Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Small delta antigen

Gene
N/A
Organism
Hepatitis delta virus genotype I (isolate Italian) (HDV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Promotes both transcription and replication of genomic RNA. Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. May interact with host RNA polymerase II thereby changing its template requirement from DNA to RNA. RNA pol II complex would then acts as an RNA-directed RNA polymerase, and transcribe and replicate HDV genome (By similarity).By similarity

Miscellaneous

This strain belongs to the genotype I found in North America, Europe, Africa, East and West Asia and the South Pacific.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processHost-virus interaction, Viral penetration into host nucleus, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Small delta antigen
Short name:
S-HDAg
Alternative name(s):
p24
OrganismiHepatitis delta virus genotype I (isolate Italian) (HDV)
Taxonomic identifieri10423 [NCBI]
Taxonomic lineageiVirusesDeltavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008106 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000381331 – 195Small delta antigenAdd BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2Phosphoserine; by host CK2By similarity1
Modified residuei13Omega-N-methylated arginine; by host PRMT1By similarity1
Modified residuei72N6-acetyllysine; by hostBy similarity1
Modified residuei123Phosphoserine; by hostBy similarity1
Modified residuei177Phosphoserine; by host MAPK1 and MAPK3By similarity1
Modified residuei182Phosphothreonine; by hostBy similarity1

Post-translational modificationi

Phosphorylated at serines and threonines by host MAPK1/3, PKR, and CK2.By similarity
Acetylation modulates nuclear localization. Neo-synthesized genomic RNA migrates from the nucleus to the cytoplasm, where they interact with S-HDAg, which once acetylated redirect both partners to the nucleus (By similarity).By similarity
Methylation plays a role in viral genome replication.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Interactioni

Subunit structurei

Homodimer. Homooctamer. Interacts with host RNA polymerase II complex, and with host NPM1.By similarity

Structurei

3D structure databases

SMRiP06934.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 195HDAgPROSITE-ProRule annotationAdd BLAST176

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 60DimerizationSequence analysisAdd BLAST49
Regioni97 – 107RNA-bindingPROSITE-ProRule annotationAdd BLAST11
Regioni130 – 195RNAPII-bindingPROSITE-ProRule annotationAdd BLAST66
Regioni136 – 146RNA-bindingPROSITE-ProRule annotationAdd BLAST11

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi66 – 75Nuclear localization signalBy similarity10

Sequence similaritiesi

Belongs to the hepatitis delta antigen family.Curated

Family and domain databases

Gene3Di4.10.220.40. 1 hit.
InterProiView protein in InterPro
IPR027403. Delta_antigen_N.
IPR002506. HDV_ag.
PfamiView protein in Pfam
PF01517. HDV_ag. 1 hit.
PROSITEiView protein in PROSITE
PS51838. HDAG. 1 hit.

Sequencei

Sequence statusi: Complete.

P06934-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSESRKNR GGREEILEQW VAGRKKLEEL ERDLRKTKKK LKKIEDENPW
60 70 80 90 100
LGNIKGILGK KDKDGEGAPP AKRARTDQME VDSGPRKRPL RGGFTDKERQ
110 120 130 140 150
DHRRRKALEN KKKQLSAGGK NLSKEEEEEL RRLTEEDERR ERRVAGPPVG
160 170 180 190
GVIPLEGGSR GAPGGGFVPS LQGVPESPFS RTGEGLDIRG NRGFP
Length:195
Mass (Da):21,895
Last modified:April 14, 2009 - v3
Checksum:i27846102C59A6B44
GO

RNA editingi

Edited at position 196.By similarity
Partially edited. RNA editing at this position occurs on the antigenomic strand and consists of a conversion of A to G catalyzed by the cellular enzyme ADAR1. The unedited RNA version gives rise to the small delta antigen, which ends with a nonsense codon at position 196. In the edited version, this amber codon is modified to a tryptophan codon and gives rise to the large delta antigen protein (AC P0C6L6). S-HDAg suppresses editing of non-replicating antigenomic RNA, thereby regulating the extent of editing (By similarity).By similarity

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04451 Genomic RNA. Translation: CAA28050.1. Sequence problems.
PIRiA26176. SAVLDV.

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Entry informationi

Entry nameiSHDAG_HDVIT
AccessioniPrimary (citable) accession number: P06934
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: April 14, 2009
Last modified: September 27, 2017
This is version 84 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families