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P06909

- CFAH_MOUSE

UniProt

P06909 - CFAH_MOUSE

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Protein
Complement factor H
Gene
Cfh, Hf1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway By similarity.

GO - Molecular functioni

  1. complement component C3b binding Source: MGI
  2. heparin binding Source: MGI

GO - Biological processi

  1. complement activation, alternative pathway Source: UniProtKB-KW
  2. regulation of complement activation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Complement alternate pathway, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_198562. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement factor H
Alternative name(s):
Protein beta-1-H
Gene namesi
Name:Cfh
Synonyms:Hf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:88385. Cfh.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 By similarity
Add
BLAST
Chaini19 – 12341216Complement factor H
PRO_0000005895Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi21 ↔ 66 By similarity
Disulfide bondi52 ↔ 80 By similarity
Disulfide bondi85 ↔ 129 By similarity
Disulfide bondi114 ↔ 141 By similarity
Disulfide bondi146 ↔ 192 By similarity
Disulfide bondi178 ↔ 205 By similarity
Disulfide bondi210 ↔ 251 By similarity
Disulfide bondi237 ↔ 262 By similarity
Disulfide bondi267 ↔ 309 By similarity
Disulfide bondi294 ↔ 320 By similarity
Disulfide bondi325 ↔ 374 By similarity
Disulfide bondi357 ↔ 385 By similarity
Disulfide bondi389 ↔ 431 By similarity
Disulfide bondi416 ↔ 442 By similarity
Disulfide bondi448 ↔ 494 By similarity
Disulfide bondi477 ↔ 505 By similarity
Disulfide bondi509 ↔ 553 By similarity
Disulfide bondi536 ↔ 564 By similarity
Disulfide bondi569 ↔ 610 By similarity
Disulfide bondi597 ↔ 622 By similarity
Disulfide bondi629 ↔ 672 By similarity
Disulfide bondi658 ↔ 683 By similarity
Glycosylationi676 – 6761N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi690 ↔ 732 By similarity
Disulfide bondi718 ↔ 743 By similarity
Glycosylationi721 – 7211N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi752 ↔ 791 By similarity
Glycosylationi773 – 7731N-linked (GlcNAc...)2 Publications
Disulfide bondi780 ↔ 802 By similarity
Glycosylationi801 – 8011N-linked (GlcNAc...)1 Publication
Disulfide bondi808 ↔ 850 By similarity
Disulfide bondi836 ↔ 861 By similarity
Disulfide bondi867 ↔ 920 By similarity
Disulfide bondi906 ↔ 931 By similarity
Disulfide bondi936 ↔ 978 By similarity
Disulfide bondi964 ↔ 989 By similarity
Disulfide bondi994 ↔ 1037 By similarity
Disulfide bondi1023 ↔ 1048 By similarity
Glycosylationi1030 – 10301N-linked (GlcNAc...)1 Publication
Disulfide bondi1053 ↔ 1096 By similarity
Glycosylationi1061 – 10611N-linked (GlcNAc...)2 Publications
Disulfide bondi1082 ↔ 1107 By similarity
Disulfide bondi1114 ↔ 1157 By similarity
Disulfide bondi1143 ↔ 1168 By similarity
Disulfide bondi1172 ↔ 1223 By similarity
Modified residuei1198 – 11981Phosphoserine1 Publication
Disulfide bondi1206 ↔ 1233 By similarity
Glycosylationi1225 – 12251N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP06909.
PRIDEiP06909.

PTM databases

PhosphoSiteiP06909.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

ArrayExpressiP06909.
CleanExiMM_CFH.
GenevestigatoriP06909.

Interactioni

Protein-protein interaction databases

IntActiP06909. 2 interactions.
MINTiMINT-1858780.
STRINGi10090.ENSMUSP00000066677.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi333 – 3353
Helixi338 – 3414
Helixi342 – 3443
Beta strandi352 – 3576
Beta strandi370 – 3756
Beta strandi378 – 3836
Beta strandi386 – 3916
Beta strandi404 – 4074
Beta strandi411 – 4133
Beta strandi423 – 4264
Beta strandi428 – 4325
Beta strandi435 – 4384

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YBYX-ray1.58A321-444[»]
ProteinModelPortaliP06909.
SMRiP06909. Positions 20-1233.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 8264Sushi 1
Add
BLAST
Domaini83 – 14361Sushi 2
Add
BLAST
Domaini144 – 20764Sushi 3
Add
BLAST
Domaini208 – 26457Sushi 4
Add
BLAST
Domaini265 – 32258Sushi 5
Add
BLAST
Domaini324 – 38663Sushi 6
Add
BLAST
Domaini387 – 44458Sushi 7
Add
BLAST
Domaini446 – 50762Sushi 8
Add
BLAST
Domaini508 – 56659Sushi 9
Add
BLAST
Domaini567 – 62458Sushi 10
Add
BLAST
Domaini627 – 68559Sushi 11
Add
BLAST
Domaini688 – 74558Sushi 12
Add
BLAST
Domaini750 – 80455Sushi 13
Add
BLAST
Domaini806 – 86358Sushi 14
Add
BLAST
Domaini865 – 93369Sushi 15
Add
BLAST
Domaini934 – 99158Sushi 16
Add
BLAST
Domaini992 – 105059Sushi 17
Add
BLAST
Domaini1051 – 110959Sushi 18
Add
BLAST
Domaini1112 – 117059Sushi 19
Add
BLAST
Domaini1171 – 123464Sushi 20
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiNOG148800.
GeneTreeiENSGT00740000115024.
HOGENOMiHOG000049040.
HOVERGENiHBG005665.
InParanoidiP06909.
KOiK04004.
OrthoDBiEOG75XGK1.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamiPF00084. Sushi. 16 hits.
[Graphical view]
SMARTiSM00032. CCP. 20 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 18 hits.
PROSITEiPS50923. SUSHI. 18 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06909-1 [UniParc]FASTAAdd to Basket

« Hide

MRLSARIIWL ILWTVCAAED CKGPPPRENS EILSGSWSEQ LYPEGTQATY     50
KCRPGYRTLG TIVKVCKNGK WVASNPSRIC RKKPCGHPGD TPFGSFRLAV 100
GSQFEFGAKV VYTCDDGYQL LGEIDYRECG ADGWINDIPL CEVVKCLPVT 150
ELENGRIVSG AAETDQEYYF GQVVRFECNS GFKIEGHKEI HCSENGLWSN 200
EKPRCVEILC TPPRVENGDG INVKPVYKEN ERYHYKCKHG YVPKERGDAV 250
CTGSGWSSQP FCEEKRCSPP YILNGIYTPH RIIHRSDDEI RYECNYGFYP 300
VTGSTVSKCT PTGWIPVPRC TLKPCEFPQF KYGRLYYEES LRPNFPVSIG 350
NKYSYKCDNG FSPPSGYSWD YLRCTAQGWE PEVPCVRKCV FHYVENGDSA 400
YWEKVYVQGQ SLKVQCYNGY SLQNGQDTMT CTENGWSPPP KCIRIKTCSA 450
SDIHIDNGFL SESSSIYALN RETSYRCKQG YVTNTGEISG SITCLQNGWS 500
PQPSCIKSCD MPVFENSITK NTRTWFKLND KLDYECLVGF ENEYKHTKGS 550
ITCTYYGWSD TPSCYERECS VPTLDRKLVV SPRKEKYRVG DLLEFSCHSG 600
HRVGPDSVQC YHFGWSPGFP TCKGQVASCA PPLEILNGEI NGAKKVEYSH 650
GEVVKYDCKP RFLLKGPNKI QCVDGNWTTL PVCIEEERTC GDIPELEHGS 700
AKCSVPPYHH GDSVEFICEE NFTMIGHGSV SCISGKWTQL PKCVATDQLE 750
KCRVLKSTGI EAIKPKLTEF THNSTMDYKC RDKQEYERSI CINGKWDPEP 800
NCTSKTSCPP PPQIPNTQVI ETTVKYLDGE KLSVLCQDNY LTQDSEEMVC 850
KDGRWQSLPR CIEKIPCSQP PTIEHGSINL PRSSEERRDS IESSSHEHGT 900
TFSYVCDDGF RIPEENRITC YMGKWSTPPR CVGLPCGPPP SIPLGTVSLE 950
LESYQHGEEV TYHCSTGFGI DGPAFIICEG GKWSDPPKCI KTDCDVLPTV 1000
KNAIIRGKSK KSYRTGEQVT FRCQSPYQMN GSDTVTCVNS RWIGQPVCKD 1050
NSCVDPPHVP NATIVTRTKN KYLHGDRVRY ECNKPLELFG QVEVMCENGI 1100
WTEKPKCRDS TGKCGPPPPI DNGDITSLSL PVYEPLSSVE YQCQKYYLLK 1150
GKKTITCRNG KWSEPPTCLH ACVIPENIME SHNIILKWRH TEKIYSHSGE 1200
DIEFGCKYGY YKARDSPPFR TKCINGTINY PTCV 1234
Length:1,234
Mass (Da):139,138
Last modified:October 3, 2012 - v2
Checksum:i0A5722F34620C9F0
GO

Polymorphismi

Two codominant alleles of factor H are present in mice.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1158 – 11581R → T in AAA37759. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M12660 mRNA. Translation: AAA37759.1.
AC161408 Genomic DNA. No translation available.
BC066092 mRNA. Translation: AAH66092.1.
J02891 mRNA. Translation: AAA37795.1.
AH001909 mRNA. Translation: AAA37762.1.
PIRiA26154. NBMSH.
RefSeqiNP_034018.2. NM_009888.3.
UniGeneiMm.8655.

Genome annotation databases

EnsembliENSMUST00000066859; ENSMUSP00000066677; ENSMUSG00000026365.
GeneIDi12628.
KEGGimmu:12628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M12660 mRNA. Translation: AAA37759.1 .
AC161408 Genomic DNA. No translation available.
BC066092 mRNA. Translation: AAH66092.1 .
J02891 mRNA. Translation: AAA37795.1 .
AH001909 mRNA. Translation: AAA37762.1 .
PIRi A26154. NBMSH.
RefSeqi NP_034018.2. NM_009888.3.
UniGenei Mm.8655.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YBY X-ray 1.58 A 321-444 [» ]
ProteinModelPortali P06909.
SMRi P06909. Positions 20-1233.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P06909. 2 interactions.
MINTi MINT-1858780.
STRINGi 10090.ENSMUSP00000066677.

PTM databases

PhosphoSitei P06909.

Proteomic databases

PaxDbi P06909.
PRIDEi P06909.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000066859 ; ENSMUSP00000066677 ; ENSMUSG00000026365 .
GeneIDi 12628.
KEGGi mmu:12628.

Organism-specific databases

CTDi 3075.
MGIi MGI:88385. Cfh.

Phylogenomic databases

eggNOGi NOG148800.
GeneTreei ENSGT00740000115024.
HOGENOMi HOG000049040.
HOVERGENi HBG005665.
InParanoidi P06909.
KOi K04004.
OrthoDBi EOG75XGK1.

Enzyme and pathway databases

Reactomei REACT_198562. Regulation of Complement cascade.

Miscellaneous databases

NextBioi 281808.
PROi P06909.
SOURCEi Search...

Gene expression databases

ArrayExpressi P06909.
CleanExi MM_CFH.
Genevestigatori P06909.

Family and domain databases

InterProi IPR000436. Sushi_SCR_CCP.
[Graphical view ]
Pfami PF00084. Sushi. 16 hits.
[Graphical view ]
SMARTi SM00032. CCP. 20 hits.
[Graphical view ]
SUPFAMi SSF57535. SSF57535. 18 hits.
PROSITEi PS50923. SUSHI. 18 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine protein H is comprised of 20 repeating units, 61 amino acids in length."
    Kristensen T., Tack B.F.
    Proc. Natl. Acad. Sci. U.S.A. 83:3963-3967(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Analysis of complement factor H mRNA expression: dexamethasone and IFN-gamma increase the level of H in L cells."
    Munoz-Canoves P., Tack B.F., Vik D.P.
    Biochemistry 28:9891-9897(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-19.
    Strain: BALB/c.
  5. "Demonstration of an unusual allelic variation of mouse factor H by the complete cDNA sequence of the H.2 allotype."
    Natsuume-Sakai S., Nonaka M., Nonaka M., Harada Y.N., Shreffler D.C., Moriwaki K.
    J. Immunol. 144:358-362(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-18.
  6. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
    Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
    J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-773 AND ASN-1061.
    Strain: C57BL/6.
    Tissue: Plasma.
  7. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
    Bernhard O.K., Kapp E.A., Simpson R.J.
    J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-773; ASN-801; ASN-1030; ASN-1061 AND ASN-1225.
    Strain: C57BL/6.
    Tissue: Plasma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1198, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCFAH_MOUSE
AccessioniPrimary (citable) accession number: P06909
Secondary accession number(s): Q6NZK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi