P06938 (VPR_HV2RO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Vpr

Alternative name(s):
R ORF protein
Viral protein R

Gene names

Name:

vpr

Organism

Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2) [Complete proteome]

Taxonomic identifier

11720 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Lentivirus › Primate lentivirus group › Human immunodeficiency virus 2 › HIV-2 subtype A

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	105 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Stimulates gene expression driven by the HIV-2 LTR. Prevents infected cells from undergoing mitosis and proliferating, by inducing arrest or delay in the G2 phase of the cell cycle. Cell cycle arrest creates a favorable environment for maximizing viral expression and production By similarity.
Subunit structure	Interacts with human UNG By similarity.
Subcellular location	Virion. Host nucleus By similarity.

Ontologies

Keywords
Biological process	Cell cycle Host G2/M cell cycle arrest by virus Host-virus interaction Modulation of host cell cycle by virus Transcription Transcription regulation Viral penetration into host nucleus Virus entry into host cell
Cellular component	Host nucleus Virion
Disease	AIDS
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW suppression by virus of G2/M transition of host mitotic cell cycle Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW viral entry into host cell Inferred from electronic annotation. Source: UniProtKB-KW viral infectious cycle Inferred from electronic annotation. Source: InterPro viral penetration into host nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell virion Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 105	105	Protein Vpr		PRO_0000085463
Amino acid modifications
	Modified residue	84	1	Phosphoserine; by host By similarity

Sequences

	Sequence		Length	Mass (Da)
	P06938 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: 4D2DABC3D4EB2BF9	FASTA	105	11,795
	10 20 30 40 50 60 MAEAPTELPP VDGTPLREPG DEWIIEILRE IKEEALKHFD PRLLIALGKY IYTRHGDTLE 70 80 90 100 GARELIKVLQ RALFTHFRAG CGHSRIGQTR GGNPLSAIPT PRNMQ

References

[1]	"Genome organization and transactivation of the human immunodeficiency virus type 2." Guyader M., Emerman M., Sonigo P., Clavel F., Montagnier L., Alizon M. Nature 326:662-669(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M15390 Genomic DNA. Translation: AAB00767.1. X05291 Genomic RNA. Translation: CAA28911.1.
PIR	ASLJR2. H26262.
3D structure databases
ProteinModelPortal	P06938.
SMR	P06938. Positions 55-87.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000012. RetroV_VpR/X. [Graphical view]
Pfam	PF00522. VPR. 1 hit. [Graphical view]
PRINTS	PR00444. HIVVPRVPX.
ProtoNet	Search...

Entry information

Entry name

VPR_HV2RO

Accession

Primary (citable) accession number: P06938

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program