Reviewed, UniProtKB/Swiss-Prot P07036 (HBB_CHLME)

Names and origin

Protein names

Recommended name:
    Hemoglobin subunit beta
Alternative name(s):
    Hemoglobin beta chain
    Beta-globin

Gene names

Name:

HBB

Organism

Chloephaga melanoptera (Andean goose)

Taxonomic identifier

8860 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Anseriformes › Anatidae › Chloephaga

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in oxygen transport from the lung to the various peripheral tissues.
Subunit structure	Heterotetramer of two alpha chains and two beta chains.
Tissue specificity	Red blood cells.
Sequence similarities	Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxygen transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	hemoglobin complex Inferred from electronic annotation. Source: InterPro
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 146	146	Hemoglobin subunit beta		PRO_0000052926
Sites
	Metal binding	63	1	Iron (heme distal ligand)
	Metal binding	92	1	Iron (heme proximal ligand)

Sequences

	Sequence		Length	Mass (Da)
	P07036-1 [UniParc]. Last modified April 1, 1988. Version 1. Checksum: AF99FCB02188F26C	FASTA	146	16,295
	10 20 30 40 50 60 VHWTAEEKQL ITGLWGKVNV ADCGAEALAR LLIVYPWTQR FFASFGNLSS PTAISGNPMV 70 80 90 100 110 120 RAHGKKVLTS FGDAVKNLDN IKNTFSQLSE LHCDKLHVDP ENFRLLGDIL IIVLAAHFTK 130 140 DFTPDCQAAW QKLVRVVAHA LARKYH

References

[1]

"The primary structures of the major and minor hemoglobin-components of adult Andean goose (Chloephaga melanoptera, Anatidae): the mutation Leu-->Ser in position 55 of the beta-chains." Hiebl I., Braunitzer G., Schneeganss D. Biol. Chem. Hoppe-Seyler 368:1559-1569(1987) [PubMed: 3442599] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	HBGSA. S00569.
3D structure databases
SMR	P07036. Positions 1-146.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P07036.
Family and domain databases
InterPro	IPR012292. Globin. IPR009050. Globin-like. IPR000971. Globin_subset. IPR002337. Haemoglobin_b. [Graphical view]
Gene3D	G3DSA:1.10.490.10. Globin_related. 1 hit.
PANTHER	PTHR11442:SF7. Beta_haem. 1 hit.
Pfam	PF00042. Globin. 1 hit. [Graphical view]
PRINTS	PR00814. BETAHAEM.
PROSITE	PS01033. GLOBIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HBB_CHLME

Accession

Primary (citable) accession number: P07036

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	April 1, 1988
Last modified:	November 24, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)