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P06909

- CFAH_MOUSE

UniProt

P06909 - CFAH_MOUSE

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Protein

Complement factor H

Gene

Cfh

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.By similarity

GO - Molecular functioni

  1. complement component C3b binding Source: MGI
  2. heparin binding Source: MGI

GO - Biological processi

  1. complement activation, alternative pathway Source: UniProtKB-KW
  2. regulation of complement activation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Complement alternate pathway, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_198562. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement factor H
Alternative name(s):
Protein beta-1-H
Gene namesi
Name:Cfh
Synonyms:Hf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:88385. Cfh.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 12341216Complement factor HPRO_0000005895Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi21 ↔ 66PROSITE-ProRule annotation
Disulfide bondi52 ↔ 80PROSITE-ProRule annotation
Disulfide bondi85 ↔ 129PROSITE-ProRule annotation
Disulfide bondi114 ↔ 141PROSITE-ProRule annotation
Disulfide bondi146 ↔ 192PROSITE-ProRule annotation
Disulfide bondi178 ↔ 205PROSITE-ProRule annotation
Disulfide bondi210 ↔ 251PROSITE-ProRule annotation
Disulfide bondi237 ↔ 262PROSITE-ProRule annotation
Disulfide bondi267 ↔ 309PROSITE-ProRule annotation
Disulfide bondi294 ↔ 320PROSITE-ProRule annotation
Disulfide bondi325 ↔ 374PROSITE-ProRule annotation
Disulfide bondi357 ↔ 385PROSITE-ProRule annotation
Disulfide bondi389 ↔ 431PROSITE-ProRule annotation
Disulfide bondi416 ↔ 442PROSITE-ProRule annotation
Disulfide bondi448 ↔ 494PROSITE-ProRule annotation
Disulfide bondi477 ↔ 505PROSITE-ProRule annotation
Disulfide bondi509 ↔ 553PROSITE-ProRule annotation
Disulfide bondi536 ↔ 564PROSITE-ProRule annotation
Disulfide bondi569 ↔ 610PROSITE-ProRule annotation
Disulfide bondi597 ↔ 622PROSITE-ProRule annotation
Disulfide bondi629 ↔ 672PROSITE-ProRule annotation
Disulfide bondi658 ↔ 683PROSITE-ProRule annotation
Glycosylationi676 – 6761N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi690 ↔ 732PROSITE-ProRule annotation
Disulfide bondi718 ↔ 743PROSITE-ProRule annotation
Glycosylationi721 – 7211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi752 ↔ 791PROSITE-ProRule annotation
Glycosylationi773 – 7731N-linked (GlcNAc...)2 Publications
Disulfide bondi780 ↔ 802PROSITE-ProRule annotation
Glycosylationi801 – 8011N-linked (GlcNAc...)1 Publication
Disulfide bondi808 ↔ 850PROSITE-ProRule annotation
Disulfide bondi836 ↔ 861PROSITE-ProRule annotation
Disulfide bondi867 ↔ 920PROSITE-ProRule annotation
Disulfide bondi906 ↔ 931PROSITE-ProRule annotation
Disulfide bondi936 ↔ 978PROSITE-ProRule annotation
Disulfide bondi964 ↔ 989PROSITE-ProRule annotation
Disulfide bondi994 ↔ 1037PROSITE-ProRule annotation
Disulfide bondi1023 ↔ 1048PROSITE-ProRule annotation
Glycosylationi1030 – 10301N-linked (GlcNAc...)1 Publication
Disulfide bondi1053 ↔ 1096PROSITE-ProRule annotation
Glycosylationi1061 – 10611N-linked (GlcNAc...)2 Publications
Disulfide bondi1082 ↔ 1107PROSITE-ProRule annotation
Disulfide bondi1114 ↔ 1157PROSITE-ProRule annotation
Disulfide bondi1143 ↔ 1168PROSITE-ProRule annotation
Disulfide bondi1172 ↔ 1223PROSITE-ProRule annotation
Modified residuei1198 – 11981Phosphoserine1 Publication
Disulfide bondi1206 ↔ 1233PROSITE-ProRule annotation
Glycosylationi1225 – 12251N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP06909.
PRIDEiP06909.

PTM databases

PhosphoSiteiP06909.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

CleanExiMM_CFH.
ExpressionAtlasiP06909. baseline and differential.
GenevestigatoriP06909.

Interactioni

Protein-protein interaction databases

IntActiP06909. 2 interactions.
MINTiMINT-1858780.
STRINGi10090.ENSMUSP00000066677.

Structurei

Secondary structure

1
1234
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi333 – 3353
Helixi338 – 3414
Helixi342 – 3443
Beta strandi352 – 3576
Beta strandi370 – 3756
Beta strandi378 – 3836
Beta strandi386 – 3916
Beta strandi404 – 4074
Beta strandi411 – 4133
Beta strandi423 – 4264
Beta strandi428 – 4325
Beta strandi435 – 4384

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YBYX-ray1.58A321-444[»]
ProteinModelPortaliP06909.
SMRiP06909. Positions 20-1233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 8264Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini83 – 14361Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini144 – 20764Sushi 3PROSITE-ProRule annotationAdd
BLAST
Domaini208 – 26457Sushi 4PROSITE-ProRule annotationAdd
BLAST
Domaini265 – 32258Sushi 5PROSITE-ProRule annotationAdd
BLAST
Domaini324 – 38663Sushi 6PROSITE-ProRule annotationAdd
BLAST
Domaini387 – 44458Sushi 7PROSITE-ProRule annotationAdd
BLAST
Domaini446 – 50762Sushi 8PROSITE-ProRule annotationAdd
BLAST
Domaini508 – 56659Sushi 9PROSITE-ProRule annotationAdd
BLAST
Domaini567 – 62458Sushi 10PROSITE-ProRule annotationAdd
BLAST
Domaini627 – 68559Sushi 11PROSITE-ProRule annotationAdd
BLAST
Domaini688 – 74558Sushi 12PROSITE-ProRule annotationAdd
BLAST
Domaini750 – 80455Sushi 13PROSITE-ProRule annotationAdd
BLAST
Domaini806 – 86358Sushi 14PROSITE-ProRule annotationAdd
BLAST
Domaini865 – 93369Sushi 15PROSITE-ProRule annotationAdd
BLAST
Domaini934 – 99158Sushi 16PROSITE-ProRule annotationAdd
BLAST
Domaini992 – 105059Sushi 17PROSITE-ProRule annotationAdd
BLAST
Domaini1051 – 110959Sushi 18PROSITE-ProRule annotationAdd
BLAST
Domaini1112 – 117059Sushi 19PROSITE-ProRule annotationAdd
BLAST
Domaini1171 – 123464Sushi 20PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 20 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiNOG148800.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000049040.
HOVERGENiHBG005665.
InParanoidiP06909.
KOiK04004.
OrthoDBiEOG75XGK1.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamiPF00084. Sushi. 16 hits.
[Graphical view]
SMARTiSM00032. CCP. 20 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 18 hits.
PROSITEiPS50923. SUSHI. 18 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06909-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLSARIIWL ILWTVCAAED CKGPPPRENS EILSGSWSEQ LYPEGTQATY
60 70 80 90 100
KCRPGYRTLG TIVKVCKNGK WVASNPSRIC RKKPCGHPGD TPFGSFRLAV
110 120 130 140 150
GSQFEFGAKV VYTCDDGYQL LGEIDYRECG ADGWINDIPL CEVVKCLPVT
160 170 180 190 200
ELENGRIVSG AAETDQEYYF GQVVRFECNS GFKIEGHKEI HCSENGLWSN
210 220 230 240 250
EKPRCVEILC TPPRVENGDG INVKPVYKEN ERYHYKCKHG YVPKERGDAV
260 270 280 290 300
CTGSGWSSQP FCEEKRCSPP YILNGIYTPH RIIHRSDDEI RYECNYGFYP
310 320 330 340 350
VTGSTVSKCT PTGWIPVPRC TLKPCEFPQF KYGRLYYEES LRPNFPVSIG
360 370 380 390 400
NKYSYKCDNG FSPPSGYSWD YLRCTAQGWE PEVPCVRKCV FHYVENGDSA
410 420 430 440 450
YWEKVYVQGQ SLKVQCYNGY SLQNGQDTMT CTENGWSPPP KCIRIKTCSA
460 470 480 490 500
SDIHIDNGFL SESSSIYALN RETSYRCKQG YVTNTGEISG SITCLQNGWS
510 520 530 540 550
PQPSCIKSCD MPVFENSITK NTRTWFKLND KLDYECLVGF ENEYKHTKGS
560 570 580 590 600
ITCTYYGWSD TPSCYERECS VPTLDRKLVV SPRKEKYRVG DLLEFSCHSG
610 620 630 640 650
HRVGPDSVQC YHFGWSPGFP TCKGQVASCA PPLEILNGEI NGAKKVEYSH
660 670 680 690 700
GEVVKYDCKP RFLLKGPNKI QCVDGNWTTL PVCIEEERTC GDIPELEHGS
710 720 730 740 750
AKCSVPPYHH GDSVEFICEE NFTMIGHGSV SCISGKWTQL PKCVATDQLE
760 770 780 790 800
KCRVLKSTGI EAIKPKLTEF THNSTMDYKC RDKQEYERSI CINGKWDPEP
810 820 830 840 850
NCTSKTSCPP PPQIPNTQVI ETTVKYLDGE KLSVLCQDNY LTQDSEEMVC
860 870 880 890 900
KDGRWQSLPR CIEKIPCSQP PTIEHGSINL PRSSEERRDS IESSSHEHGT
910 920 930 940 950
TFSYVCDDGF RIPEENRITC YMGKWSTPPR CVGLPCGPPP SIPLGTVSLE
960 970 980 990 1000
LESYQHGEEV TYHCSTGFGI DGPAFIICEG GKWSDPPKCI KTDCDVLPTV
1010 1020 1030 1040 1050
KNAIIRGKSK KSYRTGEQVT FRCQSPYQMN GSDTVTCVNS RWIGQPVCKD
1060 1070 1080 1090 1100
NSCVDPPHVP NATIVTRTKN KYLHGDRVRY ECNKPLELFG QVEVMCENGI
1110 1120 1130 1140 1150
WTEKPKCRDS TGKCGPPPPI DNGDITSLSL PVYEPLSSVE YQCQKYYLLK
1160 1170 1180 1190 1200
GKKTITCRNG KWSEPPTCLH ACVIPENIME SHNIILKWRH TEKIYSHSGE
1210 1220 1230
DIEFGCKYGY YKARDSPPFR TKCINGTINY PTCV
Length:1,234
Mass (Da):139,138
Last modified:October 3, 2012 - v2
Checksum:i0A5722F34620C9F0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1158 – 11581R → T in AAA37759. (PubMed:2940596)Curated

Polymorphismi

Two codominant alleles of factor H are present in mice.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M12660 mRNA. Translation: AAA37759.1.
AC161408 Genomic DNA. No translation available.
BC066092 mRNA. Translation: AAH66092.1.
J02891 mRNA. Translation: AAA37795.1.
AH001909 mRNA. Translation: AAA37762.1.
PIRiA26154. NBMSH.
RefSeqiNP_034018.2. NM_009888.3.
UniGeneiMm.8655.

Genome annotation databases

EnsembliENSMUST00000066859; ENSMUSP00000066677; ENSMUSG00000026365.
GeneIDi12628.
KEGGimmu:12628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M12660 mRNA. Translation: AAA37759.1 .
AC161408 Genomic DNA. No translation available.
BC066092 mRNA. Translation: AAH66092.1 .
J02891 mRNA. Translation: AAA37795.1 .
AH001909 mRNA. Translation: AAA37762.1 .
PIRi A26154. NBMSH.
RefSeqi NP_034018.2. NM_009888.3.
UniGenei Mm.8655.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YBY X-ray 1.58 A 321-444 [» ]
ProteinModelPortali P06909.
SMRi P06909. Positions 20-1233.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P06909. 2 interactions.
MINTi MINT-1858780.
STRINGi 10090.ENSMUSP00000066677.

PTM databases

PhosphoSitei P06909.

Proteomic databases

PaxDbi P06909.
PRIDEi P06909.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000066859 ; ENSMUSP00000066677 ; ENSMUSG00000026365 .
GeneIDi 12628.
KEGGi mmu:12628.

Organism-specific databases

CTDi 3075.
MGIi MGI:88385. Cfh.

Phylogenomic databases

eggNOGi NOG148800.
GeneTreei ENSGT00760000118803.
HOGENOMi HOG000049040.
HOVERGENi HBG005665.
InParanoidi P06909.
KOi K04004.
OrthoDBi EOG75XGK1.

Enzyme and pathway databases

Reactomei REACT_198562. Regulation of Complement cascade.

Miscellaneous databases

NextBioi 281808.
PROi P06909.
SOURCEi Search...

Gene expression databases

CleanExi MM_CFH.
ExpressionAtlasi P06909. baseline and differential.
Genevestigatori P06909.

Family and domain databases

InterProi IPR000436. Sushi_SCR_CCP.
[Graphical view ]
Pfami PF00084. Sushi. 16 hits.
[Graphical view ]
SMARTi SM00032. CCP. 20 hits.
[Graphical view ]
SUPFAMi SSF57535. SSF57535. 18 hits.
PROSITEi PS50923. SUSHI. 18 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine protein H is comprised of 20 repeating units, 61 amino acids in length."
    Kristensen T., Tack B.F.
    Proc. Natl. Acad. Sci. U.S.A. 83:3963-3967(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Analysis of complement factor H mRNA expression: dexamethasone and IFN-gamma increase the level of H in L cells."
    Munoz-Canoves P., Tack B.F., Vik D.P.
    Biochemistry 28:9891-9897(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-19.
    Strain: BALB/c.
  5. "Demonstration of an unusual allelic variation of mouse factor H by the complete cDNA sequence of the H.2 allotype."
    Natsuume-Sakai S., Nonaka M., Nonaka M., Harada Y.N., Shreffler D.C., Moriwaki K.
    J. Immunol. 144:358-362(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-18.
  6. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
    Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
    J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-773 AND ASN-1061.
    Strain: C57BL/6.
    Tissue: Plasma.
  7. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
    Bernhard O.K., Kapp E.A., Simpson R.J.
    J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-773; ASN-801; ASN-1030; ASN-1061 AND ASN-1225.
    Strain: C57BL/6.
    Tissue: Plasma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1198, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCFAH_MOUSE
AccessioniPrimary (citable) accession number: P06909
Secondary accession number(s): Q6NZK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3