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Protein

Prolactin

Gene

Prl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Prolactin acts primarily on the mammary gland by promoting lactation.

GO - Molecular functioni

  • hormone activity Source: MGI
  • prolactin receptor binding Source: MGI

GO - Biological processi

  • lactation Source: UniProtKB-KW
  • mammary gland development Source: MGI
  • maternal behavior Source: MGI
  • negative regulation of endothelial cell proliferation Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of JAK-STAT cascade Source: MGI
  • positive regulation of pri-miRNA transcription by RNA polymerase II Source: MGI
  • regulation of JAK-STAT cascade Source: MGI

Keywordsi

Molecular functionHormone
Biological processLactation

Enzyme and pathway databases

ReactomeiR-MMU-1170546 Prolactin receptor signaling
R-MMU-982772 Growth hormone receptor signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin
Short name:
PRL
Gene namesi
Name:Prl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:97762 Prl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Add BLAST29
ChainiPRO_000003292130 – 226ProlactinAdd BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 38By similarity
Modified residuei53PhosphoserineBy similarity1
Disulfide bondi85 ↔ 201By similarity
Modified residuei117PhosphoserineBy similarity1
Disulfide bondi218 ↔ 226By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP06879
PeptideAtlasiP06879
PRIDEiP06879

PTM databases

iPTMnetiP06879
PhosphoSitePlusiP06879

Expressioni

Gene expression databases

CleanExiMM_PRL
ExpressionAtlasiP06879 baseline and differential

Interactioni

GO - Molecular functioni

  • hormone activity Source: MGI
  • prolactin receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105998

Structurei

3D structure databases

ProteinModelPortaliP06879
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II74 Eukaryota
ENOG410XU1S LUCA
GeneTreeiENSGT00730000110805
HOVERGENiHBG104895
InParanoidiP06879

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR001400 Somatotropin/Prolactin
IPR018116 Somatotropin_CS
PANTHERiPTHR11417 PTHR11417, 1 hit
PfamiView protein in Pfam
PF00103 Hormone_1, 1 hit
PRINTSiPR00836 SOMATOTROPIN
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00338 SOMATOTROPIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06879-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSQGSAQKA GTLLLLLISN LLFCQNVQPL PICSAGDCQT SLRELFDRVV
60 70 80 90 100
ILSHYIHTLY TDMFIEFDKQ YVQDREFMVK VINDCPTSSL ATPEDKEQAL
110 120 130 140 150
KVPPEVLLNL ILSLVQSSSD PLFQLITGVG GIQEAPEYIL SRAKEIEEQN
160 170 180 190 200
KQLLEGVEKI ISQAYPEAKG NGIYFVWSQL PSLQGVDEES KILSLRNTIR
210 220
CLRRDSHKVD NFLKVLRCQI AHQNNC
Length:226
Mass (Da):25,496
Last modified:January 1, 1988 - v1
Checksum:i40B734C1FD610E6E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205D → H in CAA28018 (PubMed:3756168).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02892 mRNA Translation: CAA26651.1
X04418 mRNA Translation: CAA28018.1
AK017521 mRNA Translation: BAB30787.2
AK017579 mRNA Translation: BAB30816.2
UniGeneiMm.1270

Genome annotation databases

EnsembliENSMUST00000224228; ENSMUSP00000153245; ENSMUSG00000021342

Similar proteinsi

Entry informationi

Entry nameiPRL_MOUSE
AccessioniPrimary (citable) accession number: P06879
Secondary accession number(s): Q544X8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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