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P06879 (PRL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prolactin

Short name=PRL
Gene names
Name:Prl
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Prolactin acts primarily on the mammary gland by promoting lactation.

Subcellular location

Secreted.

Sequence similarities

Belongs to the somatotropin/prolactin family.

Ontologies

Keywords
   Biological processLactation
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMDisulfide bond
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processSTAT protein import into nucleus

Inferred from direct assay PubMed 12147240. Source: MGI

cellular response to hormone stimulus

Inferred from electronic annotation. Source: Ensembl

circadian rhythm

Inferred from electronic annotation. Source: Ensembl

lactation

Inferred from electronic annotation. Source: UniProtKB-KW

mammary gland development

Inferred from genetic interaction PubMed 18425773. Source: MGI

multicellular organismal response to stress

Inferred from electronic annotation. Source: Ensembl

ovulation cycle

Inferred from electronic annotation. Source: Ensembl

parturition

Inferred from electronic annotation. Source: Ensembl

positive regulation of JAK-STAT cascade

Inferred from genetic interaction PubMed 12388746. Source: MGI

positive regulation of cell proliferation

Inferred from genetic interaction PubMed 9247268. Source: MGI

positive regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

regulation of JAK-STAT cascade

Inferred from direct assay PubMed 12147240. Source: MGI

regulation of ossification

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to ethanol

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to nutrient

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

secretory granule

Inferred from direct assay PubMed 9247267. Source: MGI

   Molecular_functionhormone activity

Traceable author statement PubMed 12147240. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929
Chain30 – 226197Prolactin
PRO_0000032921

Amino acid modifications

Modified residue531Phosphoserine By similarity
Modified residue1171Phosphoserine By similarity
Disulfide bond33 ↔ 38 By similarity
Disulfide bond85 ↔ 201 By similarity
Disulfide bond218 ↔ 226 By similarity

Experimental info

Sequence conflict2051D → H in CAA28018. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P06879 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: 40B734C1FD610E6E

FASTA22625,496
        10         20         30         40         50         60 
MNSQGSAQKA GTLLLLLISN LLFCQNVQPL PICSAGDCQT SLRELFDRVV ILSHYIHTLY 

        70         80         90        100        110        120 
TDMFIEFDKQ YVQDREFMVK VINDCPTSSL ATPEDKEQAL KVPPEVLLNL ILSLVQSSSD 

       130        140        150        160        170        180 
PLFQLITGVG GIQEAPEYIL SRAKEIEEQN KQLLEGVEKI ISQAYPEAKG NGIYFVWSQL 

       190        200        210        220 
PSLQGVDEES KILSLRNTIR CLRRDSHKVD NFLKVLRCQI AHQNNC 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of mouse prolactin and growth hormone mRNAs and expression of these mRNAs during pregnancy."
Linzer D.I.H., Talamantes F.
J. Biol. Chem. 260:9574-9579(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"Cloning and sequence analysis of cDNA for mouse prolactin."
Harigaya T., Nakayama K., Ohkubo H., Nakanishi S., Seo H., Hoshino K.
Biochim. Biophys. Acta 868:30-38(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X02892 mRNA. Translation: CAA26651.1.
X04418 mRNA. Translation: CAA28018.1.
AK017521 mRNA. Translation: BAB30787.2.
AK017579 mRNA. Translation: BAB30816.2.
UniGeneMm.1270.

3D structure databases

ProteinModelPortalP06879.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000105998.

PTM databases

PhosphoSiteP06879.

Proteomic databases

PaxDbP06879.
PRIDEP06879.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:97762. Prl.

Phylogenomic databases

eggNOGNOG47376.
HOVERGENHBG104895.
InParanoidP06879.

Gene expression databases

BgeeP06879.
CleanExMM_PRL.
GenevestigatorP06879.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERPTHR11417. PTHR11417. 1 hit.
PfamPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSPR00836. SOMATOTROPIN.
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPRL. mouse.
PROP06879.
SOURCESearch...

Entry information

Entry namePRL_MOUSE
AccessionPrimary (citable) accession number: P06879
Secondary accession number(s): Q544X8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: April 16, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot