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Protein

Outer membrane protein C

Gene

ompC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Forms pores that allow passive diffusion of small molecules across the outer membrane.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi340Magnesium; via carbonyl oxygen1
Metal bindingi342Magnesium; via carbonyl oxygen1
Metal bindingi355Magnesium; via carbonyl oxygen1

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG10670-MONOMER.
ECOL316407:JW2203-MONOMER.
MetaCyc:EG10670-MONOMER.

Protein family/group databases

TCDBi1.B.1.1.3. the general bacterial porin (gbp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein C
Alternative name(s):
Outer membrane protein 1B
Porin OmpC
Gene namesi
Name:ompC
Synonyms:meoA, par
Ordered Locus Names:b2215, JW2203
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10670. ompC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 33Periplasmic1 PublicationAdd BLAST12
Transmembranei34 – 42Beta stranded9
Topological domaini43 – 53Extracellular1 PublicationAdd BLAST11
Transmembranei54 – 63Beta stranded10
Topological domaini64 – 73Periplasmic1 Publication10
Transmembranei74 – 84Beta strandedAdd BLAST11
Topological domaini85 – 91Extracellular1 Publication7
Transmembranei92 – 101Beta stranded10
Topological domaini102 – 106Periplasmic1 Publication5
Transmembranei107 – 115Beta stranded9
Topological domaini116 – 141Extracellular1 PublicationAdd BLAST26
Transmembranei142 – 154Beta strandedAdd BLAST13
Topological domaini155 – 163Periplasmic1 Publication9
Transmembranei164 – 171Beta stranded8
Topological domaini172 – 200Extracellular1 PublicationAdd BLAST29
Transmembranei201 – 207Beta stranded7
Topological domaini208 – 211Periplasmic1 Publication4
Transmembranei212 – 219Beta stranded8
Topological domaini220 – 241Extracellular1 PublicationAdd BLAST22
Transmembranei242 – 248Beta stranded7
Topological domaini249 – 252Periplasmic1 Publication4
Transmembranei253 – 260Beta stranded8
Topological domaini261 – 269Extracellular1 Publication9
Transmembranei270 – 286Beta strandedAdd BLAST17
Topological domaini287 – 291Periplasmic1 Publication5
Transmembranei292 – 299Beta stranded8
Topological domaini300 – 318Extracellular1 PublicationAdd BLAST19
Transmembranei319 – 326Beta stranded8
Topological domaini327 – 330Periplasmic1 Publication4
Transmembranei331 – 338Beta stranded8
Topological domaini339 – 358Extracellular1 PublicationAdd BLAST20
Transmembranei359 – 366Beta stranded8
Topological domaini367Periplasmic1 Publication1

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc
  • integral component of cell outer membrane Source: EcoliWiki
  • pore complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 213 PublicationsAdd BLAST21
ChainiPRO_000002523022 – 367Outer membrane protein CAdd BLAST346

Proteomic databases

PaxDbiP06996.
PRIDEiP06996.

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

BioGridi4261917. 276 interactors.
DIPiDIP-10397N.
IntActiP06996. 8 interactors.
MINTiMINT-1248362.
STRINGi511145.b2215.

Structurei

Secondary structure

1367
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 27Combined sources5
Beta strandi30 – 44Combined sources15
Turni48 – 50Combined sources3
Beta strandi56 – 85Combined sources30
Beta strandi92 – 103Combined sources12
Turni104 – 106Combined sources3
Beta strandi107 – 115Combined sources9
Helixi119 – 122Combined sources4
Helixi123 – 125Combined sources3
Beta strandi129 – 131Combined sources3
Beta strandi138 – 140Combined sources3
Beta strandi143 – 155Combined sources13
Helixi156 – 159Combined sources4
Beta strandi164 – 171Combined sources8
Beta strandi176 – 182Combined sources7
Beta strandi184 – 186Combined sources3
Helixi193 – 195Combined sources3
Beta strandi200 – 209Combined sources10
Beta strandi212 – 222Combined sources11
Turni225 – 227Combined sources3
Beta strandi229 – 233Combined sources5
Beta strandi237 – 250Combined sources14
Beta strandi253 – 264Combined sources12
Beta strandi271 – 273Combined sources3
Beta strandi275 – 286Combined sources12
Beta strandi291 – 305Combined sources15
Turni308 – 310Combined sources3
Beta strandi312 – 340Combined sources29
Helixi346 – 351Combined sources6
Beta strandi358 – 367Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J1NX-ray2.00A/B/C22-367[»]
2J4UX-ray2.99P/Q/R/U/V/W22-367[»]
2ZLEelectron microscopy28.00D22-367[»]
3NB3electron microscopy-D22-367[»]
4A8Delectron microscopy28.00M22-366[»]
ProteinModelPortaliP06996.
SMRiP06996.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06996.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni116 – 133Loop L3; may constrict the poreAdd BLAST18

Domaini

Loop L3 (residues 116-133) extends along the inner side of the beta barrel wall and may constrict the pore mid-length.1 Publication

Sequence similaritiesi

Belongs to the Gram-negative porin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105FCK. Bacteria.
COG3203. LUCA.
HOGENOMiHOG000272406.
InParanoidiP06996.
KOiK09475.
OMAiRTDEQNN.
PhylomeDBiP06996.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001897. Porin_gammaproteobac.
IPR001702. Porin_Gram-ve.
IPR013793. Porin_Gram-ve_CS.
[Graphical view]
PfamiPF00267. Porin_1. 1 hit.
[Graphical view]
PRINTSiPR00183. ECOLIPORIN.
PR00182. ECOLNEIPORIN.
PROSITEiPS00576. GRAM_NEG_PORIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06996-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVKVLSLLV PALLVAGAAN AAEVYNKDGN KLDLYGKVDG LHYFSDNKDV
60 70 80 90 100
DGDQTYMRLG FKGETQVTDQ LTGYGQWEYQ IQGNSAENEN NSWTRVAFAG
110 120 130 140 150
LKFQDVGSFD YGRNYGVVYD VTSWTDVLPE FGGDTYGSDN FMQQRGNGFA
160 170 180 190 200
TYRNTDFFGL VDGLNFAVQY QGKNGNPSGE GFTSGVTNNG RDALRQNGDG
210 220 230 240 250
VGGSITYDYE GFGIGGAISS SKRTDAQNTA AYIGNGDRAE TYTGGLKYDA
260 270 280 290 300
NNIYLAAQYT QTYNATRVGS LGWANKAQNF EAVAQYQFDF GLRPSLAYLQ
310 320 330 340 350
SKGKNLGRGY DDEDILKYVD VGATYYFNKN MSTYVDYKIN LLDDNQFTRD
360
AGINTDNIVA LGLVYQF
Length:367
Mass (Da):40,368
Last modified:April 1, 1988 - v1
Checksum:i6A49370CC8A1A225
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00541 Genomic DNA. Translation: AAA24243.1.
U00096 Genomic DNA. Translation: AAC75275.1.
AP009048 Genomic DNA. Translation: BAA15998.1.
U00008 Genomic DNA. Translation: AAA16412.1.
PIRiA20867. MMECPC.
RefSeqiNP_416719.1. NC_000913.3.
WP_000865568.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75275; AAC75275; b2215.
BAA15998; BAA15998; BAA15998.
GeneIDi946716.
KEGGiecj:JW2203.
eco:b2215.
PATRICi32119789. VBIEscCol129921_2304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00541 Genomic DNA. Translation: AAA24243.1.
U00096 Genomic DNA. Translation: AAC75275.1.
AP009048 Genomic DNA. Translation: BAA15998.1.
U00008 Genomic DNA. Translation: AAA16412.1.
PIRiA20867. MMECPC.
RefSeqiNP_416719.1. NC_000913.3.
WP_000865568.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J1NX-ray2.00A/B/C22-367[»]
2J4UX-ray2.99P/Q/R/U/V/W22-367[»]
2ZLEelectron microscopy28.00D22-367[»]
3NB3electron microscopy-D22-367[»]
4A8Delectron microscopy28.00M22-366[»]
ProteinModelPortaliP06996.
SMRiP06996.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261917. 276 interactors.
DIPiDIP-10397N.
IntActiP06996. 8 interactors.
MINTiMINT-1248362.
STRINGi511145.b2215.

Protein family/group databases

TCDBi1.B.1.1.3. the general bacterial porin (gbp) family.

Proteomic databases

PaxDbiP06996.
PRIDEiP06996.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75275; AAC75275; b2215.
BAA15998; BAA15998; BAA15998.
GeneIDi946716.
KEGGiecj:JW2203.
eco:b2215.
PATRICi32119789. VBIEscCol129921_2304.

Organism-specific databases

EchoBASEiEB0664.
EcoGeneiEG10670. ompC.

Phylogenomic databases

eggNOGiENOG4105FCK. Bacteria.
COG3203. LUCA.
HOGENOMiHOG000272406.
InParanoidiP06996.
KOiK09475.
OMAiRTDEQNN.
PhylomeDBiP06996.

Enzyme and pathway databases

BioCyciEcoCyc:EG10670-MONOMER.
ECOL316407:JW2203-MONOMER.
MetaCyc:EG10670-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP06996.
PROiP06996.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001897. Porin_gammaproteobac.
IPR001702. Porin_Gram-ve.
IPR013793. Porin_Gram-ve_CS.
[Graphical view]
PfamiPF00267. Porin_1. 1 hit.
[Graphical view]
PRINTSiPR00183. ECOLIPORIN.
PR00182. ECOLNEIPORIN.
PROSITEiPS00576. GRAM_NEG_PORIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOMPC_ECOLI
AccessioniPrimary (citable) accession number: P06996
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 2, 2016
This is version 159 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds 1 Mg2+ per subunit; could be Ca2+ in vivo.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.