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P06909

- CFAH_MOUSE

UniProt

P06909 - CFAH_MOUSE

Protein

Complement factor H

Gene

Cfh

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.By similarity

    GO - Molecular functioni

    1. complement component C3b binding Source: MGI
    2. heparin binding Source: MGI

    GO - Biological processi

    1. complement activation, alternative pathway Source: UniProtKB-KW
    2. regulation of complement activation Source: MGI

    Keywords - Biological processi

    Complement alternate pathway, Immunity, Innate immunity

    Enzyme and pathway databases

    ReactomeiREACT_198562. Regulation of Complement cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Complement factor H
    Alternative name(s):
    Protein beta-1-H
    Gene namesi
    Name:Cfh
    Synonyms:Hf1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:88385. Cfh.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Chaini19 – 12341216Complement factor HPRO_0000005895Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi21 ↔ 66PROSITE-ProRule annotation
    Disulfide bondi52 ↔ 80PROSITE-ProRule annotation
    Disulfide bondi85 ↔ 129PROSITE-ProRule annotation
    Disulfide bondi114 ↔ 141PROSITE-ProRule annotation
    Disulfide bondi146 ↔ 192PROSITE-ProRule annotation
    Disulfide bondi178 ↔ 205PROSITE-ProRule annotation
    Disulfide bondi210 ↔ 251PROSITE-ProRule annotation
    Disulfide bondi237 ↔ 262PROSITE-ProRule annotation
    Disulfide bondi267 ↔ 309PROSITE-ProRule annotation
    Disulfide bondi294 ↔ 320PROSITE-ProRule annotation
    Disulfide bondi325 ↔ 374PROSITE-ProRule annotation
    Disulfide bondi357 ↔ 385PROSITE-ProRule annotation
    Disulfide bondi389 ↔ 431PROSITE-ProRule annotation
    Disulfide bondi416 ↔ 442PROSITE-ProRule annotation
    Disulfide bondi448 ↔ 494PROSITE-ProRule annotation
    Disulfide bondi477 ↔ 505PROSITE-ProRule annotation
    Disulfide bondi509 ↔ 553PROSITE-ProRule annotation
    Disulfide bondi536 ↔ 564PROSITE-ProRule annotation
    Disulfide bondi569 ↔ 610PROSITE-ProRule annotation
    Disulfide bondi597 ↔ 622PROSITE-ProRule annotation
    Disulfide bondi629 ↔ 672PROSITE-ProRule annotation
    Disulfide bondi658 ↔ 683PROSITE-ProRule annotation
    Glycosylationi676 – 6761N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi690 ↔ 732PROSITE-ProRule annotation
    Disulfide bondi718 ↔ 743PROSITE-ProRule annotation
    Glycosylationi721 – 7211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi752 ↔ 791PROSITE-ProRule annotation
    Glycosylationi773 – 7731N-linked (GlcNAc...)2 Publications
    Disulfide bondi780 ↔ 802PROSITE-ProRule annotation
    Glycosylationi801 – 8011N-linked (GlcNAc...)1 Publication
    Disulfide bondi808 ↔ 850PROSITE-ProRule annotation
    Disulfide bondi836 ↔ 861PROSITE-ProRule annotation
    Disulfide bondi867 ↔ 920PROSITE-ProRule annotation
    Disulfide bondi906 ↔ 931PROSITE-ProRule annotation
    Disulfide bondi936 ↔ 978PROSITE-ProRule annotation
    Disulfide bondi964 ↔ 989PROSITE-ProRule annotation
    Disulfide bondi994 ↔ 1037PROSITE-ProRule annotation
    Disulfide bondi1023 ↔ 1048PROSITE-ProRule annotation
    Glycosylationi1030 – 10301N-linked (GlcNAc...)1 Publication
    Disulfide bondi1053 ↔ 1096PROSITE-ProRule annotation
    Glycosylationi1061 – 10611N-linked (GlcNAc...)2 Publications
    Disulfide bondi1082 ↔ 1107PROSITE-ProRule annotation
    Disulfide bondi1114 ↔ 1157PROSITE-ProRule annotation
    Disulfide bondi1143 ↔ 1168PROSITE-ProRule annotation
    Disulfide bondi1172 ↔ 1223PROSITE-ProRule annotation
    Modified residuei1198 – 11981Phosphoserine1 Publication
    Disulfide bondi1206 ↔ 1233PROSITE-ProRule annotation
    Glycosylationi1225 – 12251N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP06909.
    PRIDEiP06909.

    PTM databases

    PhosphoSiteiP06909.

    Expressioni

    Tissue specificityi

    Expressed by the liver and secreted in plasma.

    Gene expression databases

    ArrayExpressiP06909.
    CleanExiMM_CFH.
    GenevestigatoriP06909.

    Interactioni

    Protein-protein interaction databases

    IntActiP06909. 2 interactions.
    MINTiMINT-1858780.
    STRINGi10090.ENSMUSP00000066677.

    Structurei

    Secondary structure

    1
    1234
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi333 – 3353
    Helixi338 – 3414
    Helixi342 – 3443
    Beta strandi352 – 3576
    Beta strandi370 – 3756
    Beta strandi378 – 3836
    Beta strandi386 – 3916
    Beta strandi404 – 4074
    Beta strandi411 – 4133
    Beta strandi423 – 4264
    Beta strandi428 – 4325
    Beta strandi435 – 4384

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YBYX-ray1.58A321-444[»]
    ProteinModelPortaliP06909.
    SMRiP06909. Positions 20-1233.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 8264Sushi 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini83 – 14361Sushi 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini144 – 20764Sushi 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini208 – 26457Sushi 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini265 – 32258Sushi 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini324 – 38663Sushi 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini387 – 44458Sushi 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini446 – 50762Sushi 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini508 – 56659Sushi 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini567 – 62458Sushi 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini627 – 68559Sushi 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini688 – 74558Sushi 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini750 – 80455Sushi 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini806 – 86358Sushi 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini865 – 93369Sushi 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini934 – 99158Sushi 16PROSITE-ProRule annotationAdd
    BLAST
    Domaini992 – 105059Sushi 17PROSITE-ProRule annotationAdd
    BLAST
    Domaini1051 – 110959Sushi 18PROSITE-ProRule annotationAdd
    BLAST
    Domaini1112 – 117059Sushi 19PROSITE-ProRule annotationAdd
    BLAST
    Domaini1171 – 123464Sushi 20PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 20 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Sushi

    Phylogenomic databases

    eggNOGiNOG148800.
    GeneTreeiENSGT00740000115024.
    HOGENOMiHOG000049040.
    HOVERGENiHBG005665.
    InParanoidiP06909.
    KOiK04004.
    OrthoDBiEOG75XGK1.

    Family and domain databases

    InterProiIPR000436. Sushi_SCR_CCP.
    [Graphical view]
    PfamiPF00084. Sushi. 16 hits.
    [Graphical view]
    SMARTiSM00032. CCP. 20 hits.
    [Graphical view]
    SUPFAMiSSF57535. SSF57535. 18 hits.
    PROSITEiPS50923. SUSHI. 18 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P06909-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLSARIIWL ILWTVCAAED CKGPPPRENS EILSGSWSEQ LYPEGTQATY     50
    KCRPGYRTLG TIVKVCKNGK WVASNPSRIC RKKPCGHPGD TPFGSFRLAV 100
    GSQFEFGAKV VYTCDDGYQL LGEIDYRECG ADGWINDIPL CEVVKCLPVT 150
    ELENGRIVSG AAETDQEYYF GQVVRFECNS GFKIEGHKEI HCSENGLWSN 200
    EKPRCVEILC TPPRVENGDG INVKPVYKEN ERYHYKCKHG YVPKERGDAV 250
    CTGSGWSSQP FCEEKRCSPP YILNGIYTPH RIIHRSDDEI RYECNYGFYP 300
    VTGSTVSKCT PTGWIPVPRC TLKPCEFPQF KYGRLYYEES LRPNFPVSIG 350
    NKYSYKCDNG FSPPSGYSWD YLRCTAQGWE PEVPCVRKCV FHYVENGDSA 400
    YWEKVYVQGQ SLKVQCYNGY SLQNGQDTMT CTENGWSPPP KCIRIKTCSA 450
    SDIHIDNGFL SESSSIYALN RETSYRCKQG YVTNTGEISG SITCLQNGWS 500
    PQPSCIKSCD MPVFENSITK NTRTWFKLND KLDYECLVGF ENEYKHTKGS 550
    ITCTYYGWSD TPSCYERECS VPTLDRKLVV SPRKEKYRVG DLLEFSCHSG 600
    HRVGPDSVQC YHFGWSPGFP TCKGQVASCA PPLEILNGEI NGAKKVEYSH 650
    GEVVKYDCKP RFLLKGPNKI QCVDGNWTTL PVCIEEERTC GDIPELEHGS 700
    AKCSVPPYHH GDSVEFICEE NFTMIGHGSV SCISGKWTQL PKCVATDQLE 750
    KCRVLKSTGI EAIKPKLTEF THNSTMDYKC RDKQEYERSI CINGKWDPEP 800
    NCTSKTSCPP PPQIPNTQVI ETTVKYLDGE KLSVLCQDNY LTQDSEEMVC 850
    KDGRWQSLPR CIEKIPCSQP PTIEHGSINL PRSSEERRDS IESSSHEHGT 900
    TFSYVCDDGF RIPEENRITC YMGKWSTPPR CVGLPCGPPP SIPLGTVSLE 950
    LESYQHGEEV TYHCSTGFGI DGPAFIICEG GKWSDPPKCI KTDCDVLPTV 1000
    KNAIIRGKSK KSYRTGEQVT FRCQSPYQMN GSDTVTCVNS RWIGQPVCKD 1050
    NSCVDPPHVP NATIVTRTKN KYLHGDRVRY ECNKPLELFG QVEVMCENGI 1100
    WTEKPKCRDS TGKCGPPPPI DNGDITSLSL PVYEPLSSVE YQCQKYYLLK 1150
    GKKTITCRNG KWSEPPTCLH ACVIPENIME SHNIILKWRH TEKIYSHSGE 1200
    DIEFGCKYGY YKARDSPPFR TKCINGTINY PTCV 1234
    Length:1,234
    Mass (Da):139,138
    Last modified:October 3, 2012 - v2
    Checksum:i0A5722F34620C9F0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1158 – 11581R → T in AAA37759. (PubMed:2940596)Curated

    Polymorphismi

    Two codominant alleles of factor H are present in mice.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M12660 mRNA. Translation: AAA37759.1.
    AC161408 Genomic DNA. No translation available.
    BC066092 mRNA. Translation: AAH66092.1.
    J02891 mRNA. Translation: AAA37795.1.
    AH001909 mRNA. Translation: AAA37762.1.
    PIRiA26154. NBMSH.
    RefSeqiNP_034018.2. NM_009888.3.
    UniGeneiMm.8655.

    Genome annotation databases

    EnsembliENSMUST00000066859; ENSMUSP00000066677; ENSMUSG00000026365.
    GeneIDi12628.
    KEGGimmu:12628.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M12660 mRNA. Translation: AAA37759.1 .
    AC161408 Genomic DNA. No translation available.
    BC066092 mRNA. Translation: AAH66092.1 .
    J02891 mRNA. Translation: AAA37795.1 .
    AH001909 mRNA. Translation: AAA37762.1 .
    PIRi A26154. NBMSH.
    RefSeqi NP_034018.2. NM_009888.3.
    UniGenei Mm.8655.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YBY X-ray 1.58 A 321-444 [» ]
    ProteinModelPortali P06909.
    SMRi P06909. Positions 20-1233.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P06909. 2 interactions.
    MINTi MINT-1858780.
    STRINGi 10090.ENSMUSP00000066677.

    PTM databases

    PhosphoSitei P06909.

    Proteomic databases

    PaxDbi P06909.
    PRIDEi P06909.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000066859 ; ENSMUSP00000066677 ; ENSMUSG00000026365 .
    GeneIDi 12628.
    KEGGi mmu:12628.

    Organism-specific databases

    CTDi 3075.
    MGIi MGI:88385. Cfh.

    Phylogenomic databases

    eggNOGi NOG148800.
    GeneTreei ENSGT00740000115024.
    HOGENOMi HOG000049040.
    HOVERGENi HBG005665.
    InParanoidi P06909.
    KOi K04004.
    OrthoDBi EOG75XGK1.

    Enzyme and pathway databases

    Reactomei REACT_198562. Regulation of Complement cascade.

    Miscellaneous databases

    NextBioi 281808.
    PROi P06909.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P06909.
    CleanExi MM_CFH.
    Genevestigatori P06909.

    Family and domain databases

    InterProi IPR000436. Sushi_SCR_CCP.
    [Graphical view ]
    Pfami PF00084. Sushi. 16 hits.
    [Graphical view ]
    SMARTi SM00032. CCP. 20 hits.
    [Graphical view ]
    SUPFAMi SSF57535. SSF57535. 18 hits.
    PROSITEi PS50923. SUSHI. 18 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine protein H is comprised of 20 repeating units, 61 amino acids in length."
      Kristensen T., Tack B.F.
      Proc. Natl. Acad. Sci. U.S.A. 83:3963-3967(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Analysis of complement factor H mRNA expression: dexamethasone and IFN-gamma increase the level of H in L cells."
      Munoz-Canoves P., Tack B.F., Vik D.P.
      Biochemistry 28:9891-9897(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-19.
      Strain: BALB/c.
    5. "Demonstration of an unusual allelic variation of mouse factor H by the complete cDNA sequence of the H.2 allotype."
      Natsuume-Sakai S., Nonaka M., Nonaka M., Harada Y.N., Shreffler D.C., Moriwaki K.
      J. Immunol. 144:358-362(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-18.
    6. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
      Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
      J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-773 AND ASN-1061.
      Strain: C57BL/6.
      Tissue: Plasma.
    7. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
      Bernhard O.K., Kapp E.A., Simpson R.J.
      J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-773; ASN-801; ASN-1030; ASN-1061 AND ASN-1225.
      Strain: C57BL/6.
      Tissue: Plasma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1198, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiCFAH_MOUSE
    AccessioniPrimary (citable) accession number: P06909
    Secondary accession number(s): Q6NZK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3