UniProtKB - P06972 (FHUB_ECOLI)
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Protein
Iron(3+)-hydroxamate import system permease protein FhuB
Gene
fhuB
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the ABC transporter complex FhuCDB involved in iron3+-hydroxamate import. Responsible for the translocation of the substrate across the membrane.2 Publications
GO - Molecular functioni
- transporter activity Source: InterPro
GO - Biological processi
- ion transport Source: UniProtKB-KW
- iron ion homeostasis Source: UniProtKB-KW
Keywordsi
Biological process | Ion transport, Iron transport, Transport |
Ligand | Iron |
Enzyme and pathway databases
BioCyci | EcoCyc:FHUB-MONOMER. MetaCyc:FHUB-MONOMER. |
Protein family/group databases
TCDBi | 3.A.1.14.3. the atp-binding cassette (abc) superfamily. |
Names & Taxonomyi
Protein namesi | Recommended name: Iron(3+)-hydroxamate import system permease protein FhuBCuratedAlternative name(s): Ferric hydroxamate uptake protein BCurated Ferrichrome transport system permease protein FhuBCurated Ferrichrome uptake protein FhuBCurated Iron(III)-hydroxamate import system permease protein FhuBCurated |
Gene namesi | Name:fhuB Ordered Locus Names:b0153, JW0149 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Organism-specific databases
EcoGenei | EG10303. fhuB. |
Subcellular locationi
- Cell inner membrane 1 Publication; Multi-pass membrane protein Sequence analysis1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 5 – 25 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 62 – 82 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 93 – 113 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 118 – 138 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 147 – 167 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 197 – 217 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 240 – 260 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 277 – 297 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 303 – 323 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 348 – 368 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 391 – 411 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 424 – 444 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 447 – 467 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 479 – 499 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 528 – 548 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 567 – 587 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 607 – 627 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 635 – 655 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- ATP-binding cassette (ABC) transporter complex Source: EcoCyc
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000060028 | 1 – 660 | Iron(3+)-hydroxamate import system permease protein FhuBAdd BLAST | 660 |
Proteomic databases
PaxDbi | P06972. |
PRIDEi | P06972. |
Expressioni
Inductioni
Induced 2.1-fold by hydroxyurea.1 Publication
Interactioni
Subunit structurei
The complex is composed of two ATP-binding proteins (FhuC), two transmembrane proteins (FhuB) and a solute-binding protein (FhuD) (Probable). FhuB interacts with FhuC and FhuD (PubMed:1551849, PubMed:8522527, PubMed:9426146).Curated3 Publications
Protein-protein interaction databases
BioGridi | 4259735. 165 interactors. |
DIPi | DIP-9603N. |
IntActi | P06972. 1 interactor. |
STRINGi | 316385.ECDH10B_0133. |
Structurei
3D structure databases
ProteinModelPortali | P06972. |
SMRi | P06972. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domaini
FhuD interacts with a periplasmic and a transmembrane/cytoplasmic region of FhuB. The transmembrane region may be part of a pore through which a portion of FhuD inserts into the cytoplasmic membrane during transport.1 Publication
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4105S6R. Bacteria. COG0609. LUCA. |
HOGENOMi | HOG000260186. |
InParanoidi | P06972. |
KOi | K02015. |
OMAi | MFPYQIP. |
Family and domain databases
Gene3Di | 1.10.3470.10. 2 hits. |
InterProi | View protein in InterPro IPR037294. ABC_BtuC-like. IPR000522. ABC_transptr_FecCD. |
PANTHERi | PTHR30472. PTHR30472. 3 hits. |
Pfami | View protein in Pfam PF01032. FecCD. 2 hits. |
SUPFAMi | SSF81345. SSF81345. 2 hits. |
i Sequence
Sequence statusi: Complete.
P06972-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKRIALFPA LLLALLVIVA TALTWMNFSQ ALPRSQWAQA AWSPDIDVIE
60 70 80 90 100
QMIFHYSLLP RLAISLLVGA GLGLVGVLFQ QVLRNPLAEP TTLGVATGAQ
110 120 130 140 150
LGITVTTLWA IPGAMASQFA AQAGACVVGL IVFGVAWGKR LSPVTLILAG
160 170 180 190 200
LVVSLYCGAI NQLLVIFHHD QLQSMFLWST GTLTQTDWGG VERLWPQLLG
210 220 230 240 250
GVMLTLLLLR PLTLMGLDDG VARNLGLALS LARLAALSLA IVISALLVNA
260 270 280 290 300
VGIIGFIGLF APLLAKMLGA RRLLPRLMLA SLIGALILWL SDQIILWLTR
310 320 330 340 350
VWMEVSTGSV TALIGAPLLL WLLPRLRSIS APDMKVNDRV AAERQHVLAF
360 370 380 390 400
ALAGGVLLLM AVVVALSFGR DAHGWTWASG ALLEDLMPWR WPRIMAALFA
410 420 430 440 450
GVMLAVAGCI IQRLTGNPMA SPEVLGISSG AAFGVVLMLF LVPGNAFGWL
460 470 480 490 500
LPAGSLGAAV TLLIIMIAAG RGGFSPHRML LAGMALSTAF TMLLMMLQAS
510 520 530 540 550
GDPRMAQVLT WISGSTYNAT DAQVWRTGIV MVILLAITPL CRRWLTILPL
560 570 580 590 600
GGDTARAVGM ALTPTRIALL LLAACLTATA TMTIGPLSFV GLMAPHIARM
610 620 630 640 650
MGFRRTMPHI VISALVGGLL LVFADWCGRM VLFPFQIPAG LLSTFIGAPY
660
FIYLLRKQSR
Sequence cautioni
The sequence CAA27853 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 | L → V in CAA29256 (PubMed:2823072).Curated | 1 | |
Sequence conflicti | 311 | T → I in CAA27852 (PubMed:3020380).Curated | 1 | |
Sequence conflicti | 311 | T → I in CAA27853 (PubMed:3020380).Curated | 1 | |
Sequence conflicti | 364 | Missing in CAA27852 (PubMed:3020380).Curated | 1 | |
Sequence conflicti | 364 | Missing in CAA27853 (PubMed:3020380).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04319 Genomic DNA. Translation: CAA27852.1. X04319 Genomic DNA. Translation: CAA27853.1. Different initiation. U70214 Genomic DNA. Translation: AAB08583.1. U00096 Genomic DNA. Translation: AAC73264.1. AP009048 Genomic DNA. Translation: BAB96729.2. X05810 Genomic DNA. Translation: CAA29256.1. |
PIRi | A64739. |
RefSeqi | NP_414695.1. NC_000913.3. WP_000044072.1. NZ_LN832404.1. |
Genome annotation databases
EnsemblBacteriai | AAC73264; AAC73264; b0153. BAB96729; BAB96729; BAB96729. |
GeneIDi | 946890. |
KEGGi | ecj:JW0149. eco:b0153. |
PATRICi | fig|1411691.4.peg.2127. |
Similar proteinsi
Entry informationi
Entry namei | FHUB_ECOLI | |
Accessioni | P06972Primary (citable) accession number: P06972 Secondary accession number(s): P77372 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1988 |
Last sequence update: | November 1, 1997 | |
Last modified: | March 28, 2018 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |