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Protein

Non-structural protein 1

Gene

NS

Organism
Influenza C virus (strain C/California/1978)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents the establishment of the cellular antiviral state initiated by host DDX58, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. Participates also in the upregulation of the splicing of viral mRNAs.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host RIG-I by virus, Inhibition of host RLR pathway by virus, Interferon antiviral system evasion, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 1UniRule annotation
Short name:
NS1UniRule annotation
Alternative name(s):
NS1AUniRule annotation
Gene namesi
Name:NSUniRule annotation
OrganismiInfluenza C virus (strain C/California/1978)
Taxonomic identifieri203224 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus C
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]

Subcellular locationi

  • Host cytoplasm UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000445861 – 246Non-structural protein 1Add BLAST246

Family & Domainsi

Sequence similaritiesi

Belongs to the influenza C viruses NS1 family.UniRule annotation

Family and domain databases

HAMAPiMF_04066. INFV_NS1. 1 hit.
InterProiView protein in InterPro
IPR004208. Flu_B_NS1.
IPR005187. Flu_C_NS1.
IPR005188. Flu_C_NS2.
PfamiView protein in Pfam
PF03506. Flu_C_NS1. 1 hit.
PF03555. Flu_C_NS2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform NS1 (identifier: P06944-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDKTVKSTN LMAFVATKML ERQEDLDTCT EMQVEKMKTS TKARLRTESS
60 70 80 90 100
FAPRTWEDAI KDGELLFNGT ILQAESTTMT PASVEMKGKK FPIDFVPSNI
110 120 130 140 150
APIGQNPIYL SPCIPNFDGN VWEATMYHHR GATLTKTMNC NCFQRTIWCH
160 170 180 190 200
PNPSRMRLSY AFVLYCRNTK KICGYLIAKQ VAGIETGIRK CFRCIKSGFV
210 220 230 240
MATDEISLII LQSIKSGAQL DPYWGNETPD IDKTEAYMLS LREAGP
Length:246
Mass (Da):27,739
Last modified:February 21, 2006 - v2
Checksum:i0C6CD2063F16B4E7
GO
Isoform NEP (identifier: P33493-1) [UniParc]FASTAAdd to basket
Also known as: NS2
The sequence of this isoform can be found in the external entry P33493.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:182
Mass (Da):20,837
GO

Sequence cautioni

The sequence AAA43780 differs from that shown. Reason: Frameshift at position 225.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10087 Genomic RNA. Translation: AAA43780.1. Frameshift.
AB099625 Genomic RNA. Translation: BAD37133.1.
PIRiA25320. MNIVC7.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNS1_INCCA
AccessioniPrimary (citable) accession number: P06944
Secondary accession number(s): Q68BV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 21, 2006
Last modified: December 20, 2017
This is version 58 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families