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P06871

- TRY1_CANFA

UniProt

P06871 - TRY1_CANFA

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Protein
Cationic trypsin
Gene
N/A
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei63 – 631Charge relay system By similarity
Metal bindingi75 – 751Calcium By similarity
Metal bindingi77 – 771Calcium; via carbonyl oxygen By similarity
Metal bindingi80 – 801Calcium; via carbonyl oxygen By similarity
Metal bindingi85 – 851Calcium By similarity
Active sitei107 – 1071Charge relay system By similarity
Sitei194 – 1941Required for specificity By similarity
Active sitei200 – 2001Charge relay system By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. digestion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

MEROPSiS01.151.

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic trypsin (EC:3.4.21.4)
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515
Add
BLAST
Propeptidei16 – 238Activation peptide
PRO_0000028191
Chaini24 – 246223Cationic trypsin
PRO_0000028192Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 160 By similarity
Disulfide bondi48 ↔ 64 By similarity
Disulfide bondi132 ↔ 233 By similarity
Disulfide bondi139 ↔ 206 By similarity
Disulfide bondi171 ↔ 185 By similarity
Disulfide bondi196 ↔ 220 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP06871.
PRIDEiP06871.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000005682.

Structurei

3D structure databases

ProteinModelPortaliP06871.
SMRiP06871. Positions 24-246.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 244221Peptidase S1
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP06871.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06871-1 [UniParc]FASTAAdd to Basket

« Hide

MKTFIFLALL GATVAFPIDD DDKIVGGYTC SRNSVPYQVS LNSGYHFCGG    50
SLINSQWVVS AAHCYKSRIQ VRLGEYNIAV SEGGEQFINA AKIIRHPRYN 100
ANTIDNDIML IKLSSPATLN SRVSAIALPK SCPAAGTQCL ISGWGNTQSI 150
GQNYPDVLQC LKAPILSDSV CRNAYPGQIS SNMMCLGYME GGKDSCQGDS 200
GGPVVCNGEL QGVVSWGAGC AQKGKPGVSP KVCKYVSWIQ QTIAAN 246
Length:246
Mass (Da):26,170
Last modified:January 1, 1988 - v1
Checksum:iE9E5A1DE2391BBBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11590 mRNA. Translation: AAA30900.1.
PIRiB26273. TRDGC.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11590 mRNA. Translation: AAA30900.1 .
PIRi B26273. TRDGC.

3D structure databases

ProteinModelPortali P06871.
SMRi P06871. Positions 24-246.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000005682.

Protein family/group databases

MEROPSi S01.151.

Proteomic databases

PaxDbi P06871.
PRIDEi P06871.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P06871.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Differential regulation of trypsinogen mRNA translation: full-length mRNA sequences encoding two oppositely charged trypsinogen isoenzymes in the dog pancreas."
    Pinsky S.D., Laforge K.S., Scheele G.
    Mol. Cell. Biol. 5:2669-2676(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTRY1_CANFA
AccessioniPrimary (citable) accession number: P06871
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 14, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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