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Protein

Myelin basic protein

Gene

MBP

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin basic protein
Short name:
MBP
Gene namesi
Name:MBP
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Autoimmune encephalomyelitis

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001589921 – 171Myelin basic proteinAdd BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylalanine1 Publication1
Modified residuei7PhosphoserineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei14PhosphotyrosineBy similarity1
Modified residuei17PhosphothreonineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Modified residuei20PhosphothreonineBy similarity1
Modified residuei25CitrullineBy similarity1
Modified residuei31CitrullineBy similarity1
Modified residuei35PhosphothreonineBy similarity1
Modified residuei40PhosphoserineBy similarity1
Modified residuei43Omega-N-methylarginineBy similarity1
Modified residuei49Omega-N-methylarginineBy similarity1
Modified residuei56PhosphoserineBy similarity1
Modified residuei69PhosphotyrosineBy similarity1
Modified residuei76PhosphoserineBy similarity1
Modified residuei80PhosphothreonineBy similarity1
Modified residuei95PhosphothreonineBy similarity1
Modified residuei98PhosphothreonineBy similarity1
Modified residuei103Deamidated glutamineBy similarity1
Modified residuei107Omega-N-methylarginine; alternateBy similarity1
Modified residuei107Symmetric dimethylarginine; alternateBy similarity1
Modified residuei115PhosphoserineBy similarity1
Modified residuei122CitrullineBy similarity1
Modified residuei130CitrullineBy similarity1
Modified residuei148Deamidated glutamineBy similarity1
Modified residuei160CitrullineBy similarity1
Modified residuei162PhosphoserineBy similarity1
Modified residuei166Phosphoserine; by UHMK1By similarity1
Modified residuei171CitrullineBy similarity1

Post-translational modificationi

As in other animals, several charge isomers may be produced as a result of optional post-translatonial modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues.
Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1.By similarity

Keywords - PTMi

Acetylation, Citrullination, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP06906.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000056200.

Structurei

3D structure databases

ProteinModelPortaliP06906.
SMRiP06906.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the myelin basic protein family.Curated

Phylogenomic databases

eggNOGiENOG410IIUJ. Eukaryota.
ENOG4111PMJ. LUCA.
HOGENOMiHOG000293395.
HOVERGENiHBG008347.
InParanoidiP06906.

Family and domain databases

InterProiIPR000548. Myelin_BP.
[Graphical view]
PANTHERiPTHR11429. PTHR11429. 1 hit.
PfamiPF01669. Myelin_MBP. 1 hit.
[Graphical view]
PRINTSiPR00212. MYELINMBP.
PROSITEiPS00569. MYELIN_MBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06906-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASQKRPSQRH GSKYLATAST MDHARHGFLP RHRDTGILDS IGRFFGGDRG
60 70 80 90 100
APKRGSGKDS HHPARTAHYG SLPQKSGHRT QDENPVVHFF KNIVTPRTPP
110 120 130 140 150
PSQGKGRGLS LSRFSWGAEG QRPGFGYGGR ASDYKSAHKG FKGAQDAQGT
160 170
LSKIFKLGGR DSRSGSPMAR R
Length:171
Mass (Da):18,560
Last modified:January 1, 1988 - v1
Checksum:iE9FED59DE6933293
GO

Sequence databases

PIRiA03139. MBCZB.
UniGeneiPtr.55.

Cross-referencesi

Sequence databases

PIRiA03139. MBCZB.
UniGeneiPtr.55.

3D structure databases

ProteinModelPortaliP06906.
SMRiP06906.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000056200.

Proteomic databases

PaxDbiP06906.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IIUJ. Eukaryota.
ENOG4111PMJ. LUCA.
HOGENOMiHOG000293395.
HOVERGENiHBG008347.
InParanoidiP06906.

Family and domain databases

InterProiIPR000548. Myelin_BP.
[Graphical view]
PANTHERiPTHR11429. PTHR11429. 1 hit.
PfamiPF01669. Myelin_MBP. 1 hit.
[Graphical view]
PRINTSiPR00212. MYELINMBP.
PROSITEiPS00569. MYELIN_MBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMBP_PANTR
AccessioniPrimary (citable) accession number: P06906
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.