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P06810

- COX5_NEUCR

UniProt

P06810 - COX5_NEUCR

Protein

Cytochrome c oxidase polypeptide 5, mitochondrial

Gene

cya-4

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase polypeptide 5, mitochondrial (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide V
    Gene namesi
    Name:cya-4
    ORF Names:B8B20.30, NCU05457
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 6, Linkage Group II

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2727MitochondrionAdd
    BLAST
    Chaini28 – 171144Cytochrome c oxidase polypeptide 5, mitochondrialPRO_0000006095Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5141.NCU05457.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP06810.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei101 – 11919HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c oxidase IV family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG263759.
    HOGENOMiHOG000175160.
    KOiK02263.
    OMAiKRWEGMP.
    OrthoDBiEOG7JHMJ1.

    Family and domain databases

    Gene3Di1.10.442.10. 1 hit.
    InterProiIPR004203. Cyt_c_oxidase_su4_fam.
    [Graphical view]
    PfamiPF02936. COX4. 1 hit.
    [Graphical view]
    SUPFAMiSSF81406. SSF81406. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P06810-1 [UniParc]FASTAAdd to Basket

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    MLRTPTVSAL VRNVAVRAAK PTMAVRAAST MPISNPTLAN IEKRWEQMPM    50
    QEQAELWMAL RDRMKGNWAD LTLQEKKAAY YIAFGPHGPR ALPPPGEQKK 100
    VLAYTVAGVF LSFVIFATMR AFAKPPPATM TKEWQEATNE FLKAQKSDPL 150
    TGLTSEGYNG KGHVQSPSAS A 171
    Length:171
    Mass (Da):18,804
    Last modified:November 1, 1990 - v2
    Checksum:i5E866BE18B59440D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24389 Genomic DNA. Translation: AAA31957.2.
    AL355933 Genomic DNA. Translation: CAB91450.1.
    CM002237 Genomic DNA. Translation: EAA34212.1.
    M12117 Genomic DNA. Translation: AAA33575.1.
    PIRiA30134. OTNCV.
    RefSeqiXP_963448.1. XM_958355.1.
    UniGeneiNcr.15259.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000006595; EFNCRP00000006586; EFNCRG00000006583.
    GeneIDi3879597.
    KEGGincr:NCU05457.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24389 Genomic DNA. Translation: AAA31957.2 .
    AL355933 Genomic DNA. Translation: CAB91450.1 .
    CM002237 Genomic DNA. Translation: EAA34212.1 .
    M12117 Genomic DNA. Translation: AAA33575.1 .
    PIRi A30134. OTNCV.
    RefSeqi XP_963448.1. XM_958355.1.
    UniGenei Ncr.15259.

    3D structure databases

    ProteinModelPortali P06810.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU05457.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000006595 ; EFNCRP00000006586 ; EFNCRG00000006583 .
    GeneIDi 3879597.
    KEGGi ncr:NCU05457.

    Phylogenomic databases

    eggNOGi NOG263759.
    HOGENOMi HOG000175160.
    KOi K02263.
    OMAi KRWEGMP.
    OrthoDBi EOG7JHMJ1.

    Family and domain databases

    Gene3Di 1.10.442.10. 1 hit.
    InterProi IPR004203. Cyt_c_oxidase_su4_fam.
    [Graphical view ]
    Pfami PF02936. COX4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81406. SSF81406. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cytochrome oxidase subunit V gene of Neurospora crassa: DNA sequences, chromosomal mapping, and evidence that the cya-4 locus specifies the structural gene for subunit V."
      Sachs M.S., Bertrand H., Metzenberg R.L., RajBhandary U.L.
      Mol. Cell. Biol. 9:566-577(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
      Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
      Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
    3. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
    4. "Nuclear genes for cytochrome c oxidase subunits of Neurospora crassa. Isolation and characterization of cDNA clones for subunits IV, V, VI, and possibly VII."
      Sachs M.S., David M., Werner S., RajBhandary U.L.
      J. Biol. Chem. 261:869-873(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-67.

    Entry informationi

    Entry nameiCOX5_NEUCR
    AccessioniPrimary (citable) accession number: P06810
    Secondary accession number(s): Q7RVI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3