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Protein

Myelin basic protein

Gene

MBP

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin basic protein
Short name:
MBP
Gene namesi
Name:MBP
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
Proteomesi
  • UP000002277 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Autoimmune encephalomyelitis

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 171171Myelin basic proteinPRO_0000158992Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylalanine1 Publication
Modified residuei7 – 71PhosphoserineBy similarity
Modified residuei12 – 121PhosphoserineBy similarity
Modified residuei14 – 141PhosphotyrosineBy similarity
Modified residuei17 – 171PhosphothreonineBy similarity
Modified residuei19 – 191PhosphoserineBy similarity
Modified residuei20 – 201PhosphothreonineBy similarity
Modified residuei25 – 251CitrullineBy similarity
Modified residuei31 – 311CitrullineBy similarity
Modified residuei35 – 351PhosphothreonineBy similarity
Modified residuei40 – 401PhosphoserineBy similarity
Modified residuei56 – 561PhosphoserineBy similarity
Modified residuei69 – 691PhosphotyrosineBy similarity
Modified residuei76 – 761PhosphoserineBy similarity
Modified residuei80 – 801PhosphothreonineBy similarity
Modified residuei95 – 951PhosphothreonineBy similarity
Modified residuei98 – 981PhosphothreonineBy similarity
Modified residuei103 – 1031Deamidated glutamineBy similarity
Modified residuei107 – 1071Omega-N-methylarginine; alternateBy similarity
Modified residuei107 – 1071Symmetric dimethylarginine; alternateBy similarity
Modified residuei115 – 1151PhosphoserineBy similarity
Modified residuei122 – 1221CitrullineBy similarity
Modified residuei130 – 1301CitrullineBy similarity
Modified residuei148 – 1481Deamidated glutamineBy similarity
Modified residuei160 – 1601CitrullineBy similarity
Modified residuei162 – 1621PhosphoserineBy similarity
Modified residuei166 – 1661Phosphoserine; by UHMK1By similarity
Modified residuei171 – 1711CitrullineBy similarity

Post-translational modificationi

As in other animals, several charge isomers may be produced as a result of optional post-translatonial modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues.
Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1.By similarity

Keywords - PTMi

Acetylation, Citrullination, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP06906.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000056200.

Family & Domainsi

Sequence similaritiesi

Belongs to the myelin basic protein family.Curated

Phylogenomic databases

eggNOGiENOG410IIUJ. Eukaryota.
ENOG4111PMJ. LUCA.
HOGENOMiHOG000293395.
HOVERGENiHBG008347.
InParanoidiP06906.

Family and domain databases

InterProiIPR000548. Myelin_BP.
[Graphical view]
PANTHERiPTHR11429. PTHR11429. 1 hit.
PfamiPF01669. Myelin_MBP. 1 hit.
[Graphical view]
PRINTSiPR00212. MYELINMBP.
PROSITEiPS00569. MYELIN_MBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06906-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASQKRPSQRH GSKYLATAST MDHARHGFLP RHRDTGILDS IGRFFGGDRG
60 70 80 90 100
APKRGSGKDS HHPARTAHYG SLPQKSGHRT QDENPVVHFF KNIVTPRTPP
110 120 130 140 150
PSQGKGRGLS LSRFSWGAEG QRPGFGYGGR ASDYKSAHKG FKGAQDAQGT
160 170
LSKIFKLGGR DSRSGSPMAR R
Length:171
Mass (Da):18,560
Last modified:January 1, 1988 - v1
Checksum:iE9FED59DE6933293
GO

Sequence databases

PIRiA03139. MBCZB.
UniGeneiPtr.55.

Cross-referencesi

Sequence databases

PIRiA03139. MBCZB.
UniGeneiPtr.55.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000056200.

Proteomic databases

PaxDbiP06906.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IIUJ. Eukaryota.
ENOG4111PMJ. LUCA.
HOGENOMiHOG000293395.
HOVERGENiHBG008347.
InParanoidiP06906.

Family and domain databases

InterProiIPR000548. Myelin_BP.
[Graphical view]
PANTHERiPTHR11429. PTHR11429. 1 hit.
PfamiPF01669. Myelin_MBP. 1 hit.
[Graphical view]
PRINTSiPR00212. MYELINMBP.
PROSITEiPS00569. MYELIN_MBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The proposed sequence of the encephalitogenic protein from chimpanzee brain."
    Westall F.C., Thompson M., Kalter S.S.
    Life Sci. 17:219-223(1975) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY PROTEIN SEQUENCE, ACETYLATION AT ALA-1.

Entry informationi

Entry nameiMBP_PANTR
AccessioniPrimary (citable) accession number: P06906
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: June 8, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.