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Protein

HTH-type transcriptional regulator EbgR

Gene

ebgR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Repressor for beta galactosidase alpha and beta subunits (ebgA and ebgC). Binds lactose as an inducer.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi4 – 2320H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD03254.
ECOL316407:JW3046-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator EbgR
Alternative name(s):
Ebg operon repressor
Gene namesi
Name:ebgR
Ordered Locus Names:b3075, JW3046
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10254. ebgR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327HTH-type transcriptional regulator EbgRPRO_0000107943Add
BLAST

Proteomic databases

PaxDbiP06846.
PRIDEiP06846.

Interactioni

Protein-protein interaction databases

BioGridi4260843. 14 interactions.
DIPiDIP-9488N.
IntActiP06846. 1 interaction.
STRINGi511145.b3075.

Structurei

3D structure databases

ProteinModelPortaliP06846.
SMRiP06846. Positions 3-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5757HTH lacI-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH lacI-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105CQ4. Bacteria.
COG1609. LUCA.
HOGENOMiHOG000220180.
InParanoidiP06846.
KOiK12113.
OMAiKAFFIAN.
PhylomeDBiP06846.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
Gene3Di1.10.260.40. 1 hit.
InterProiIPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06846-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLKDIAIE AGVSLATVSR VLNDDPTLNV KEETKHRILE IAEKLEYKTS
60 70 80 90 100
SARKLQTGAV NQHHILAIYS YQQELEINDP YYLAIRHGIE TQCEKLGIEL
110 120 130 140 150
TNCYEHSGLP DIKNVTGILI VGKPTPALRA AASALTDNIC FIDFHEPGSG
160 170 180 190 200
YDAVDIDLAR ISKEIIDFYI NQGVNRIGFI GGEDEPGKAD IREVAFAEYG
210 220 230 240 250
RLKQVVREED IWRGGFSSSS GYELAKQMLA REDYPKALFV ASDSIAIGVL
260 270 280 290 300
RAIHERGLNI PQDISLISVN DIPTARFTFP PLSTVRIHSE MMGSQGVNLV
310 320
YEKARDGRAL PLLVFVPSKL KLRGTTR
Length:327
Mass (Da):36,210
Last modified:March 1, 1992 - v2
Checksum:i2A8688B46A00EE03
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti190 – 1901D → E Broaden the specificity of inducer recognition.
Natural varianti195 – 1951A → T Broaden the specificity of inducer recognition.
Natural varianti196 – 1961F → C Broaden the specificity of inducer recognition.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64441 Genomic DNA. Translation: AAA61970.1.
X52031 Genomic DNA. Translation: CAA36273.1.
U18997 Genomic DNA. Translation: AAA57876.1.
U00096 Genomic DNA. Translation: AAC76110.1.
AP009048 Genomic DNA. Translation: BAE77125.1.
PIRiA25752. RPECEG.
RefSeqiNP_417546.1. NC_000913.3.
WP_000212475.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76110; AAC76110; b3075.
BAE77125; BAE77125; BAE77125.
GeneIDi947586.
KEGGiecj:JW3046.
eco:b3075.
PATRICi32121566. VBIEscCol129921_3169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64441 Genomic DNA. Translation: AAA61970.1.
X52031 Genomic DNA. Translation: CAA36273.1.
U18997 Genomic DNA. Translation: AAA57876.1.
U00096 Genomic DNA. Translation: AAC76110.1.
AP009048 Genomic DNA. Translation: BAE77125.1.
PIRiA25752. RPECEG.
RefSeqiNP_417546.1. NC_000913.3.
WP_000212475.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP06846.
SMRiP06846. Positions 3-326.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260843. 14 interactions.
DIPiDIP-9488N.
IntActiP06846. 1 interaction.
STRINGi511145.b3075.

Proteomic databases

PaxDbiP06846.
PRIDEiP06846.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76110; AAC76110; b3075.
BAE77125; BAE77125; BAE77125.
GeneIDi947586.
KEGGiecj:JW3046.
eco:b3075.
PATRICi32121566. VBIEscCol129921_3169.

Organism-specific databases

EchoBASEiEB0250.
EcoGeneiEG10254. ebgR.

Phylogenomic databases

eggNOGiENOG4105CQ4. Bacteria.
COG1609. LUCA.
HOGENOMiHOG000220180.
InParanoidiP06846.
KOiK12113.
OMAiKAFFIAN.
PhylomeDBiP06846.

Enzyme and pathway databases

BioCyciEcoCyc:PD03254.
ECOL316407:JW3046-MONOMER.

Miscellaneous databases

PROiP06846.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
Gene3Di1.10.260.40. 1 hit.
InterProiIPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEBGR_ECOLI
AccessioniPrimary (citable) accession number: P06846
Secondary accession number(s): Q2M9D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: March 1, 1992
Last modified: September 7, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.