Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Somatotropin

Gene

Gh1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451ZincBy similarity
Metal bindingi198 – 1981ZincBy similarity

GO - Molecular functioni

  • growth hormone receptor binding Source: MGI
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1170546. Prolactin receptor signaling.
R-MMU-422085. Synthesis, secretion, and deacylation of Ghrelin.
R-MMU-982772. Growth hormone receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatotropin
Alternative name(s):
Growth hormone
Gene namesi
Name:Gh1
Synonyms:Gh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:95707. Gh.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Ensembl
  • extracellular region Source: Reactome
  • extracellular space Source: MGI
  • mitochondrion Source: Ensembl
  • nucleus Source: MGI
  • plasma membrane Source: MGI
  • secretory granule Source: MGI
  • trans-Golgi network Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Chaini27 – 216190SomatotropinPRO_0000032992Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi78 ↔ 189By similarity
Modified residuei131 – 1311PhosphoserineBy similarity
Disulfide bondi206 ↔ 214By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiP06880.
PaxDbiP06880.
PRIDEiP06880.

PTM databases

PhosphoSiteiP06880.

Expressioni

Gene expression databases

BgeeiP06880.
CleanExiMM_GH.
ExpressionAtlasiP06880. baseline and differential.
GenevisibleiP06880. MM.

Interactioni

GO - Molecular functioni

  • growth hormone receptor binding Source: MGI

Protein-protein interaction databases

BioGridi199914. 2 interactions.
IntActiP06880. 1 interaction.
MINTiMINT-4135221.
STRINGi10090.ENSMUSP00000099360.

Structurei

3D structure databases

ProteinModelPortaliP06880.
SMRiP06880. Positions 27-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFR6. Eukaryota.
ENOG4111HU8. LUCA.
GeneTreeiENSGT00730000111012.
HOGENOMiHOG000068443.
HOVERGENiHBG011318.
InParanoidiP06880.
KOiK05438.
OMAiTYLRVMK.
OrthoDBiEOG7F7W9X.
PhylomeDBiP06880.
TreeFamiTF332592.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDSRTSWL LTVSLLCLLW PQEASAFPAM PLSSLFSNAV LRAQHLHQLA
60 70 80 90 100
ADTYKEFERA YIPEGQRYSI QNAQAAFCFS ETIPAPTGKE EAQQRTDMEL
110 120 130 140 150
LRFSLLLIQS WLGPVQFLSR IFTNSLMFGT SDRVYEKLKD LEEGIQALMQ
160 170 180 190 200
ELEDGSPRVG QILKQTYDKF DANMRSDDAL LKNYGLLSCF KKDLHKAETY
210
LRVMKCRRFV ESSCAF
Length:216
Mass (Da):24,716
Last modified:January 1, 1988 - v1
Checksum:i98666A3AE25D65FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02891 mRNA. Translation: CAA26650.1.
Z46663 Genomic DNA. Translation: CAA86658.1.
AK019952 mRNA. Translation: BAB31931.1.
AK019954 mRNA. Translation: BAB31932.1.
AK019956 mRNA. Translation: BAB31933.1.
AK019959 mRNA. Translation: BAB31935.1.
AK019961 mRNA. Translation: BAB31937.1.
AK030715 mRNA. Translation: BAC27096.1.
BC061157 mRNA. Translation: AAH61157.1.
CCDSiCCDS25554.1.
PIRiB23911. STMS.
RefSeqiNP_032143.1. NM_008117.3.
UniGeneiMm.343934.

Genome annotation databases

EnsembliENSMUST00000103071; ENSMUSP00000099360; ENSMUSG00000020713.
GeneIDi14599.
KEGGimmu:14599.
UCSCiuc007lys.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02891 mRNA. Translation: CAA26650.1.
Z46663 Genomic DNA. Translation: CAA86658.1.
AK019952 mRNA. Translation: BAB31931.1.
AK019954 mRNA. Translation: BAB31932.1.
AK019956 mRNA. Translation: BAB31933.1.
AK019959 mRNA. Translation: BAB31935.1.
AK019961 mRNA. Translation: BAB31937.1.
AK030715 mRNA. Translation: BAC27096.1.
BC061157 mRNA. Translation: AAH61157.1.
CCDSiCCDS25554.1.
PIRiB23911. STMS.
RefSeqiNP_032143.1. NM_008117.3.
UniGeneiMm.343934.

3D structure databases

ProteinModelPortaliP06880.
SMRiP06880. Positions 27-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199914. 2 interactions.
IntActiP06880. 1 interaction.
MINTiMINT-4135221.
STRINGi10090.ENSMUSP00000099360.

PTM databases

PhosphoSiteiP06880.

Proteomic databases

MaxQBiP06880.
PaxDbiP06880.
PRIDEiP06880.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103071; ENSMUSP00000099360; ENSMUSG00000020713.
GeneIDi14599.
KEGGimmu:14599.
UCSCiuc007lys.2. mouse.

Organism-specific databases

CTDi14599.
MGIiMGI:95707. Gh.

Phylogenomic databases

eggNOGiENOG410IFR6. Eukaryota.
ENOG4111HU8. LUCA.
GeneTreeiENSGT00730000111012.
HOGENOMiHOG000068443.
HOVERGENiHBG011318.
InParanoidiP06880.
KOiK05438.
OMAiTYLRVMK.
OrthoDBiEOG7F7W9X.
PhylomeDBiP06880.
TreeFamiTF332592.

Enzyme and pathway databases

ReactomeiR-MMU-1170546. Prolactin receptor signaling.
R-MMU-422085. Synthesis, secretion, and deacylation of Ghrelin.
R-MMU-982772. Growth hormone receptor signaling.

Miscellaneous databases

NextBioi286364.
PROiP06880.
SOURCEiSearch...

Gene expression databases

BgeeiP06880.
CleanExiMM_GH.
ExpressionAtlasiP06880. baseline and differential.
GenevisibleiP06880. MM.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of mouse prolactin and growth hormone mRNAs and expression of these mRNAs during pregnancy."
    Linzer D.I.H., Talamantes F.
    J. Biol. Chem. 260:9574-9579(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure of the growth hormone-encoding gene and its promoter in mice."
    Das P., Meyer L., Seyfert H.-M., Brockmann G., Schwerin M.
    Gene 169:209-213(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FZTDU.
    Tissue: Liver.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiSOMA_MOUSE
AccessioniPrimary (citable) accession number: P06880
Secondary accession number(s): Q544X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 11, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.