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Protein

Prolactin

Gene

Prl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Prolactin acts primarily on the mammary gland by promoting lactation.

GO - Molecular functioni

  • hormone activity Source: MGI
  • prolactin receptor binding Source: MGI

GO - Biological processi

  • lactation Source: UniProtKB-KW
  • mammary gland development Source: MGI
  • maternal behavior Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of JAK-STAT cascade Source: MGI
  • regulation of JAK-STAT cascade Source: MGI
  • STAT protein import into nucleus Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Lactation

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin
Short name:
PRL
Gene namesi
Name:Prl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:97762. Prl.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • secretory granule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Add
BLAST
Chaini30 – 226197ProlactinPRO_0000032921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 38By similarity
Modified residuei53 – 531PhosphoserineBy similarity
Disulfide bondi85 ↔ 201By similarity
Modified residuei117 – 1171PhosphoserineBy similarity
Disulfide bondi218 ↔ 226By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiP06879.
PaxDbiP06879.
PeptideAtlasiP06879.
PRIDEiP06879.

PTM databases

iPTMnetiP06879.
PhosphoSiteiP06879.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021342.
CleanExiMM_PRL.

Interactioni

GO - Molecular functioni

  • hormone activity Source: MGI
  • prolactin receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105998.

Structurei

3D structure databases

ProteinModelPortaliP06879.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
HOVERGENiHBG104895.
InParanoidiP06879.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06879-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSQGSAQKA GTLLLLLISN LLFCQNVQPL PICSAGDCQT SLRELFDRVV
60 70 80 90 100
ILSHYIHTLY TDMFIEFDKQ YVQDREFMVK VINDCPTSSL ATPEDKEQAL
110 120 130 140 150
KVPPEVLLNL ILSLVQSSSD PLFQLITGVG GIQEAPEYIL SRAKEIEEQN
160 170 180 190 200
KQLLEGVEKI ISQAYPEAKG NGIYFVWSQL PSLQGVDEES KILSLRNTIR
210 220
CLRRDSHKVD NFLKVLRCQI AHQNNC
Length:226
Mass (Da):25,496
Last modified:January 1, 1988 - v1
Checksum:i40B734C1FD610E6E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti205 – 2051D → H in CAA28018 (PubMed:3756168).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02892 mRNA. Translation: CAA26651.1.
X04418 mRNA. Translation: CAA28018.1.
AK017521 mRNA. Translation: BAB30787.2.
AK017579 mRNA. Translation: BAB30816.2.
UniGeneiMm.1270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02892 mRNA. Translation: CAA26651.1.
X04418 mRNA. Translation: CAA28018.1.
AK017521 mRNA. Translation: BAB30787.2.
AK017579 mRNA. Translation: BAB30816.2.
UniGeneiMm.1270.

3D structure databases

ProteinModelPortaliP06879.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105998.

PTM databases

iPTMnetiP06879.
PhosphoSiteiP06879.

Proteomic databases

MaxQBiP06879.
PaxDbiP06879.
PeptideAtlasiP06879.
PRIDEiP06879.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:97762. Prl.

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
HOVERGENiHBG104895.
InParanoidiP06879.

Miscellaneous databases

ChiTaRSiPrl. mouse.
PROiP06879.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021342.
CleanExiMM_PRL.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRL_MOUSE
AccessioniPrimary (citable) accession number: P06879
Secondary accession number(s): Q544X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: September 7, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.