P06854 (TYSY_SHV21) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate synthase
Short name=TS
Short name=TSase
EC=2.1.1.45

Gene names

Name:	70
Synonyms:	ECLF4

Organism

Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) [Reference proteome]

Taxonomic identifier

10383 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Rhadinovirus › Saimiriine herpesvirus 2

Virus host

Saimiri sciureus (Common squirrel monkey) [TaxID: 9521]

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
Pathway	Pyrimidine metabolism; dTTP biosynthesis.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the thymidylate synthase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dTMP biosynthetic process Inferred from electronic annotation. Source: InterPro dTTP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	thymidylate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Thymidylate synthase		PRO_0000141063
Sites
	Active site	176	1	By similarity
Experimental info
	Sequence conflict	226	1	P → L in AAA46174. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P06854 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: CC583E13AC0A0930	FASTA	294	33,497
	10 20 30 40 50 60 MSTHTEEQHG EHQYLSQVQH ILNYGSFKND RTGTGTLSIF GTQSRFSLEN EFPLLTTKRV 70 80 90 100 110 120 FWRGVVEELL WFIRGSTDSK ELSAAGVHIW DANGSRSFLD KLGFYDRDEG DLGPVYGFQW 130 140 150 160 170 180 RHFGAEYKGV GRDYKGEGVD QLKQLIDTIK TNPTDRRMLM CAWNVSDIPK MVLPPCHVLS 190 200 210 220 230 240 QFYVCDGKLS CQLYQRSADM GLGVPFNIAS YSLLTCMIAH VTNLVPGEFI HTIGDAHIYV 250 260 270 280 290 DHIDALKMQL TRTPRPFPTL RFARNVSCID DFKADDIILE NYNPHPIIKM HMAV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The A+T-rich genome of Herpesvirus saimiri contains a highly conserved gene for thymidylate synthase." Honess R.W., Bodemer W., Cameron K.R., Niller H.H., Fleckenstein B., Randall R.E. Proc. Natl. Acad. Sci. U.S.A. 83:3604-3608(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Organization of the thymidylate synthase gene of herpesvirus saimiri." Bodemer W., Niller H.H., Nitsche N., Scholz B., Fleckenstein B. J. Virol. 60:114-123(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Primary structure of the herpesvirus saimiri genome." Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B., Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B., Honess R.W. J. Virol. 66:5047-5058(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Analysis of nucleotide sequence of the rightmost 43 kbp of herpesvirus saimiri (HVS) L-DNA: general conservation of genetic organization between HVS and Epstein-Barr virus." Nicholas J., Cameron K.R., Coleman H., Newman C., Honess R.W. Virology 188:296-310(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X64346 Genomic DNA. Translation: CAA45693.1. M14080 Genomic DNA. Translation: AAA46174.1. M13190 Genomic DNA. Translation: AAA46175.1. M86409 Genomic DNA. Translation: AAA46146.1.
RefSeq	NP_040272.1. NC_001350.1.
3D structure databases
ProteinModelPortal	P06854.
SMR	P06854. Positions 9-294.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1682482.
Phylogenomic databases
ProtClustDB	CLSP2509595.
Enzyme and pathway databases
UniPathway	UPA00575.
Family and domain databases
Gene3D	3.30.572.10. 1 hit.
InterPro	IPR023451. Thymidate_synth/dCMP_Mease. IPR000398. Thymidylate_synthase. IPR020940. Thymidylate_synthase_AS. [Graphical view]
Pfam	PF00303. Thymidylat_synt. 1 hit. [Graphical view]
PRINTS	PR00108. THYMDSNTHASE.
SUPFAM	SSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMs	TIGR03284. thym_sym. 1 hit.
PROSITE	PS00091. THYMIDYLATE_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYSY_SHV21

Accession

Primary (citable) accession number: P06854

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program