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P06854 (TYSY_SHV21) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidylate synthase

Short name=TS
Short name=TSase
EC=2.1.1.45
Gene names
Name:70
Synonyms:ECLF4
OrganismSaimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) [Reference proteome]
Taxonomic identifier10383 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostSaimiri sciureus (Common squirrel monkey) [TaxID: 9521]

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP-Rule MF_00008

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP-Rule MF_00008

Subunit structure

Homodimer.

Sequence similarities

Belongs to the thymidylate synthase family.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdTMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

dTTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionthymidylate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Thymidylate synthase HAMAP-Rule MF_00008
PRO_0000141063

Sites

Active site1761 By similarity

Experimental info

Sequence conflict2261P → L in AAA46174. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P06854 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: CC583E13AC0A0930

FASTA29433,497
        10         20         30         40         50         60 
MSTHTEEQHG EHQYLSQVQH ILNYGSFKND RTGTGTLSIF GTQSRFSLEN EFPLLTTKRV 

        70         80         90        100        110        120 
FWRGVVEELL WFIRGSTDSK ELSAAGVHIW DANGSRSFLD KLGFYDRDEG DLGPVYGFQW 

       130        140        150        160        170        180 
RHFGAEYKGV GRDYKGEGVD QLKQLIDTIK TNPTDRRMLM CAWNVSDIPK MVLPPCHVLS 

       190        200        210        220        230        240 
QFYVCDGKLS CQLYQRSADM GLGVPFNIAS YSLLTCMIAH VTNLVPGEFI HTIGDAHIYV 

       250        260        270        280        290 
DHIDALKMQL TRTPRPFPTL RFARNVSCID DFKADDIILE NYNPHPIIKM HMAV 

« Hide

References

« Hide 'large scale' references
[1]"The A+T-rich genome of Herpesvirus saimiri contains a highly conserved gene for thymidylate synthase."
Honess R.W., Bodemer W., Cameron K.R., Niller H.H., Fleckenstein B., Randall R.E.
Proc. Natl. Acad. Sci. U.S.A. 83:3604-3608(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Organization of the thymidylate synthase gene of herpesvirus saimiri."
Bodemer W., Niller H.H., Nitsche N., Scholz B., Fleckenstein B.
J. Virol. 60:114-123(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Primary structure of the herpesvirus saimiri genome."
Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B., Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B., Honess R.W.
J. Virol. 66:5047-5058(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Analysis of nucleotide sequence of the rightmost 43 kbp of herpesvirus saimiri (HVS) L-DNA: general conservation of genetic organization between HVS and Epstein-Barr virus."
Nicholas J., Cameron K.R., Coleman H., Newman C., Honess R.W.
Virology 188:296-310(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64346 Genomic DNA. Translation: CAA45693.1.
M14080 Genomic DNA. Translation: AAA46174.1.
M13190 Genomic DNA. Translation: AAA46175.1.
M86409 Genomic DNA. Translation: AAA46146.1.
RefSeqNP_040272.1. NC_001350.1.

3D structure databases

ProteinModelPortalP06854.
SMRP06854. Positions 9-294.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1682482.

Enzyme and pathway databases

UniPathwayUPA00575.

Family and domain databases

Gene3D3.30.572.10. 1 hit.
HAMAPMF_00008. Thymidy_synth_bact.
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. SSF55831. 1 hit.
TIGRFAMsTIGR03284. thym_sym. 1 hit.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYSY_SHV21
AccessionPrimary (citable) accession number: P06854
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways