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Protein

Recombinase cre

Gene

cre

Organism
Enterobacteria phage P1 (Bacteriophage P1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes site-specific recombination between two 34-base-pair LOXP sites. Its role is to maintain the phage genome as a monomeric unit-copy plasmid in the lysogenic state.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1731
Active sitei2891
Active sitei2921
Active sitei324O-(3'-phospho-DNA)-tyrosine intermediate1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA integration, DNA recombination

Names & Taxonomyi

Protein namesi
Recommended name:
Recombinase cre
Gene namesi
Name:cre
OrganismiEnterobacteria phage P1 (Bacteriophage P1)
Taxonomic identifieri10678 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaePunalikevirus
Virus hostiEnterobacteriaceae [TaxID: 543]
Proteomesi
  • UP000008091 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001975291 – 343Recombinase creAdd BLAST343

Interactioni

Subunit structurei

Homotetramer when bound to DNA.

Structurei

Secondary structure

1343
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni16 – 18Combined sources3
Helixi21 – 32Combined sources12
Helixi34 – 36Combined sources3
Helixi39 – 59Combined sources21
Turni63 – 66Combined sources4
Helixi68 – 80Combined sources13
Helixi85 – 102Combined sources18
Helixi107 – 109Combined sources3
Helixi111 – 126Combined sources16
Helixi139 – 149Combined sources11
Helixi155 – 170Combined sources16
Helixi174 – 179Combined sources6
Helixi182 – 184Combined sources3
Beta strandi185 – 189Combined sources5
Beta strandi192 – 197Combined sources6
Beta strandi202 – 205Combined sources4
Beta strandi209 – 213Combined sources5
Helixi215 – 228Combined sources14
Helixi230 – 232Combined sources3
Beta strandi233 – 235Combined sources3
Beta strandi236 – 239Combined sources4
Beta strandi241 – 243Combined sources3
Turni244 – 246Combined sources3
Beta strandi247 – 249Combined sources3
Beta strandi252 – 254Combined sources3
Helixi258 – 273Combined sources16
Beta strandi278 – 280Combined sources3
Beta strandi282 – 285Combined sources4
Helixi290 – 301Combined sources12
Helixi306 – 313Combined sources8
Beta strandi316 – 320Combined sources5
Helixi321 – 324Combined sources4
Turni325 – 327Combined sources3
Helixi329 – 331Combined sources3
Helixi334 – 339Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CRXX-ray2.40A/B20-341[»]
1DRGX-ray2.55A21-343[»]
1F44X-ray2.05A20-343[»]
1KBUX-ray2.20A/B1-343[»]
1MA7X-ray2.30A/B1-343[»]
1NZBX-ray3.10A/B/E/F1-343[»]
1OUQX-ray3.20A/B/E/F1-343[»]
1PVPX-ray2.35A/B2-343[»]
1PVQX-ray2.75A/B2-343[»]
1PVRX-ray2.65A/B2-343[»]
1Q3UX-ray2.90A/B/E/F1-343[»]
1Q3VX-ray2.91A/B/E/F1-343[»]
1XNSX-ray2.80A/B20-343[»]
1XO0X-ray2.00A/B20-343[»]
2CRXX-ray2.50A/B1-343[»]
2HOFX-ray2.40A/B1-343[»]
2HOIX-ray2.60A/B/G/H1-343[»]
3C28X-ray2.60A/B20-341[»]
3C29X-ray2.20A/B/G/H20-341[»]
3CRXX-ray2.50A/B1-343[»]
3MGVX-ray2.29A/B/C/D1-343[»]
4CRXX-ray2.20A/B20-341[»]
5CRXX-ray2.70A/B1-343[»]
ProteinModelPortaliP06956.
SMRiP06956.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06956.

Family & Domainsi

Sequence similaritiesi

Belongs to the 'phage' integrase family.Curated

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat.
IPR002104. Integrase_catalytic.
IPR010998. Integrase_Lambda-type_N.
IPR023109. Integrase_recombinase_N.
[Graphical view]
PfamiPF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF47823. SSF47823. 1 hit.
SSF56349. SSF56349. 1 hit.

Sequencei

Sequence statusi: Complete.

P06956-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNLLTVHQN LPALPVDATS DEVRKNLMDM FRDRQAFSEH TWKMLLSVCR
60 70 80 90 100
SWAAWCKLNN RKWFPAEPED VRDYLLYLQA RGLAVKTIQQ HLGQLNMLHR
110 120 130 140 150
RSGLPRPSDS NAVSLVMRRI RKENVDAGER AKQALAFERT DFDQVRSLME
160 170 180 190 200
NSDRCQDIRN LAFLGIAYNT LLRIAEIARI RVKDISRTDG GRMLIHIGRT
210 220 230 240 250
KTLVSTAGVE KALSLGVTKL VERWISVSGV ADDPNNYLFC RVRKNGVAAP
260 270 280 290 300
SATSQLSTRA LEGIFEATHR LIYGAKDDSG QRYLAWSGHS ARVGAARDMA
310 320 330 340
RAGVSIPEIM QAGGWTNVNI VMNYIRNLDS ETGAMVRLLE DGD
Length:343
Mass (Da):38,540
Last modified:January 1, 1988 - v1
Checksum:iA05AC4300003FF34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03453 Genomic DNA. Translation: CAA27178.1.
AF234172 Genomic DNA. Translation: AAQ13978.1.
PIRiB24836. RGBPP1.
RefSeqiYP_006472.1. NC_005856.1.

Genome annotation databases

GeneIDi2777477.
KEGGivg:2777477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03453 Genomic DNA. Translation: CAA27178.1.
AF234172 Genomic DNA. Translation: AAQ13978.1.
PIRiB24836. RGBPP1.
RefSeqiYP_006472.1. NC_005856.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CRXX-ray2.40A/B20-341[»]
1DRGX-ray2.55A21-343[»]
1F44X-ray2.05A20-343[»]
1KBUX-ray2.20A/B1-343[»]
1MA7X-ray2.30A/B1-343[»]
1NZBX-ray3.10A/B/E/F1-343[»]
1OUQX-ray3.20A/B/E/F1-343[»]
1PVPX-ray2.35A/B2-343[»]
1PVQX-ray2.75A/B2-343[»]
1PVRX-ray2.65A/B2-343[»]
1Q3UX-ray2.90A/B/E/F1-343[»]
1Q3VX-ray2.91A/B/E/F1-343[»]
1XNSX-ray2.80A/B20-343[»]
1XO0X-ray2.00A/B20-343[»]
2CRXX-ray2.50A/B1-343[»]
2HOFX-ray2.40A/B1-343[»]
2HOIX-ray2.60A/B/G/H1-343[»]
3C28X-ray2.60A/B20-341[»]
3C29X-ray2.20A/B/G/H20-341[»]
3CRXX-ray2.50A/B1-343[»]
3MGVX-ray2.29A/B/C/D1-343[»]
4CRXX-ray2.20A/B20-341[»]
5CRXX-ray2.70A/B1-343[»]
ProteinModelPortaliP06956.
SMRiP06956.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2777477.
KEGGivg:2777477.

Miscellaneous databases

EvolutionaryTraceiP06956.

Family and domain databases

Gene3Di1.10.150.130. 1 hit.
1.10.443.10. 1 hit.
InterProiIPR011010. DNA_brk_join_enz.
IPR013762. Integrase-like_cat.
IPR002104. Integrase_catalytic.
IPR010998. Integrase_Lambda-type_N.
IPR023109. Integrase_recombinase_N.
[Graphical view]
PfamiPF00589. Phage_integrase. 1 hit.
[Graphical view]
SUPFAMiSSF47823. SSF47823. 1 hit.
SSF56349. SSF56349. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRECR_BPP1
AccessioniPrimary (citable) accession number: P06956
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.