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Protein

Somatotropin

Gene

Gh1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45ZincBy similarity1
Metal bindingi198ZincBy similarity1

GO - Molecular functioni

  • growth hormone receptor binding Source: MGI
  • hormone activity Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionHormone
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1170546 Prolactin receptor signaling
R-MMU-422085 Synthesis, secretion, and deacylation of Ghrelin
R-MMU-982772 Growth hormone receptor signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Somatotropin
Alternative name(s):
Growth hormone
Gene namesi
Name:Gh1
Synonyms:Gh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:95707 Gh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000003299227 – 216SomatotropinAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi78 ↔ 189By similarity
Modified residuei131PhosphoserineBy similarity1
Disulfide bondi206 ↔ 214By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiP06880
PaxDbiP06880
PeptideAtlasiP06880
PRIDEiP06880

PTM databases

iPTMnetiP06880
PhosphoSitePlusiP06880

Expressioni

Gene expression databases

BgeeiENSMUSG00000020713
CleanExiMM_GH
ExpressionAtlasiP06880 baseline and differential
GenevisibleiP06880 MM

Interactioni

GO - Molecular functioni

  • growth hormone receptor binding Source: MGI
  • hormone activity Source: UniProtKB-KW

Protein-protein interaction databases

BioGridi199914, 2 interactors
IntActiP06880, 1 interactor
MINTiP06880
STRINGi10090.ENSMUSP00000099360

Structurei

3D structure databases

ProteinModelPortaliP06880
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFR6 Eukaryota
ENOG4111HU8 LUCA
GeneTreeiENSGT00730000111012
HOGENOMiHOG000068443
HOVERGENiHBG011318
InParanoidiP06880
KOiK05438
OMAiTYLRVMK
OrthoDBiEOG091G0KPU
PhylomeDBiP06880
TreeFamiTF332592

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR034975 Somatotropin
IPR001400 Somatotropin/Prolactin
IPR018116 Somatotropin_CS
PANTHERiPTHR11417 PTHR11417, 1 hit
PTHR11417:SF2 PTHR11417:SF2, 1 hit
PfamiView protein in Pfam
PF00103 Hormone_1, 1 hit
PRINTSiPR00836 SOMATOTROPIN
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00266 SOMATOTROPIN_1, 1 hit
PS00338 SOMATOTROPIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDSRTSWL LTVSLLCLLW PQEASAFPAM PLSSLFSNAV LRAQHLHQLA
60 70 80 90 100
ADTYKEFERA YIPEGQRYSI QNAQAAFCFS ETIPAPTGKE EAQQRTDMEL
110 120 130 140 150
LRFSLLLIQS WLGPVQFLSR IFTNSLMFGT SDRVYEKLKD LEEGIQALMQ
160 170 180 190 200
ELEDGSPRVG QILKQTYDKF DANMRSDDAL LKNYGLLSCF KKDLHKAETY
210
LRVMKCRRFV ESSCAF
Length:216
Mass (Da):24,716
Last modified:January 1, 1988 - v1
Checksum:i98666A3AE25D65FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02891 mRNA Translation: CAA26650.1
Z46663 Genomic DNA Translation: CAA86658.1
AK019952 mRNA Translation: BAB31931.1
AK019954 mRNA Translation: BAB31932.1
AK019956 mRNA Translation: BAB31933.1
AK019959 mRNA Translation: BAB31935.1
AK019961 mRNA Translation: BAB31937.1
AK030715 mRNA Translation: BAC27096.1
BC061157 mRNA Translation: AAH61157.1
CCDSiCCDS25554.1
PIRiB23911 STMS
RefSeqiNP_032143.1, NM_008117.3
UniGeneiMm.343934

Genome annotation databases

EnsembliENSMUST00000103071; ENSMUSP00000099360; ENSMUSG00000020713
GeneIDi14599
KEGGimmu:14599
UCSCiuc007lys.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSOMA_MOUSE
AccessioniPrimary (citable) accession number: P06880
Secondary accession number(s): Q544X1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 23, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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