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Protein

Glia-derived nexin

Gene

Serpine2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei364 – 365Reactive bondSequence analysis2

GO - Molecular functioni

  • heparin binding Source: RGD
  • serine-type endopeptidase inhibitor activity Source: RGD

GO - Biological processi

  • dense core granule biogenesis Source: RGD
  • embryo implantation Source: RGD
  • negative regulation of blood coagulation Source: BHF-UCL
  • negative regulation of proteolysis Source: BHF-UCL
  • positive regulation of neuron projection development Source: RGD
  • response to radiation Source: RGD
  • secretory granule organization Source: RGD

Keywordsi

Molecular functionDevelopmental protein, Heparin-binding, Protease inhibitor, Serine protease inhibitor
Biological processDifferentiation, Neurogenesis

Protein family/group databases

MEROPSiI04.021

Names & Taxonomyi

Protein namesi
Recommended name:
Glia-derived nexin
Short name:
GDN
Alternative name(s):
Peptidase inhibitor 7
Short name:
PI-7
Protease nexin 1
Short name:
PN-1
Protease nexin I
Serpin E2
Gene namesi
Name:Serpine2
Synonyms:Pi7, Pn1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3748 Serpine2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000003250620 – 397Glia-derived nexinAdd BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP07092
PRIDEiP07092

PTM databases

PhosphoSitePlusiP07092

Interactioni

Protein-protein interaction databases

BioGridi248020, 1 interactor
IntActiP07092, 1 interactor
STRINGi10116.ENSRNOP00000020919

Structurei

3D structure databases

ProteinModelPortaliP07092
SMRiP07092
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
HOGENOMiHOG000238519
HOVERGENiHBG106493
InParanoidiP07092
KOiK16643
PhylomeDBiP07092

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWHFPFFIL TTVTLSSVYS QLNSLSLEEL GSDTGIQVFN QIIKSQPHEN
60 70 80 90 100
VVISPHGIAS ILGMLQLGAD GRTKKQLSTV MRYNVNGVGK VLKKINKAIV
110 120 130 140 150
SKKNKDIVTV ANAVFVRNGF KVEVPFAARN KEVFQCEVQS VNFQDPASAC
160 170 180 190 200
DAINFWVKNE TRGMIDNLLS PNLIDSALTK LVLVNAVYFK GLWKSRFQPE
210 220 230 240 250
NTKKRTFVAG DGKSYQVPML AQLSVFRSGS TKTPNGLWYN FIELPYHGES
260 270 280 290 300
ISMLIALPTE SSTPLSAIIP HISTKTINSW MNTMVPKRMQ LVLPKFTALA
310 320 330 340 350
QTDLKEPLKA LGITEMFEPS KANFAKITRS ESLHVSHILQ KAKIEVSEDG
360 370 380 390
TKAAVVTTAI LIARSSPPWF IVDRPFLFCI RHNPTGAILF LGQVNKP
Length:397
Mass (Da):44,063
Last modified:April 1, 1988 - v1
Checksum:i11EF0790C7297646
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17784 mRNA Translation: AAA41209.1
PIRiB27496
RefSeqiNP_062070.1, NM_019197.1
UniGeneiRn.2271

Genome annotation databases

GeneIDi29366
KEGGirno:29366
UCSCiRGD:3748 rat

Similar proteinsi

Entry informationi

Entry nameiGDN_RAT
AccessioniPrimary (citable) accession number: P07092
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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