Reviewed, UniProtKB/Swiss-Prot P06914 (CSP_PLAYO)

Names and origin

Protein names	Recommended name:     Circumsporozoite protein       Short name=CS
Organism	Plasmodium yoelii yoelii [Complete proteome]
Taxonomic identifier	73239 [NCBI]
Taxonomic lineage	Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Vinckeia)

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	The circumsporozoite protein is the immunodominant surface antigen on the sporozoite (the infective stage of the malaria parasite that is transmitted from the mosquito to the vertebrate host).
Domain	The C-terminal region is probably used for anchoring the protein to the cell membrane. The repeat sequences would be the surface antigen of the organism.
Sequence similarities	Belongs to the plasmodium circumsporozoite protein family. Contains 1 TSP type-1 domain.

Ontologies

Keywords
Developmental stage	Sporozoite
Disease	Malaria
Domain	Repeat Signal
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cell surface Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
KPNA1	P52294	1	EBI-1555692,EBI-358383	From a different organism.
KPNA3	O00505	1	EBI-1555692,EBI-358297	From a different organism.
KPNA4	O00629	1	EBI-1555692,EBI-396343	From a different organism.
KPNA5	O15131	1	EBI-1555692,EBI-540602	From a different organism.
KPNA6	O60684	1	EBI-1555692,EBI-359923	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19
	Chain	20 – 367	348	Circumsporozoite protein		PRO_0000024536
Regions
	Repeat	139 – 144	6	1-1
	Repeat	145 – 150	6	1-2
	Repeat	151 – 156	6	1-3
	Repeat	157 – 162	6	1-4
	Repeat	163 – 168	6	1-5
	Repeat	169 – 174	6	1-6
	Repeat	175 – 180	6	1-7
	Repeat	181 – 186	6	1-8
	Repeat	187 – 192	6	1-9
	Repeat	193 – 198	6	1-10
	Repeat	199 – 204	6	1-11
	Repeat	205 – 210	6	1-12
	Repeat	211 – 216	6	1-13
	Repeat	217 – 222	6	1-14
	Repeat	223 – 228	6	1-15
	Repeat	229 – 232	4	2-1; approximate
	Repeat	233 – 236	4	2-2
	Repeat	237 – 240	4	2-3
	Repeat	241 – 244	4	2-4
	Repeat	245 – 248	4	2-5
	Repeat	249 – 252	4	2-6
	Repeat	253 – 256	4	2-7
	Repeat	257 – 260	4	2-8; approximate
	Domain	294 – 345	52	TSP type-1
	Region	139 – 228	90	15 X 6 AA tandem repeats of Q-G-P-G-A-P
	Region	229 – 260	32	8 X 4 AA approximate tandem repeats of Q-Q-P-P

Sequences

	Sequence		Length	Mass (Da)
	P06914-1 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: 1EA56AFF7FFCB5E3	FASTA	367	38,888
	10 20 30 40 50 60 MKKCTILVVA SLLLVDSLLP GYGQNKSVQA QRNLNELCYN EENDNKLYHV LNSKNGKIYN 70 80 90 100 110 120 RNIVNRLLGD ALNGKPEEKK DDPPKDGNKD DLPKEEKKDD LPKEEKKDDP PKDPKKDDPP 130 140 150 160 170 180 KEAQNKLNQP VVADENVDQG PGAPQGPGAP QGPGAPQGPG APQGPGAPQG PGAPQGPGAP 190 200 210 220 230 240 QGPGAPQGPG APQGPGAPQG PGAPQGPGAP QGPGAPQGPG APQGPGAPQE PPQQPPQQPP 250 260 270 280 290 300 QQPPQQPPQQ PPQQPPQQPR PQPDGNNNNN NNNGNNNEDS YVPSAEQILE FVKQISSQLT 310 320 330 340 350 360 EEWSQCSVTC GSGVRVRKRK NVNKQPENLT LEDIDTEICK MDKCSSIFNI VSNSLGFVIL LVLVFFN

References

[1]	"Structure of the gene encoding the circumsporozoite protein of Plasmodium yoelii. A rodent model for examining antimalarial sporozoite vaccines." Lal A.A., de la Cruz V.F., Welsh J.A., Charoenvit Y., Maloy W.L., McCutchan T.F. J. Biol. Chem. 262:2937-2940(1987) [PubMed: 3102479] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Variation among circumsporozoite protein genes from rodent malarias." de la Cruz V.F., Lal A.A., McCutchan T.F. Mol. Biochem. Parasitol. 28:31-38(1988) [PubMed: 3287156] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-140 AND 260-367.

Cross-references

Sequence databases
EMBLGenBankDDBJ	J02695 Genomic DNA. Translation: AAA29558.1. M18821 Genomic DNA. Translation: AAA29559.1. M22698 Genomic DNA. Translation: AAA29560.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P06914. 5 interactions.
Family and domain databases
InterPro	IPR003067. Crcmsprzoite. IPR000884. Thrombospondin_1_rpt. [Graphical view]
Pfam	PF00090. TSP_1. 1 hit. [Graphical view]
PRINTS	PR01303. CRCMSPRZOITE.
SMART	SM00209. TSP1. 1 hit. [Graphical view]
PROSITE	PS50092. TSP1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CSP_PLAYO

Accession

Primary (citable) accession number: P06914

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	March 3, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)