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P06879

- PRL_MOUSE

UniProt

P06879 - PRL_MOUSE

Protein

Prolactin

Gene

Prl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Jan 1988)
      Previous versions | rss
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    Functioni

    Prolactin acts primarily on the mammary gland by promoting lactation.

    GO - Molecular functioni

    1. hormone activity Source: MGI

    GO - Biological processi

    1. cellular response to hormone stimulus Source: Ensembl
    2. circadian rhythm Source: Ensembl
    3. lactation Source: UniProtKB-KW
    4. mammary gland development Source: MGI
    5. maternal behavior Source: MGI
    6. multicellular organismal response to stress Source: Ensembl
    7. ovulation cycle Source: Ensembl
    8. parturition Source: Ensembl
    9. positive regulation of cell proliferation Source: MGI
    10. positive regulation of epithelial cell proliferation Source: Ensembl
    11. positive regulation of JAK-STAT cascade Source: MGI
    12. regulation of JAK-STAT cascade Source: MGI
    13. regulation of ossification Source: Ensembl
    14. response to drug Source: Ensembl
    15. response to estradiol Source: Ensembl
    16. response to ethanol Source: Ensembl
    17. response to lipopolysaccharide Source: Ensembl
    18. response to nutrient Source: Ensembl
    19. STAT protein import into nucleus Source: MGI

    Keywords - Molecular functioni

    Hormone

    Keywords - Biological processi

    Lactation

    Enzyme and pathway databases

    ReactomeiREACT_198561. Prolactin receptor signaling.
    REACT_198563. Amyloids.
    REACT_198614. Growth hormone receptor signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prolactin
    Short name:
    PRL
    Gene namesi
    Name:Prl
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:97762. Prl.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. secretory granule Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Add
    BLAST
    Chaini30 – 226197ProlactinPRO_0000032921Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 38By similarity
    Modified residuei53 – 531PhosphoserineBy similarity
    Disulfide bondi85 ↔ 201By similarity
    Modified residuei117 – 1171PhosphoserineBy similarity
    Disulfide bondi218 ↔ 226By similarity

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    PaxDbiP06879.
    PRIDEiP06879.

    PTM databases

    PhosphoSiteiP06879.

    Expressioni

    Gene expression databases

    BgeeiP06879.
    CleanExiMM_PRL.
    GenevestigatoriP06879.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000105998.

    Structurei

    3D structure databases

    ProteinModelPortaliP06879.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the somatotropin/prolactin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47376.
    HOVERGENiHBG104895.
    InParanoidiP06879.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR001400. Somatotropin.
    IPR018116. Somatotropin_CS.
    [Graphical view]
    PANTHERiPTHR11417. PTHR11417. 1 hit.
    PfamiPF00103. Hormone_1. 1 hit.
    [Graphical view]
    PRINTSiPR00836. SOMATOTROPIN.
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P06879-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSQGSAQKA GTLLLLLISN LLFCQNVQPL PICSAGDCQT SLRELFDRVV    50
    ILSHYIHTLY TDMFIEFDKQ YVQDREFMVK VINDCPTSSL ATPEDKEQAL 100
    KVPPEVLLNL ILSLVQSSSD PLFQLITGVG GIQEAPEYIL SRAKEIEEQN 150
    KQLLEGVEKI ISQAYPEAKG NGIYFVWSQL PSLQGVDEES KILSLRNTIR 200
    CLRRDSHKVD NFLKVLRCQI AHQNNC 226
    Length:226
    Mass (Da):25,496
    Last modified:January 1, 1988 - v1
    Checksum:i40B734C1FD610E6E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti205 – 2051D → H in CAA28018. (PubMed:3756168)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02892 mRNA. Translation: CAA26651.1.
    X04418 mRNA. Translation: CAA28018.1.
    AK017521 mRNA. Translation: BAB30787.2.
    AK017579 mRNA. Translation: BAB30816.2.
    UniGeneiMm.1270.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02892 mRNA. Translation: CAA26651.1 .
    X04418 mRNA. Translation: CAA28018.1 .
    AK017521 mRNA. Translation: BAB30787.2 .
    AK017579 mRNA. Translation: BAB30816.2 .
    UniGenei Mm.1270.

    3D structure databases

    ProteinModelPortali P06879.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000105998.

    PTM databases

    PhosphoSitei P06879.

    Proteomic databases

    PaxDbi P06879.
    PRIDEi P06879.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:97762. Prl.

    Phylogenomic databases

    eggNOGi NOG47376.
    HOVERGENi HBG104895.
    InParanoidi P06879.

    Enzyme and pathway databases

    Reactomei REACT_198561. Prolactin receptor signaling.
    REACT_198563. Amyloids.
    REACT_198614. Growth hormone receptor signaling.

    Miscellaneous databases

    ChiTaRSi PRL. mouse.
    PROi P06879.
    SOURCEi Search...

    Gene expression databases

    Bgeei P06879.
    CleanExi MM_PRL.
    Genevestigatori P06879.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR001400. Somatotropin.
    IPR018116. Somatotropin_CS.
    [Graphical view ]
    PANTHERi PTHR11417. PTHR11417. 1 hit.
    Pfami PF00103. Hormone_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00836. SOMATOTROPIN.
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00338. SOMATOTROPIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of mouse prolactin and growth hormone mRNAs and expression of these mRNAs during pregnancy."
      Linzer D.I.H., Talamantes F.
      J. Biol. Chem. 260:9574-9579(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiPRL_MOUSE
    AccessioniPrimary (citable) accession number: P06879
    Secondary accession number(s): Q544X8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 1, 1988
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3