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Reviewed, UniProtKB/Swiss-Prot P06872 (TRY2_CANFA)

Last modified June 16, 2009. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Anionic trypsin
    EC=3.4.21.4
OrganismCanis familiaris (Dog)
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactor

Binds 1 calcium ion per subunit By similarity.

Subcellular location

Secretedextracellular space.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515
Propeptide16 – 238Activation peptide
PRO_0000028193
Chain24 – 247224Anionic trypsin
PRO_0000028194

Regions

Domain24 – 244221Peptidase S1

Sites

Active site631Charge relay system By similarity
Active site1071Charge relay system By similarity
Active site2001Charge relay system By similarity
Metal binding751Calcium By similarity
Metal binding771Calcium; via carbonyl oxygen By similarity
Metal binding801Calcium; via carbonyl oxygen By similarity
Metal binding851Calcium By similarity
Site1941Required for specificity By similarity

Amino acid modifications

Disulfide bond30 ↔ 160 By similarity
Disulfide bond48 ↔ 64 By similarity
Disulfide bond132 ↔ 233 By similarity
Disulfide bond139 ↔ 206 By similarity
Disulfide bond171 ↔ 185 By similarity
Disulfide bond196 ↔ 220 By similarity

Sequences

Sequence LengthMass (Da)Tools
P06872-1 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: 374E9D31D6DB8EAF

FASTA24726,423
        10         20         30         40         50         60 
MNPLLILAFL GAAVATPTDD DDKIVGGYTC EENSVPYQVS LNAGYHFCGG SLISDQWVVS 

        70         80         90        100        110        120 
AAHCYKSRIQ VRLGEYNIDV LEGNEQFINS AKVIRHPNYN SWILDNDIML IKLSSPAVLN 

       130        140        150        160        170        180 
ARVATISLPR ACAAPGTQCL ISGWGNTLSS GTNYPELLQC LDAPILTQAQ CEASYPGQIT 

       190        200        210        220        230        240 
ENMICAGFLE GGKDSCQGDS GGPVVCNGEL QGIVSWGYGC AQKNKPGVYT KVCNFVDWIQ 


STIAANS 

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References

[1]"Differential regulation of trypsinogen mRNA translation: full-length mRNA sequences encoding two oppositely charged trypsinogen isoenzymes in the dog pancreas."
Pinsky S.D., Laforge K.S., Scheele G.
Mol. Cell. Biol. 5:2669-2676(1985) [PubMed: 3841794] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

M11589 mRNA. Translation: AAA30899.1.
PIRTRDG. A26273.

3D structure databases

HSSPHSSP built from PDB template 1EZX based on UniProtKB P00760.
SMRP06872. Positions 24-246.
ModBaseSearch...

Protein family/group databases

MEROPSS01.120.

Genome annotation databases

EnsemblENSCAFG00000014481. Canis familiaris. [Contig view]

Phylogenomic databases

HOVERGENP06872.
OMAP06872. RITLNND.

Enzyme and pathway databases

BRENDA3.4.21.4. 463.

Family and domain databases

InterProIPR018114. Peptidase_S1/S6_AS.
IPR001254. Peptidase_S1_S6.
IPR001314. Peptidase_S1A.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRY2_CANFA
AccessionPrimary (citable) accession number: P06872
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: June 16, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents