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P07000

- PLDB_ECOLI

UniProt

P07000 - PLDB_ECOLI

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Protein

Lysophospholipase L2

Gene
pldB, b3825, JW5584
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: EcoliWiki
  2. protein binding Source: IntAct

GO - Biological processi

  1. lipid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:EG10739-MONOMER.
ECOL316407:JW5584-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase L2 (EC:3.1.1.5)
Alternative name(s):
Lecithinase B
Gene namesi
Name:pldB
Ordered Locus Names:b3825, JW5584
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG10739. pldB.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: EcoliWiki
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Lysophospholipase L2PRO_0000058456Add
BLAST

Proteomic databases

PaxDbiP07000.
PRIDEiP07000.

Expressioni

Gene expression databases

GenevestigatoriP07000.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
mqsAQ468642EBI-9134416,EBI-1120353

Protein-protein interaction databases

IntActiP07000. 11 interactions.
STRINGi511145.b3825.

Structurei

3D structure databases

ProteinModelPortaliP07000.
SMRiP07000. Positions 56-307.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2267.
HOGENOMiHOG000285163.
KOiK01048.
OMAiYHWVREG.
OrthoDBiEOG6CCH34.
PhylomeDBiP07000.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

P07000-1 [UniParc]FASTAAdd to Basket

« Hide

MFQQQKDWET RENAFAAFTM GPLTDFWRQR DEAEFTGVDD IPVRFVRFRA    50
QHHDRVVVIC PGRIESYVKY AELAYDLFHL GFDVLIIDHR GQGRSGRLLA 100
DPHLGHVNRF NDYVDDLAAF WQQEVQPGPW RKRYILAHSM GGAISTLFLQ 150
RHPGVCDAIA LTAPMFGIVI RMPSFMARQI LNWAEAHPRF RDGYAIGTGR 200
WRALPFAINV LTHSRQRYRR NLRFYADDPT IRVGGPTYHW VRESILAGEQ 250
VLAGAGDDAT PTLLLQAEEE RVVDNRMHDR FCELRTAAGH PVEGGRPLVI 300
KGAYHEILFE KDAMRSVALH AIVDFFNRHN SPSGNRSTEV 340
Length:340
Mass (Da):38,978
Last modified:October 11, 2004 - v4
Checksum:iA032DB05FD203C05
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti164 – 1641P → A in AAA67621. 1 Publication
Sequence conflicti315 – 3151R → A in AAA67621. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X03155 Genomic DNA. Translation: CAA26932.1.
M87049 Genomic DNA. Translation: AAA67621.1.
U00096 Genomic DNA. Translation: AAT48224.1.
AP009048 Genomic DNA. Translation: BAE77476.1.
PIRiB65187. PSECL2.
RefSeqiYP_026266.1. NC_000913.3.
YP_491617.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAT48224; AAT48224; b3825.
BAE77476; BAE77476; BAE77476.
GeneIDi12933622.
948314.
KEGGiecj:Y75_p3353.
eco:b3825.
PATRICi32123151. VBIEscCol129921_3941.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X03155 Genomic DNA. Translation: CAA26932.1 .
M87049 Genomic DNA. Translation: AAA67621.1 .
U00096 Genomic DNA. Translation: AAT48224.1 .
AP009048 Genomic DNA. Translation: BAE77476.1 .
PIRi B65187. PSECL2.
RefSeqi YP_026266.1. NC_000913.3.
YP_491617.1. NC_007779.1.

3D structure databases

ProteinModelPortali P07000.
SMRi P07000. Positions 56-307.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P07000. 11 interactions.
STRINGi 511145.b3825.

Proteomic databases

PaxDbi P07000.
PRIDEi P07000.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAT48224 ; AAT48224 ; b3825 .
BAE77476 ; BAE77476 ; BAE77476 .
GeneIDi 12933622.
948314.
KEGGi ecj:Y75_p3353.
eco:b3825.
PATRICi 32123151. VBIEscCol129921_3941.

Organism-specific databases

EchoBASEi EB0732.
EcoGenei EG10739. pldB.

Phylogenomic databases

eggNOGi COG2267.
HOGENOMi HOG000285163.
KOi K01048.
OMAi YHWVREG.
OrthoDBi EOG6CCH34.
PhylomeDBi P07000.

Enzyme and pathway databases

BioCyci EcoCyc:EG10739-MONOMER.
ECOL316407:JW5584-MONOMER.

Miscellaneous databases

PROi P07000.

Gene expression databases

Genevestigatori P07000.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view ]
Pfami PF00561. Abhydrolase_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the pldB gene and characteristics of deduced amino acid sequence of lysophospholipase L2 in Escherichia coli."
    Kobayashi T., Kudo I., Karasawa K., Mizushima H., Inoue K., Nojima S.
    J. Biochem. 98:1017-1025(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12 / KL16-99.
  2. "Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes."
    Daniels D.L., Plunkett G. III, Burland V.D., Blattner F.R.
    Science 257:771-778(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION TO 164.
    Strain: K12 / MG1655 / ATCC 47076.
  4. Cited for: SEQUENCE REVISION TO 315.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiPLDB_ECOLI
AccessioniPrimary (citable) accession number: P07000
Secondary accession number(s): P78127, Q2M8D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 120 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

In addition this protein catalyzes a transacylation reaction to produce acyl phosphatidylglycerol by transfer of the acidyl residue of 2-acyl lysophospholipid to phosphatidylglycerol.
Lysophospholipases from various sources vary widely in molecular weight, substrate specificity, and subcellular localization.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

External Data

Dasty 3

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