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Protein

Myelin protein P0

Gene

Mpz

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.By similarity

GO - Biological processi

  • negative regulation of apoptotic process Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin protein P0
Alternative name(s):
Myelin peripheral protein
Short name:
MPP
Myelin protein zero
Gene namesi
Name:Mpz
Synonyms:P0
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi3109. Mpz.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 153124ExtracellularAdd
BLAST
Transmembranei154 – 17926HelicalAdd
BLAST
Topological domaini180 – 24869CytoplasmicAdd
BLAST

GO - Cellular componenti

  • basolateral plasma membrane Source: RGD
  • integral component of plasma membrane Source: InterPro
  • lysosome Source: RGD
  • myelin sheath Source: InterPro
  • plasma membrane Source: CACAO
  • rough endoplasmic reticulum Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Add
BLAST
Chaini30 – 248219Myelin protein P0PRO_0000019302Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 127PROSITE-ProRule annotation1 Publication
Glycosylationi122 – 1221N-linked (GlcNAc...) (complex)Sequence analysis
Modified residuei210 – 2101Phosphoserine; by PKCBy similarity
Modified residuei226 – 2261PhosphoserineBy similarity
Modified residuei228 – 2281PhosphoserineBy similarity
Modified residuei233 – 2331Phosphoserine; by PKCBy similarity
Modified residuei237 – 2371PhosphoserineBy similarity
Modified residuei243 – 2431Phosphoserine; by PKCBy similarity

Post-translational modificationi

N-glycosylated; contains sulfate-substituted glycan.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP06907.

PTM databases

iPTMnetiP06907.
PhosphoSiteiP06907.

Expressioni

Tissue specificityi

Found only in peripheral nervous system Schwann cells.

Gene expression databases

GenevisibleiP06907. RN.

Interactioni

Subunit structurei

Homodimer and homotetramer.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004279.

Structurei

Secondary structure

1
248
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi31 – 333Combined sources
Beta strandi36 – 416Combined sources
Beta strandi46 – 483Combined sources
Beta strandi51 – 533Combined sources
Beta strandi63 – 708Combined sources
Beta strandi77 – 837Combined sources
Beta strandi86 – 894Combined sources
Beta strandi91 – 933Combined sources
Turni94 – 974Combined sources
Beta strandi99 – 1013Combined sources
Helixi105 – 1073Combined sources
Beta strandi112 – 1143Combined sources
Helixi119 – 1213Combined sources
Beta strandi123 – 1308Combined sources
Beta strandi138 – 14710Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NEUX-ray1.90A30-153[»]
ProteinModelPortaliP06907.
SMRiP06907. Positions 30-148.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06907.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 143114Ig-like V-typeAdd
BLAST

Sequence similaritiesi

Belongs to the myelin P0 protein family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJG4. Eukaryota.
ENOG4111R0Y. LUCA.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000232144.
HOVERGENiHBG096384.
InParanoidiP06907.
KOiK06770.
OMAiYAMLDHS.
OrthoDBiEOG7G1V80.
PhylomeDBiP06907.
TreeFamiTF331728.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR019566. Myelin-PO_C.
IPR000920. Myelin_P0-rel.
IPR019738. Myelin_P0_CS.
IPR029869. P0.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PTHR13869:SF7. PTHR13869:SF7. 1 hit.
PfamiPF10570. Myelin-PO_C. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00568. MYELIN_P0. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGAPSSSP SPILAALLFS SLVLSPTLAI VVYTDREVYG AVGSQVTLHC
60 70 80 90 100
SFWSSEWVSD DISFTWRYQP EGGRDAISIF HYAKGQPYID EVGTFKERIQ
110 120 130 140 150
WVGDPSWKDG SIVIHNLDYS DNGTFTCDVK NPPDIVGKTS QVTLYVFEKV
160 170 180 190 200
PTRYGVVLGA VIGGILGVVL LLLLLFYLIR YCWLRRQAAL QRRLSAMEKG
210 220 230 240
KFHKSSKDSS KRGRQTPVLY AMLDHSRSTK AASEKKSKGL GESRKDKK
Length:248
Mass (Da):27,571
Last modified:January 1, 1988 - v1
Checksum:iBB703F173466119B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431G → R in AAA41576 (PubMed:2578885).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03242 mRNA. Translation: AAA41576.1.
PIRiJQ0622. MPRT0.
RefSeqiNP_058723.2. NM_017027.2.
UniGeneiRn.8997.

Genome annotation databases

EnsembliENSRNOT00000004279; ENSRNOP00000004279; ENSRNOG00000003171.
GeneIDi24564.
KEGGirno:24564.
UCSCiRGD:3109. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03242 mRNA. Translation: AAA41576.1.
PIRiJQ0622. MPRT0.
RefSeqiNP_058723.2. NM_017027.2.
UniGeneiRn.8997.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NEUX-ray1.90A30-153[»]
ProteinModelPortaliP06907.
SMRiP06907. Positions 30-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004279.

PTM databases

iPTMnetiP06907.
PhosphoSiteiP06907.

Proteomic databases

PaxDbiP06907.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004279; ENSRNOP00000004279; ENSRNOG00000003171.
GeneIDi24564.
KEGGirno:24564.
UCSCiRGD:3109. rat.

Organism-specific databases

CTDi4359.
RGDi3109. Mpz.

Phylogenomic databases

eggNOGiENOG410IJG4. Eukaryota.
ENOG4111R0Y. LUCA.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000232144.
HOVERGENiHBG096384.
InParanoidiP06907.
KOiK06770.
OMAiYAMLDHS.
OrthoDBiEOG7G1V80.
PhylomeDBiP06907.
TreeFamiTF331728.

Miscellaneous databases

EvolutionaryTraceiP06907.
NextBioi603692.
PROiP06907.

Gene expression databases

GenevisibleiP06907. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR019566. Myelin-PO_C.
IPR000920. Myelin_P0-rel.
IPR019738. Myelin_P0_CS.
IPR029869. P0.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PTHR13869:SF7. PTHR13869:SF7. 1 hit.
PfamiPF10570. Myelin-PO_C. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00568. MYELIN_P0. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and sequence of a cDNA encoding the major structural protein of peripheral myelin."
    Lemke G., Axel R.
    Cell 40:501-508(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and analysis of the gene encoding peripheral myelin protein zero."
    Lemke G., Lamar E., Patterson J.
    Neuron 1:73-83(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Lubec G., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 85-96, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  4. "Crystal structure of the extracellular domain from P0, the major structural protein of peripheral nerve myelin."
    Shapiro L., Doyle J.P., Hensley P., Colman D.R., Hendrickson W.A.
    Neuron 17:435-449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 30-148, SUBUNIT, DISULFIDE BOND.

Entry informationi

Entry nameiMYP0_RAT
AccessioniPrimary (citable) accession number: P06907
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 11, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.