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Protein

Complement factor H

Gene

Cfh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.By similarity

GO - Molecular functioni

  • complement component C3b binding Source: MGI
  • heparan sulfate proteoglycan binding Source: MGI
  • heparin binding Source: MGI

GO - Biological processi

  • complement activation Source: MGI
  • complement activation, alternative pathway Source: UniProtKB-KW
  • positive regulation of cytolysis Source: UniProtKB
  • regulation of complement activation Source: MGI

Keywordsi

Biological processComplement alternate pathway, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Complement factor H
Alternative name(s):
Protein beta-1-H
Gene namesi
Name:Cfh
Synonyms:Hf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88385 Cfh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000000589519 – 1234Complement factor HAdd BLAST1216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi21 ↔ 66PROSITE-ProRule annotation
Disulfide bondi52 ↔ 80PROSITE-ProRule annotation
Disulfide bondi85 ↔ 129PROSITE-ProRule annotation
Disulfide bondi114 ↔ 141PROSITE-ProRule annotation
Disulfide bondi146 ↔ 192PROSITE-ProRule annotation
Disulfide bondi178 ↔ 205PROSITE-ProRule annotation
Disulfide bondi210 ↔ 251PROSITE-ProRule annotation
Disulfide bondi237 ↔ 262PROSITE-ProRule annotation
Disulfide bondi267 ↔ 309PROSITE-ProRule annotation
Disulfide bondi294 ↔ 320PROSITE-ProRule annotation
Disulfide bondi325 ↔ 374PROSITE-ProRule annotation
Disulfide bondi357 ↔ 385PROSITE-ProRule annotation
Disulfide bondi389 ↔ 431PROSITE-ProRule annotation
Disulfide bondi416 ↔ 442PROSITE-ProRule annotation
Disulfide bondi448 ↔ 494PROSITE-ProRule annotation
Disulfide bondi477 ↔ 505PROSITE-ProRule annotation
Disulfide bondi509 ↔ 553PROSITE-ProRule annotation
Disulfide bondi536 ↔ 564PROSITE-ProRule annotation
Disulfide bondi569 ↔ 610PROSITE-ProRule annotation
Disulfide bondi597 ↔ 622PROSITE-ProRule annotation
Disulfide bondi629 ↔ 672PROSITE-ProRule annotation
Disulfide bondi658 ↔ 683PROSITE-ProRule annotation
Glycosylationi676N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi690 ↔ 732PROSITE-ProRule annotation
Disulfide bondi718 ↔ 743PROSITE-ProRule annotation
Glycosylationi721N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi752 ↔ 791PROSITE-ProRule annotation
Glycosylationi773N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi780 ↔ 802PROSITE-ProRule annotation
Glycosylationi801N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi808 ↔ 850PROSITE-ProRule annotation
Disulfide bondi836 ↔ 861PROSITE-ProRule annotation
Disulfide bondi867 ↔ 920PROSITE-ProRule annotation
Disulfide bondi906 ↔ 931PROSITE-ProRule annotation
Disulfide bondi936 ↔ 978PROSITE-ProRule annotation
Disulfide bondi964 ↔ 989PROSITE-ProRule annotation
Disulfide bondi994 ↔ 1037PROSITE-ProRule annotation
Disulfide bondi1023 ↔ 1048PROSITE-ProRule annotation
Glycosylationi1030N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi1053 ↔ 1096PROSITE-ProRule annotation
Glycosylationi1061N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi1082 ↔ 1107PROSITE-ProRule annotation
Disulfide bondi1114 ↔ 1157PROSITE-ProRule annotation
Disulfide bondi1143 ↔ 1168PROSITE-ProRule annotation
Disulfide bondi1172 ↔ 1223PROSITE-ProRule annotation
Modified residuei1198PhosphoserineCombined sources1
Disulfide bondi1206 ↔ 1233PROSITE-ProRule annotation
Glycosylationi1225N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP06909
PRIDEiP06909

PTM databases

GlyConnecti817
iPTMnetiP06909
PhosphoSitePlusiP06909
SwissPalmiP06909

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiENSMUSG00000026365
CleanExiMM_CFH
ExpressionAtlasiP06909 baseline and differential
GenevisibleiP06909 MM

Interactioni

GO - Molecular functioni

  • complement component C3b binding Source: MGI
  • heparan sulfate proteoglycan binding Source: MGI

Protein-protein interaction databases

IntActiP06909, 2 interactors
MINTiP06909
STRINGi10090.ENSMUSP00000107607

Structurei

Secondary structure

11234
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi333 – 335Combined sources3
Helixi338 – 341Combined sources4
Helixi342 – 344Combined sources3
Beta strandi352 – 357Combined sources6
Beta strandi370 – 375Combined sources6
Beta strandi378 – 383Combined sources6
Beta strandi386 – 391Combined sources6
Beta strandi404 – 407Combined sources4
Beta strandi411 – 413Combined sources3
Beta strandi423 – 426Combined sources4
Beta strandi428 – 432Combined sources5
Beta strandi435 – 438Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YBYX-ray1.58A321-444[»]
ProteinModelPortaliP06909
SMRiP06909
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 82Sushi 1PROSITE-ProRule annotationAdd BLAST64
Domaini83 – 143Sushi 2PROSITE-ProRule annotationAdd BLAST61
Domaini144 – 207Sushi 3PROSITE-ProRule annotationAdd BLAST64
Domaini208 – 264Sushi 4PROSITE-ProRule annotationAdd BLAST57
Domaini265 – 322Sushi 5PROSITE-ProRule annotationAdd BLAST58
Domaini324 – 386Sushi 6PROSITE-ProRule annotationAdd BLAST63
Domaini387 – 444Sushi 7PROSITE-ProRule annotationAdd BLAST58
Domaini446 – 507Sushi 8PROSITE-ProRule annotationAdd BLAST62
Domaini508 – 566Sushi 9PROSITE-ProRule annotationAdd BLAST59
Domaini567 – 624Sushi 10PROSITE-ProRule annotationAdd BLAST58
Domaini627 – 685Sushi 11PROSITE-ProRule annotationAdd BLAST59
Domaini688 – 745Sushi 12PROSITE-ProRule annotationAdd BLAST58
Domaini750 – 804Sushi 13PROSITE-ProRule annotationAdd BLAST55
Domaini806 – 863Sushi 14PROSITE-ProRule annotationAdd BLAST58
Domaini865 – 933Sushi 15PROSITE-ProRule annotationAdd BLAST69
Domaini934 – 991Sushi 16PROSITE-ProRule annotationAdd BLAST58
Domaini992 – 1050Sushi 17PROSITE-ProRule annotationAdd BLAST59
Domaini1051 – 1109Sushi 18PROSITE-ProRule annotationAdd BLAST59
Domaini1112 – 1170Sushi 19PROSITE-ProRule annotationAdd BLAST59
Domaini1171 – 1234Sushi 20PROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IVQ9 Eukaryota
ENOG410YBAR LUCA
GeneTreeiENSGT00910000143999
HOGENOMiHOG000049040
HOVERGENiHBG005665
InParanoidiP06909
KOiK04004

Family and domain databases

CDDicd00033 CCP, 16 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 16 hits
SMARTiView protein in SMART
SM00032 CCP, 20 hits
SUPFAMiSSF57535 SSF57535, 18 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 18 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSARIIWL ILWTVCAAED CKGPPPRENS EILSGSWSEQ LYPEGTQATY
60 70 80 90 100
KCRPGYRTLG TIVKVCKNGK WVASNPSRIC RKKPCGHPGD TPFGSFRLAV
110 120 130 140 150
GSQFEFGAKV VYTCDDGYQL LGEIDYRECG ADGWINDIPL CEVVKCLPVT
160 170 180 190 200
ELENGRIVSG AAETDQEYYF GQVVRFECNS GFKIEGHKEI HCSENGLWSN
210 220 230 240 250
EKPRCVEILC TPPRVENGDG INVKPVYKEN ERYHYKCKHG YVPKERGDAV
260 270 280 290 300
CTGSGWSSQP FCEEKRCSPP YILNGIYTPH RIIHRSDDEI RYECNYGFYP
310 320 330 340 350
VTGSTVSKCT PTGWIPVPRC TLKPCEFPQF KYGRLYYEES LRPNFPVSIG
360 370 380 390 400
NKYSYKCDNG FSPPSGYSWD YLRCTAQGWE PEVPCVRKCV FHYVENGDSA
410 420 430 440 450
YWEKVYVQGQ SLKVQCYNGY SLQNGQDTMT CTENGWSPPP KCIRIKTCSA
460 470 480 490 500
SDIHIDNGFL SESSSIYALN RETSYRCKQG YVTNTGEISG SITCLQNGWS
510 520 530 540 550
PQPSCIKSCD MPVFENSITK NTRTWFKLND KLDYECLVGF ENEYKHTKGS
560 570 580 590 600
ITCTYYGWSD TPSCYERECS VPTLDRKLVV SPRKEKYRVG DLLEFSCHSG
610 620 630 640 650
HRVGPDSVQC YHFGWSPGFP TCKGQVASCA PPLEILNGEI NGAKKVEYSH
660 670 680 690 700
GEVVKYDCKP RFLLKGPNKI QCVDGNWTTL PVCIEEERTC GDIPELEHGS
710 720 730 740 750
AKCSVPPYHH GDSVEFICEE NFTMIGHGSV SCISGKWTQL PKCVATDQLE
760 770 780 790 800
KCRVLKSTGI EAIKPKLTEF THNSTMDYKC RDKQEYERSI CINGKWDPEP
810 820 830 840 850
NCTSKTSCPP PPQIPNTQVI ETTVKYLDGE KLSVLCQDNY LTQDSEEMVC
860 870 880 890 900
KDGRWQSLPR CIEKIPCSQP PTIEHGSINL PRSSEERRDS IESSSHEHGT
910 920 930 940 950
TFSYVCDDGF RIPEENRITC YMGKWSTPPR CVGLPCGPPP SIPLGTVSLE
960 970 980 990 1000
LESYQHGEEV TYHCSTGFGI DGPAFIICEG GKWSDPPKCI KTDCDVLPTV
1010 1020 1030 1040 1050
KNAIIRGKSK KSYRTGEQVT FRCQSPYQMN GSDTVTCVNS RWIGQPVCKD
1060 1070 1080 1090 1100
NSCVDPPHVP NATIVTRTKN KYLHGDRVRY ECNKPLELFG QVEVMCENGI
1110 1120 1130 1140 1150
WTEKPKCRDS TGKCGPPPPI DNGDITSLSL PVYEPLSSVE YQCQKYYLLK
1160 1170 1180 1190 1200
GKKTITCRNG KWSEPPTCLH ACVIPENIME SHNIILKWRH TEKIYSHSGE
1210 1220 1230
DIEFGCKYGY YKARDSPPFR TKCINGTINY PTCV
Length:1,234
Mass (Da):139,138
Last modified:October 3, 2012 - v2
Checksum:i0A5722F34620C9F0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1158R → T in AAA37759 (PubMed:2940596).Curated1

Polymorphismi

Two codominant alleles of factor H are present in mice.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12660 mRNA Translation: AAA37759.1
AC161408 Genomic DNA No translation available.
BC066092 mRNA Translation: AAH66092.1
J02891 mRNA Translation: AAA37795.1
AH001909 mRNA Translation: AAA37762.1
PIRiA26154 NBMSH
RefSeqiNP_034018.2, NM_009888.3
UniGeneiMm.8655

Genome annotation databases

EnsembliENSMUST00000066859; ENSMUSP00000066677; ENSMUSG00000026365
GeneIDi12628
KEGGimmu:12628

Similar proteinsi

Entry informationi

Entry nameiCFAH_MOUSE
AccessioniPrimary (citable) accession number: P06909
Secondary accession number(s): Q6NZK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: October 3, 2012
Last modified: April 25, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health