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Protein

Myelin protein P0

Gene

Mpz

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin protein P0
Alternative name(s):
Myelin peripheral protein
Short name:
MPP
Myelin protein zero
Gene namesi
Name:Mpz
Synonyms:P0
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi3109. Mpz.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 153ExtracellularAdd BLAST124
Transmembranei154 – 179HelicalAdd BLAST26
Topological domaini180 – 248CytoplasmicAdd BLAST69

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Add BLAST29
ChainiPRO_000001930230 – 248Myelin protein P0Add BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 127PROSITE-ProRule annotation1 Publication
Glycosylationi122N-linked (GlcNAc...) (complex) asparagineSequence analysis1
Modified residuei210Phosphoserine; by PKCBy similarity1
Modified residuei226PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1
Modified residuei233Phosphoserine; by PKCBy similarity1
Modified residuei237PhosphoserineBy similarity1
Modified residuei243Phosphoserine; by PKCBy similarity1

Post-translational modificationi

N-glycosylated; contains sulfate-substituted glycan.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP06907.
PRIDEiP06907.

PTM databases

iPTMnetiP06907.
PhosphoSitePlusiP06907.

Expressioni

Tissue specificityi

Found only in peripheral nervous system Schwann cells.

Gene expression databases

BgeeiENSRNOG00000003171.
GenevisibleiP06907. RN.

Interactioni

Subunit structurei

Homodimer and homotetramer.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004279.

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 33Combined sources3
Beta strandi36 – 41Combined sources6
Beta strandi46 – 48Combined sources3
Beta strandi51 – 53Combined sources3
Beta strandi63 – 70Combined sources8
Beta strandi77 – 83Combined sources7
Beta strandi86 – 89Combined sources4
Beta strandi91 – 93Combined sources3
Turni94 – 97Combined sources4
Beta strandi99 – 101Combined sources3
Helixi105 – 107Combined sources3
Beta strandi112 – 114Combined sources3
Helixi119 – 121Combined sources3
Beta strandi123 – 130Combined sources8
Beta strandi138 – 147Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NEUX-ray1.90A30-153[»]
ProteinModelPortaliP06907.
SMRiP06907.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06907.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 143Ig-like V-typeAdd BLAST114

Sequence similaritiesi

Belongs to the myelin P0 protein family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJG4. Eukaryota.
ENOG4111R0Y. LUCA.
GeneTreeiENSGT00900000140913.
HOGENOMiHOG000232144.
HOVERGENiHBG096384.
InParanoidiP06907.
KOiK06770.
OMAiERIQWVG.
OrthoDBiEOG091G0H91.
PhylomeDBiP06907.
TreeFamiTF331728.

Family and domain databases

Gene3Di1.20.5.100. 1 hit.
2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR021157. Cyt_c1_TM_anchor_C.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR019566. Myelin-PO_C.
IPR000920. Myelin_P0-rel.
IPR019738. Myelin_P0_CS.
IPR029869. P0.
PANTHERiPTHR13869. PTHR13869. 1 hit.
PTHR13869:SF7. PTHR13869:SF7. 1 hit.
PfamiView protein in Pfam
PF10570. Myelin-PO_C. 1 hit.
PF07686. V-set. 1 hit.
PRINTSiPR00213. MYELINP0.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00568. MYELIN_P0. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGAPSSSP SPILAALLFS SLVLSPTLAI VVYTDREVYG AVGSQVTLHC
60 70 80 90 100
SFWSSEWVSD DISFTWRYQP EGGRDAISIF HYAKGQPYID EVGTFKERIQ
110 120 130 140 150
WVGDPSWKDG SIVIHNLDYS DNGTFTCDVK NPPDIVGKTS QVTLYVFEKV
160 170 180 190 200
PTRYGVVLGA VIGGILGVVL LLLLLFYLIR YCWLRRQAAL QRRLSAMEKG
210 220 230 240
KFHKSSKDSS KRGRQTPVLY AMLDHSRSTK AASEKKSKGL GESRKDKK
Length:248
Mass (Da):27,571
Last modified:January 1, 1988 - v1
Checksum:iBB703F173466119B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43G → R in AAA41576 (PubMed:2578885).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K03242 mRNA. Translation: AAA41576.1.
PIRiJQ0622. MPRT0.
RefSeqiNP_058723.2. NM_017027.2.
UniGeneiRn.8997.

Genome annotation databases

EnsembliENSRNOT00000004279; ENSRNOP00000004279; ENSRNOG00000003171.
GeneIDi24564.
KEGGirno:24564.
UCSCiRGD:3109. rat.

Similar proteinsi

Entry informationi

Entry nameiMYP0_RAT
AccessioniPrimary (citable) accession number: P06907
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: October 25, 2017
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families