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P06837

- NEUM_MOUSE

UniProt

P06837 - NEUM_MOUSE

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Protein

Neuromodulin

Gene
Gap43, Basp2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

GO - Biological processi

  1. axon choice point recognition Source: MGI
  2. axon guidance Source: MGI
  3. cell fate commitment Source: MGI
  4. glial cell differentiation Source: MGI
  5. regulation of filopodium assembly Source: Ensembl
  6. regulation of growth Source: UniProtKB-KW
  7. tissue regeneration Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Growth regulation, Neurogenesis

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromodulin
Alternative name(s):
Axonal membrane protein GAP-43
Calmodulin-binding protein P-57
Growth-associated protein 43
Gene namesi
Name:Gap43
Synonyms:Basp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:95639. Gap43.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: MGI
  2. cell junction Source: UniProtKB-KW
  3. cell periphery Source: MGI
  4. cytoplasm Source: Ensembl
  5. filopodium membrane Source: UniProtKB-SubCell
  6. growth cone membrane Source: UniProtKB-SubCell
  7. plasma membrane Source: MGI
  8. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227NeuromodulinPRO_0000159597Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi3 – 31S-palmitoyl cysteine By similarity
Lipidationi4 – 41S-palmitoyl cysteine By similarity
Modified residuei41 – 411Phosphoserine; by PHK Inferred
Modified residuei172 – 1721Phosphothreonine By similarity
Modified residuei192 – 1921Phosphoserine; by CK2 By similarity
Modified residuei193 – 1931Phosphoserine; by CK2 By similarity

Post-translational modificationi

Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2 By similarity.
Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP06837.
PaxDbiP06837.
PRIDEiP06837.

PTM databases

PhosphoSiteiP06837.

Expressioni

Gene expression databases

BgeeiP06837.
CleanExiMM_GAP43.
GenevestigatoriP06837.

Interactioni

Subunit structurei

Binds calmodulin with a greater affinity in the absence of Ca2+ than in its presence By similarity. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN.1 Publication

Protein-protein interaction databases

BioGridi199828. 1 interaction.
IntActiP06837. 5 interactions.
MINTiMINT-4103374.
STRINGi10090.ENSMUSP00000099881.

Structurei

Secondary structure

1
227
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi35 – 5117

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4E53X-ray2.69A/B34-57[»]
ProteinModelPortaliP06837.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 6030IQAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 44Important for membrane binding

Sequence similaritiesi

Belongs to the neuromodulin family.
Contains 1 IQ domain.

Phylogenomic databases

eggNOGiNOG120480.
GeneTreeiENSGT00730000111265.
HOGENOMiHOG000013014.
HOVERGENiHBG006468.
InParanoidiP06837.
OMAiVEKKGEG.
OrthoDBiEOG744TBB.
PhylomeDBiP06837.
TreeFamiTF333213.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001422. Neuromodulin.
IPR017454. Neuromodulin_C.
IPR018947. Neuromodulin_gap-junction_N.
IPR018243. Neuromodulin_palmitoyl/P_site.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF06614. Neuromodulin. 1 hit.
PF10580. Neuromodulin_N. 1 hit.
[Graphical view]
PRINTSiPR00215. NEUROMODULIN.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]
PROSITEiPS50096. IQ. 1 hit.
PS00412. NEUROMODULIN_1. 1 hit.
PS00413. NEUROMODULIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06837-1 [UniParc]FASTAAdd to Basket

« Hide

MLCCMRRTKQ VEKNDEDQKI EQDGVKPEDK AHKAATKIQA SFRGHITRKK    50
LKGEKKGDAP AAEAEAKEKD DAPVADGVEK KEGDGSATTD AAPATSPKAE 100
EPSKAGDAPS EEKKGEGDAA PSEEKAGSAE TESAAKATTD NSPSSKAEDG 150
PAKEEPKQAD VPAAVTDAAA TTPAAEDAAT KAAQPPTETA ESSQAEEEKD 200
AVDEAKPKES ARQDEGKEDP EADQEHA 227
Length:227
Mass (Da):23,632
Last modified:January 1, 1988 - v1
Checksum:i14803B2F8F0649F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02809 mRNA. Translation: AAA37377.1.
BC028288 mRNA. Translation: AAH28288.1.
BC080758 mRNA. Translation: AAH80758.1.
CCDSiCCDS28177.1.
PIRiA29800.
RefSeqiNP_032109.1. NM_008083.2.
UniGeneiMm.1222.

Genome annotation databases

EnsembliENSMUST00000102817; ENSMUSP00000099881; ENSMUSG00000047261.
GeneIDi14432.
KEGGimmu:14432.
UCSCiuc007zfv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02809 mRNA. Translation: AAA37377.1 .
BC028288 mRNA. Translation: AAH28288.1 .
BC080758 mRNA. Translation: AAH80758.1 .
CCDSi CCDS28177.1.
PIRi A29800.
RefSeqi NP_032109.1. NM_008083.2.
UniGenei Mm.1222.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4E53 X-ray 2.69 A/B 34-57 [» ]
ProteinModelPortali P06837.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199828. 1 interaction.
IntActi P06837. 5 interactions.
MINTi MINT-4103374.
STRINGi 10090.ENSMUSP00000099881.

PTM databases

PhosphoSitei P06837.

Proteomic databases

MaxQBi P06837.
PaxDbi P06837.
PRIDEi P06837.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102817 ; ENSMUSP00000099881 ; ENSMUSG00000047261 .
GeneIDi 14432.
KEGGi mmu:14432.
UCSCi uc007zfv.1. mouse.

Organism-specific databases

CTDi 2596.
MGIi MGI:95639. Gap43.

Phylogenomic databases

eggNOGi NOG120480.
GeneTreei ENSGT00730000111265.
HOGENOMi HOG000013014.
HOVERGENi HBG006468.
InParanoidi P06837.
OMAi VEKKGEG.
OrthoDBi EOG744TBB.
PhylomeDBi P06837.
TreeFami TF333213.

Miscellaneous databases

NextBioi 286053.
PROi P06837.
SOURCEi Search...

Gene expression databases

Bgeei P06837.
CleanExi MM_GAP43.
Genevestigatori P06837.

Family and domain databases

InterProi IPR000048. IQ_motif_EF-hand-BS.
IPR001422. Neuromodulin.
IPR017454. Neuromodulin_C.
IPR018947. Neuromodulin_gap-junction_N.
IPR018243. Neuromodulin_palmitoyl/P_site.
[Graphical view ]
Pfami PF00612. IQ. 1 hit.
PF06614. Neuromodulin. 1 hit.
PF10580. Neuromodulin_N. 1 hit.
[Graphical view ]
PRINTSi PR00215. NEUROMODULIN.
SMARTi SM00015. IQ. 1 hit.
[Graphical view ]
PROSITEi PS50096. IQ. 1 hit.
PS00412. NEUROMODULIN_1. 1 hit.
PS00413. NEUROMODULIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of murine cDNAs encoding P-57, a neural-specific calmodulin-binding protein."
    Cimler B.M., Giebelhaus D.H., Wakim B.T., Storm D.R., Moon R.T.
    J. Biol. Chem. 262:12158-12163(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Retina.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 84-104, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  4. "N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling."
    Cavallaro U., Niedermeyer J., Fuxa M., Christofori G.
    Nat. Cell Biol. 3:650-657(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH NCAM1; CDH2; PLCG1; FRS2; SRC; FGFR4 AND CTTN.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  6. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiNEUM_MOUSE
AccessioniPrimary (citable) accession number: P06837
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: July 9, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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