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P07023 (TYRA_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 137. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-protein

Including the following 2 domains:

  1. Chorismate mutase
    Short name=CM
    EC=5.4.99.5
  2. Prephenate dehydrogenase
    Short name=PDH
    EC=1.3.1.12
Gene names
Name:tyrA
Ordered Locus Names:b2600, JW2581
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 373373T-protein
PRO_0000119195

Regions

Domain1 – 9090Chorismate mutase
Domain99 – 361263Prephenate/arogenate dehydrogenase

Sequences

Sequence LengthMass (Da)Tools
P07023 [UniParc].

Last modified April 1, 1988. Version 1.
Checksum: 481D0A03DE2AC832

FASTA37342,043
        10         20         30         40         50         60 
MVAELTALRD QIDEVDKALL NLLAKRLELV AEVGEVKSRF GLPIYVPERE ASMLASRRAE 

        70         80         90        100        110        120 
AEALGVPPDL IEDVLRRVMR ESYSSENDKG FKTLCPSLRP VVIVGGGGQM GRLFEKMLTL 

       130        140        150        160        170        180 
SGYQVRILEQ HDWDRAADIV ADAGMVIVSV PIHVTEQVIG KLPPLPKDCI LVDLASVKNG 

       190        200        210        220        230        240 
PLQAMLVAHD GPVLGLHPMF GPDSGSLAKQ VVVWCDGRKP EAYQWFLEQI QVWGARLHRI 

       250        260        270        280        290        300 
SAVEHDQNMA FIQALRHFAT FAYGLHLAEE NVQLEQLLAL SSPIYRLELA MVGRLFAQDP 

       310        320        330        340        350        360 
QLYADIIMSS ERNLALIKRY YKRFGEAIEL LEQGDKQAFI DSFRKVEHWF GDYAQRFQSE 

       370 
SRVLLRQAND NRQ 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence and transcription of the phenylalanine and tyrosine operons of Escherichia coli K12."
Hudson G.S., Davidson B.E.
J. Mol. Biol. 180:1023-1051(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12.
[2]"Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T. expand/collapse author list , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]"Escherichia coli proteome analysis using the gene-protein database."
VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R., Neidhardt F.C.
Electrophoresis 18:1243-1251(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY 2D-GEL.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M10431 Genomic DNA. Translation: AAA24331.1.
U00096 Genomic DNA. Translation: AAC75649.1.
AP009048 Genomic DNA. Translation: BAA16485.2.
PIRKMECTD. A30274.
RefSeqNP_417091.1. NC_000913.3.
YP_490823.1. NC_007779.1.

3D structure databases

ProteinModelPortalP07023.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-11059N.
IntActP07023. 1 interaction.
MINTMINT-1255670.
STRING511145.b2600.

Proteomic databases

PaxDbP07023.
PRIDEP07023.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC75649; AAC75649; b2600.
BAA16485; BAA16485; BAA16485.
GeneID12932244.
947115.
KEGGecj:Y75_p2548.
eco:b2600.
PATRIC32120599. VBIEscCol129921_2698.

Organism-specific databases

EchoBASEEB1032.
EcoGeneEG11039. tyrA.

Phylogenomic databases

eggNOGCOG0287.
HOGENOMHOG000275725.
KOK14187.
OMAQANDSRQ.
OrthoDBEOG618R0Z.
PhylomeDBP07023.

Enzyme and pathway databases

BioCycEcoCyc:CHORISMUTPREPHENDEHYDROG-MONOMER.
ECOL316407:JW2581-MONOMER.
MetaCyc:CHORISMUTPREPHENDEHYDROG-MONOMER.
SABIO-RKP07023.
UniPathwayUPA00120; UER00203.
UPA00122; UER00961.

Gene expression databases

GenevestigatorP07023.

Family and domain databases

Gene3D1.20.59.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR008244. Chor_mut/prephenate_DH_T.
IPR002701. Chorismate_mutase.
IPR020822. Chorismate_mutase_type_II.
IPR011277. CM_T.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamPF01817. CM_2. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view]
PIRSFPIRSF001499. Chor_mut_pdh_Tpr. 1 hit.
SMARTSM00830. CM_2. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
SSF48600. SSF48600. 1 hit.
TIGRFAMsTIGR01799. CM_T. 1 hit.
PROSITEPS51168. CHORISMATE_MUT_2. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP07023.

Entry information

Entry nameTYRA_ECOLI
AccessionPrimary (citable) accession number: P07023
Secondary accession number(s): P78205, P78206
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: June 11, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene