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P07023

- TYRA_ECOLI

UniProt

P07023 - TYRA_ECOLI

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Protein

T-protein

Gene

tyrA

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Chorismate = prephenate.
Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi

GO - Molecular functioni

  1. chorismate mutase activity Source: EcoCyc
  2. prephenate dehydrogenase (NADP+) activity Source: InterPro
  3. prephenate dehydrogenase activity Source: EcoCyc

GO - Biological processi

  1. chorismate metabolic process Source: InterPro
  2. L-phenylalanine biosynthetic process Source: EcoCyc
  3. tyrosine biosynthetic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciEcoCyc:CHORISMUTPREPHENDEHYDROG-MONOMER.
ECOL316407:JW2581-MONOMER.
MetaCyc:CHORISMUTPREPHENDEHYDROG-MONOMER.
SABIO-RKP07023.
UniPathwayiUPA00120; UER00203.
UPA00122; UER00961.

Names & Taxonomyi

Protein namesi
Recommended name:
T-protein
Including the following 2 domains:
Chorismate mutase (EC:5.4.99.5)
Short name:
CM
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:b2600, JW2581
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG11039. tyrA.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373T-proteinPRO_0000119195Add
BLAST

Proteomic databases

PaxDbiP07023.
PRIDEiP07023.

Expressioni

Gene expression databases

GenevestigatoriP07023.

Interactioni

Protein-protein interaction databases

DIPiDIP-11059N.
IntActiP07023. 1 interaction.
MINTiMINT-1255670.
STRINGi511145.b2600.

Structurei

3D structure databases

ProteinModelPortaliP07023.
SMRiP07023. Positions 5-88, 90-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9090Chorismate mutasePROSITE-ProRule annotationAdd
BLAST
Domaini99 – 361263Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 chorismate mutase domain.PROSITE-ProRule annotation
Contains 1 prephenate/arogenate dehydrogenase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0287.
HOGENOMiHOG000275725.
InParanoidiP07023.
KOiK14187.
OMAiQANDSRQ.
OrthoDBiEOG618R0Z.
PhylomeDBiP07023.

Family and domain databases

Gene3Di1.20.59.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR008244. Chor_mut/prephenate_DH_T.
IPR002701. Chorismate_mutase.
IPR020822. Chorismate_mutase_type_II.
IPR011277. CM_T.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamiPF01817. CM_2. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view]
PIRSFiPIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
SMARTiSM00830. CM_2. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF48600. SSF48600. 1 hit.
TIGRFAMsiTIGR01799. CM_T. 1 hit.
PROSITEiPS51168. CHORISMATE_MUT_2. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P07023-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVAELTALRD QIDEVDKALL NLLAKRLELV AEVGEVKSRF GLPIYVPERE
60 70 80 90 100
ASMLASRRAE AEALGVPPDL IEDVLRRVMR ESYSSENDKG FKTLCPSLRP
110 120 130 140 150
VVIVGGGGQM GRLFEKMLTL SGYQVRILEQ HDWDRAADIV ADAGMVIVSV
160 170 180 190 200
PIHVTEQVIG KLPPLPKDCI LVDLASVKNG PLQAMLVAHD GPVLGLHPMF
210 220 230 240 250
GPDSGSLAKQ VVVWCDGRKP EAYQWFLEQI QVWGARLHRI SAVEHDQNMA
260 270 280 290 300
FIQALRHFAT FAYGLHLAEE NVQLEQLLAL SSPIYRLELA MVGRLFAQDP
310 320 330 340 350
QLYADIIMSS ERNLALIKRY YKRFGEAIEL LEQGDKQAFI DSFRKVEHWF
360 370
GDYAQRFQSE SRVLLRQAND NRQ
Length:373
Mass (Da):42,043
Last modified:April 1, 1988 - v1
Checksum:i481D0A03DE2AC832
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M10431 Genomic DNA. Translation: AAA24331.1.
U00096 Genomic DNA. Translation: AAC75649.1.
AP009048 Genomic DNA. Translation: BAA16485.2.
PIRiA30274. KMECTD.
RefSeqiNP_417091.1. NC_000913.3.
YP_490823.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75649; AAC75649; b2600.
BAA16485; BAA16485; BAA16485.
GeneIDi12932244.
947115.
KEGGiecj:Y75_p2548.
eco:b2600.
PATRICi32120599. VBIEscCol129921_2698.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M10431 Genomic DNA. Translation: AAA24331.1 .
U00096 Genomic DNA. Translation: AAC75649.1 .
AP009048 Genomic DNA. Translation: BAA16485.2 .
PIRi A30274. KMECTD.
RefSeqi NP_417091.1. NC_000913.3.
YP_490823.1. NC_007779.1.

3D structure databases

ProteinModelPortali P07023.
SMRi P07023. Positions 5-88, 90-367.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-11059N.
IntActi P07023. 1 interaction.
MINTi MINT-1255670.
STRINGi 511145.b2600.

Proteomic databases

PaxDbi P07023.
PRIDEi P07023.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC75649 ; AAC75649 ; b2600 .
BAA16485 ; BAA16485 ; BAA16485 .
GeneIDi 12932244.
947115.
KEGGi ecj:Y75_p2548.
eco:b2600.
PATRICi 32120599. VBIEscCol129921_2698.

Organism-specific databases

EchoBASEi EB1032.
EcoGenei EG11039. tyrA.

Phylogenomic databases

eggNOGi COG0287.
HOGENOMi HOG000275725.
InParanoidi P07023.
KOi K14187.
OMAi QANDSRQ.
OrthoDBi EOG618R0Z.
PhylomeDBi P07023.

Enzyme and pathway databases

UniPathwayi UPA00120 ; UER00203 .
UPA00122 ; UER00961 .
BioCyci EcoCyc:CHORISMUTPREPHENDEHYDROG-MONOMER.
ECOL316407:JW2581-MONOMER.
MetaCyc:CHORISMUTPREPHENDEHYDROG-MONOMER.
SABIO-RK P07023.

Miscellaneous databases

PROi P07023.

Gene expression databases

Genevestigatori P07023.

Family and domain databases

Gene3Di 1.20.59.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR008244. Chor_mut/prephenate_DH_T.
IPR002701. Chorismate_mutase.
IPR020822. Chorismate_mutase_type_II.
IPR011277. CM_T.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view ]
Pfami PF01817. CM_2. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
SMARTi SM00830. CM_2. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
SSF48600. SSF48600. 1 hit.
TIGRFAMsi TIGR01799. CM_T. 1 hit.
PROSITEi PS51168. CHORISMATE_MUT_2. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and transcription of the phenylalanine and tyrosine operons of Escherichia coli K12."
    Hudson G.S., Davidson B.E.
    J. Mol. Biol. 180:1023-1051(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
    Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
    , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
    DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Escherichia coli proteome analysis using the gene-protein database."
    VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R., Neidhardt F.C.
    Electrophoresis 18:1243-1251(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY 2D-GEL.

Entry informationi

Entry nameiTYRA_ECOLI
AccessioniPrimary (citable) accession number: P07023
Secondary accession number(s): P78205, P78206
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: October 29, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3