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P06810

- COX5_NEUCR

UniProt

P06810 - COX5_NEUCR

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Protein

Cytochrome c oxidase polypeptide 5, mitochondrial

Gene

cya-4

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase polypeptide 5, mitochondrial (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide V
Gene namesi
Name:cya-4
ORF Names:B8B20.30, NCU05457
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 6, Linkage Group II

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727MitochondrionAdd
BLAST
Chaini28 – 171144Cytochrome c oxidase polypeptide 5, mitochondrialPRO_0000006095Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU05457.1.

Structurei

3D structure databases

ProteinModelPortaliP06810.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei101 – 11919HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263759.
HOGENOMiHOG000175160.
InParanoidiP06810.
KOiK02263.
OMAiKRWEGMP.
OrthoDBiEOG7JHMJ1.

Family and domain databases

Gene3Di1.10.442.10. 1 hit.
InterProiIPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PfamiPF02936. COX4. 1 hit.
[Graphical view]
SUPFAMiSSF81406. SSF81406. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06810-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRTPTVSAL VRNVAVRAAK PTMAVRAAST MPISNPTLAN IEKRWEQMPM
60 70 80 90 100
QEQAELWMAL RDRMKGNWAD LTLQEKKAAY YIAFGPHGPR ALPPPGEQKK
110 120 130 140 150
VLAYTVAGVF LSFVIFATMR AFAKPPPATM TKEWQEATNE FLKAQKSDPL
160 170
TGLTSEGYNG KGHVQSPSAS A
Length:171
Mass (Da):18,804
Last modified:November 1, 1990 - v2
Checksum:i5E866BE18B59440D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24389 Genomic DNA. Translation: AAA31957.2.
AL355933 Genomic DNA. Translation: CAB91450.1.
CM002237 Genomic DNA. Translation: EAA34212.1.
M12117 Genomic DNA. Translation: AAA33575.1.
PIRiA30134. OTNCV.
RefSeqiXP_963448.1. XM_958355.1.
UniGeneiNcr.15259.

Genome annotation databases

EnsemblFungiiEFNCRT00000006595; EFNCRP00000006586; EFNCRG00000006583.
GeneIDi3879597.
KEGGincr:NCU05457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24389 Genomic DNA. Translation: AAA31957.2 .
AL355933 Genomic DNA. Translation: CAB91450.1 .
CM002237 Genomic DNA. Translation: EAA34212.1 .
M12117 Genomic DNA. Translation: AAA33575.1 .
PIRi A30134. OTNCV.
RefSeqi XP_963448.1. XM_958355.1.
UniGenei Ncr.15259.

3D structure databases

ProteinModelPortali P06810.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU05457.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000006595 ; EFNCRP00000006586 ; EFNCRG00000006583 .
GeneIDi 3879597.
KEGGi ncr:NCU05457.

Phylogenomic databases

eggNOGi NOG263759.
HOGENOMi HOG000175160.
InParanoidi P06810.
KOi K02263.
OMAi KRWEGMP.
OrthoDBi EOG7JHMJ1.

Family and domain databases

Gene3Di 1.10.442.10. 1 hit.
InterProi IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view ]
Pfami PF02936. COX4. 1 hit.
[Graphical view ]
SUPFAMi SSF81406. SSF81406. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cytochrome oxidase subunit V gene of Neurospora crassa: DNA sequences, chromosomal mapping, and evidence that the cya-4 locus specifies the structural gene for subunit V."
    Sachs M.S., Bertrand H., Metzenberg R.L., RajBhandary U.L.
    Mol. Cell. Biol. 9:566-577(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
    Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
    Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  3. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  4. "Nuclear genes for cytochrome c oxidase subunits of Neurospora crassa. Isolation and characterization of cDNA clones for subunits IV, V, VI, and possibly VII."
    Sachs M.S., David M., Werner S., RajBhandary U.L.
    J. Biol. Chem. 261:869-873(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-67.

Entry informationi

Entry nameiCOX5_NEUCR
AccessioniPrimary (citable) accession number: P06810
Secondary accession number(s): Q7RVI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 1, 1990
Last modified: October 29, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3