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P06872

- TRY2_CANFA

UniProt

P06872 - TRY2_CANFA

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Protein

Anionic trypsin

Gene
N/A
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei63 – 631Charge relay system By similarity
Metal bindingi75 – 751Calcium By similarity
Metal bindingi77 – 771Calcium; via carbonyl oxygen By similarity
Metal bindingi80 – 801Calcium; via carbonyl oxygen By similarity
Metal bindingi85 – 851Calcium By similarity
Active sitei107 – 1071Charge relay system By similarity
Sitei194 – 1941Required for specificity By similarity
Active sitei200 – 2001Charge relay system By similarity

GO - Molecular functioni

  1. calcium ion binding Source: UniProtKB
  2. serine-type endopeptidase activity Source: UniProtKB

GO - Biological processi

  1. collagen catabolic process Source: UniProtKB
  2. digestion Source: UniProtKB-KW
  3. proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_174078. Cobalamin (Cbl, vitamin B12) transport and metabolism.
REACT_182220. Activation of Matrix Metalloproteinases.

Protein family/group databases

MEROPSiS01.120.

Names & Taxonomyi

Protein namesi
Recommended name:
Anionic trypsin (EC:3.4.21.4)
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 16

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Add
BLAST
Propeptidei16 – 238Activation peptidePRO_0000028193
Chaini24 – 247224Anionic trypsinPRO_0000028194Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 160 By similarity
Disulfide bondi48 ↔ 64 By similarity
Disulfide bondi132 ↔ 233 By similarity
Disulfide bondi139 ↔ 206 By similarity
Disulfide bondi171 ↔ 185 By similarity
Disulfide bondi196 ↔ 220 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP06872.
PRIDEiP06872.

Structurei

3D structure databases

ProteinModelPortaliP06872.
SMRiP06872. Positions 24-246.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 244221Peptidase S1Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00740000115192.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP06872.
KOiK01312.
OMAiHPKYSSW.
OrthoDBiEOG75B84T.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06872-1 [UniParc]FASTAAdd to Basket

« Hide

MNPLLILAFL GAAVATPTDD DDKIVGGYTC EENSVPYQVS LNAGYHFCGG    50
SLISDQWVVS AAHCYKSRIQ VRLGEYNIDV LEGNEQFINS AKVIRHPNYN 100
SWILDNDIML IKLSSPAVLN ARVATISLPR ACAAPGTQCL ISGWGNTLSS 150
GTNYPELLQC LDAPILTQAQ CEASYPGQIT ENMICAGFLE GGKDSCQGDS 200
GGPVVCNGEL QGIVSWGYGC AQKNKPGVYT KVCNFVDWIQ STIAANS 247
Length:247
Mass (Da):26,423
Last modified:January 1, 1988 - v1
Checksum:i374E9D31D6DB8EAF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11589 mRNA. Translation: AAA30899.1.
PIRiA26273. TRDG.
RefSeqiXP_003432104.1. XM_003432056.2.

Genome annotation databases

EnsembliENSCAFT00000022998; ENSCAFP00000021363; ENSCAFG00000014481.
GeneIDi100686744.
KEGGicfa:100686744.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11589 mRNA. Translation: AAA30899.1 .
PIRi A26273. TRDG.
RefSeqi XP_003432104.1. XM_003432056.2.

3D structure databases

ProteinModelPortali P06872.
SMRi P06872. Positions 24-246.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.120.

Proteomic databases

PaxDbi P06872.
PRIDEi P06872.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000022998 ; ENSCAFP00000021363 ; ENSCAFG00000014481 .
GeneIDi 100686744.
KEGGi cfa:100686744.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00740000115192.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P06872.
KOi K01312.
OMAi HPKYSSW.
OrthoDBi EOG75B84T.
TreeFami TF331065.

Enzyme and pathway databases

Reactomei REACT_174078. Cobalamin (Cbl, vitamin B12) transport and metabolism.
REACT_182220. Activation of Matrix Metalloproteinases.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Differential regulation of trypsinogen mRNA translation: full-length mRNA sequences encoding two oppositely charged trypsinogen isoenzymes in the dog pancreas."
    Pinsky S.D., Laforge K.S., Scheele G.
    Mol. Cell. Biol. 5:2669-2676(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTRY2_CANFA
AccessioniPrimary (citable) accession number: P06872
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi