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Protein

HTH-type transcriptional regulator DicA

Gene

dicA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein is a repressor of division inhibition gene dicB.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi23 – 42H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Cell cycle, Cell division, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG10226-MONOMER.
ECOL316407:JW1562-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator DicA
Alternative name(s):
Repressor protein of division inhibition gene dicA
Gene namesi
Name:dicA
Ordered Locus Names:b1570, JW1562
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10226. dicA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001497251 – 135HTH-type transcriptional regulator DicAAdd BLAST135

Proteomic databases

PaxDbiP06966.
PRIDEiP06966.

Interactioni

Protein-protein interaction databases

IntActiP06966. 5 interactors.
STRINGi511145.b1570.

Structurei

3D structure databases

ProteinModelPortaliP06966.
SMRiP06966.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 66HTH cro/C1-typePROSITE-ProRule annotationAdd BLAST55

Sequence similaritiesi

Contains 1 HTH cro/C1-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG41087BU. Bacteria.
COG1396. LUCA.
HOGENOMiHOG000120198.
InParanoidiP06966.
OMAiNESIGAR.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
InterProiIPR001387. Cro/C1-type_HTH.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF01381. HTH_3. 1 hit.
[Graphical view]
SMARTiSM00530. HTH_XRE. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
PROSITEiPS50943. HTH_CROC1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METKNLTIGE RIRYRRKNLK HTQRSLAKAL KISHVSVSQW ERGDSEPTGK
60 70 80 90 100
NLFALSKVLQ CSPTWILFGD EDKQPTPPVE KPVALSPKEL ELLELFNALP
110 120 130
ESEQDTQLAE MRARVKNFNK LFEELLKARQ RTNKR
Length:135
Mass (Da):15,656
Last modified:April 1, 1988 - v1
Checksum:iF95F3BB666D6C6B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07465 Genomic DNA. Translation: CAA30349.1.
U00096 Genomic DNA. Translation: AAC74643.1.
AP009048 Genomic DNA. Translation: BAA15275.1.
PIRiS05260. BVECDA.
RefSeqiNP_416088.1. NC_000913.3.
WP_000448564.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74643; AAC74643; b1570.
BAA15275; BAA15275; BAA15275.
GeneIDi946241.
KEGGiecj:JW1562.
eco:b1570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07465 Genomic DNA. Translation: CAA30349.1.
U00096 Genomic DNA. Translation: AAC74643.1.
AP009048 Genomic DNA. Translation: BAA15275.1.
PIRiS05260. BVECDA.
RefSeqiNP_416088.1. NC_000913.3.
WP_000448564.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP06966.
SMRiP06966.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP06966. 5 interactors.
STRINGi511145.b1570.

Proteomic databases

PaxDbiP06966.
PRIDEiP06966.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74643; AAC74643; b1570.
BAA15275; BAA15275; BAA15275.
GeneIDi946241.
KEGGiecj:JW1562.
eco:b1570.

Organism-specific databases

EchoBASEiEB0222.
EcoGeneiEG10226. dicA.

Phylogenomic databases

eggNOGiENOG41087BU. Bacteria.
COG1396. LUCA.
HOGENOMiHOG000120198.
InParanoidiP06966.
OMAiNESIGAR.

Enzyme and pathway databases

BioCyciEcoCyc:EG10226-MONOMER.
ECOL316407:JW1562-MONOMER.

Miscellaneous databases

PROiP06966.

Family and domain databases

Gene3Di1.10.260.40. 1 hit.
InterProiIPR001387. Cro/C1-type_HTH.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF01381. HTH_3. 1 hit.
[Graphical view]
SMARTiSM00530. HTH_XRE. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
PROSITEiPS50943. HTH_CROC1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDICA_ECOLI
AccessioniPrimary (citable) accession number: P06966
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 1, 1988
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.