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Protein

Protein E6

Gene

E6

Organism
Bovine papillomavirus type 1
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri17 – 53UniRule annotationAdd BLAST37
Zinc fingeri90 – 127UniRule annotationAdd BLAST38

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • zinc ion binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Modulation of host cell apoptosis by virus, Transcription, Transcription regulation, Viral immunoevasion
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein E6UniRule annotation
Gene namesi
Name:E6UniRule annotation
OrganismiBovine papillomavirus type 1
Taxonomic identifieri10559 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeDeltapapillomavirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000006567 Componenti: Genome

Subcellular locationi

  • Host cytoplasm UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001333151 – 137Protein E6Add BLAST137

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Forms homodimers. Interacts with ubiquitin-protein ligase UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity. Interacts with host BAK1. Interacts with human FBLN1.UniRule annotation1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

DIPiDIP-41442N.
IntActiP06931. 7 interactors.
MINTiMINT-245691.

Structurei

Secondary structure

1137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni18 – 20Combined sources3
Helixi26 – 34Combined sources9
Beta strandi40 – 42Combined sources3
Beta strandi45 – 48Combined sources4
Helixi51 – 64Combined sources14
Beta strandi68 – 70Combined sources3
Helixi72 – 78Combined sources7
Helixi83 – 85Combined sources3
Turni91 – 93Combined sources3
Helixi99 – 107Combined sources9
Beta strandi112 – 114Combined sources3
Helixi116 – 118Combined sources3
Beta strandi120 – 122Combined sources3
Helixi125 – 127Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PY7X-ray2.29A1-137[»]
ProteinModelPortaliP06931.
SMRiP06931.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the papillomaviridae E6 protein family.UniRule annotationCurated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri17 – 53UniRule annotationAdd BLAST37
Zinc fingeri90 – 127UniRule annotationAdd BLAST38

Keywords - Domaini

Zinc-finger

Phylogenomic databases

OrthoDBiVOG0900011D.

Family and domain databases

HAMAPiMF_04006. HPV_E6. 1 hit.
InterProiView protein in InterPro
IPR001334. E6.
PfamiView protein in Pfam
PF00518. E6. 1 hit.

Sequencei

Sequence statusi: Complete.

P06931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLKPFARTN PFSGLDCLWC REPLTEVDAF RCMVKDFHVV IREGCRYGAC
60 70 80 90 100
TICLENCLAT ERRLWQGVPV TGEEAELLHG KTLDRLCIRC CYCGGKLTKN
110 120 130
EKHRHVLFNE PFCKTRANII RGRCYDCCRH GSRSKYP
Length:137
Mass (Da):15,850
Last modified:January 1, 1988 - v1
Checksum:i36FADDDA55444566
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02346 Genomic DNA. Translation: CAB46509.1.
PIRiC18151. W6WLEB.
RefSeqiNP_056737.1. NC_001522.1.

Genome annotation databases

GeneIDi1489017.
KEGGivg:1489017.

Similar proteinsi

Entry informationi

Entry nameiVE6_BPV1
AccessioniPrimary (citable) accession number: P06931
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: October 25, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families