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P06879

- PRL_MOUSE

UniProt

P06879 - PRL_MOUSE

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Protein
Prolactin
Gene
Prl
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Prolactin acts primarily on the mammary gland by promoting lactation.

GO - Molecular functioni

  1. hormone activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. STAT protein import into nucleus Source: MGI
  2. cellular response to hormone stimulus Source: Ensembl
  3. circadian rhythm Source: Ensembl
  4. lactation Source: UniProtKB-KW
  5. mammary gland development Source: MGI
  6. multicellular organismal response to stress Source: Ensembl
  7. ovulation cycle Source: Ensembl
  8. parturition Source: Ensembl
  9. positive regulation of JAK-STAT cascade Source: MGI
  10. positive regulation of cell proliferation Source: MGI
  11. positive regulation of epithelial cell proliferation Source: Ensembl
  12. regulation of JAK-STAT cascade Source: MGI
  13. regulation of ossification Source: Ensembl
  14. response to drug Source: Ensembl
  15. response to estradiol Source: Ensembl
  16. response to ethanol Source: Ensembl
  17. response to lipopolysaccharide Source: Ensembl
  18. response to nutrient Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Lactation

Enzyme and pathway databases

ReactomeiREACT_198561. Prolactin receptor signaling.
REACT_198563. Amyloids.
REACT_198614. Growth hormone receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin
Short name:
PRL
Gene namesi
Name:Prl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:97762. Prl.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. secretory granule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929
Add
BLAST
Chaini30 – 226197Prolactin
PRO_0000032921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 38 By similarity
Modified residuei53 – 531Phosphoserine By similarity
Disulfide bondi85 ↔ 201 By similarity
Modified residuei117 – 1171Phosphoserine By similarity
Disulfide bondi218 ↔ 226 By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP06879.
PRIDEiP06879.

PTM databases

PhosphoSiteiP06879.

Expressioni

Gene expression databases

BgeeiP06879.
CleanExiMM_PRL.
GenevestigatoriP06879.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105998.

Structurei

3D structure databases

ProteinModelPortaliP06879.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47376.
HOVERGENiHBG104895.
InParanoidiP06879.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06879-1 [UniParc]FASTAAdd to Basket

« Hide

MNSQGSAQKA GTLLLLLISN LLFCQNVQPL PICSAGDCQT SLRELFDRVV    50
ILSHYIHTLY TDMFIEFDKQ YVQDREFMVK VINDCPTSSL ATPEDKEQAL 100
KVPPEVLLNL ILSLVQSSSD PLFQLITGVG GIQEAPEYIL SRAKEIEEQN 150
KQLLEGVEKI ISQAYPEAKG NGIYFVWSQL PSLQGVDEES KILSLRNTIR 200
CLRRDSHKVD NFLKVLRCQI AHQNNC 226
Length:226
Mass (Da):25,496
Last modified:January 1, 1988 - v1
Checksum:i40B734C1FD610E6E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti205 – 2051D → H in CAA28018. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02892 mRNA. Translation: CAA26651.1.
X04418 mRNA. Translation: CAA28018.1.
AK017521 mRNA. Translation: BAB30787.2.
AK017579 mRNA. Translation: BAB30816.2.
UniGeneiMm.1270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X02892 mRNA. Translation: CAA26651.1 .
X04418 mRNA. Translation: CAA28018.1 .
AK017521 mRNA. Translation: BAB30787.2 .
AK017579 mRNA. Translation: BAB30816.2 .
UniGenei Mm.1270.

3D structure databases

ProteinModelPortali P06879.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000105998.

PTM databases

PhosphoSitei P06879.

Proteomic databases

PaxDbi P06879.
PRIDEi P06879.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:97762. Prl.

Phylogenomic databases

eggNOGi NOG47376.
HOVERGENi HBG104895.
InParanoidi P06879.

Enzyme and pathway databases

Reactomei REACT_198561. Prolactin receptor signaling.
REACT_198563. Amyloids.
REACT_198614. Growth hormone receptor signaling.

Miscellaneous databases

ChiTaRSi PRL. mouse.
PROi P06879.
SOURCEi Search...

Gene expression databases

Bgeei P06879.
CleanExi MM_PRL.
Genevestigatori P06879.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view ]
PANTHERi PTHR11417. PTHR11417. 1 hit.
Pfami PF00103. Hormone_1. 1 hit.
[Graphical view ]
PRINTSi PR00836. SOMATOTROPIN.
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of mouse prolactin and growth hormone mRNAs and expression of these mRNAs during pregnancy."
    Linzer D.I.H., Talamantes F.
    J. Biol. Chem. 260:9574-9579(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiPRL_MOUSE
AccessioniPrimary (citable) accession number: P06879
Secondary accession number(s): Q544X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: September 3, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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