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P07092

- GDN_RAT

UniProt

P07092 - GDN_RAT

Protein

Glia-derived nexin

Gene

Serpine2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Apr 1988)
      Previous versions | rss
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    Functioni

    Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei364 – 3652Reactive bondSequence Analysis

    GO - Molecular functioni

    1. heparin binding Source: RGD
    2. serine-type endopeptidase inhibitor activity Source: RGD

    GO - Biological processi

    1. dense core granule biogenesis Source: RGD
    2. embryo implantation Source: RGD
    3. negative regulation of blood coagulation Source: BHF-UCL
    4. negative regulation of endopeptidase activity Source: RefGenome
    5. negative regulation of proteolysis Source: BHF-UCL
    6. positive regulation of neuron projection development Source: RGD
    7. response to radiation Source: RGD
    8. secretory granule organization Source: RGD

    Keywords - Molecular functioni

    Developmental protein, Protease inhibitor, Serine protease inhibitor

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Keywords - Ligandi

    Heparin-binding

    Protein family/group databases

    MEROPSiI04.021.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glia-derived nexin
    Short name:
    GDN
    Alternative name(s):
    Peptidase inhibitor 7
    Short name:
    PI-7
    Protease nexin 1
    Short name:
    PN-1
    Protease nexin I
    Serpin E2
    Gene namesi
    Name:Serpine2
    Synonyms:Pi7, Pn1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3748. Serpine2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: RGD
    2. membrane Source: RGD
    3. neuronal cell body Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919By similarityAdd
    BLAST
    Chaini20 – 397378Glia-derived nexinPRO_0000032506Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP07092.
    PRIDEiP07092.

    PTM databases

    PhosphoSiteiP07092.

    Expressioni

    Gene expression databases

    GenevestigatoriP07092.

    Interactioni

    Protein-protein interaction databases

    BioGridi248020. 1 interaction.
    IntActiP07092. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP07092.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000238519.
    HOVERGENiHBG106493.
    InParanoidiP07092.
    KOiK16643.
    PhylomeDBiP07092.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P07092-1 [UniParc]FASTAAdd to Basket

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    MNWHFPFFIL TTVTLSSVYS QLNSLSLEEL GSDTGIQVFN QIIKSQPHEN    50
    VVISPHGIAS ILGMLQLGAD GRTKKQLSTV MRYNVNGVGK VLKKINKAIV 100
    SKKNKDIVTV ANAVFVRNGF KVEVPFAARN KEVFQCEVQS VNFQDPASAC 150
    DAINFWVKNE TRGMIDNLLS PNLIDSALTK LVLVNAVYFK GLWKSRFQPE 200
    NTKKRTFVAG DGKSYQVPML AQLSVFRSGS TKTPNGLWYN FIELPYHGES 250
    ISMLIALPTE SSTPLSAIIP HISTKTINSW MNTMVPKRMQ LVLPKFTALA 300
    QTDLKEPLKA LGITEMFEPS KANFAKITRS ESLHVSHILQ KAKIEVSEDG 350
    TKAAVVTTAI LIARSSPPWF IVDRPFLFCI RHNPTGAILF LGQVNKP 397
    Length:397
    Mass (Da):44,063
    Last modified:April 1, 1988 - v1
    Checksum:i11EF0790C7297646
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17784 mRNA. Translation: AAA41209.1.
    PIRiB27496.
    RefSeqiNP_062070.1. NM_019197.1.
    UniGeneiRn.2271.

    Genome annotation databases

    GeneIDi29366.
    KEGGirno:29366.
    UCSCiRGD:3748. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M17784 mRNA. Translation: AAA41209.1 .
    PIRi B27496.
    RefSeqi NP_062070.1. NM_019197.1.
    UniGenei Rn.2271.

    3D structure databases

    ProteinModelPortali P07092.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248020. 1 interaction.
    IntActi P07092. 1 interaction.

    Protein family/group databases

    MEROPSi I04.021.

    PTM databases

    PhosphoSitei P07092.

    Proteomic databases

    PaxDbi P07092.
    PRIDEi P07092.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29366.
    KEGGi rno:29366.
    UCSCi RGD:3748. rat.

    Organism-specific databases

    CTDi 5270.
    RGDi 3748. Serpine2.

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000238519.
    HOVERGENi HBG106493.
    InParanoidi P07092.
    KOi K16643.
    PhylomeDBi P07092.

    Miscellaneous databases

    NextBioi 608908.
    PROi P07092.

    Gene expression databases

    Genevestigatori P07092.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily."
      Sommer J., Gloor S.M., Rovelli G.F., Hofsteenge J., Nick H., Meier R., Monard D.
      Biochemistry 26:6407-6410(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterization of the heparin-binding site of glia-derived nexin/protease nexin-1."
      Rovelli G., Stone S.R., Guidolin A., Sommer J., Monard D.
      Biochemistry 31:3542-3549(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 82-96; 165-178 AND 317-333, HEPARIN-BINDING.
    3. "Functional sites of glia-derived nexin (GDN): importance of the site reacting with the protease."
      Nick H., Hofsteenge J., Shaw E., Rovelli G., Monard D.
      Biochemistry 29:2417-2421(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 133-153 AND 347-397, FUNCTION.

    Entry informationi

    Entry nameiGDN_RAT
    AccessioniPrimary (citable) accession number: P07092
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3