##gff-version 3
P06850	UniProtKB	Signal peptide	1	24	.	.	.	Ontology_term=ECO:0000305;evidence=ECO:0000305	
P06850	UniProtKB	Propeptide	25	153	.	.	.	ID=PRO_0000006212;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:3262120;Dbxref=PMID:3262120	
P06850	UniProtKB	Peptide	154	194	.	.	.	ID=PRO_0000006213;Note=Corticoliberin	
P06850	UniProtKB	Region	32	61	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P06850	UniProtKB	Region	85	105	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P06850	UniProtKB	Region	136	158	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P06850	UniProtKB	Compositional bias	43	57	.	.	.	Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P06850	UniProtKB	Compositional bias	144	158	.	.	.	Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
P06850	UniProtKB	Modified residue	194	194	.	.	.	Note=Isoleucine amide;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6605851;Dbxref=PMID:6605851	
P06850	UniProtKB	Natural variant	30	30	.	.	.	ID=VAR_075504;Note=Found in patients with autosomal dominant nocturnal frontal lobe epilepsy%3B uncertain significance%3B results in decreased protein levels%3B decreased protein secretion. P->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23593457;Dbxref=dbSNP:rs748404250,PMID:23593457	
P06850	UniProtKB	Mutagenesis	183	183	.	.	.	Note=Strongly reduced affinity for CRFR1. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18801728;Dbxref=PMID:18801728	
P06850	UniProtKB	Mutagenesis	187	187	.	.	.	Note=No effect on affinity for CRFR1. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18801728;Dbxref=PMID:18801728	
P06850	UniProtKB	Mutagenesis	188	188	.	.	.	Note=Strongly reduced affinity for CRFR1. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18801728;Dbxref=PMID:18801728	
P06850	UniProtKB	Mutagenesis	190	190	.	.	.	Note=Strongly reduced affinity for CRFR1. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18801728;Dbxref=PMID:18801728	
P06850	UniProtKB	Mutagenesis	191	191	.	.	.	Note=Strongly reduced affinity for CRFR1. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18801728;Dbxref=PMID:18801728	
P06850	UniProtKB	Mutagenesis	192	192	.	.	.	Note=No effect on affinity for CRFR1. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18801728;Dbxref=PMID:18801728	
P06850	UniProtKB	Helix	160	162	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6P9X	
P06850	UniProtKB	Helix	180	193	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3EHU