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Protein

Plasma membrane ATPase

Gene

pma-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3784-aspartylphosphate intermediateBy similarity1
Metal bindingi634MagnesiumBy similarity1
Metal bindingi638MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHydrogen ion transport, Ion transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Protein family/group databases

TCDBi3.A.3.3.1 the p-type atpase (p-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane ATPase (EC:3.6.3.6)
Alternative name(s):
Proton pump
Gene namesi
Name:pma-1
ORF Names:B1D1.210, NCU01680
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 6, Linkage Group II

Organism-specific databases

EuPathDBiFungiDB:NCU01680

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 115CytoplasmicCuratedAdd BLAST115
Transmembranei116 – 138Helical; Name=1CuratedAdd BLAST23
Topological domaini139 – 140ExtracellularCurated2
Transmembranei141 – 160Helical; Name=2CuratedAdd BLAST20
Topological domaini161 – 291CytoplasmicCuratedAdd BLAST131
Transmembranei292 – 314Helical; Name=3CuratedAdd BLAST23
Topological domaini315 – 321ExtracellularCurated7
Transmembranei322 – 354Helical; Name=4CuratedAdd BLAST33
Topological domaini355 – 687CytoplasmicCuratedAdd BLAST333
Transmembranei688 – 713Helical; Name=5CuratedAdd BLAST26
Topological domaini714 – 720ExtracellularCurated7
Transmembranei721 – 738Helical; Name=6CuratedAdd BLAST18
Topological domaini739 – 754CytoplasmicCuratedAdd BLAST16
Transmembranei755 – 779Helical; Name=7CuratedAdd BLAST25
Topological domaini780 – 806ExtracellularCuratedAdd BLAST27
Transmembranei807 – 826Helical; Name=8CuratedAdd BLAST20
Transmembranei827 – 847Helical; Name=9CuratedAdd BLAST21
Topological domaini848 – 853ExtracellularCurated6
Transmembranei854 – 878Helical; Name=10CuratedAdd BLAST25
Topological domaini879 – 920CytoplasmicCuratedAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462681 – 920Plasma membrane ATPaseAdd BLAST920

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP07038

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MHSelectron microscopy8.00A/B1-920[»]
ProteinModelPortaliP07038
SMRiP07038
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07038

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000160005
InParanoidiP07038
KOiK01535
OrthoDBiEOG092C0HLD

Family and domain databases

CDDicd02076 P-type_ATPase_H, 1 hit
Gene3Di3.40.1110.101 hit
InterProiView protein in InterPro
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR006534 P-type_ATPase_IIIA
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01647 ATPase-IIIA_H, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

P07038-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADHSASGAP ALSTNIESGK FDEKAAEAAA YQPKPKVEDD EDEDIDALIE
60 70 80 90 100
DLESHDGHDA EEEEEEATPG GGRVVPEDML QTDTRVGLTS EEVVQRRRKY
110 120 130 140 150
GLNQMKEEKE NHFLKFLGFF VGPIQFVMEG AAVLAAGLED WVDFGVICGL
160 170 180 190 200
LLLNAVVGFV QEFQAGSIVD ELKKTLALKA VVLRDGTLKE IEAPEVVPGD
210 220 230 240 250
ILQVEEGTII PADGRIVTDD AFLQVDQSAL TGESLAVDKH KGDQVFASSA
260 270 280 290 300
VKRGEAFVVI TATGDNTFVG RAAALVNAAS GGSGHFTEVL NGIGTILLIL
310 320 330 340 350
VIFTLLIVWV SSFYRSNPIV QILEFTLAIT IIGVPVGLPA VVTTTMAVGA
360 370 380 390 400
AYLAKKKAIV QKLSAIESLA GVEILCSDKT GTLTKNKLSL HDPYTVAGVD
410 420 430 440 450
PEDLMLTACL AASRKKKGID AIDKAFLKSL KYYPRAKSVL SKYKVLQFHP
460 470 480 490 500
FDPVSKKVVA VVESPQGERI TCVKGAPLFV LKTVEEDHPI PEEVDQAYKN
510 520 530 540 550
KVAEFATRGF RSLGVARKRG EGSWEILGIM PCMDPPRHDT YKTVCEAKTL
560 570 580 590 600
GLSIKMLTGD AVGIARETSR QLGLGTNIYN AERLGLGGGG DMPGSEVYDF
610 620 630 640 650
VEAADGFAEV FPQHKYNVVE ILQQRGYLVA MTGDGVNDAP SLKKADTGIA
660 670 680 690 700
VEGSSDAARS AADIVFLAPG LGAIIDALKT SRQIFHRMYA YVVYRIALSI
710 720 730 740 750
HLEIFLGLWI AILNRSLNIE LVVFIAIFAD VATLAIAYDN APYSQTPVKW
760 770 780 790 800
NLPKLWGMSV LLGVVLAVGT WITVTTMYAQ GENGGIVQNF GNMDEVLFLQ
810 820 830 840 850
ISLTENWLIF ITRANGPFWS SIPSWQLSGA IFLVDILATC FTIWGWFEHS
860 870 880 890 900
DTSIVAVVRI WIFSFGIFCI MGGVYYILQD SVGFDNLMHG KSPKGNQKQR
910 920
SLEDFVVSLQ RVSTQHEKSQ
Length:920
Mass (Da):99,887
Last modified:April 1, 1988 - v1
Checksum:i2A8F035F26337CF7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8G → A in AAA33563 (PubMed:2876992).Curated1
Sequence conflicti801I → M in AAA33563 (PubMed:2876992).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14085 Genomic DNA Translation: AAA33561.1
J02602 Genomic DNA Translation: AAA33563.1
AL355927 Genomic DNA Translation: CAB91270.1
CM002237 Genomic DNA Translation: EAA27650.1
PIRiA26497 PXNCP
RefSeqiXP_956886.1, XM_951793.3

Genome annotation databases

EnsemblFungiiEAA27650; EAA27650; NCU01680
GeneIDi3873048
KEGGincr:NCU01680

Similar proteinsi

Entry informationi

Entry nameiPMA1_NEUCR
AccessioniPrimary (citable) accession number: P07038
Secondary accession number(s): Q7RV59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: March 28, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome