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Protein

Inactive pancreatic lipase-related protein 1

Gene

PNLIPRP1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro).

Caution

Was originally (PubMed:3562437 and PubMed:2502543) thought to be the pancreatic lipase, but has been shown to lack lipase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei171Nucleophile1
Active sitei194Charge relay system1
Metal bindingi205Calcium; via carbonyl oxygen1
Metal bindingi208Calcium; via carbonyl oxygen1
Metal bindingi210Calcium1
Metal bindingi213Calcium1
Active sitei281Charge relay system1

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • carboxylic ester hydrolase activity Source: InterPro

GO - Biological processi

Keywordsi

Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.26 1153

Protein family/group databases

ESTHERicanfa-1plip Pancreatic_lipase

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive pancreatic lipase-related protein 1
Short name:
PL-RP1
Gene namesi
Name:PNLIPRP1
Synonyms:PLRP1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 28

Organism-specific databases

VGNCiVGNC:44746 PNLIPRP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi196V → A: Removes steric hindrance and restores lipase activity; when associated with P-198. 1 Publication1
Mutagenesisi198A → P: Removes steric hindrance and restores lipase activity; when associated with A-196. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
ChainiPRO_000001778918 – 467Inactive pancreatic lipase-related protein 1Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi21 ↔ 27PROSITE-ProRule annotation1 Publication
Disulfide bondi109 ↔ 120PROSITE-ProRule annotation1 Publication
Glycosylationi157N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi255 ↔ 279PROSITE-ProRule annotation1 Publication
Disulfide bondi303 ↔ 314PROSITE-ProRule annotation1 Publication
Disulfide bondi317 ↔ 322PROSITE-ProRule annotation1 Publication
Disulfide bondi451 ↔ 467PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP06857

PTM databases

iPTMnetiP06857

Expressioni

Tissue specificityi

Detected in pancreas (at protein level).1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000017453

Structurei

Secondary structure

1467
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi19 – 22Combined sources4
Turni23 – 25Combined sources3
Beta strandi26 – 29Combined sources4
Turni32 – 34Combined sources3
Beta strandi35 – 40Combined sources6
Helixi49 – 52Combined sources4
Beta strandi55 – 59Combined sources5
Beta strandi61 – 66Combined sources6
Beta strandi68 – 70Combined sources3
Helixi76 – 79Combined sources4
Beta strandi87 – 93Combined sources7
Helixi104 – 112Combined sources9
Turni113 – 115Combined sources3
Beta strandi118 – 124Combined sources7
Helixi126 – 129Combined sources4
Helixi133 – 158Combined sources26
Helixi162 – 164Combined sources3
Beta strandi165 – 170Combined sources6
Helixi173 – 182Combined sources10
Beta strandi189 – 194Combined sources6
Turni198 – 202Combined sources5
Turni205 – 207Combined sources3
Helixi211 – 213Combined sources3
Beta strandi214 – 220Combined sources7
Helixi227 – 230Combined sources4
Beta strandi240 – 246Combined sources7
Turni247 – 250Combined sources4
Helixi266 – 270Combined sources5
Helixi279 – 293Combined sources15
Turni295 – 298Combined sources4
Helixi306 – 310Combined sources5
Beta strandi324 – 326Combined sources3
Helixi327 – 331Combined sources5
Beta strandi342 – 345Combined sources4
Beta strandi349 – 351Combined sources3
Beta strandi356 – 367Combined sources12
Beta strandi369 – 379Combined sources11
Beta strandi387 – 394Combined sources8
Beta strandi399 – 408Combined sources10
Beta strandi411 – 422Combined sources12
Beta strandi432 – 441Combined sources10
Beta strandi448 – 451Combined sources4
Beta strandi462 – 466Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RP1X-ray2.10A18-467[»]
ProteinModelPortaliP06857
SMRiP06857
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06857

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini356 – 467PLATPROSITE-ProRule annotationAdd BLAST112

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHRX Eukaryota
ENOG410Y92X LUCA
GeneTreeiENSGT00760000119069
HOGENOMiHOG000038552
HOVERGENiHBG003243
InParanoidiP06857
KOiK14074
OMAiDQGCPQM
OrthoDBiEOG091G0DJ5
TreeFamiTF324997

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR002331 Lipase_panc
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00823 PANCLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06857-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSIWTIALF LLGAAKAKEV CYEQIGCFSD AEPWAGTAIR PLKVLPWSPE
60 70 80 90 100
RIGTRFLLYT NKNPNNFQTL LPSDPSTIEA SNFQTDKKTR FIIHGFIDKG
110 120 130 140 150
EENWLLDMCK NMFKVEEVNC ICVDWKKGSQ TSYTQAANNV RVVGAQVAQM
160 170 180 190 200
LSMLSANYSY SPSQVQLIGH SLGAHVAGEA GSRTPGLGRI TGLDPVEASF
210 220 230 240 250
QGTPEEVRLD PTDADFVDVI HTDAAPLIPF LGFGTSQQMG HLDFFPNGGE
260 270 280 290 300
EMPGCKKNAL SQIVDLDGIW EGTRDFVACN HLRSYKYYSE SILNPDGFAS
310 320 330 340 350
YPCASYRAFE SNKCFPCPDQ GCPQMGHYAD KFAVKTSDET QKYFLNTGDS
360 370 380 390 400
SNFARWRYGV SITLSGKRAT GQAKVALFGS KGNTHQFNIF KGILKPGSTH
410 420 430 440 450
SNEFDAKLDV GTIEKVKFLW NNNVVNPTFP KVGAAKITVQ KGEEKTVHSF
460
CSESTVREDV LLTLTPC
Length:467
Mass (Da):51,482
Last modified:November 1, 1990 - v2
Checksum:i5B186845404E5B5C
GO

Sequence cautioni

The sequence AAA30840 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92I → T in AAA30885 (PubMed:3562437).Curated1
Sequence conflicti98D → N in AAA30885 (PubMed:3562437).Curated1
Sequence conflicti265D → N in AAA30885 (PubMed:3562437).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35302 mRNA Translation: AAA30885.1
M28151
, M28141, M28142, M28143, M28145, M28148, M28147, M28146, M28144, M28149, M28150 Genomic DNA Translation: AAA30840.1 Sequence problems.
PIRiB24392 LIDG
RefSeqiNP_001003319.2, NM_001003319.2
UniGeneiCfa.3881

Genome annotation databases

EnsembliENSCAFT00000018834; ENSCAFP00000017453; ENSCAFG00000011852
GeneIDi404010
KEGGicfa:404010

Similar proteinsi

Entry informationi

Entry nameiLIPR1_CANLF
AccessioniPrimary (citable) accession number: P06857
Secondary accession number(s): Q28287
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 1, 1990
Last modified: March 28, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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