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P07023

- TYRA_ECOLI

UniProt

P07023 - TYRA_ECOLI

Protein

T-protein

Gene

tyrA

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 Apr 1988)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Chorismate = prephenate.
    Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

    Pathwayi

    GO - Molecular functioni

    1. chorismate mutase activity Source: EcoCyc
    2. prephenate dehydrogenase (NADP+) activity Source: InterPro
    3. prephenate dehydrogenase activity Source: EcoCyc

    GO - Biological processi

    1. chorismate metabolic process Source: InterPro
    2. L-phenylalanine biosynthetic process Source: EcoCyc
    3. tyrosine biosynthetic process Source: EcoCyc

    Keywords - Molecular functioni

    Isomerase, Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciEcoCyc:CHORISMUTPREPHENDEHYDROG-MONOMER.
    ECOL316407:JW2581-MONOMER.
    MetaCyc:CHORISMUTPREPHENDEHYDROG-MONOMER.
    SABIO-RKP07023.
    UniPathwayiUPA00120; UER00203.
    UPA00122; UER00961.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-protein
    Including the following 2 domains:
    Chorismate mutase (EC:5.4.99.5)
    Short name:
    CM
    Prephenate dehydrogenase (EC:1.3.1.12)
    Short name:
    PDH
    Gene namesi
    Name:tyrA
    Ordered Locus Names:b2600, JW2581
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG11039. tyrA.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 373373T-proteinPRO_0000119195Add
    BLAST

    Proteomic databases

    PaxDbiP07023.
    PRIDEiP07023.

    Expressioni

    Gene expression databases

    GenevestigatoriP07023.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-11059N.
    IntActiP07023. 1 interaction.
    MINTiMINT-1255670.
    STRINGi511145.b2600.

    Structurei

    3D structure databases

    ProteinModelPortaliP07023.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 9090Chorismate mutasePROSITE-ProRule annotationAdd
    BLAST
    Domaini99 – 361263Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 chorismate mutase domain.PROSITE-ProRule annotation
    Contains 1 prephenate/arogenate dehydrogenase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0287.
    HOGENOMiHOG000275725.
    KOiK14187.
    OMAiQANDSRQ.
    OrthoDBiEOG618R0Z.
    PhylomeDBiP07023.

    Family and domain databases

    Gene3Di1.20.59.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR008244. Chor_mut/prephenate_DH_T.
    IPR002701. Chorismate_mutase.
    IPR020822. Chorismate_mutase_type_II.
    IPR011277. CM_T.
    IPR016040. NAD(P)-bd_dom.
    IPR003099. Prephen_DH.
    [Graphical view]
    PfamiPF01817. CM_2. 1 hit.
    PF02153. PDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
    SMARTiSM00830. CM_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    SSF48600. SSF48600. 1 hit.
    TIGRFAMsiTIGR01799. CM_T. 1 hit.
    PROSITEiPS51168. CHORISMATE_MUT_2. 1 hit.
    PS51176. PDH_ADH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P07023-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVAELTALRD QIDEVDKALL NLLAKRLELV AEVGEVKSRF GLPIYVPERE    50
    ASMLASRRAE AEALGVPPDL IEDVLRRVMR ESYSSENDKG FKTLCPSLRP 100
    VVIVGGGGQM GRLFEKMLTL SGYQVRILEQ HDWDRAADIV ADAGMVIVSV 150
    PIHVTEQVIG KLPPLPKDCI LVDLASVKNG PLQAMLVAHD GPVLGLHPMF 200
    GPDSGSLAKQ VVVWCDGRKP EAYQWFLEQI QVWGARLHRI SAVEHDQNMA 250
    FIQALRHFAT FAYGLHLAEE NVQLEQLLAL SSPIYRLELA MVGRLFAQDP 300
    QLYADIIMSS ERNLALIKRY YKRFGEAIEL LEQGDKQAFI DSFRKVEHWF 350
    GDYAQRFQSE SRVLLRQAND NRQ 373
    Length:373
    Mass (Da):42,043
    Last modified:April 1, 1988 - v1
    Checksum:i481D0A03DE2AC832
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M10431 Genomic DNA. Translation: AAA24331.1.
    U00096 Genomic DNA. Translation: AAC75649.1.
    AP009048 Genomic DNA. Translation: BAA16485.2.
    PIRiA30274. KMECTD.
    RefSeqiNP_417091.1. NC_000913.3.
    YP_490823.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC75649; AAC75649; b2600.
    BAA16485; BAA16485; BAA16485.
    GeneIDi12932244.
    947115.
    KEGGiecj:Y75_p2548.
    eco:b2600.
    PATRICi32120599. VBIEscCol129921_2698.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M10431 Genomic DNA. Translation: AAA24331.1 .
    U00096 Genomic DNA. Translation: AAC75649.1 .
    AP009048 Genomic DNA. Translation: BAA16485.2 .
    PIRi A30274. KMECTD.
    RefSeqi NP_417091.1. NC_000913.3.
    YP_490823.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P07023.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-11059N.
    IntActi P07023. 1 interaction.
    MINTi MINT-1255670.
    STRINGi 511145.b2600.

    Proteomic databases

    PaxDbi P07023.
    PRIDEi P07023.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC75649 ; AAC75649 ; b2600 .
    BAA16485 ; BAA16485 ; BAA16485 .
    GeneIDi 12932244.
    947115.
    KEGGi ecj:Y75_p2548.
    eco:b2600.
    PATRICi 32120599. VBIEscCol129921_2698.

    Organism-specific databases

    EchoBASEi EB1032.
    EcoGenei EG11039. tyrA.

    Phylogenomic databases

    eggNOGi COG0287.
    HOGENOMi HOG000275725.
    KOi K14187.
    OMAi QANDSRQ.
    OrthoDBi EOG618R0Z.
    PhylomeDBi P07023.

    Enzyme and pathway databases

    UniPathwayi UPA00120 ; UER00203 .
    UPA00122 ; UER00961 .
    BioCyci EcoCyc:CHORISMUTPREPHENDEHYDROG-MONOMER.
    ECOL316407:JW2581-MONOMER.
    MetaCyc:CHORISMUTPREPHENDEHYDROG-MONOMER.
    SABIO-RK P07023.

    Miscellaneous databases

    PROi P07023.

    Gene expression databases

    Genevestigatori P07023.

    Family and domain databases

    Gene3Di 1.20.59.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR008244. Chor_mut/prephenate_DH_T.
    IPR002701. Chorismate_mutase.
    IPR020822. Chorismate_mutase_type_II.
    IPR011277. CM_T.
    IPR016040. NAD(P)-bd_dom.
    IPR003099. Prephen_DH.
    [Graphical view ]
    Pfami PF01817. CM_2. 1 hit.
    PF02153. PDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
    SMARTi SM00830. CM_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    SSF48600. SSF48600. 1 hit.
    TIGRFAMsi TIGR01799. CM_T. 1 hit.
    PROSITEi PS51168. CHORISMATE_MUT_2. 1 hit.
    PS51176. PDH_ADH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence and transcription of the phenylalanine and tyrosine operons of Escherichia coli K12."
      Hudson G.S., Davidson B.E.
      J. Mol. Biol. 180:1023-1051(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: K12.
    2. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
      Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
      , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
      DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    5. "Escherichia coli proteome analysis using the gene-protein database."
      VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R., Neidhardt F.C.
      Electrophoresis 18:1243-1251(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY 2D-GEL.

    Entry informationi

    Entry nameiTYRA_ECOLI
    AccessioniPrimary (citable) accession number: P07023
    Secondary accession number(s): P78205, P78206
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1988
    Last sequence update: April 1, 1988
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3