gene expression databases

    ArrayExpressiP07093.
    BgeeiP07093.
    CleanExiHS_SERPINE2.
    GenevestigatoriP07093.

    Organism-specific databases

    HPAiHPA051263.

    Interactioni

    Protein-protein interaction databases

    BioGridi111288. 10 interactions.
    STRINGi9606.ENSP00000415786.

    Structurei

    Secondary structure

    1
    398
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi24 – 4522
    Beta strandi51 – 533
    Helixi55 – 6612
    Helixi71 – 8111
    Turni86 – 883
    Helixi89 – 10012
    Helixi102 – 1043
    Beta strandi109 – 1179
    Helixi124 – 13411
    Beta strandi136 – 1405
    Helixi146 – 16015
    Turni161 – 1633
    Helixi171 – 1733
    Turni176 – 1783
    Beta strandi181 – 1899
    Beta strandi193 – 1953
    Helixi199 – 2013
    Beta strandi203 – 2086
    Beta strandi210 – 2123
    Beta strandi214 – 23219
    Beta strandi238 – 2469
    Beta strandi249 – 26012
    Helixi265 – 2673
    Helixi269 – 2713
    Helixi274 – 2818
    Beta strandi285 – 29410
    Beta strandi296 – 3038
    Helixi305 – 3106
    Helixi315 – 3173
    Turni319 – 3213
    Turni325 – 3273
    Beta strandi328 – 3303
    Beta strandi338 – 34710
    Beta strandi354 – 3563
    Helixi357 – 3604
    Beta strandi370 – 3723
    Beta strandi377 – 3837
    Turni384 – 3874
    Beta strandi388 – 3969

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DY0X-ray2.35A/B20-398[»]
    4DY7X-ray2.80C/F20-398[»]
    ProteinModelPortaliP07093.
    SMRiP07093. Positions 21-398.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000238519.
    HOVERGENiHBG106493.
    InParanoidiP07093.
    KOiK16643.
    OMAiIQVFNQI.
    OrthoDBiEOG7327PB.
    PhylomeDBiP07093.
    TreeFamiTF352620.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P07093-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNWHLPLFLL ASVTLPSICS HFNPLSLEEL GSNTGIQVFN QIVKSRPHDN    50
    IVISPHGIAS VLGMLQLGAD GRTKKQLAMV MRYGVNGVGK ILKKINKAIV 100
    SKKNKDIVTV ANAVFVKNAS EIEVPFVTRN KDVFQCEVRN VNFEDPASAC 150
    DSINAWVKNE TRDMIDNLLS PDLIDGVLTR LVLVNAVYFK GLWKSRFQPE 200
    NTKKRTFVAA DGKSYQVPML AQLSVFRCGS TSAPNDLWYN FIELPYHGES 250
    ISMLIALPTE SSTPLSAIIP HISTKTIDSW MSIMVPKRVQ VILPKFTAVA 300
    QTDLKEPLKV LGITDMFDSS KANFAKITTG SENLHVSHIL QKAKIEVSED 350
    GTKASAATTA ILIARSSPPW FIVDRPFLFF IRHNPTGAVL FMGQINKP 398
    Length:398
    Mass (Da):44,002
    Last modified:April 1, 1988 - v1
    Checksum:i2A165604E2CBE6B8
    GO
    Isoform 2 (identifier: P07093-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         329-330: TG → R

    Show »
    Length:397
    Mass (Da):44,000
    Checksum:i45A9C934A800D7EB
    GO
    Isoform 3 (identifier: P07093-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MSDCRSSLVEGTM
         329-330: TG → R

    Note: No experimental confirmation available.

    Show »
    Length:409
    Mass (Da):45,267
    Checksum:i6315691891B53A7B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti159 – 1591N → D in BAG35401. (PubMed:14702039)Curated
    Sequence conflicti261 – 2611S → E(PubMed:2877744)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti51 – 511I → M.
    Corresponds to variant rs3795875 [ dbSNP | Ensembl ].
    VAR_051955
    Natural varianti204 – 2041K → N in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036027

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MSDCRSSLVEGTM in isoform 3. 1 PublicationVSP_043668
    Alternative sequencei329 – 3302TG → R in isoform 2 and isoform 3. 3 PublicationsVSP_038367

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17783 mRNA. Translation: AAA35883.1.
    AK295564 mRNA. Translation: BAG58464.1.
    AK312499 mRNA. Translation: BAG35401.1.
    AC073641 Genomic DNA. Translation: AAY14926.1.
    CH471063 Genomic DNA. Translation: EAW70821.1.
    CH471063 Genomic DNA. Translation: EAW70823.1.
    BC015663 mRNA. Translation: AAH15663.1.
    BC042628 mRNA. Translation: AAH42628.1.
    CCDSiCCDS2460.1. [P07093-1]
    CCDS46525.1. [P07093-3]
    CCDS46526.1. [P07093-2]
    PIRiA37274.
    RefSeqiNP_001130000.1. NM_001136528.1. [P07093-2]
    NP_001130002.1. NM_001136530.1. [P07093-3]
    NP_006207.1. NM_006216.3. [P07093-1]
    XP_005246699.1. XM_005246642.1. [P07093-1]
    UniGeneiHs.38449.
    Hs.708453.

    Genome annotation databases

    EnsembliENST00000258405; ENSP00000258405; ENSG00000135919. [P07093-1]
    ENST00000409304; ENSP00000386412; ENSG00000135919. [P07093-2]
    ENST00000409840; ENSP00000386969; ENSG00000135919. [P07093-2]
    ENST00000447280; ENSP00000415786; ENSG00000135919. [P07093-3]
    GeneIDi5270.
    KEGGihsa:5270.
    UCSCiuc002vnu.2. human. [P07093-1]
    uc002vnv.2. human. [P07093-2]
    uc010zlr.1. human. [P07093-3]

    Polymorphism databases

    DMDMi121110.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17783 mRNA. Translation: AAA35883.1 .
    AK295564 mRNA. Translation: BAG58464.1 .
    AK312499 mRNA. Translation: BAG35401.1 .
    AC073641 Genomic DNA. Translation: AAY14926.1 .
    CH471063 Genomic DNA. Translation: EAW70821.1 .
    CH471063 Genomic DNA. Translation: EAW70823.1 .
    BC015663 mRNA. Translation: AAH15663.1 .
    BC042628 mRNA. Translation: AAH42628.1 .
    CCDSi CCDS2460.1. [P07093-1 ]
    CCDS46525.1. [P07093-3 ]
    CCDS46526.1. [P07093-2 ]
    PIRi A37274.
    RefSeqi NP_001130000.1. NM_001136528.1. [P07093-2 ]
    NP_001130002.1. NM_001136530.1. [P07093-3 ]
    NP_006207.1. NM_006216.3. [P07093-1 ]
    XP_005246699.1. XM_005246642.1. [P07093-1 ]
    UniGenei Hs.38449.
    Hs.708453.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DY0 X-ray 2.35 A/B 20-398 [» ]
    4DY7 X-ray 2.80 C/F 20-398 [» ]
    ProteinModelPortali P07093.
    SMRi P07093. Positions 21-398.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111288. 10 interactions.
    STRINGi 9606.ENSP00000415786.

    Protein family/group databases

    MEROPSi I04.021.

    PTM databases

    PhosphoSitei P07093.

    Polymorphism databases

    DMDMi 121110.

    Proteomic databases

    MaxQBi P07093.
    PaxDbi P07093.
    PeptideAtlasi P07093.
    PRIDEi P07093.

    Protocols and materials databases

    DNASUi 5270.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258405 ; ENSP00000258405 ; ENSG00000135919 . [P07093-1 ]
    ENST00000409304 ; ENSP00000386412 ; ENSG00000135919 . [P07093-2 ]
    ENST00000409840 ; ENSP00000386969 ; ENSG00000135919 . [P07093-2 ]
    ENST00000447280 ; ENSP00000415786 ; ENSG00000135919 . [P07093-3 ]
    GeneIDi 5270.
    KEGGi hsa:5270.
    UCSCi uc002vnu.2. human. [P07093-1 ]
    uc002vnv.2. human. [P07093-2 ]
    uc010zlr.1. human. [P07093-3 ]

    Organism-specific databases

    CTDi 5270.
    GeneCardsi GC02M224839.
    HGNCi HGNC:8951. SERPINE2.
    HPAi HPA051263.
    MIMi 177010. gene.
    neXtProti NX_P07093.
    PharmGKBi PA269.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000238519.
    HOVERGENi HBG106493.
    InParanoidi P07093.
    KOi K16643.
    OMAi IQVFNQI.
    OrthoDBi EOG7327PB.
    PhylomeDBi P07093.
    TreeFami TF352620.

    Enzyme and pathway databases

    Reactomei REACT_641. Dissolution of Fibrin Clot.

    Miscellaneous databases

    ChiTaRSi SERPINE2. human.
    GeneWikii SERPINE2.
    GenomeRNAii 5270.
    NextBioi 20360.
    PMAP-CutDB P07093.
    PROi P07093.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P07093.
    Bgeei P07093.
    CleanExi HS_SERPINE2.
    Genevestigatori P07093.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily."
      Sommer J., Gloor S.M., Rovelli G.F., Hofsteenge J., Nick H., Meier R., Monard D.
      Biochemistry 26:6407-6410(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins."
      Gloor S.M., Odink K., Guenther J., Nick H., Monard D.
      Cell 47:687-693(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Molecular cloning and expression of two forms of human protease nexin I."
      McGrogan M., Kennedy J., Li M.P., Hsu C., Scott R.W., Simonsen C.C., Baker J.B.
      Biotechnology (N.Y.) 6:172-177(1988)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Hippocampus and Thalamus.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Skin and Testis.
    8. "Protease nexin. Properties and a modified purification procedure."
      Scott R.W., Bergman B.L., Bajpai A., Hersh R.T., Rodriguez H., Jones B.N., Barreda C., Watts S., Baker J.B.
      J. Biol. Chem. 260:7029-7034(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-47, CHARACTERIZATION.
    9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 20-34.
    10. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-204.

    Entry informationi

    Entry nameiGDN_HUMAN
    AccessioniPrimary (citable) accession number: P07093
    Secondary accession number(s): B2R6A4
    , B4DIF2, Q53S15, Q5D0C4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 150 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3