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Protein

Protein S100-A4

Gene

S100a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinityPROSITE-ProRule annotationAdd BLAST14
Calcium bindingi63 – 742; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: MGI
  • identical protein binding Source: IntAct
  • poly(A) RNA binding Source: MGI
  • RAGE receptor binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A4
Alternative name(s):
Metastasin
Metastatic cell protein
PEL98
Placental calcium-binding protein
Protein 18A2
Protein Mts1
S100 calcium-binding protein A4
Gene namesi
Name:S100a4
Synonyms:Capl, Mts1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1330282. S100a4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001439782 – 101Protein S100-A4Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei35N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP07091.
PaxDbiP07091.
PeptideAtlasiP07091.
PRIDEiP07091.

PTM databases

iPTMnetiP07091.
PhosphoSitePlusiP07091.

Expressioni

Tissue specificityi

Specifically expressed in different metastatic cells.

Inductioni

The mRNA coding for this protein increases in abundance after serum stimulation of quiescent mouse fibroblasts.

Gene expression databases

BgeeiENSMUSG00000001020.
CleanExiMM_S100A4.
ExpressionAtlasiP07091. baseline and differential.
GenevisibleiP07091. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-1544173,EBI-1544173
S100a1P565656EBI-1544173,EBI-1544186

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • RAGE receptor binding Source: MGI

Protein-protein interaction databases

BioGridi203053. 2 interactors.
IntActiP07091. 4 interactors.
MINTiMINT-4133552.
STRINGi10090.ENSMUSP00000001046.

Structurei

3D structure databases

ProteinModelPortaliP07091.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYVZ. Eukaryota.
ENOG4111DV3. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP07091.
OMAiFFEGCPD.
OrthoDBiEOG091G10JX.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P07091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPLEEALD VIVSTFHKYS GKEGDKFKLN KTELKELLTR ELPSFLGKRT
60 70 80 90 100
DEAAFQKVMS NLDSNRDNEV DFQEYCVFLS CIAMMCNEFF EGCPDKEPRK

K
Length:101
Mass (Da):11,721
Last modified:April 1, 1988 - v1
Checksum:i2302254B67A4C873
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47G → GVSGSXFNGQ in CAA34224 (PubMed:8423998).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05835 mRNA. Translation: CAA29282.1.
D00208 mRNA. Translation: BAA00148.1.
X16190 mRNA. Translation: CAA34316.1.
M36578 Genomic DNA. Translation: AAA39749.1.
M36579 Genomic DNA. Translation: AAA39750.1.
X16094 Genomic DNA. Translation: CAA34224.1.
CCDSiCCDS17538.1.
PIRiS06207.
RefSeqiNP_035441.1. NM_011311.2.
XP_006501240.1. XM_006501177.3.
XP_006501241.1. XM_006501178.2.
UniGeneiMm.3925.

Genome annotation databases

EnsembliENSMUST00000001046; ENSMUSP00000001046; ENSMUSG00000001020.
GeneIDi20198.
KEGGimmu:20198.
UCSCiuc008qcz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05835 mRNA. Translation: CAA29282.1.
D00208 mRNA. Translation: BAA00148.1.
X16190 mRNA. Translation: CAA34316.1.
M36578 Genomic DNA. Translation: AAA39749.1.
M36579 Genomic DNA. Translation: AAA39750.1.
X16094 Genomic DNA. Translation: CAA34224.1.
CCDSiCCDS17538.1.
PIRiS06207.
RefSeqiNP_035441.1. NM_011311.2.
XP_006501240.1. XM_006501177.3.
XP_006501241.1. XM_006501178.2.
UniGeneiMm.3925.

3D structure databases

ProteinModelPortaliP07091.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203053. 2 interactors.
IntActiP07091. 4 interactors.
MINTiMINT-4133552.
STRINGi10090.ENSMUSP00000001046.

PTM databases

iPTMnetiP07091.
PhosphoSitePlusiP07091.

Proteomic databases

EPDiP07091.
PaxDbiP07091.
PeptideAtlasiP07091.
PRIDEiP07091.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001046; ENSMUSP00000001046; ENSMUSG00000001020.
GeneIDi20198.
KEGGimmu:20198.
UCSCiuc008qcz.2. mouse.

Organism-specific databases

CTDi6275.
MGIiMGI:1330282. S100a4.

Phylogenomic databases

eggNOGiENOG410IYVZ. Eukaryota.
ENOG4111DV3. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP07091.
OMAiFFEGCPD.
OrthoDBiEOG091G10JX.
TreeFamiTF332727.

Miscellaneous databases

PROiP07091.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001020.
CleanExiMM_S100A4.
ExpressionAtlasiP07091. baseline and differential.
GenevisibleiP07091. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
PfamiPF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS10A4_MOUSE
AccessioniPrimary (citable) accession number: P07091
Secondary accession number(s): P20066
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.