##gff-version 3 P06935 UniProtKB Chain 1 3430 . . . ID=PRO_0000441418;Note=Genome polyprotein P06935 UniProtKB Chain 1 105 . . . ID=PRO_0000037743;Note=Capsid protein C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Propeptide 106 123 . . . ID=PRO_0000037744;Note=ER anchor for the capsid protein C%2C removed in mature form by serine protease NS3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Chain 124 290 . . . ID=PRO_0000405150;Note=Protein prM;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Chain 124 215 . . . ID=PRO_0000405151;Note=Peptide pr;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Chain 216 290 . . . ID=PRO_0000037745;Note=Small envelope protein M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Chain 291 787 . . . ID=PRO_0000037746;Note=Envelope protein E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Chain 788 1139 . . . ID=PRO_0000037747;Note=Non-structural protein 1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Chain 1140 1370 . . . ID=PRO_0000037748;Note=Non-structural protein 2A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Chain 1371 1501 . . . ID=PRO_0000037749;Note=Serine protease subunit NS2B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Chain 1502 2120 . . . ID=PRO_0000037750;Note=Serine protease/Helicase NS3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Chain 2121 2246 . . . ID=PRO_0000037751;Note=Non-structural protein 4A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Peptide 2247 2269 . . . ID=PRO_0000405152;Note=Peptide 2k;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Chain 2270 2525 . . . ID=PRO_0000037752;Note=Non-structural protein 4B;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Chain 2526 3430 . . . ID=PRO_0000037753;Note=RNA-directed RNA polymerase NS5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Topological domain 2 105 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Transmembrane 106 126 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 127 248 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Transmembrane 249 269 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 270 275 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Transmembrane 276 290 . . . Note=Helical;Ontology_term=ECO:0000305;evidence=ECO:0000305 P06935 UniProtKB Topological domain 291 739 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Transmembrane 740 760 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 761 766 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Transmembrane 767 787 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 788 1212 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Transmembrane 1213 1233 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 1234 1243 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Transmembrane 1244 1264 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 1265 1278 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Transmembrane 1279 1299 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 1300 1307 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Transmembrane 1308 1328 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 1329 1340 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Transmembrane 1341 1361 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 1362 1371 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Transmembrane 1372 1392 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 1393 1395 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Transmembrane 1396 1416 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 1417 1473 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Intramembrane 1474 1494 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 1495 2170 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Transmembrane 2171 2191 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 2192 2196 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Intramembrane 2197 2217 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 2218 2218 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Transmembrane 2219 2239 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 2240 2254 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Transmembrane 2255 2275 . . . Note=Helical%3B Note%3DSignal for NS4B;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 2276 2309 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Intramembrane 2310 2330 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 2331 2377 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Transmembrane 2378 2398 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 2399 2441 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Transmembrane 2442 2462 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 2463 2467 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Transmembrane 2468 2488 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Topological domain 2489 3430 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P06935 UniProtKB Domain 1502 1679 . . . Note=Peptidase S7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00860 P06935 UniProtKB Domain 1682 1838 . . . Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541 P06935 UniProtKB Domain 1849 2014 . . . Note=Helicase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00542 P06935 UniProtKB Domain 2526 2791 . . . Note=MRNA cap 0-1 NS5-type MT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Domain 3055 3207 . . . Note=RdRp catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00539 P06935 UniProtKB Region 2 15 . . . Note=Interaction with host EXOC1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19889084;Dbxref=PMID:19889084 P06935 UniProtKB Region 37 72 . . . Note=Hydrophobic%3B homodimerization of capsid protein C;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29990 P06935 UniProtKB Region 388 401 . . . Note=Fusion peptide;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14336 P06935 UniProtKB Region 1424 1463 . . . Note=Interacts with and activates NS3 protease;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00859 P06935 UniProtKB Region 1686 1689 . . . Note=Important for RNA-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14340 P06935 UniProtKB Region 2165 2169 . . . Note=Regulates the ATPase activity of NS3 helicase;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Q6P4 P06935 UniProtKB Motif 1786 1789 . . . Note=DEAH box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541 P06935 UniProtKB Motif 2914 2916 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14335 P06935 UniProtKB Motif 3428 3430 . . . Note=PDZ-binding;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33547379;Dbxref=PMID:33547379 P06935 UniProtKB Active site 1552 1552 . . . Note=Charge relay system%3B for serine protease NS3 activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00860 P06935 UniProtKB Active site 1576 1576 . . . Note=Charge relay system%3B for serine protease NS3 activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00860 P06935 UniProtKB Active site 1636 1636 . . . Note=Charge relay system%3B for serine protease NS3 activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00860 P06935 UniProtKB Active site 2586 2586 . . . Note=For 2'-O-MTase activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6YMS4 P06935 UniProtKB Active site 2671 2671 . . . Note=For 2'-O-MTase activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6YMS4 P06935 UniProtKB Active site 2707 2707 . . . Note=For 2'-O-MTase activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6YMS4 P06935 UniProtKB Active site 2743 2743 . . . Note=For 2'-O-MTase activity;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q6YMS4 P06935 UniProtKB Binding site 1695 1702 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541 P06935 UniProtKB Binding site 2581 2581 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Binding site 2611 2611 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Binding site 2612 2612 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Binding site 2629 2629 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Binding site 2630 2630 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Binding site 2656 2656 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Binding site 2657 2657 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Binding site 2672 2672 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Binding site 2745 2745 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Binding site 2965 2965 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14335 P06935 UniProtKB Binding site 2969 2969 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14335 P06935 UniProtKB Binding site 2974 2974 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14335 P06935 UniProtKB Binding site 2977 2977 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14335 P06935 UniProtKB Binding site 3242 3242 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14335 P06935 UniProtKB Binding site 3258 3258 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14335 P06935 UniProtKB Binding site 3377 3377 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14335 P06935 UniProtKB Site 105 106 . . . Note=Cleavage%3B by viral protease NS3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Site 123 124 . . . Note=Cleavage%3B by host signal peptidase;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Site 215 216 . . . Note=Cleavage%3B by host furin;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Site 290 291 . . . Note=Cleavage%3B by host signal peptidase;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Site 787 788 . . . Note=Cleavage%3B by host signal peptidase;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Site 1139 1140 . . . Note=Cleavage%3B by host;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Site 1370 1371 . . . Note=Cleavage%3B by viral protease NS3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Site 1501 1502 . . . Note=Cleavage%3B by autolysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Site 1959 1959 . . . Note=Involved in NS3 ATPase and RTPase activities;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14335 P06935 UniProtKB Site 1962 1962 . . . Note=Involved in NS3 ATPase and RTPase activities;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14335 P06935 UniProtKB Site 2120 2121 . . . Note=Cleavage%3B by autolysis;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Site 2246 2247 . . . Note=Cleavage%3B by viral protease NS3;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Site 2269 2270 . . . Note=Cleavage%3B by host signal peptidase;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Site 2525 2526 . . . Note=Cleavage%3B by viral protease NS3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Site 2538 2538 . . . Note=MRNA cap binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Site 2541 2541 . . . Note=MRNA cap binding%3B via carbonyl oxygen;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Site 2542 2542 . . . Note=MRNA cap binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Site 2544 2544 . . . Note=MRNA cap binding%3B via carbonyl oxygen;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Site 2549 2549 . . . Note=MRNA cap binding;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00924,ECO:0000269|PubMed:17067286;Dbxref=PMID:17067286 P06935 UniProtKB Site 2553 2553 . . . Note=MRNA cap binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Site 2586 2586 . . . Note=Essential for 2'-O-methyltransferase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Site 2671 2671 . . . Note=Essential for 2'-O-methyltransferase and N-7 methyltransferase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Site 2675 2675 . . . Note=MRNA cap binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Site 2707 2707 . . . Note=Essential for 2'-O-methyltransferase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Site 2738 2738 . . . Note=MRNA cap binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Site 2740 2740 . . . Note=MRNA cap binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Site 2743 2743 . . . Note=Essential for 2'-O-methyltransferase activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00924 P06935 UniProtKB Modified residue 2581 2581 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03314 P06935 UniProtKB Glycosylation 138 138 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P14335 P06935 UniProtKB Glycosylation 917 917 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Q6P4 P06935 UniProtKB Glycosylation 962 962 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Q6P4 P06935 UniProtKB Glycosylation 994 994 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Q6P4 P06935 UniProtKB Disulfide bond 293 320 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3811228;Dbxref=PMID:3811228 P06935 UniProtKB Disulfide bond 350 411 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Q6P4 P06935 UniProtKB Disulfide bond 350 406 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3811228;Dbxref=PMID:3811228 P06935 UniProtKB Disulfide bond 364 395 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3811228;Dbxref=PMID:3811228 P06935 UniProtKB Disulfide bond 382 411 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3811228;Dbxref=PMID:3811228 P06935 UniProtKB Disulfide bond 382 406 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Q6P4 P06935 UniProtKB Disulfide bond 476 574 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3811228;Dbxref=PMID:3811228 P06935 UniProtKB Disulfide bond 591 622 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3811228;Dbxref=PMID:3811228 P06935 UniProtKB Disulfide bond 791 802 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Q6P4 P06935 UniProtKB Disulfide bond 842 930 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Q6P4 P06935 UniProtKB Disulfide bond 966 1010 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Q6P4 P06935 UniProtKB Disulfide bond 1067 1116 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Q6P4 P06935 UniProtKB Disulfide bond 1078 1099 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Q6P4 P06935 UniProtKB Disulfide bond 1100 1103 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Q6P4 P06935 UniProtKB Mutagenesis 14 14 . . . Note=Loss of interaction between capsid protein C and host EXOC1. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23522008;Dbxref=PMID:23522008 P06935 UniProtKB Mutagenesis 2586 2586 . . . Note=Complete loss of 2'-O-methyltransferase activity. No effect on N-7 methyltransferase activity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17267492;Dbxref=PMID:17267492 P06935 UniProtKB Mutagenesis 2671 2671 . . . Note=Lethal for the virus. Complete loss of 2'-O and N-7 methyltransferase activities. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17267492;Dbxref=PMID:17267492 P06935 UniProtKB Mutagenesis 2707 2707 . . . Note=Complete loss of 2'-O-methyltransferase activity. No effect on N-7 methyltransferase activity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17267492;Dbxref=PMID:17267492 P06935 UniProtKB Mutagenesis 2743 2743 . . . Note=Complete loss of 2'-O-methyltransferase activity. No effect on N-7 methyltransferase activity. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17267492;Dbxref=PMID:17267492 P06935 UniProtKB Beta strand 595 603 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2P5P P06935 UniProtKB Beta strand 605 607 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2P5P P06935 UniProtKB Beta strand 609 615 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2P5P P06935 UniProtKB Beta strand 621 623 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2P5P P06935 UniProtKB Beta strand 626 631 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2P5P P06935 UniProtKB Beta strand 634 637 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2P5P P06935 UniProtKB Beta strand 639 643 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2P5P P06935 UniProtKB Beta strand 657 662 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2P5P P06935 UniProtKB Beta strand 665 673 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2P5P P06935 UniProtKB Beta strand 679 685 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2P5P P06935 UniProtKB Beta strand 1422 1428 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Helix 1434 1439 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2GGV P06935 UniProtKB Beta strand 1440 1443 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2GGV P06935 UniProtKB Beta strand 1444 1449 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Beta strand 1451 1453 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2YOL P06935 UniProtKB Beta strand 1455 1457 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Beta strand 1503 1505 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Beta strand 1521 1532 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Beta strand 1534 1543 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Beta strand 1546 1549 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Helix 1551 1554 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Beta strand 1559 1561 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Beta strand 1564 1566 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Beta strand 1568 1572 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Turn 1573 1576 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Beta strand 1577 1583 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Beta strand 1592 1594 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Beta strand 1596 1600 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Beta strand 1608 1612 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Beta strand 1615 1618 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Beta strand 1623 1627 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Helix 1633 1635 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2FP7 P06935 UniProtKB Beta strand 1639 1641 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Beta strand 1647 1650 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Beta strand 1654 1656 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Beta strand 1662 1665 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5IDK P06935 UniProtKB Beta strand 1672 1674 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2IJO