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P06810 (COX5_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome c oxidase polypeptide 5, mitochondrial

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide V
Gene names
Name:cya-4
ORF Names:B8B20.30, NCU05457
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length171 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the cytochrome c oxidase IV family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2727Mitochondrion
Chain28 – 171144Cytochrome c oxidase polypeptide 5, mitochondrial
PRO_0000006095

Regions

Transmembrane101 – 11919Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P06810 [UniParc].

Last modified November 1, 1990. Version 2.
Checksum: 5E866BE18B59440D

FASTA17118,804
        10         20         30         40         50         60 
MLRTPTVSAL VRNVAVRAAK PTMAVRAAST MPISNPTLAN IEKRWEQMPM QEQAELWMAL 

        70         80         90        100        110        120 
RDRMKGNWAD LTLQEKKAAY YIAFGPHGPR ALPPPGEQKK VLAYTVAGVF LSFVIFATMR 

       130        140        150        160        170 
AFAKPPPATM TKEWQEATNE FLKAQKSDPL TGLTSEGYNG KGHVQSPSAS A 

« Hide

References

« Hide 'large scale' references
[1]"Cytochrome oxidase subunit V gene of Neurospora crassa: DNA sequences, chromosomal mapping, and evidence that the cya-4 locus specifies the structural gene for subunit V."
Sachs M.S., Bertrand H., Metzenberg R.L., RajBhandary U.L.
Mol. Cell. Biol. 9:566-577(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[4]"Nuclear genes for cytochrome c oxidase subunits of Neurospora crassa. Isolation and characterization of cDNA clones for subunits IV, V, VI, and possibly VII."
Sachs M.S., David M., Werner S., RajBhandary U.L.
J. Biol. Chem. 261:869-873(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-67.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M24389 Genomic DNA. Translation: AAA31957.2.
AL355933 Genomic DNA. Translation: CAB91450.1.
CM002237 Genomic DNA. Translation: EAA34212.1.
M12117 Genomic DNA. Translation: AAA33575.1.
PIROTNCV. A30134.
RefSeqXP_963448.1. XM_958355.1.
UniGeneNcr.15259.

3D structure databases

ProteinModelPortalP06810.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU05457.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000006595; EFNCRP00000006586; EFNCRG00000006583.
GeneID3879597.
KEGGncr:NCU05457.

Phylogenomic databases

eggNOGNOG263759.
HOGENOMHOG000175160.
KOK02263.
OMAKRWEGMP.
OrthoDBEOG7JHMJ1.

Family and domain databases

Gene3D1.10.442.10. 1 hit.
InterProIPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PfamPF02936. COX4. 1 hit.
[Graphical view]
SUPFAMSSF81406. SSF81406. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCOX5_NEUCR
AccessionPrimary (citable) accession number: P06810
Secondary accession number(s): Q7RVI9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 1, 1990
Last modified: April 16, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families