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Protein

Toxic shock syndrome toxin-1

Gene

tst

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the symptoms of toxic shock syndrome.

GO - Biological processi

  • pathogenesis Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Superantigen, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Toxic shock syndrome toxin-1
Short name:
TSST-1
Gene namesi
Name:tst
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2143. Sta a TSST.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4040Add
BLAST
Chaini41 – 234194Toxic shock syndrome toxin-1PRO_0000035619Add
BLAST

Proteomic databases

PaxDbiP06886.

Interactioni

Protein-protein interaction databases

IntActiP06886. 2 interactions.
MINTiMINT-4328940.
STRINGi158878.SAV2011.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi44 – 5310Combined sources
Beta strandi58 – 6811Combined sources
Beta strandi70 – 767Combined sources
Beta strandi82 – 865Combined sources
Beta strandi90 – 923Combined sources
Beta strandi101 – 11414Combined sources
Beta strandi116 – 1183Combined sources
Beta strandi120 – 1267Combined sources
Beta strandi128 – 1303Combined sources
Beta strandi133 – 1397Combined sources
Beta strandi143 – 1464Combined sources
Beta strandi149 – 1513Combined sources
Beta strandi158 – 1647Combined sources
Helixi166 – 18116Combined sources
Turni183 – 1853Combined sources
Helixi187 – 1893Combined sources
Beta strandi190 – 1989Combined sources
Beta strandi203 – 2075Combined sources
Helixi214 – 2163Combined sources
Helixi223 – 2253Combined sources
Beta strandi226 – 2349Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AW7X-ray1.95A/B/C/D41-234[»]
1QILX-ray2.50A/B/C41-234[»]
1TS2X-ray2.30A/B/C41-234[»]
1TS3X-ray2.00A/B/C41-234[»]
1TS4X-ray3.40A/B41-234[»]
1TS5X-ray3.10A/B41-234[»]
2IJ0X-ray2.25A/B41-234[»]
2QILX-ray2.07A/B/C41-234[»]
2TSSX-ray2.05A/B/C41-234[»]
3TSSX-ray1.90A41-234[»]
4OHJX-ray1.28A/B22-234[»]
4TSSX-ray2.75A41-234[»]
5TSSX-ray2.90A/B41-234[»]
ProteinModelPortaliP06886.
SMRiP06886. Positions 41-234.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06886.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
[Graphical view]
PRINTSiPR01501. TOXICSSTOXIN.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKLLMNFF IVSPLLLATT ATDFTPVPLS SNQIIKTAKA STNDNIKDLL
60 70 80 90 100
DWYSSGSDTF TNSEVLDNSL GSMRIKNTDG SISLIIFPSP YYSPAFTKGE
110 120 130 140 150
KVDLNTKRTK KSQHTSEGTY IHFQISGVTN TEKLPTPIEL PLKVKVHGKD
160 170 180 190 200
SPLKYGPKFD KKQLAISTLD FEIRHQLTQI HGLYRSSDKT GGYWKITMND
210 220 230
GSTYQSDLSK KFEYNTEKPP INIDEIKTIE AEIN
Length:234
Mass (Da):26,306
Last modified:January 1, 1988 - v1
Checksum:iE95789FF9A1D7AB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02615 Genomic DNA. Translation: AAA26682.1.
PIRiA24606. XCSAS1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02615 Genomic DNA. Translation: AAA26682.1.
PIRiA24606. XCSAS1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AW7X-ray1.95A/B/C/D41-234[»]
1QILX-ray2.50A/B/C41-234[»]
1TS2X-ray2.30A/B/C41-234[»]
1TS3X-ray2.00A/B/C41-234[»]
1TS4X-ray3.40A/B41-234[»]
1TS5X-ray3.10A/B41-234[»]
2IJ0X-ray2.25A/B41-234[»]
2QILX-ray2.07A/B/C41-234[»]
2TSSX-ray2.05A/B/C41-234[»]
3TSSX-ray1.90A41-234[»]
4OHJX-ray1.28A/B22-234[»]
4TSSX-ray2.75A41-234[»]
5TSSX-ray2.90A/B41-234[»]
ProteinModelPortaliP06886.
SMRiP06886. Positions 41-234.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP06886. 2 interactions.
MINTiMINT-4328940.
STRINGi158878.SAV2011.

Protein family/group databases

Allergomei2143. Sta a TSST.

Proteomic databases

PaxDbiP06886.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP06886.
PROiP06886.

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
[Graphical view]
PRINTSiPR01501. TOXICSSTOXIN.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSST_STAAU
AccessioniPrimary (citable) accession number: P06886
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: March 16, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.