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P07092 (GDN_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glia-derived nexin

Short name=GDN
Alternative name(s):
Peptidase inhibitor 7
Short name=PI-7
Protease nexin 1
Short name=PN-1
Protease nexin I
Serpin E2
Gene names
Name:Serpine2
Synonyms:Pi7, Pn1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. Ref.3

Subcellular location

Secretedextracellular space.

Sequence similarities

Belongs to the serpin family.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
   Cellular componentSecreted
   DomainSignal
   LigandHeparin-binding
   Molecular functionDevelopmental protein
Protease inhibitor
Serine protease inhibitor
   PTMGlycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processdense core granule biogenesis

Inferred from direct assay PubMed 16319172. Source: RGD

embryo implantation

Inferred from expression pattern PubMed 11457471. Source: RGD

negative regulation of blood coagulation

Inferred from direct assay PubMed 17379830. Source: BHF-UCL

negative regulation of endopeptidase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of proteolysis

Inferred from direct assay PubMed 17379830. Source: BHF-UCL

positive regulation of neuron projection development

Inferred from direct assay PubMed 19167525. Source: RGD

response to radiation

Inferred from expression pattern PubMed 8373421. Source: RGD

secretory granule organization

Inferred from direct assay PubMed 16319172. Source: RGD

   Cellular_componentextracellular space

Inferred from direct assay PubMed 16192390. Source: RGD

membrane

Inferred from direct assay PubMed 15281096. Source: RGD

neuronal cell body

Inferred from direct assay PubMed 9751132. Source: RGD

   Molecular_functionheparin binding

Inferred from direct assay PubMed 19167525. Source: RGD

serine-type endopeptidase inhibitor activity

Inferred from direct assay PubMed 19167525. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 397378Glia-derived nexin
PRO_0000032506

Sites

Site364 – 3652Reactive bond Potential

Amino acid modifications

Glycosylation1591N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P07092 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: 11EF0790C7297646

FASTA39744,063
        10         20         30         40         50         60 
MNWHFPFFIL TTVTLSSVYS QLNSLSLEEL GSDTGIQVFN QIIKSQPHEN VVISPHGIAS 

        70         80         90        100        110        120 
ILGMLQLGAD GRTKKQLSTV MRYNVNGVGK VLKKINKAIV SKKNKDIVTV ANAVFVRNGF 

       130        140        150        160        170        180 
KVEVPFAARN KEVFQCEVQS VNFQDPASAC DAINFWVKNE TRGMIDNLLS PNLIDSALTK 

       190        200        210        220        230        240 
LVLVNAVYFK GLWKSRFQPE NTKKRTFVAG DGKSYQVPML AQLSVFRSGS TKTPNGLWYN 

       250        260        270        280        290        300 
FIELPYHGES ISMLIALPTE SSTPLSAIIP HISTKTINSW MNTMVPKRMQ LVLPKFTALA 

       310        320        330        340        350        360 
QTDLKEPLKA LGITEMFEPS KANFAKITRS ESLHVSHILQ KAKIEVSEDG TKAAVVTTAI 

       370        380        390 
LIARSSPPWF IVDRPFLFCI RHNPTGAILF LGQVNKP 

« Hide

References

[1]"cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily."
Sommer J., Gloor S.M., Rovelli G.F., Hofsteenge J., Nick H., Meier R., Monard D.
Biochemistry 26:6407-6410(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization of the heparin-binding site of glia-derived nexin/protease nexin-1."
Rovelli G., Stone S.R., Guidolin A., Sommer J., Monard D.
Biochemistry 31:3542-3549(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 82-96; 165-178 AND 317-333, HEPARIN-BINDING.
[3]"Functional sites of glia-derived nexin (GDN): importance of the site reacting with the protease."
Nick H., Hofsteenge J., Shaw E., Rovelli G., Monard D.
Biochemistry 29:2417-2421(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 133-153 AND 347-397, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M17784 mRNA. Translation: AAA41209.1.
PIRB27496.
RefSeqNP_062070.1. NM_019197.1.
UniGeneRn.2271.

3D structure databases

ProteinModelPortalP07092.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid248020. 1 interaction.
IntActP07092. 1 interaction.

Protein family/group databases

MEROPSI04.021.

PTM databases

PhosphoSiteP07092.

Proteomic databases

PaxDbP07092.
PRIDEP07092.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29366.
KEGGrno:29366.
UCSCRGD:3748. rat.

Organism-specific databases

CTD5270.
RGD3748. Serpine2.

Phylogenomic databases

eggNOGCOG4826.
HOGENOMHOG000238519.
HOVERGENHBG106493.
InParanoidP07092.
KOK16643.
PhylomeDBP07092.

Gene expression databases

GenevestigatorP07092.

Family and domain databases

InterProIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio608908.
PROP07092.

Entry information

Entry nameGDN_RAT
AccessionPrimary (citable) accession number: P07092
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: April 16, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families