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Protein

T-protein

Gene

tyrA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Chorismate = prephenate.
Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi: L-tyrosine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route).
Proteins known to be involved in this subpathway in this organism are:
  1. T-protein (tyrA)
This subpathway is part of the pathway L-tyrosine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route), the pathway L-tyrosine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: prephenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes prephenate from chorismate.
Proteins known to be involved in this subpathway in this organism are:
  1. P-protein (pheA), T-protein (tyrA)
This subpathway is part of the pathway prephenate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes prephenate from chorismate, the pathway prephenate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

  • chorismate mutase activity Source: EcoCyc
  • NAD+ binding Source: GO_Central
  • prephenate dehydrogenase (NAD+) activity Source: EcoCyc
  • prephenate dehydrogenase (NADP+) activity Source: InterPro

GO - Biological processi

  • chorismate metabolic process Source: InterPro
  • L-phenylalanine biosynthetic process Source: EcoCyc
  • tyrosine biosynthetic process Source: EcoCyc

Keywordsi

Molecular functionIsomerase, Multifunctional enzyme, Oxidoreductase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis
LigandNAD

Enzyme and pathway databases

BioCyciEcoCyc:CHORISMUTPREPHENDEHYDROG-MONOMER
MetaCyc:CHORISMUTPREPHENDEHYDROG-MONOMER
SABIO-RKP07023
UniPathwayiUPA00120; UER00203
UPA00122; UER00961

Names & Taxonomyi

Protein namesi
Recommended name:
T-protein
Including the following 2 domains:
Chorismate mutase (EC:5.4.99.5)
Short name:
CM
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:b2600, JW2581
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11039 tyrA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191951 – 373T-proteinAdd BLAST373

Proteomic databases

PaxDbiP07023
PRIDEiP07023

Interactioni

Protein-protein interaction databases

BioGridi4261238, 17 interactors
DIPiDIP-11059N
IntActiP07023, 1 interactor
STRINGi316385.ECDH10B_2767

Structurei

3D structure databases

ProteinModelPortaliP07023
SMRiP07023
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 90Chorismate mutasePROSITE-ProRule annotationAdd BLAST90
Domaini99 – 361Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd BLAST263

Sequence similaritiesi

In the C-terminal section; belongs to the prephenate/arogenate dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4105EHE Bacteria
COG0287 LUCA
COG1605 LUCA
HOGENOMiHOG000275725
InParanoidiP07023
KOiK14187
OMAiQIQIWGA
PhylomeDBiP07023

Family and domain databases

Gene3Di1.20.59.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR008244 Chor_mut/prephenate_DH_T
IPR036263 Chorismate_II_sf
IPR036979 CM_dom_sf
IPR002701 CM_II_prokaryot
IPR011277 CM_T
IPR036291 NAD(P)-bd_dom_sf
IPR003099 Prephen_DH
PfamiView protein in Pfam
PF01817 CM_2, 1 hit
PF02153 PDH, 1 hit
PIRSFiPIRSF001499 Chor_mut_pdh_Tpr, 1 hit
SMARTiView protein in SMART
SM00830 CM_2, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF48600 SSF48600, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01799 CM_T, 1 hit
PROSITEiView protein in PROSITE
PS51168 CHORISMATE_MUT_2, 1 hit
PS51176 PDH_ADH, 1 hit

Sequencei

Sequence statusi: Complete.

P07023-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAELTALRD QIDEVDKALL NLLAKRLELV AEVGEVKSRF GLPIYVPERE
60 70 80 90 100
ASMLASRRAE AEALGVPPDL IEDVLRRVMR ESYSSENDKG FKTLCPSLRP
110 120 130 140 150
VVIVGGGGQM GRLFEKMLTL SGYQVRILEQ HDWDRAADIV ADAGMVIVSV
160 170 180 190 200
PIHVTEQVIG KLPPLPKDCI LVDLASVKNG PLQAMLVAHD GPVLGLHPMF
210 220 230 240 250
GPDSGSLAKQ VVVWCDGRKP EAYQWFLEQI QVWGARLHRI SAVEHDQNMA
260 270 280 290 300
FIQALRHFAT FAYGLHLAEE NVQLEQLLAL SSPIYRLELA MVGRLFAQDP
310 320 330 340 350
QLYADIIMSS ERNLALIKRY YKRFGEAIEL LEQGDKQAFI DSFRKVEHWF
360 370
GDYAQRFQSE SRVLLRQAND NRQ
Length:373
Mass (Da):42,043
Last modified:April 1, 1988 - v1
Checksum:i481D0A03DE2AC832
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10431 Genomic DNA Translation: AAA24331.1
U00096 Genomic DNA Translation: AAC75649.1
AP009048 Genomic DNA Translation: BAA16485.2
PIRiA30274 KMECTD
RefSeqiNP_417091.1, NC_000913.3
WP_000225229.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75649; AAC75649; b2600
BAA16485; BAA16485; BAA16485
GeneIDi947115
KEGGiecj:JW2581
eco:b2600
PATRICifig|1411691.4.peg.4139

Similar proteinsi

Entry informationi

Entry nameiTYRA_ECOLI
AccessioniPrimary (citable) accession number: P07023
Secondary accession number(s): P78205, P78206
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: March 28, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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