P06810 (COX5_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase polypeptide 5, mitochondrial
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide V

Gene names

Name:	cya-4
ORF Names:	B8B20.30, NCU05457

Organism

Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]

Taxonomic identifier

367110 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › Neurospora crassa

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the cytochrome c oxidase IV family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 27	27	Mitochondrion
	Chain	28 – 171	144	Cytochrome c oxidase polypeptide 5, mitochondrial		PRO_0000006095
Regions
	Transmembrane	101 – 119	19	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P06810 [UniParc]. Last modified November 1, 1990. Version 2. Checksum: 5E866BE18B59440D	FASTA	171	18,804
	10 20 30 40 50 60 MLRTPTVSAL VRNVAVRAAK PTMAVRAAST MPISNPTLAN IEKRWEQMPM QEQAELWMAL 70 80 90 100 110 120 RDRMKGNWAD LTLQEKKAAY YIAFGPHGPR ALPPPGEQKK VLAYTVAGVF LSFVIFATMR 130 140 150 160 170 AFAKPPPATM TKEWQEATNE FLKAQKSDPL TGLTSEGYNG KGHVQSPSAS A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cytochrome oxidase subunit V gene of Neurospora crassa: DNA sequences, chromosomal mapping, and evidence that the cya-4 locus specifies the structural gene for subunit V." Sachs M.S., Bertrand H., Metzenberg R.L., RajBhandary U.L. Mol. Cell. Biol. 9:566-577(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence." Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U. Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]	"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[4]	"Nuclear genes for cytochrome c oxidase subunits of Neurospora crassa. Isolation and characterization of cDNA clones for subunits IV, V, VI, and possibly VII." Sachs M.S., David M., Werner S., RajBhandary U.L. J. Biol. Chem. 261:869-873(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-67.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M24389 Genomic DNA. Translation: AAA31957.2. AL355933 Genomic DNA. Translation: CAB91450.1. AABX02000030 Genomic DNA. Translation: EAA34212.1. M12117 Genomic DNA. Translation: AAA33575.1.
PIR	OTNCV. A30134.
RefSeq	XP_963448.1. XM_958355.1.
UniGene	Ncr.15259.
3D structure databases
ProteinModelPortal	P06810.
ModBase	Search...
Protein-protein interaction databases
STRING	5141.NCU05457.1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFNCRT00000006595; EFNCRP00000006586; EFNCRG00000006583.
GeneID	3879597.
KEGG	ncr:NCU05457.
Phylogenomic databases
eggNOG	NOG263759.
HOGENOM	HOG000175160.
KO	K02263.
OMA	QEQAELW.
OrthoDB	EOG4T1MWV.
Family and domain databases
Gene3D	1.10.442.10. 1 hit.
InterPro	IPR004203. Cyt_c_oxidase_su4_fam. [Graphical view]
Pfam	PF02936. COX4. 1 hit. [Graphical view]
SUPFAM	SSF81406. COX4. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COX5_NEUCR

Accession

Primary (citable) accession number: P06810
Secondary accession number(s): Q7RVI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	November 1, 1990
Last modified:	April 3, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program