Reviewed,
UniProtKB/Swiss-Prot P07023 (TYRA_ECOLI)
Last modified
June 16, 2009.
Version 92.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: T-protein Including the following 2 domains: 1- Recommended name: Chorismate mutase Short name=CM EC=5.4.99.5 2- Recommended name: Prephenate dehydrogenase Short name=PDH EC=1.3.1.12 | ||||
| Gene names |
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| Organism | Escherichia coli (strain K12) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 83333 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 373 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | Chorismate = prephenate. Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH. |
| Pathway | Amino-acid biosynthesis; L-tyrosine biosynthesis; L-tyrosine from prephenate: step 1/2. Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1. |
| Subcellular location | |
| Sequence similarities | Contains 1 chorismate mutase domain. Contains 1 prephenate/arogenate dehydrogenase domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Aromatic amino acid biosynthesis Tyrosine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | NAD |
| Molecular function | Isomerase Oxidoreductase |
| Technical term | Complete proteome Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro chorismate mutase activityInferred from electronic annotation. Source: EC prephenate dehydrogenase (NADP+) activityInferred from electronic annotation. Source: InterPro prephenate dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| M10431 Genomic DNA. Translation: AAA24331.1. U00096 Genomic DNA. Translation: AAC75649.1. AP009048 Genomic DNA. Translation: BAA16485.2. | |
| PIR | KMECTD. A30274. |
| RefSeq | AP_003181.1. NP_417091.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:11059N. |
2-D gel databases | |
| ECO2DBASE | F037.9. 6TH EDITION. |
Genome annotation databases | |
| GeneID | 947115. |
| GenomeReviews | Gene locus JW2581 in contig AP009048_GR. Gene locus b2600 in contig U00096_GR. |
| KEGG | ecj:JW2581. eco:b2600. |
Organism-specific databases | |
| EchoBASE | EB1032. |
| EcoGene | EG11039. tyrA. |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P07023. |
| OMA | P07023. RTMRESY. |
Enzyme and pathway databases | |
| BioCyc | EcoCyc:CHORISMUTPREPHENDEHYDROG-MON. MetaCyc:CHORISMUTPREPHENDEHYDROG-MON. |
Family and domain databases | |
| InterPro | IPR008244. Chor_mut/prephenate_DH_T. IPR002701. Chorismate_mut. IPR011277. CM_T. IPR003099. Prephen_DH. [Graphical view] |
| PANTHER | PTHR21363. Prephen_DH. 1 hit. |
| Pfam | PF01817. CM_2. 1 hit. PF02153. PDH. 1 hit. [Graphical view] |
| PIRSF | PIRSF001499. Chor_mut_pdh_Tpr. 1 hit. |
| TIGRFAMs | TIGR01799. CM_T. 1 hit. |
| PROSITE | PS51168. CHORISMATE_MUT_2. 1 hit. PS51176. PDH_ADH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | TYRA_ECOLI | ||||||||
| Accession | Primary (citable) accession number: P07023 Secondary accession number(s): P78205, P78206 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Escherichia coli Escherichia coli (strain K12): entries and cross-references to EcoGene |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


