Reviewed,
UniProtKB/Swiss-Prot P06850 (CRF_HUMAN)
Last modified
January 19, 2010.
Version 100.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Corticoliberin Alternative name(s): Corticotropin-releasing hormone Corticotropin-releasing factor Short name=CRF | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 196 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | This hormone from hypothalamus regulates the release of corticotropin from pituitary gland. |
| Subcellular location | |
| Sequence similarities | Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 24 | 24 | Probable | ||||||||
| Propeptide | 25 – 153 | 129 | PRO_0000006212 | ||||||||
| Peptide | 154 – 194 | 41 | Corticoliberin | PRO_0000006213 | |||||||
Amino acid modifications | |||||||||||
| Modified residue | 194 | 1 | Isoleucine amide | ||||||||
Secondary structure | |||||||||||
Helix Strand Turn | |||||||||||
| Helix | 180 – 193 | 14 | |||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation and sequence analysis of the human corticotropin-releasing factor precursor gene." Shibahara S., Morimoto Y., Furutani Y., Notake M., Takahashi H., Shimizu S., Horikawa S., Numa S. EMBO J. 2:775-779(1983) [PubMed: 6605851] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Preprocorticotropin releasing hormone: cDNA sequence and in vitro processing." Robinson B.G., D'Angio L.A. Jr., Pasieka K.B., Majzoub J.A. Mol. Cell. Endocrinol. 61:175-180(1989) [PubMed: 2783917] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. Isogai T.DNA Res. 12:117-126(2005) [PubMed: 16303743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [7] | "Isolation and characterization of a corticotropin-releasing hormone-like peptide from human placenta." Sasaki A., Tempst P., Liotta A.S., Margioris A.N., Hood L.E., Kent S.B., Sato S., Shinkawa O., Yoshinaga K., Krieger D.T. J. Clin. Endocrinol. Metab. 67:768-773(1988) [PubMed: 3262120] [Abstract] Cited for: PROTEIN SEQUENCE OF 154-186. |
| [8] | "Solution structure of human corticotropin releasing factor by 1H NMR and distance geometry with restrained molecular dynamics." Romier C., Bernassau J.-M., Cambillau C., Darbon H. Protein Eng. 6:149-156(1993) [PubMed: 8386360] [Abstract] Cited for: STRUCTURE BY NMR OF 154-194. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | V00571 Genomic DNA. Translation: CAA23834.1. BT007453 mRNA. Translation: AAP36121.1. AK075431 mRNA. Translation: BAG52136.1. CH471068 Genomic DNA. Translation: EAW86897.1. BC002599 mRNA. Translation: AAH02599.1. BC011031 mRNA. Translation: AAH11031.1. | ||||||||||||||||||
| IPI | IPI00027839. | ||||||||||||||||||
| PIR | A30327. | ||||||||||||||||||
| RefSeq | NP_000747.1. | ||||||||||||||||||
| UniGene | Hs.75294 | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||||||||
| SMR | P06850. Positions 154-194. | ||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| STRING | P06850. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | P06850. | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENST00000276571; ENSP00000276571; ENSG00000147571; Homo sapiens. [Genome view] | ||||||||||||||||||
| GeneID | 1392. | ||||||||||||||||||
| KEGG | hsa:1392. | ||||||||||||||||||
| UCSC | uc003xvy.1. human. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| CTD | 1392. | ||||||||||||||||||
| GeneCards | GC08M067251. | ||||||||||||||||||
| H-InvDB | HIX0007552. | ||||||||||||||||||
| HGNC | HGNC:2355. CRH. | ||||||||||||||||||
| MIM | 122560. gene+phenotype. | ||||||||||||||||||
| PharmGKB | PA119. | ||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| eggNOG | prNOG21212. | ||||||||||||||||||
| HOGENOM | HBG715743. | ||||||||||||||||||
| HOVERGEN | P06850. | ||||||||||||||||||
| InParanoid | P06850. | ||||||||||||||||||
| OMA | AANFFRV. | ||||||||||||||||||
| OrthoDB | EOG9GB9RN. | ||||||||||||||||||
| PhylomeDB | P06850. | ||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||
| Reactome | REACT_14797. Signaling by GPCR. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | P06850. | ||||||||||||||||||
| Bgee | P06850. | ||||||||||||||||||
| CleanEx | HS_CRH. | ||||||||||||||||||
| Genevestigator | P06850. | ||||||||||||||||||
| GermOnline | ENSG00000147571. Homo sapiens. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR018447. Corticotropin-releasing_fac_C. IPR018446. Corticotropin-releasing_fac_CS. IPR000187. Corticotropin-releasing_factor. IPR003620. Urocortin_CRF. [Graphical view] | ||||||||||||||||||
| PANTHER | PTHR15035. Urocortin_CRF. 1 hit. | ||||||||||||||||||
| Pfam | PF00473. CRF. 1 hit. [Graphical view] | ||||||||||||||||||
| PRINTS | PR01612. CRFFAMILY. | ||||||||||||||||||
| SMART | SM00039. CRF. 1 hit. [Graphical view] | ||||||||||||||||||
| PROSITE | PS00511. CRF. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other Resources | |||||||||||||||||||
| DrugBank | DB01285. Corticotropin. | ||||||||||||||||||
| NextBio | 5695. | ||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||
Entry information
| Entry name | CRF_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P06850 Secondary accession number(s): B3KQS4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 8 Human chromosome 8: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


