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Protein

Calcitonin gene-related peptide 1

Gene

CALCA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.1 Publication

GO - Molecular functioni

  • protein complex binding Source: UniProtKB
  • receptor binding Source: UniProtKB

GO - Biological processi

  • activation of adenylate cyclase activity Source: UniProtKB
  • antibacterial humoral response Source: UniProtKB
  • antifungal humoral response Source: UniProtKB
  • cell-cell signaling Source: ProtInc
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • endothelial cell migration Source: UniProtKB
  • endothelial cell proliferation Source: UniProtKB
  • G-protein coupled receptor internalization Source: UniProtKB
  • innate immune response Source: UniProtKB
  • leukocyte cell-cell adhesion Source: UniProtKB
  • negative regulation of blood pressure Source: MGI
  • negative regulation of bone resorption Source: UniProtKB
  • negative regulation of calcium ion transport into cytosol Source: UniProtKB
  • negative regulation of osteoclast differentiation Source: UniProtKB
  • neurological system process involved in regulation of systemic arterial blood pressure Source: MGI
  • positive regulation of cAMP biosynthetic process Source: UniProtKB
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: UniProtKB
  • positive regulation of interleukin-1 alpha production Source: UniProtKB
  • positive regulation of interleukin-8 production Source: UniProtKB
  • positive regulation of macrophage differentiation Source: UniProtKB
  • positive regulation of vasodilation Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • receptor internalization Source: UniProtKB
  • regulation of blood pressure Source: UniProtKB
  • regulation of cytosolic calcium ion concentration Source: UniProtKB
  • response to yeast Source: UniProtKB
  • vasculature development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000110680-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.
R-HSA-419812. Calcitonin-like ligand receptors.

Protein family/group databases

TCDBi1.C.49.1.2. the cytotoxic amylin (amylin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin gene-related peptide 1
Alternative name(s):
Alpha-type CGRP
Calcitonin gene-related peptide I
Short name:
CGRP-I
Gene namesi
Name:CALCA
Synonyms:CALC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:1437. CALCA.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi796.
PharmGKBiPA26029.

Chemistry databases

ChEMBLiCHEMBL5293.

Polymorphism and mutation databases

BioMutaiCYP2R1.
DMDMi308153625.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000000405326 – 80Add BLAST55
PeptideiPRO_000000405483 – 119Calcitonin gene-related peptide 1Add BLAST37
PropeptideiPRO_0000004055125 – 1284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi84 ↔ 891 Publication
Modified residuei119Phenylalanine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PeptideAtlasiP06881.
PRIDEiP06881.

PTM databases

iPTMnetiP06881.

Expressioni

Gene expression databases

BgeeiENSG00000110680.
CleanExiHS_CALCA.
ExpressionAtlasiP06881. baseline and differential.
GenevisibleiP06881. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CALCRLQ166022EBI-962928,EBI-962878

GO - Molecular functioni

  • protein complex binding Source: UniProtKB
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi107247. 4 interactors.
IntActiP06881. 3 interactors.

Chemistry databases

BindingDBiP06881.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LS7model-A1-125[»]
ProteinModelPortaliP06881.
SMRiP06881.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000038203.
HOVERGENiHBG031362.

Family and domain databases

InterProiIPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR015476. Calcitonin_gene-rel_peptide.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00817. CALCITONINB.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: P06881-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFQKFSPFL ALSILVLLQA GSLHAAPFRS ALESSPADPA TLSEDEARLL
60 70 80 90 100
LAALVQNYVQ MKASELEQEQ EREGSRIIAQ KRACDTATCV THRLAGLLSR
110 120
SGGVVKNNFV PTNVGSKAFG RRRRDLQA
Length:128
Mass (Da):13,898
Last modified:October 5, 2010 - v3
Checksum:i2AA1A9AC3060D9B6
GO
Isoform 1 (identifier: P01258-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P01258.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:141
Mass (Da):15,466
GO
Isoform 2 (identifier: P01258-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P01258.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Length:141
Mass (Da):15,534
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04858457N → D.3 PublicationsCorresponds to variant rs5239dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12667, M12664, M12665 Genomic DNA. Translation: AAA51914.1.
X15943 Genomic DNA. Translation: CAA34070.1.
AC090835 Genomic DNA. No translation available.
K03512 mRNA. Translation: AAA52011.1.
X02330 mRNA. Translation: CAA26190.1.
M28637 Genomic DNA. Translation: AAA52012.1.
M26094 Genomic DNA. Translation: AAA51912.1.
CCDSiCCDS31432.1. [P06881-1]
PIRiS07644. TCHUR.
RefSeqiNP_001029125.1. NM_001033953.2.
UniGeneiHs.37058.

Genome annotation databases

EnsembliENST00000361010; ENSP00000354286; ENSG00000110680.
ENST00000486207; ENSP00000417833; ENSG00000110680.
GeneIDi796.
UCSCiuc001mlt.2. human. [P06881-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12667, M12664, M12665 Genomic DNA. Translation: AAA51914.1.
X15943 Genomic DNA. Translation: CAA34070.1.
AC090835 Genomic DNA. No translation available.
K03512 mRNA. Translation: AAA52011.1.
X02330 mRNA. Translation: CAA26190.1.
M28637 Genomic DNA. Translation: AAA52012.1.
M26094 Genomic DNA. Translation: AAA51912.1.
CCDSiCCDS31432.1. [P06881-1]
PIRiS07644. TCHUR.
RefSeqiNP_001029125.1. NM_001033953.2.
UniGeneiHs.37058.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LS7model-A1-125[»]
ProteinModelPortaliP06881.
SMRiP06881.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107247. 4 interactors.
IntActiP06881. 3 interactors.

Chemistry databases

BindingDBiP06881.
ChEMBLiCHEMBL5293.

Protein family/group databases

TCDBi1.C.49.1.2. the cytotoxic amylin (amylin) family.

PTM databases

iPTMnetiP06881.

Polymorphism and mutation databases

BioMutaiCYP2R1.
DMDMi308153625.

Proteomic databases

PeptideAtlasiP06881.
PRIDEiP06881.

Protocols and materials databases

DNASUi796.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361010; ENSP00000354286; ENSG00000110680.
ENST00000486207; ENSP00000417833; ENSG00000110680.
GeneIDi796.
UCSCiuc001mlt.2. human. [P06881-1]

Organism-specific databases

CTDi796.
DisGeNETi796.
GeneCardsiCALCA.
HGNCiHGNC:1437. CALCA.
MIMi114130. gene.
neXtProtiNX_P06881.
PharmGKBiPA26029.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000038203.
HOVERGENiHBG031362.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000110680-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.
R-HSA-419812. Calcitonin-like ligand receptors.

Miscellaneous databases

GenomeRNAii796.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110680.
CleanExiHS_CALCA.
ExpressionAtlasiP06881. baseline and differential.
GenevisibleiP06881. HS.

Family and domain databases

InterProiIPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR015476. Calcitonin_gene-rel_peptide.
IPR001693. Calcitonin_peptide-like.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00817. CALCITONINB.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALCA_HUMAN
AccessioniPrimary (citable) accession number: P06881
Secondary accession number(s): Q93048, Q9UCP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: October 5, 2010
Last modified: November 2, 2016
This is version 168 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.