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Protein

Protein E6

Gene

E6

Organism
Bovine papillomavirus type 1
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional transactivator. Binds double-stranded DNA.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri17 – 53Sequence analysisAdd BLAST37
Zinc fingeri90 – 127Sequence analysisAdd BLAST38

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • zinc ion binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Host-virus interaction, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein E6
Gene namesi
Name:E6
OrganismiBovine papillomavirus type 1
Taxonomic identifieri10559 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeDeltapapillomavirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000006567 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001333151 – 137Protein E6Add BLAST137

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Interacts with human FBLN1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PXNP490245EBI-7281937,EBI-2896280From a different organism.
UBE3AQ050862EBI-7281937,EBI-954357From a different organism.

Protein-protein interaction databases

DIPiDIP-41442N.
IntActiP06931. 7 interactors.
MINTiMINT-245691.

Structurei

Secondary structure

1137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni18 – 20Combined sources3
Helixi26 – 34Combined sources9
Beta strandi40 – 42Combined sources3
Beta strandi45 – 48Combined sources4
Helixi51 – 64Combined sources14
Beta strandi68 – 70Combined sources3
Helixi72 – 78Combined sources7
Helixi83 – 85Combined sources3
Turni91 – 93Combined sources3
Helixi99 – 107Combined sources9
Beta strandi112 – 114Combined sources3
Helixi116 – 118Combined sources3
Beta strandi120 – 122Combined sources3
Helixi125 – 127Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PY7X-ray2.29A1-137[»]
ProteinModelPortaliP06931.
SMRiP06931.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the papillomaviridae E6 protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri17 – 53Sequence analysisAdd BLAST37
Zinc fingeri90 – 127Sequence analysisAdd BLAST38

Keywords - Domaini

Zinc-finger

Family and domain databases

InterProiIPR001334. E6.
[Graphical view]
PfamiPF00518. E6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLKPFARTN PFSGLDCLWC REPLTEVDAF RCMVKDFHVV IREGCRYGAC
60 70 80 90 100
TICLENCLAT ERRLWQGVPV TGEEAELLHG KTLDRLCIRC CYCGGKLTKN
110 120 130
EKHRHVLFNE PFCKTRANII RGRCYDCCRH GSRSKYP
Length:137
Mass (Da):15,850
Last modified:January 1, 1988 - v1
Checksum:i36FADDDA55444566
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02346 Genomic DNA. Translation: CAB46509.1.
PIRiC18151. W6WLEB.
RefSeqiNP_056737.1. NC_001522.1.

Genome annotation databases

GeneIDi1489017.
KEGGivg:1489017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02346 Genomic DNA. Translation: CAB46509.1.
PIRiC18151. W6WLEB.
RefSeqiNP_056737.1. NC_001522.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PY7X-ray2.29A1-137[»]
ProteinModelPortaliP06931.
SMRiP06931.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-41442N.
IntActiP06931. 7 interactors.
MINTiMINT-245691.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1489017.
KEGGivg:1489017.

Family and domain databases

InterProiIPR001334. E6.
[Graphical view]
PfamiPF00518. E6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVE6_BPV1
AccessioniPrimary (citable) accession number: P06931
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 30, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.