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Protein

Corticoliberin

Gene

CRH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).By similarity

GO - Molecular functioni

  • corticotropin-releasing hormone activity Source: GO_Central
  • hormone activity Source: ProtInc
  • neuropeptide hormone activity Source: ProtInc
  • receptor binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-HSA-373080. Class B/2 (Secretin family receptors).
R-HSA-418555. G alpha (s) signalling events.
SIGNORiP06850.

Names & Taxonomyi

Protein namesi
Recommended name:
Corticoliberin
Alternative name(s):
Corticotropin-releasing factor
Short name:
CRF
Corticotropin-releasing hormone
Gene namesi
Name:CRH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:2355. CRH.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • perikaryon Source: Ensembl
  • varicosity Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi183 – 1831Q → A: Strongly reduced affinity for CRFR1. 1 Publication
Mutagenesisi187 – 1871N → A: No effect on affinity for CRFR1. 1 Publication
Mutagenesisi188 – 1881R → A: Strongly reduced affinity for CRFR1. 1 Publication
Mutagenesisi190 – 1901L → A: Strongly reduced affinity for CRFR1. 1 Publication
Mutagenesisi191 – 1911M → A: Strongly reduced affinity for CRFR1. 1 Publication
Mutagenesisi192 – 1921E → A: No effect on affinity for CRFR1. 1 Publication

Organism-specific databases

MalaCardsiCRH.
MIMi122560. gene+phenotype.
Orphaneti98784. Autosomal dominant nocturnal frontal lobe epilepsy.
PharmGKBiPA119.

Chemistry

DrugBankiDB01285. Corticotropin.

Polymorphism and mutation databases

BioMutaiCRH.
DMDMi117445.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424CuratedAdd
BLAST
Propeptidei25 – 1531291 PublicationPRO_0000006212Add
BLAST
Peptidei154 – 19441CorticoliberinPRO_0000006213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei194 – 1941Isoleucine amide1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP06850.
PeptideAtlasiP06850.
PRIDEiP06850.
TopDownProteomicsiP06850.

PTM databases

PhosphoSiteiP06850.

Expressioni

Tissue specificityi

Produced by the hypothalamus and placenta.2 Publications

Gene expression databases

BgeeiENSG00000147571.
CleanExiHS_CRH.
GenevisibleiP06850. HS.

Organism-specific databases

HPAiCAB010885.
HPA062111.

Interactioni

Subunit structurei

Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CRHR1P349982EBI-3870390,EBI-3870393
KRT31Q153233EBI-3870390,EBI-948001

GO - Molecular functioni

  • corticotropin-releasing hormone activity Source: GO_Central
  • hormone activity Source: ProtInc
  • neuropeptide hormone activity Source: ProtInc
  • receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi107782. 7 interactions.
IntActiP06850. 2 interactions.
STRINGi9606.ENSP00000276571.

Structurei

Secondary structure

1
196
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi159 – 17113Combined sources
Helixi180 – 19314Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GOENMR-A154-194[»]
3EHTX-ray3.40B180-194[»]
3EHUX-ray1.96C/D175-194[»]
ProteinModelPortaliP06850.
SMRiP06850. Positions 154-194.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06850.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZK. Eukaryota.
ENOG4111ZIN. LUCA.
GeneTreeiENSGT00510000048573.
HOGENOMiHOG000004762.
HOVERGENiHBG001951.
InParanoidiP06850.
KOiK05256.
OMAiSALGGHQ.
OrthoDBiEOG091G0QDI.
PhylomeDBiP06850.
TreeFamiTF332956.

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. CRF.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPLLVSAG VLLVALLPCP PCRALLSRGP VPGARQAPQH PQPLDFFQPP
60 70 80 90 100
PQSEQPQQPQ ARPVLLRMGE EYFLRLGNLN KSPAAPLSPA SSLLAGGSGS
110 120 130 140 150
RPSPEQATAN FFRVLLQQLL LPRRSLDSPA ALAERGARNA LGGHQEAPER
160 170 180 190
ERRSEEPPIS LDLTFHLLRE VLEMARAEQL AQQAHSNRKL MEIIGK
Length:196
Mass (Da):21,422
Last modified:January 1, 1988 - v1
Checksum:i0CCDFF05BE364E92
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301P → R Found in patients with autosomal dominant nocturnal frontal lobe epilepsy; unknown pathological significance; results in decreased protein levels; decreased protein secretion. 1 Publication
Corresponds to variant rs748404250 [ dbSNP | Ensembl ].
VAR_075504

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00571 Genomic DNA. Translation: CAA23834.1.
BT007453 mRNA. Translation: AAP36121.1.
AK075431 mRNA. Translation: BAG52136.1.
CH471068 Genomic DNA. Translation: EAW86897.1.
BC002599 mRNA. Translation: AAH02599.1.
BC011031 mRNA. Translation: AAH11031.1.
CCDSiCCDS6188.1.
PIRiA30327.
RefSeqiNP_000747.1. NM_000756.3.
UniGeneiHs.75294.

Genome annotation databases

EnsembliENST00000276571; ENSP00000276571; ENSG00000147571.
GeneIDi1392.
KEGGihsa:1392.
UCSCiuc003xvy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Corticotropin-releasing hormone entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00571 Genomic DNA. Translation: CAA23834.1.
BT007453 mRNA. Translation: AAP36121.1.
AK075431 mRNA. Translation: BAG52136.1.
CH471068 Genomic DNA. Translation: EAW86897.1.
BC002599 mRNA. Translation: AAH02599.1.
BC011031 mRNA. Translation: AAH11031.1.
CCDSiCCDS6188.1.
PIRiA30327.
RefSeqiNP_000747.1. NM_000756.3.
UniGeneiHs.75294.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GOENMR-A154-194[»]
3EHTX-ray3.40B180-194[»]
3EHUX-ray1.96C/D175-194[»]
ProteinModelPortaliP06850.
SMRiP06850. Positions 154-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107782. 7 interactions.
IntActiP06850. 2 interactions.
STRINGi9606.ENSP00000276571.

Chemistry

DrugBankiDB01285. Corticotropin.

PTM databases

PhosphoSiteiP06850.

Polymorphism and mutation databases

BioMutaiCRH.
DMDMi117445.

Proteomic databases

PaxDbiP06850.
PeptideAtlasiP06850.
PRIDEiP06850.
TopDownProteomicsiP06850.

Protocols and materials databases

DNASUi1392.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276571; ENSP00000276571; ENSG00000147571.
GeneIDi1392.
KEGGihsa:1392.
UCSCiuc003xvy.3. human.

Organism-specific databases

CTDi1392.
GeneCardsiCRH.
GeneReviewsiCRH.
HGNCiHGNC:2355. CRH.
HPAiCAB010885.
HPA062111.
MalaCardsiCRH.
MIMi122560. gene+phenotype.
neXtProtiNX_P06850.
Orphaneti98784. Autosomal dominant nocturnal frontal lobe epilepsy.
PharmGKBiPA119.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWZK. Eukaryota.
ENOG4111ZIN. LUCA.
GeneTreeiENSGT00510000048573.
HOGENOMiHOG000004762.
HOVERGENiHBG001951.
InParanoidiP06850.
KOiK05256.
OMAiSALGGHQ.
OrthoDBiEOG091G0QDI.
PhylomeDBiP06850.
TreeFamiTF332956.

Enzyme and pathway databases

ReactomeiR-HSA-373080. Class B/2 (Secretin family receptors).
R-HSA-418555. G alpha (s) signalling events.
SIGNORiP06850.

Miscellaneous databases

EvolutionaryTraceiP06850.
GeneWikiiCorticotropin-releasing_hormone.
GenomeRNAii1392.
PROiP06850.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147571.
CleanExiHS_CRH.
GenevisibleiP06850. HS.

Family and domain databases

InterProiIPR018446. Corticotropin-releasing_fac_CS.
IPR000187. CRF.
IPR003620. Urocortin_CRF.
[Graphical view]
PANTHERiPTHR15035. PTHR15035. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
PRINTSiPR01612. CRFFAMILY.
SMARTiSM00039. CRF. 1 hit.
[Graphical view]
PROSITEiPS00511. CRF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRF_HUMAN
AccessioniPrimary (citable) accession number: P06850
Secondary accession number(s): B3KQS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: September 7, 2016
This is version 163 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.