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Protein

Laccase

Gene

lacc

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi144Copper 1; type 2By similarity1
Metal bindingi146Copper 2; type 3By similarity1
Metal bindingi189Copper 2; type 3By similarity1
Metal bindingi191Copper 3; type 3By similarity1
Metal bindingi477Copper 4; type 1By similarity1
Metal bindingi480Copper 1; type 2By similarity1
Metal bindingi482Copper 3; type 3By similarity1
Metal bindingi548Copper 3; type 3By similarity1
Metal bindingi549Copper 4; type 1By similarity1
Metal bindingi550Copper 2; type 3By similarity1
Metal bindingi554Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Protein family/group databases

CAZyiAA1. Auxiliary Activities 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase
Diphenol oxidase
Urishiol oxidase
Gene namesi
Name:lacc
ORF Names:NCU04528
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 7, Linkage Group VII

Organism-specific databases

EuPathDBiFungiDB:NCU04528.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000000292122 – 49Add BLAST28
ChainiPRO_000000292250 – 606LaccaseAdd BLAST557
PropeptideiPRO_0000002923607 – 619Add BLAST13

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi139N-linked (GlcNAc...)Sequence analysis1
Glycosylationi282N-linked (GlcNAc...)Sequence analysis1
Glycosylationi295N-linked (GlcNAc...)Sequence analysis1
Glycosylationi340N-linked (GlcNAc...)Sequence analysis1
Glycosylationi422N-linked (GlcNAc...)Sequence analysis1
Glycosylationi444N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP06811.

Structurei

3D structure databases

ProteinModelPortaliP06811.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 207Plastocyanin-like 1Add BLAST124
Domaini216 – 373Plastocyanin-like 2Add BLAST158
Domaini431 – 566Plastocyanin-like 3Add BLAST136

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOGENOMiHOG000216827.
InParanoidiP06811.
OMAiAININWN.
OrthoDBiEOG092C1CWL.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLGIAALV AGLLAPSLVL GAPAPGTEGV NLLTPVDKRQ DSQAERYGGG
60 70 80 90 100
GGGGCNSPTN RQCWSPGFNI NTDYELGTPN TGKTRRYKLT LTETDNWIGP
110 120 130 140 150
DGVIKDKVMM VNDKIIGPTI QADWGDYIEI TVINKLKSNG TSIHWHGMHQ
160 170 180 190 200
RNSNIQDGVN GVTECPIPPR GGSKVYRWRA TQYGTSWYHS HFSAQYGNGI
210 220 230 240 250
VGPIVINGPA SANYDVDLGP FPLTDYYYDT ADRLVLLTQH AGPPPSNNVL
260 270 280 290 300
FNGFAKHPTT GAGQYATVSL TKGKKHRLRL INTSVENHFQ LSLVNHSMTI
310 320 330 340 350
ISADLVPVQP YKVDSLFLGV GQRYDVIIDA NQAVGNYWFN VTFGGSKLCG
360 370 380 390 400
DSDNHYPAAI FRYQGAPKAL PTNQGVAPVD HQCLDLNDLK PVLQRSLNTN
410 420 430 440 450
SIALNTGNTI PITLDGFVWR VNGTAININW NKPVLEYVLT GNTNYSQSDN
460 470 480 490 500
IVQVEGVNQW KYWLIENDPD GAFSLPHPIH LHGHDFLILG RSPDVTAISQ
510 520 530 540 550
TRYVFDPAVD MARLNGNNPT RRDTAMLPAK GWLLIAFRTD NPGSWLMHCH
560 570 580 590 600
IAWHVSGGLS NQFLERAQDL RNSISPADKK AFNDNCDAWR AYFPDNAPFP
610
KDDSGLRSGV KAREVKMKW
Length:619
Mass (Da):68,148
Last modified:November 28, 2006 - v3
Checksum:iDD7C67B9135FC08A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti17S → P in strain: Oak Ridge. 1
Natural varianti21G → A in strain: Oak Ridge. 1
Natural varianti98I → L in strain: TS. 1
Natural varianti114K → N in strain: TS. 1
Natural varianti292S → L in strain: Oak Ridge. 1
Natural varianti317F → L in strain: TS. 1
Natural varianti320V → I in strain: TS. 1
Natural varianti346 – 347SK → ND in strain: TS. 2
Natural varianti351D → T in strain: TS. 1
Natural varianti355H → K in strain: TS. 1
Natural varianti374Q → K in strain: TS. 1
Natural varianti379V → P in strain: TS. 1
Natural varianti439L → M in strain: TS. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18333 Genomic DNA. Translation: AAA33591.1.
M18334 Genomic DNA. Translation: AAA33592.1.
CM002242 Genomic DNA. Translation: EAA27703.1.
M14554 Genomic DNA. Translation: AAA33590.1.
PIRiA28523. KSNCLO.
B28523. KSNCLT.
RefSeqiXP_956939.1. XM_951846.3.

Genome annotation databases

EnsemblFungiiEAA27703; EAA27703; NCU04528.
GeneIDi3873077.
KEGGincr:NCU04528.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18333 Genomic DNA. Translation: AAA33591.1.
M18334 Genomic DNA. Translation: AAA33592.1.
CM002242 Genomic DNA. Translation: EAA27703.1.
M14554 Genomic DNA. Translation: AAA33590.1.
PIRiA28523. KSNCLO.
B28523. KSNCLT.
RefSeqiXP_956939.1. XM_951846.3.

3D structure databases

ProteinModelPortaliP06811.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiAA1. Auxiliary Activities 1.

Proteomic databases

PRIDEiP06811.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAA27703; EAA27703; NCU04528.
GeneIDi3873077.
KEGGincr:NCU04528.

Organism-specific databases

EuPathDBiFungiDB:NCU04528.

Phylogenomic databases

HOGENOMiHOG000216827.
InParanoidiP06811.
OMAiAININWN.
OrthoDBiEOG092C1CWL.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC1_NEUCR
AccessioniPrimary (citable) accession number: P06811
Secondary accession number(s): P10574, Q7RV60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 28, 2006
Last modified: November 2, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.