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Protein

Lysophospholipase L2

Gene

pldB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

In addition this protein catalyzes a transacylation reaction to produce acyl phosphatidylglycerol by transfer of the acidyl residue of 2-acyl lysophospholipid to phosphatidylglycerol.
Lysophospholipases from various sources vary widely in molecular weight, substrate specificity, and subcellular localization.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  • lysophospholipase activity Source: EcoCyc
  • transferase activity, transferring acyl groups other than amino-acyl groups Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:EG10739-MONOMER.
MetaCyc:EG10739-MONOMER.

Protein family/group databases

ESTHERiecoli-pldb. Monoglyceridelipase_lysophospholip.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase L2 (EC:3.1.1.5)
Alternative name(s):
Lecithinase B
Gene namesi
Name:pldB
Ordered Locus Names:b3825, JW5584
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10739. pldB.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: EcoliWiki
  • plasma membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584561 – 340Lysophospholipase L2Add BLAST340

Proteomic databases

PaxDbiP07000.
PRIDEiP07000.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
mqsAQ468642EBI-9134416,EBI-1120353

Protein-protein interaction databases

BioGridi4262616. 216 interactors.
IntActiP07000. 11 interactors.
STRINGi316385.ECDH10B_4016.

Structurei

3D structure databases

ProteinModelPortaliP07000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4108EUD. Bacteria.
COG2267. LUCA.
HOGENOMiHOG000285163.
InParanoidiP07000.
KOiK01048.
PhylomeDBiP07000.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR022742. Hydrolase_4.
PfamiView protein in Pfam
PF12146. Hydrolase_4. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

P07000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQQQKDWET RENAFAAFTM GPLTDFWRQR DEAEFTGVDD IPVRFVRFRA
60 70 80 90 100
QHHDRVVVIC PGRIESYVKY AELAYDLFHL GFDVLIIDHR GQGRSGRLLA
110 120 130 140 150
DPHLGHVNRF NDYVDDLAAF WQQEVQPGPW RKRYILAHSM GGAISTLFLQ
160 170 180 190 200
RHPGVCDAIA LTAPMFGIVI RMPSFMARQI LNWAEAHPRF RDGYAIGTGR
210 220 230 240 250
WRALPFAINV LTHSRQRYRR NLRFYADDPT IRVGGPTYHW VRESILAGEQ
260 270 280 290 300
VLAGAGDDAT PTLLLQAEEE RVVDNRMHDR FCELRTAAGH PVEGGRPLVI
310 320 330 340
KGAYHEILFE KDAMRSVALH AIVDFFNRHN SPSGNRSTEV
Length:340
Mass (Da):38,978
Last modified:October 11, 2004 - v4
Checksum:iA032DB05FD203C05
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti164P → A in AAA67621 (PubMed:1379743).Curated1
Sequence conflicti315R → A in AAA67621 (PubMed:1379743).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03155 Genomic DNA. Translation: CAA26932.1.
M87049 Genomic DNA. Translation: AAA67621.1.
U00096 Genomic DNA. Translation: AAT48224.1.
AP009048 Genomic DNA. Translation: BAE77476.1.
PIRiB65187. PSECL2.
RefSeqiWP_000487654.1. NZ_LN832404.1.
YP_026266.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48224; AAT48224; b3825.
BAE77476; BAE77476; BAE77476.
GeneIDi948314.
KEGGiecj:JW5584.
eco:b3825.
PATRICifig|1411691.4.peg.2882.

Similar proteinsi

Entry informationi

Entry nameiPLDB_ECOLI
AccessioniPrimary (citable) accession number: P07000
Secondary accession number(s): P78127, Q2M8D0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: October 11, 2004
Last modified: September 27, 2017
This is version 140 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene