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P06872

- TRY2_CANFA

UniProt

P06872 - TRY2_CANFA

Protein

Anionic trypsin

Gene
N/A
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Jan 1988)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei63 – 631Charge relay systemBy similarity
    Metal bindingi75 – 751CalciumBy similarity
    Metal bindingi77 – 771Calcium; via carbonyl oxygenBy similarity
    Metal bindingi80 – 801Calcium; via carbonyl oxygenBy similarity
    Metal bindingi85 – 851CalciumBy similarity
    Active sitei107 – 1071Charge relay systemBy similarity
    Sitei194 – 1941Required for specificityBy similarity
    Active sitei200 – 2001Charge relay systemBy similarity

    GO - Molecular functioni

    1. calcium ion binding Source: UniProtKB
    2. serine-type endopeptidase activity Source: UniProtKB

    GO - Biological processi

    1. collagen catabolic process Source: UniProtKB
    2. digestion Source: UniProtKB-KW
    3. proteolysis Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Digestion

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_174078. Cobalamin (Cbl, vitamin B12) transport and metabolism.
    REACT_182220. Activation of Matrix Metalloproteinases.

    Protein family/group databases

    MEROPSiS01.120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anionic trypsin (EC:3.4.21.4)
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 16

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Add
    BLAST
    Propeptidei16 – 238Activation peptidePRO_0000028193
    Chaini24 – 247224Anionic trypsinPRO_0000028194Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 160PROSITE-ProRule annotation
    Disulfide bondi48 ↔ 64PROSITE-ProRule annotation
    Disulfide bondi132 ↔ 233PROSITE-ProRule annotation
    Disulfide bondi139 ↔ 206PROSITE-ProRule annotation
    Disulfide bondi171 ↔ 185PROSITE-ProRule annotation
    Disulfide bondi196 ↔ 220PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Proteomic databases

    PaxDbiP06872.
    PRIDEiP06872.

    Structurei

    3D structure databases

    ProteinModelPortaliP06872.
    SMRiP06872. Positions 24-246.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 244221Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00740000115192.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP06872.
    KOiK01312.
    OMAiHPKYSSW.
    OrthoDBiEOG75B84T.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P06872-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPLLILAFL GAAVATPTDD DDKIVGGYTC EENSVPYQVS LNAGYHFCGG    50
    SLISDQWVVS AAHCYKSRIQ VRLGEYNIDV LEGNEQFINS AKVIRHPNYN 100
    SWILDNDIML IKLSSPAVLN ARVATISLPR ACAAPGTQCL ISGWGNTLSS 150
    GTNYPELLQC LDAPILTQAQ CEASYPGQIT ENMICAGFLE GGKDSCQGDS 200
    GGPVVCNGEL QGIVSWGYGC AQKNKPGVYT KVCNFVDWIQ STIAANS 247
    Length:247
    Mass (Da):26,423
    Last modified:January 1, 1988 - v1
    Checksum:i374E9D31D6DB8EAF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11589 mRNA. Translation: AAA30899.1.
    PIRiA26273. TRDG.
    RefSeqiXP_003432104.1. XM_003432056.2.

    Genome annotation databases

    EnsembliENSCAFT00000022998; ENSCAFP00000021363; ENSCAFG00000014481.
    GeneIDi100686744.
    KEGGicfa:100686744.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M11589 mRNA. Translation: AAA30899.1 .
    PIRi A26273. TRDG.
    RefSeqi XP_003432104.1. XM_003432056.2.

    3D structure databases

    ProteinModelPortali P06872.
    SMRi P06872. Positions 24-246.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S01.120.

    Proteomic databases

    PaxDbi P06872.
    PRIDEi P06872.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000022998 ; ENSCAFP00000021363 ; ENSCAFG00000014481 .
    GeneIDi 100686744.
    KEGGi cfa:100686744.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00740000115192.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P06872.
    KOi K01312.
    OMAi HPKYSSW.
    OrthoDBi EOG75B84T.
    TreeFami TF331065.

    Enzyme and pathway databases

    Reactomei REACT_174078. Cobalamin (Cbl, vitamin B12) transport and metabolism.
    REACT_182220. Activation of Matrix Metalloproteinases.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential regulation of trypsinogen mRNA translation: full-length mRNA sequences encoding two oppositely charged trypsinogen isoenzymes in the dog pancreas."
      Pinsky S.D., Laforge K.S., Scheele G.
      Mol. Cell. Biol. 5:2669-2676(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiTRY2_CANFA
    AccessioniPrimary (citable) accession number: P06872
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 1, 1988
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3