P07032 (ACYP1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acylphosphatase-1
EC=3.6.1.7

Alternative name(s):
Acylphosphatase isozyme CH2
Acylphosphatase, organ-common type isozyme
Acylphosphate phosphohydrolase 1

Gene names

Name:

ACYP1

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	99 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Its physiological role is not yet clear.
Catalytic activity	An acylphosphate + H2O = a carboxylate + phosphate.
Tissue specificity	Organ-common type isozyme is found in many different tissues.
Sequence similarities	Belongs to the acylphosphatase family. Contains 1 acylphosphatase-like domain.

Ontologies

Keywords
Molecular function	Hydrolase
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Molecular function	acylphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 99	98	Acylphosphatase-1		PRO_0000158538
Regions
	Domain	9 – 99	91	Acylphosphatase-like
Sites
	Active site	24	1	Potential
	Active site	42	1	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P07032 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 8F6A3C0BF281AE75	FASTA	99	11,151
	10 20 30 40 50 60 MAGSEGLMSV DYEVSGRVQG VFFRKYTQSE AKRLGLVGWV RNTSHGTVQG QAQGPAARVR 70 80 90 ELQEWLRKIG SPQSRISRAE FTNEKEIAAL EHTDFQIRK

References

[1]	"The primary structure of chicken muscle acylphosphatase isozyme Ch2." Ohba Y., Minowa O., Mizuno Y., Shiokawa H. J. Biochem. 102:1221-1229(1987) [PubMed: 2830254] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-99. Tissue: Muscle.
+	Additional computationally mapped references.

Cross-references

Sequence databases
IPI	IPI00603087.
PIR	QPCH2. A41513.
RefSeq	NP_001161477.1. NM_001168005.1.
UniGene	Gga.4647.
3D structure databases
ProteinModelPortal	P07032.
SMR	P07032. Positions 2-99.
ModBase	Search...
Protein-protein interaction databases
STRING	P07032.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000016768; ENSGALP00000016749; ENSGALG00000010307.
GeneID	423361.
KEGG	gga:423361.
Organism-specific databases
CTD	97.
Phylogenomic databases
eggNOG	veNOG21224.
GeneTree	ENSGT00390000011103.
HOGENOM	HBG750266.
HOVERGEN	HBG050454.
InParanoid	P07032.
OrthoDB	EOG4XD3SN.
PhylomeDB	P07032.
Family and domain databases
InterPro	IPR020456. Acylphosphatase. IPR001792. Acylphosphatase-like. IPR017968. Acylphosphatase_CS. [Graphical view]
KO	K01512.
Pfam	PF00708. Acylphosphatase. 1 hit. [Graphical view]
PRINTS	PR00112. ACYLPHPHTASE.
SUPFAM	SSF54975. Acylphosphatase. 1 hit.
PROSITE	PS00150. ACYLPHOSPHATASE_1. 1 hit. PS00151. ACYLPHOSPHATASE_2. 1 hit. PS51160. ACYLPHOSPHATASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACYP1_CHICK

Accession

Primary (citable) accession number: P07032

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	January 23, 2007
Last modified:	November 16, 2011
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program