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Protein

Plasma membrane ATPase

Gene

pma-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3784-aspartylphosphate intermediateBy similarity1
Metal bindingi634MagnesiumBy similarity1
Metal bindingi638MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Protein family/group databases

TCDBi3.A.3.3.1. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane ATPase (EC:3.6.3.6)
Alternative name(s):
Proton pump
Gene namesi
Name:pma-1
ORF Names:B1D1.210, NCU01680
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 6, Linkage Group II

Organism-specific databases

EuPathDBiFungiDB:NCU01680.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 115CytoplasmicCuratedAdd BLAST115
Transmembranei116 – 138Helical; Name=1CuratedAdd BLAST23
Topological domaini139 – 140ExtracellularCurated2
Transmembranei141 – 160Helical; Name=2CuratedAdd BLAST20
Topological domaini161 – 291CytoplasmicCuratedAdd BLAST131
Transmembranei292 – 314Helical; Name=3CuratedAdd BLAST23
Topological domaini315 – 321ExtracellularCurated7
Transmembranei322 – 354Helical; Name=4CuratedAdd BLAST33
Topological domaini355 – 687CytoplasmicCuratedAdd BLAST333
Transmembranei688 – 713Helical; Name=5CuratedAdd BLAST26
Topological domaini714 – 720ExtracellularCurated7
Transmembranei721 – 738Helical; Name=6CuratedAdd BLAST18
Topological domaini739 – 754CytoplasmicCuratedAdd BLAST16
Transmembranei755 – 779Helical; Name=7CuratedAdd BLAST25
Topological domaini780 – 806ExtracellularCuratedAdd BLAST27
Transmembranei807 – 826Helical; Name=8CuratedAdd BLAST20
Transmembranei827 – 847Helical; Name=9CuratedAdd BLAST21
Topological domaini848 – 853ExtracellularCurated6
Transmembranei854 – 878Helical; Name=10CuratedAdd BLAST25
Topological domaini879 – 920CytoplasmicCuratedAdd BLAST42

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462681 – 920Plasma membrane ATPaseAdd BLAST920

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP07038.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MHSelectron microscopy8.00A/B1-920[»]
ProteinModelPortaliP07038.
SMRiP07038.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP07038.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000160005.
InParanoidiP07038.
KOiK01535.
OrthoDBiEOG092C0HLD.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006534. P-type_ATPase_IIIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07038-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADHSASGAP ALSTNIESGK FDEKAAEAAA YQPKPKVEDD EDEDIDALIE
60 70 80 90 100
DLESHDGHDA EEEEEEATPG GGRVVPEDML QTDTRVGLTS EEVVQRRRKY
110 120 130 140 150
GLNQMKEEKE NHFLKFLGFF VGPIQFVMEG AAVLAAGLED WVDFGVICGL
160 170 180 190 200
LLLNAVVGFV QEFQAGSIVD ELKKTLALKA VVLRDGTLKE IEAPEVVPGD
210 220 230 240 250
ILQVEEGTII PADGRIVTDD AFLQVDQSAL TGESLAVDKH KGDQVFASSA
260 270 280 290 300
VKRGEAFVVI TATGDNTFVG RAAALVNAAS GGSGHFTEVL NGIGTILLIL
310 320 330 340 350
VIFTLLIVWV SSFYRSNPIV QILEFTLAIT IIGVPVGLPA VVTTTMAVGA
360 370 380 390 400
AYLAKKKAIV QKLSAIESLA GVEILCSDKT GTLTKNKLSL HDPYTVAGVD
410 420 430 440 450
PEDLMLTACL AASRKKKGID AIDKAFLKSL KYYPRAKSVL SKYKVLQFHP
460 470 480 490 500
FDPVSKKVVA VVESPQGERI TCVKGAPLFV LKTVEEDHPI PEEVDQAYKN
510 520 530 540 550
KVAEFATRGF RSLGVARKRG EGSWEILGIM PCMDPPRHDT YKTVCEAKTL
560 570 580 590 600
GLSIKMLTGD AVGIARETSR QLGLGTNIYN AERLGLGGGG DMPGSEVYDF
610 620 630 640 650
VEAADGFAEV FPQHKYNVVE ILQQRGYLVA MTGDGVNDAP SLKKADTGIA
660 670 680 690 700
VEGSSDAARS AADIVFLAPG LGAIIDALKT SRQIFHRMYA YVVYRIALSI
710 720 730 740 750
HLEIFLGLWI AILNRSLNIE LVVFIAIFAD VATLAIAYDN APYSQTPVKW
760 770 780 790 800
NLPKLWGMSV LLGVVLAVGT WITVTTMYAQ GENGGIVQNF GNMDEVLFLQ
810 820 830 840 850
ISLTENWLIF ITRANGPFWS SIPSWQLSGA IFLVDILATC FTIWGWFEHS
860 870 880 890 900
DTSIVAVVRI WIFSFGIFCI MGGVYYILQD SVGFDNLMHG KSPKGNQKQR
910 920
SLEDFVVSLQ RVSTQHEKSQ
Length:920
Mass (Da):99,887
Last modified:April 1, 1988 - v1
Checksum:i2A8F035F26337CF7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8G → A in AAA33563 (PubMed:2876992).Curated1
Sequence conflicti801I → M in AAA33563 (PubMed:2876992).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14085 Genomic DNA. Translation: AAA33561.1.
J02602 Genomic DNA. Translation: AAA33563.1.
AL355927 Genomic DNA. Translation: CAB91270.1.
CM002237 Genomic DNA. Translation: EAA27650.1.
PIRiA26497. PXNCP.
RefSeqiXP_956886.1. XM_951793.3.

Genome annotation databases

EnsemblFungiiEAA27650; EAA27650; NCU01680.
GeneIDi3873048.
KEGGincr:NCU01680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14085 Genomic DNA. Translation: AAA33561.1.
J02602 Genomic DNA. Translation: AAA33563.1.
AL355927 Genomic DNA. Translation: CAB91270.1.
CM002237 Genomic DNA. Translation: EAA27650.1.
PIRiA26497. PXNCP.
RefSeqiXP_956886.1. XM_951793.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MHSelectron microscopy8.00A/B1-920[»]
ProteinModelPortaliP07038.
SMRiP07038.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi3.A.3.3.1. the p-type atpase (p-atpase) superfamily.

Proteomic databases

PRIDEiP07038.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAA27650; EAA27650; NCU01680.
GeneIDi3873048.
KEGGincr:NCU01680.

Organism-specific databases

EuPathDBiFungiDB:NCU01680.

Phylogenomic databases

HOGENOMiHOG000160005.
InParanoidiP07038.
KOiK01535.
OrthoDBiEOG092C0HLD.

Miscellaneous databases

EvolutionaryTraceiP07038.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006534. P-type_ATPase_IIIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPMA1_NEUCR
AccessioniPrimary (citable) accession number: P07038
Secondary accession number(s): Q7RV59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 2, 2016
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.