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P06811

- LAC1_NEUCR

UniProt

P06811 - LAC1_NEUCR

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Protein

Laccase

Gene

lacc

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi144 – 1441Copper 1; type 2By similarity
Metal bindingi146 – 1461Copper 2; type 3By similarity
Metal bindingi189 – 1891Copper 2; type 3By similarity
Metal bindingi191 – 1911Copper 3; type 3By similarity
Metal bindingi477 – 4771Copper 4; type 1By similarity
Metal bindingi480 – 4801Copper 1; type 2By similarity
Metal bindingi482 – 4821Copper 3; type 3By similarity
Metal bindingi548 – 5481Copper 3; type 3By similarity
Metal bindingi549 – 5491Copper 4; type 1By similarity
Metal bindingi550 – 5501Copper 2; type 3By similarity
Metal bindingi554 – 5541Copper 4; type 1By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase
Diphenol oxidase
Urishiol oxidase
Gene namesi
Name:lacc
ORF Names:NCU04528
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 7, Linkage Group VII

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 4928PRO_0000002921Add
BLAST
Chaini50 – 606557LaccasePRO_0000002922Add
BLAST
Propeptidei607 – 61913PRO_0000002923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi282 – 2821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi340 – 3401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi422 – 4221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi444 – 4441N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP06811.

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU04528.1.

Structurei

3D structure databases

ProteinModelPortaliP06811.
SMRiP06811. Positions 55-606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 207124Plastocyanin-like 1Add
BLAST
Domaini216 – 373158Plastocyanin-like 2Add
BLAST
Domaini431 – 566136Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000216827.
InParanoidiP06811.
OMAiTAININW.
OrthoDBiEOG7H79B9.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06811-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFLGIAALV AGLLAPSLVL GAPAPGTEGV NLLTPVDKRQ DSQAERYGGG
60 70 80 90 100
GGGGCNSPTN RQCWSPGFNI NTDYELGTPN TGKTRRYKLT LTETDNWIGP
110 120 130 140 150
DGVIKDKVMM VNDKIIGPTI QADWGDYIEI TVINKLKSNG TSIHWHGMHQ
160 170 180 190 200
RNSNIQDGVN GVTECPIPPR GGSKVYRWRA TQYGTSWYHS HFSAQYGNGI
210 220 230 240 250
VGPIVINGPA SANYDVDLGP FPLTDYYYDT ADRLVLLTQH AGPPPSNNVL
260 270 280 290 300
FNGFAKHPTT GAGQYATVSL TKGKKHRLRL INTSVENHFQ LSLVNHSMTI
310 320 330 340 350
ISADLVPVQP YKVDSLFLGV GQRYDVIIDA NQAVGNYWFN VTFGGSKLCG
360 370 380 390 400
DSDNHYPAAI FRYQGAPKAL PTNQGVAPVD HQCLDLNDLK PVLQRSLNTN
410 420 430 440 450
SIALNTGNTI PITLDGFVWR VNGTAININW NKPVLEYVLT GNTNYSQSDN
460 470 480 490 500
IVQVEGVNQW KYWLIENDPD GAFSLPHPIH LHGHDFLILG RSPDVTAISQ
510 520 530 540 550
TRYVFDPAVD MARLNGNNPT RRDTAMLPAK GWLLIAFRTD NPGSWLMHCH
560 570 580 590 600
IAWHVSGGLS NQFLERAQDL RNSISPADKK AFNDNCDAWR AYFPDNAPFP
610
KDDSGLRSGV KAREVKMKW
Length:619
Mass (Da):68,148
Last modified:November 28, 2006 - v3
Checksum:iDD7C67B9135FC08A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171S → P in strain: Oak Ridge.
Natural varianti21 – 211G → A in strain: Oak Ridge.
Natural varianti98 – 981I → L in strain: TS.
Natural varianti114 – 1141K → N in strain: TS.
Natural varianti292 – 2921S → L in strain: Oak Ridge.
Natural varianti317 – 3171F → L in strain: TS.
Natural varianti320 – 3201V → I in strain: TS.
Natural varianti346 – 3472SK → ND in strain: TS.
Natural varianti351 – 3511D → T in strain: TS.
Natural varianti355 – 3551H → K in strain: TS.
Natural varianti374 – 3741Q → K in strain: TS.
Natural varianti379 – 3791V → P in strain: TS.
Natural varianti439 – 4391L → M in strain: TS.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18333 Genomic DNA. Translation: AAA33591.1.
M18334 Genomic DNA. Translation: AAA33592.1.
CM002242 Genomic DNA. Translation: EAA27703.1.
M14554 Genomic DNA. Translation: AAA33590.1.
PIRiA28523. KSNCLO.
B28523. KSNCLT.
RefSeqiXP_956939.1. XM_951846.2.
UniGeneiNcr.23952.

Genome annotation databases

EnsemblFungiiEFNCRT00000005393; EFNCRP00000005387; EFNCRG00000005386.
GeneIDi3873077.
KEGGincr:NCU04528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18333 Genomic DNA. Translation: AAA33591.1 .
M18334 Genomic DNA. Translation: AAA33592.1 .
CM002242 Genomic DNA. Translation: EAA27703.1 .
M14554 Genomic DNA. Translation: AAA33590.1 .
PIRi A28523. KSNCLO.
B28523. KSNCLT.
RefSeqi XP_956939.1. XM_951846.2.
UniGenei Ncr.23952.

3D structure databases

ProteinModelPortali P06811.
SMRi P06811. Positions 55-606.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU04528.1.

Proteomic databases

PRIDEi P06811.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000005393 ; EFNCRP00000005387 ; EFNCRG00000005386 .
GeneIDi 3873077.
KEGGi ncr:NCU04528.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000216827.
InParanoidi P06811.
OMAi TAININW.
OrthoDBi EOG7H79B9.

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of two allelic forms of Neurospora crassa laccase. Amino- and carboxyl-terminal processing of a precursor."
    Germann U.A., Mueller G., Hunziker P.E., Lerch K.
    J. Biol. Chem. 263:885-896(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    Strain: Oak Ridge and TS.
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  3. "Isolation and partial nucleotide sequence of the laccase gene from Neurospora crassa: amino acid sequence homology of the protein to human ceruloplasmin."
    Germann U.A., Lerch K.
    Proc. Natl. Acad. Sci. U.S.A. 83:8854-8858(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 379-619.

Entry informationi

Entry nameiLAC1_NEUCR
AccessioniPrimary (citable) accession number: P06811
Secondary accession number(s): P10574, Q7RV60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 28, 2006
Last modified: October 29, 2014
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3