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P06835 (BGLS_HANAN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-glucosidase

EC=3.2.1.21
Alternative name(s):
Beta-D-glucoside glucohydrolase
Cellobiase
Gentiobiase
OrganismHansenula anomala (Yeast) (Candida pelliculosa)
Taxonomic identifier4927 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeWickerhamomyces

Protein attributes

Sequence length825 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathway

Glycan metabolism; cellulose degradation.

Subunit structure

Homotetramer.

Sequence similarities

Belongs to the glycosyl hydrolase 3 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Cellulose degradation
Polysaccharide degradation
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological_processcellulose catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionbeta-glucosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 825805Beta-glucosidase
PRO_0000011777

Sites

Active site2991 By similarity

Amino acid modifications

Glycosylation211N-linked (GlcNAc...) Potential
Glycosylation341N-linked (GlcNAc...) Potential
Glycosylation741N-linked (GlcNAc...) Potential
Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation2301N-linked (GlcNAc...) Potential
Glycosylation2711N-linked (GlcNAc...) Potential
Glycosylation3281N-linked (GlcNAc...) Potential
Glycosylation3351N-linked (GlcNAc...) Potential
Glycosylation5371N-linked (GlcNAc...) Potential
Glycosylation5501N-linked (GlcNAc...) Potential
Glycosylation5561N-linked (GlcNAc...) Potential
Glycosylation5781N-linked (GlcNAc...) Potential
Glycosylation6051N-linked (GlcNAc...) Potential
Glycosylation6671N-linked (GlcNAc...) Potential
Glycosylation6901N-linked (GlcNAc...) Potential
Glycosylation7181N-linked (GlcNAc...) Potential
Glycosylation7331N-linked (GlcNAc...) Potential
Glycosylation7611N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P06835 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: A43852FF3DE58B74

FASTA82589,561
        10         20         30         40         50         60 
MLLPLYGLAS FLVLSQAALV NTSAPQASND DPFNHSPSFY PTPQGGRIND GKWQAAFYRA 

        70         80         90        100        110        120 
RELVDQMSIA EKVNLTTGVG SASGPCSGNT GSVPRLNISS ICVQDGPLSV RAADLTDVFP 

       130        140        150        160        170        180 
CGMAASSSFN KQLIYDRAVA IGSEFKGKGA DAILGPVYGP MGVKAAGGRG WEGHGPDPYL 

       190        200        210        220        230        240 
EGVIAYLQTI GIQSQGVVST AKHLIGNEQE HFRFAKKDKH AGKIDPGMFN TSSSLSSEID 

       250        260        270        280        290        300 
DRAMHEIYLW PFAEAVRGGV SSIMCSYNKL NGSHACQNSY LLNYLLKEEL GFQGFVMTDW 

       310        320        330        340        350        360 
GALYSGIDAA NAGLDMDMPC EAQYFGGNLT TAVLNGTLPQ DRLDDMATRI LSALIYSGVH 

       370        380        390        400        410        420 
NPDGPNYNAQ TFLTEGHEYF KQQEGDIVVL NKHVDVRSDI NRAVALRSAV EGVVLLKNEH 

       430        440        450        460        470        480 
ETLPLGREKV KRISILGQAA GDDSKGTSCS LRGCGSGAIG TGYGSGAGTF SYFVTPADGI 

       490        500        510        520        530        540 
GARAQQEKIS YEFIGDSWNQ AAAMDSALYA DAAIEVANSV AGEEIGDVDG NYGDLNNLTL 

       550        560        570        580        590        600 
WHNAVPLIKN ISSINNNTIV IVTSGQQIDL EPFIDNENVT AVIYSSYLGQ DFGTVLAKVL 

       610        620        630        640        650        660 
FGDENPSGKL PFTIAKDVND YIPVIEKVDV PDPVDKFTES IYVDYRYFDK YNKPVRYEFG 

       670        680        690        700        710        720 
YGLSYSNFSL SDIEIQTLQP FSENAEPAAN YSETYQYKQS NMDPSEYTVP EGFKELANYT 

       730        740        750        760        770        780 
YPYIHDASSI KANSSYDYPE GYSTEQLDGP KSLAAGGLGG NHTCGMLVTL SLLKSQIKVL 

       790        800        810        820 
MLVGLHLNCM LDIQIMMNSQ HLQCNYVDLK RCFWIKIILK LFLLN 

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References

[1]"Nucleotide sequence of Candida pelliculosa beta-glucosidase gene."
Kohchi C., Toh-e A.
Nucleic Acids Res. 13:6273-6282(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Acetaetherius.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X02903 Genomic DNA. Translation: CAA26662.1.
PIRGLHQ. B23783.

3D structure databases

ProteinModelPortalP06835.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP06835.
ChEMBLCHEMBL4168.

Protein family/group databases

CAZyGH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00696.

Family and domain databases

Gene3D3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProIPR026892. Glyco_hydro_3.
IPR019800. Glyco_hydro_3_AS.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR30620. PTHR30620. 1 hit.
PfamPF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSPR00133. GLHYDRLASE3.
SUPFAMSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 1 hit.
PROSITEPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBGLS_HANAN
AccessionPrimary (citable) accession number: P06835
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: December 11, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries