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P06870

- KLK1_HUMAN

UniProt

P06870 - KLK1_HUMAN

Protein

Kallikrein-1

Gene

KLK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 160 (01 Oct 2014)
      Sequence version 2 (24 Nov 2009)
      Previous versions | rss
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    Functioni

    Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

    Catalytic activityi

    Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Charge relay system
    Active sitei120 – 1201Charge relay system
    Active sitei214 – 2141Charge relay system

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BRENDAi3.4.21.35. 2681.
    ReactomeiREACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kallikrein-1 (EC:3.4.21.35)
    Alternative name(s):
    Kidney/pancreas/salivary gland kallikrein
    Tissue kallikrein
    Gene namesi
    Name:KLK1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6357. KLK1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. nucleus Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    MIMi147910. gene+phenotype.
    PharmGKBiPA224.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818CuratedAdd
    BLAST
    Propeptidei19 – 246Activation peptideCuratedPRO_0000027923
    Chaini25 – 262238Kallikrein-1PRO_0000027924Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 1741 PublicationPROSITE-ProRule annotation
    Disulfide bondi50 ↔ 661 PublicationPROSITE-ProRule annotation
    Glycosylationi93 – 931O-linked (GalNAc...)1 Publication
    Glycosylationi102 – 1021N-linked (GlcNAc...)1 Publication
    Glycosylationi104 – 1041O-linked (GalNAc...)1 Publication
    Glycosylationi108 – 1081N-linked (GlcNAc...)2 Publications
    Disulfide bondi153 ↔ 2201 PublicationPROSITE-ProRule annotation
    Glycosylationi165 – 1651N-linked (GlcNAc...); partial1 Publication
    Glycosylationi167 – 1671O-linked (GalNAc...)1 Publication
    Disulfide bondi185 ↔ 1991 PublicationPROSITE-ProRule annotation
    Disulfide bondi210 ↔ 2351 PublicationPROSITE-ProRule annotation

    Post-translational modificationi

    The O-linked polysaccharides on Ser-93, Ser-104 and Ser-167 are probably the mucin type linked to GalNAc. In PubMed:3163150, GalNAc was detected with the corresponding peptides but not located.2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiP06870.
    PRIDEiP06870.

    PTM databases

    UniCarbKBiP06870.

    Expressioni

    Tissue specificityi

    Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84.1 Publication

    Gene expression databases

    ArrayExpressiP06870.
    BgeeiP06870.
    CleanExiHS_KLK1.
    GenevestigatoriP06870.

    Interactioni

    Protein-protein interaction databases

    BioGridi110016. 1 interaction.
    STRINGi9606.ENSP00000301420.

    Structurei

    Secondary structure

    1
    262
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi39 – 446
    Beta strandi47 – 5610
    Beta strandi59 – 624
    Helixi64 – 663
    Beta strandi69 – 768
    Beta strandi88 – 903
    Beta strandi92 – 976
    Helixi103 – 1064
    Turni112 – 1143
    Beta strandi122 – 1287
    Beta strandi152 – 1598
    Beta strandi161 – 1655
    Beta strandi173 – 1808
    Helixi182 – 1887
    Beta strandi197 – 2015
    Beta strandi206 – 2083
    Beta strandi217 – 2204
    Beta strandi223 – 2308
    Beta strandi242 – 2465
    Helixi247 – 2504
    Helixi251 – 26010

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1SPJX-ray1.70A25-262[»]
    ProteinModelPortaliP06870.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP06870.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 259235Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOVERGENiHBG013304.
    InParanoidiP06870.
    KOiK01325.
    OMAiLWLGRHN.
    PhylomeDBiP06870.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P06870-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWFLVLCLAL SLGGTGAAPP IQSRIVGGWE CEQHSQPWQA ALYHFSTFQC    50
    GGILVHRQWV LTAAHCISDN YQLWLGRHNL FDDENTAQFV HVSESFPHPG 100
    FNMSLLENHT RQADEDYSHD LMLLRLTEPA DTITDAVKVV ELPTEEPEVG 150
    STCLASGWGS IEPENFSFPD DLQCVDLKIL PNDECKKAHV QKVTDFMLCV 200
    GHLEGGKDTC VGDSGGPLMC DGVLQGVTSW GYVPCGTPNK PSVAVRVLSY 250
    VKWIEDTIAE NS 262
    Length:262
    Mass (Da):28,890
    Last modified:November 24, 2009 - v2
    Checksum:i7D8A715E9E104D60
    GO
    Isoform 2 (identifier: P06870-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-69: MWFLVLCLAL...VLTAAHCISD → MLPCPIPFSPSRLLIPPFPSFPS

    Show »
    Length:216
    Mass (Da):23,835
    Checksum:i8FD0C1CEB83D6750
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti114 – 1141D → N in AAU12569. 1 PublicationCurated
    Sequence conflicti139 – 1391V → F in AAU12569. 1 PublicationCurated
    Sequence conflicti188 – 1881A → V in AAP35917. 1 PublicationCurated
    Sequence conflicti188 – 1881A → V in AAH05313. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 771R → H.
    Corresponds to variant rs5515 [ dbSNP | Ensembl ].
    VAR_014567
    Natural varianti145 – 1451E → Q.7 Publications
    Corresponds to variant rs5516 [ dbSNP | Ensembl ].
    VAR_006625
    Natural varianti186 – 1861K → E.3 Publications
    Corresponds to variant rs5517 [ dbSNP | Ensembl ].
    VAR_006626
    Natural varianti193 – 1931V → E.
    Corresponds to variant rs5518 [ dbSNP | Ensembl ].
    VAR_014568

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6969MWFLV…HCISD → MLPCPIPFSPSRLLIPPFPS FPS in isoform 2. 1 PublicationVSP_037483Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25629 mRNA. Translation: AAA36136.1.
    M33109
    , M33105, M33106, M33107, M33108 Genomic DNA. Translation: AAA59455.1.
    X13561 mRNA. Translation: CAA31912.1.
    AF277050 Genomic DNA. Translation: AAF86333.1.
    AF243527 Genomic DNA. Translation: AAG33353.1.
    AY703451 mRNA. Translation: AAU12569.1.
    BT007253 mRNA. Translation: AAP35917.1.
    AY094609 Genomic DNA. Translation: AAM11874.1.
    AC010325 Genomic DNA. No translation available.
    BC005313 mRNA. Translation: AAH05313.1.
    M12706 mRNA. Translation: AAA59201.1.
    CCDSiCCDS12804.1. [P06870-1]
    PIRiA24696. KQHU.
    B24696.
    RefSeqiNP_002248.1. NM_002257.3. [P06870-1]
    UniGeneiHs.123107.

    Genome annotation databases

    EnsembliENST00000301420; ENSP00000301420; ENSG00000167748. [P06870-1]
    GeneIDi3816.
    KEGGihsa:3816.
    UCSCiuc002ptk.1. human. [P06870-1]

    Polymorphism databases

    DMDMi269849612.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Kallikrein entry

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25629 mRNA. Translation: AAA36136.1 .
    M33109
    , M33105 , M33106 , M33107 , M33108 Genomic DNA. Translation: AAA59455.1 .
    X13561 mRNA. Translation: CAA31912.1 .
    AF277050 Genomic DNA. Translation: AAF86333.1 .
    AF243527 Genomic DNA. Translation: AAG33353.1 .
    AY703451 mRNA. Translation: AAU12569.1 .
    BT007253 mRNA. Translation: AAP35917.1 .
    AY094609 Genomic DNA. Translation: AAM11874.1 .
    AC010325 Genomic DNA. No translation available.
    BC005313 mRNA. Translation: AAH05313.1 .
    M12706 mRNA. Translation: AAA59201.1 .
    CCDSi CCDS12804.1. [P06870-1 ]
    PIRi A24696. KQHU.
    B24696.
    RefSeqi NP_002248.1. NM_002257.3. [P06870-1 ]
    UniGenei Hs.123107.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1SPJ X-ray 1.70 A 25-262 [» ]
    ProteinModelPortali P06870.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110016. 1 interaction.
    STRINGi 9606.ENSP00000301420.

    Chemistry

    ChEMBLi CHEMBL2319.
    DrugBanki DB00009. Alteplase.
    DB00029. Anistreplase.
    DB00015. Reteplase.
    DB00031. Tenecteplase.

    PTM databases

    UniCarbKBi P06870.

    Polymorphism databases

    DMDMi 269849612.

    Proteomic databases

    PaxDbi P06870.
    PRIDEi P06870.

    Protocols and materials databases

    DNASUi 3816.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301420 ; ENSP00000301420 ; ENSG00000167748 . [P06870-1 ]
    GeneIDi 3816.
    KEGGi hsa:3816.
    UCSCi uc002ptk.1. human. [P06870-1 ]

    Organism-specific databases

    CTDi 3816.
    GeneCardsi GC19M051322.
    HGNCi HGNC:6357. KLK1.
    MIMi 147910. gene+phenotype.
    neXtProti NX_P06870.
    PharmGKBi PA224.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOVERGENi HBG013304.
    InParanoidi P06870.
    KOi K01325.
    OMAi LWLGRHN.
    PhylomeDBi P06870.
    TreeFami TF331065.

    Enzyme and pathway databases

    BRENDAi 3.4.21.35. 2681.
    Reactomei REACT_15428. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

    Miscellaneous databases

    EvolutionaryTracei P06870.
    GeneWikii KLK1.
    GenomeRNAii 3816.
    NextBioi 15001.
    PROi P06870.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P06870.
    Bgeei P06870.
    CleanExi HS_KLK1.
    Genevestigatori P06870.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of cloned cDNA for human pancreatic kallikrein."
      Fukushima D., Kitamura N., Nakanishi S.
      Biochemistry 24:8037-8043(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS GLN-145 AND GLU-186.
      Tissue: Pancreas.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-145.
      Tissue: Kidney.
    3. "Cloning and expression of human salivary-gland kallikrein in Escherichia coli."
      Angermann A., Bergmann C., Appelhans H.
      Biochem. J. 262:787-793(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Salivary gland.
    4. "Molecular cloning and characterization of a novel kallikrein transcript in colon and its distribution in human tissues."
      Chen L.-M., Murray S.R., Chai K.X., Chao L., Chao J.
      Braz. J. Med. Biol. Res. 27:1829-1838(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    5. "Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4."
      Yousef G.M., Chang A., Scorilas A., Diamandis E.P.
      Biochem. Biophys. Res. Commun. 276:125-133(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
      Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.
      Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "Kallikrein cDNA from the pancreas of a Chinese patient."
      Li T., Du G., Dai Y.
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS GLN-145 AND GLU-186.
    8. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-145.
    9. SeattleSNPs variation discovery resource
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-145.
    10. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-145.
      Tissue: Pancreas.
    12. "Human kidney kallikrein: cDNA cloning and sequence analysis."
      Baker A.R., Shine J.
      DNA 4:445-450(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-262 (ISOFORM 1), VARIANTS GLN-145 AND GLU-186.
      Tissue: Kidney.
    13. "Human urinary kallikrein -- amino acid sequence and carbohydrate attachment sites."
      Kellermann J., Lottspeich F., Geiger R., Deutzmann R.
      Protein Seq. Data Anal. 1:177-182(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-262 (ISOFORM 1), GLYCOSYLATION AT SER-93; ASN-102; SER-104; ASN-108; ASN-165 AND SER-167.
      Tissue: Urine.
    14. "Human urinary kallikrein. Complete amino acid sequence and sites of glycosylation."
      Lu H.S., Lin F.-K., Chao L., Chao J.
      Int. J. Pept. Protein Res. 33:237-249(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-262 (ISOFORM 1).
      Tissue: Urine.
    15. "N-terminal amino acid sequence of human urinary kallikrein homology with other serine proteases."
      Lottspeich F., Geiger R., Henschen A., Kutzbach C.
      Hoppe-Seyler's Z. Physiol. Chem. 360:1947-1950(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-55 (ISOFORM 1).
      Tissue: Urine.
    16. "N-terminal amino acid sequence of human urinary prokallikrein."
      Takahashi S., Irie A., Katayama Y., Ito K., Miyake Y.
      J. Biochem. 99:989-992(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 28-47 (ISOFORM 1).
      Tissue: Urine.
    17. "1.70 A X-ray structure of human apo kallikrein 1: structural changes upon peptide inhibitor/substrate binding."
      Laxmikanthan G., Blaber S.I., Bernett M.J., Scarisbrick I.A., Juliano M.A., Blaber M.
      Proteins 58:802-814(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 25-262, GLYCOSYLATION AT ASN-108, DISULFIDE BONDS.

    Entry informationi

    Entry nameiKLK1_HUMAN
    AccessioniPrimary (citable) accession number: P06870
    Secondary accession number(s): Q66US9
    , Q86U61, Q8TCV8, Q9BS53, Q9NQU4, Q9UD19, Q9UMJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 160 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Peptidase families
      Classification of peptidase families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3