P06804 (TNFA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tumor necrosis factor

Alternative name(s):
Cachectin
TNF-alpha
Tumor necrosis factor ligand superfamily member 2
Short name=TNF-a

Cleaved into the following 6 chains:

1. Tumor necrosis factor, membrane form
   Alternative name(s):
   N-terminal fragment
   Short name=NTF
2. Intracellular domain 1
   Short name=ICD1
3. Intracellular domain 2
   Short name=ICD2
4. C-domain 1
5. C-domain 2
6. Tumor necrosis factor, soluble form

Gene names

Name:	Tnf
Synonyms:	Tnfa, Tnfsf2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	235 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells By similarity.
Subunit structure	Interacts with SPPL2B By similarity. Homotrimer.
Subcellular location	Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein By similarity. Tumor necrosis factor, soluble form: Secreted. C-domain 1: Secreted By similarity. C-domain 2: Secreted By similarity.
Post-translational modification	The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space By similarity. The soluble form derives from the membrane form by proteolytic processing. The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 By similarity. O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid By similarity.
Sequence similarities	Belongs to the tumor necrosis factor family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Polymorphism
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein Lipoprotein Myristate Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	JNK cascade Inferred from genetic interaction PubMed 17015619. Source: MGI activation of MAPK activity Inferred from electronic annotation. Source: Compara activation of MAPKKK activity Inferred from electronic annotation. Source: Compara activation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from electronic annotation. Source: Compara activation of necroptosis by extracellular signals Inferred from electronic annotation. Source: Compara calcium-mediated signaling Inferred from electronic annotation. Source: Compara cell activation Inferred from electronic annotation. Source: Compara cellular extravasation Inferred from direct assay PubMed 10528208. Source: MGI cellular response to amino acid stimulus Inferred from direct assay PubMed 20548288. Source: MGI cellular response to nicotine Inferred from electronic annotation. Source: Compara chronic inflammatory response to antigenic stimulus Inferred from electronic annotation. Source: Compara defense response to Gram-positive bacterium Inferred from genetic interaction PubMed 9834074. Source: MGI embryonic digestive tract development Inferred from electronic annotation. Source: Compara epithelial cell proliferation involved in salivary gland morphogenesis Inferred from direct assay PubMed 11241200. Source: MGI extracellular matrix organization Inferred from direct assay PubMed 15381731. Source: MGI extrinsic apoptotic signaling pathway via death domain receptors Inferred from genetic interaction PubMed 12431371. Source: MGI glucose metabolic process Inferred from direct assay PubMed 12068289. Source: MGI humoral immune response Inferred from mutant phenotype PubMed 8879212. Source: MGI induction of apoptosis Inferred from direct assay PubMed 8208546. Source: MGI inflammatory response Traceable author statement PubMed 8171322PubMed 8387893. Source: MGI leukocyte tethering or rolling Inferred from electronic annotation. Source: Compara lipopolysaccharide-mediated signaling pathway Inferred from electronic annotation. Source: Compara necrotic cell death Inferred from electronic annotation. Source: Compara negative regulation of L-glutamate transport Inferred from electronic annotation. Source: Compara negative regulation of alkaline phosphatase activity Inferred from direct assay PubMed 21689636. Source: BHF-UCL negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of branching involved in lung morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of cytokine secretion involved in immune response Inferred from electronic annotation. Source: Compara negative regulation of glucose import Inferred from direct assay PubMed 12068289. Source: MGI negative regulation of growth of symbiont in host Inferred from genetic interaction PubMed 9834074. Source: MGI negative regulation of interleukin-6 production Inferred from electronic annotation. Source: Compara negative regulation of lipid catabolic process Inferred from electronic annotation. Source: Compara negative regulation of osteoblast differentiation Inferred from direct assay PubMed 21689636. Source: BHF-UCL negative regulation of protein complex disassembly Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 21689636. Source: BHF-UCL negative regulation of viral genome replication Inferred from electronic annotation. Source: Compara organ morphogenesis Inferred from mutant phenotype PubMed 8879212. Source: MGI osteoclast differentiation Inferred from genetic interaction PubMed 15485831. Source: MGI positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from direct assay PubMed 12867038PubMed 16260493. Source: MGI positive regulation of JNK cascade Inferred from direct assay PubMed 16260493PubMed 20080598. Source: MGI positive regulation of JUN kinase activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of NF-kappaB import into nucleus Inferred from mutant phenotype PubMed 21689636. Source: BHF-UCL positive regulation of NF-kappaB transcription factor activity Inferred from sequence orthology PubMed 15790681. Source: MGI positive regulation of NFAT protein import into nucleus Inferred from electronic annotation. Source: Compara positive regulation of calcidiol 1-monooxygenase activity Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Traceable author statement PubMed 8171322. Source: MGI positive regulation of chemokine (C-X-C motif) ligand 2 production Inferred from electronic annotation. Source: Compara positive regulation of chemokine biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of chronic inflammatory response to antigenic stimulus Inferred from genetic interaction PubMed 9834074. Source: MGI positive regulation of cytokine secretion Inferred from electronic annotation. Source: Compara positive regulation of fever generation Inferred from direct assay PubMed 19940926. Source: BHF-UCL positive regulation of hair follicle development Inferred from mutant phenotype PubMed 16702408. Source: UniProtKB positive regulation of heterotypic cell-cell adhesion Inferred from electronic annotation. Source: Compara positive regulation of humoral immune response mediated by circulating immunoglobulin Inferred from genetic interaction PubMed 9834074. Source: MGI positive regulation of interferon-gamma production Inferred from genetic interaction PubMed 9834074. Source: MGI positive regulation of interleukin-6 production Inferred from direct assay PubMed 11894098. Source: MGI positive regulation of interleukin-8 biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of membrane protein ectodomain proteolysis Inferred from electronic annotation. Source: Compara positive regulation of mitosis Inferred from electronic annotation. Source: Compara positive regulation of neuron apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of nitric oxide biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of osteoclast differentiation Inferred from electronic annotation. Source: Compara positive regulation of peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of podosome assembly Inferred from electronic annotation. Source: Compara positive regulation of protein complex disassembly Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of protein kinase B signaling cascade Inferred from direct assay PubMed 20080598. Source: MGI positive regulation of protein localization to cell surface Inferred from electronic annotation. Source: Compara positive regulation of smooth muscle cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of synaptic transmission Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 17670746PubMed 19404405PubMed 9305915. Source: MGI positive regulation of translational initiation by iron Inferred from direct assay PubMed 11588035. Source: MGI positive regulation of vitamin D biosynthetic process Inferred from electronic annotation. Source: Compara protein import into nucleus, translocation Inferred from electronic annotation. Source: Compara protein kinase B signaling cascade Inferred from electronic annotation. Source: Compara receptor biosynthetic process Inferred from electronic annotation. Source: Compara regulation of branching involved in salivary gland morphogenesis Inferred from direct assay PubMed 11241200. Source: MGI regulation of immunoglobulin secretion Inferred from direct assay PubMed 12958312. Source: MGI regulation of insulin secretion Inferred from electronic annotation. Source: Compara regulation of osteoclast differentiation Inferred from direct assay PubMed 12490655. Source: MGI response to activity Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to glucocorticoid stimulus Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara response to mechanical stimulus Inferred from electronic annotation. Source: Compara response to virus Inferred from electronic annotation. Source: Compara sequestering of triglyceride Inferred from electronic annotation. Source: Compara skeletal muscle contraction Inferred from electronic annotation. Source: Compara transformed cell apoptotic process Traceable author statement PubMed 7636227PubMed 8171322PubMed 9368616. Source: MGI tumor necrosis factor-mediated signaling pathway Inferred from direct assay Ref.2. Source: MGI
Cellular_component	external side of plasma membrane Inferred from direct assay PubMed 16282525. Source: BHF-UCL extracellular space Inferred from direct assay PubMed 10545106PubMed 10549626PubMed 10899905PubMed 11168643PubMed 11728336PubMed 11894098PubMed 12855817PubMed 12872135PubMed 14764707PubMed 15220916PubMed 1577194PubMed 16236719PubMed 16239543PubMed 16275384PubMed 17693256PubMed 18261938PubMed 18997793. Source: MGI integral to plasma membrane Traceable author statement PubMed 8879212. Source: MGI membrane raft Inferred from direct assay PubMed 17010968. Source: BHF-UCL phagocytic cup Inferred from direct assay PubMed 16282525. Source: BHF-UCL recycling endosome Inferred from direct assay PubMed 16282525. Source: BHF-UCL secretory granule Traceable author statement PubMed 8879212. Source: MGI
Molecular_function	cytokine activity Inferred from direct assay PubMed 11588035PubMed 11894098. Source: MGI transcription regulatory region DNA binding Inferred from electronic annotation. Source: Compara tumor necrosis factor receptor binding Inferred from direct assay PubMed 11588035. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 235

235

Tumor necrosis factor, membrane form

PRO_0000034435

Chain

1 – 39

39

Intracellular domain 1 By similarity

PRO_0000417255

Chain

1 – 35

35

Intracellular domain 2 By similarity

PRO_0000417256

Chain

50 – ?

C-domain 1 By similarity

PRO_0000417257

Chain

52 – ?

C-domain 2 By similarity

PRO_0000417258

Chain

80 – 235

156

Tumor necrosis factor, soluble form

PRO_0000034436

Regions

Topological domain

1 – 35

35

Cytoplasmic Potential

Transmembrane

36 – 56

21

Helical; Signal-anchor for type II membrane protein; Potential

Topological domain

57 – 235

179

Extracellular Potential

Sites

Site

34 – 35

2

Cleavage; by SPPL2A or SPPL2B By similarity

Site

39 – 40

2

Cleavage; by SPPL2A or SPPL2B By similarity

Site

49 – 50

2

Cleavage; by SPPL2A or SPPL2B By similarity

Site

51 – 52

2

Cleavage; by SPPL2A or SPPL2B By similarity

Site

79 – 80

2

Cleavage; by ADAM17 By similarity

Amino acid modifications

Modified residue

2

1

Phosphoserine; by CK1 By similarity

Lipidation

20

1

N6-myristoyl lysine By similarity

Glycosylation

83

1

O-linked (GalNAc...); in soluble form By similarity

Glycosylation

86

1

N-linked (GlcNAc...)

Disulfide bond

148 ↔ 179

Natural variations

Natural variant

7

1

I → T in strain: BALB/c and C57BL/6. Ref.8

Natural variant

77

1

T → A in strain: BALB/c and C57BL/6. Ref.8

Experimental info

Sequence conflict

79 – 81

3

Missing in AAB65593. Ref.8

Sequence conflict

231

1

G → R Ref.3

Sequence conflict

231

1

G → R Ref.4

Secondary structure

1

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235

Helix Strand Turn

Details...

Beta strand

92 – 97

6

Beta strand

99 – 101

3

Beta strand

107 – 109

3

Beta strand

115 – 117

3

Beta strand

121 – 123

3

Beta strand

126 – 128

3

Beta strand

130 – 147

18

Beta strand

154 – 161

8

Turn

163 – 165

3

Beta strand

168 – 176

9

Beta strand

191 – 204

14

Beta strand

209 – 215

7

Helix

217 – 219

3

Beta strand

227 – 234

8

Sequences

	Sequence		Length	Mass (Da)
	P06804 [UniParc]. Last modified July 1, 1989. Version 2. Checksum: 16DD2A9676D68C5D	FASTA	235	25,896
	10 20 30 40 50 60 MSTESMIRDV ELAEEALPQK MGGFQNSRRC LCLSLFSFLL VAGATTLFCL LNFGVIGPQR 70 80 90 100 110 120 DEKFPNGLPL ISSMAQTLTL RSSSQNSSDK PVAHVVANHQ VEEQLEWLSQ RANALLANGM 130 140 150 160 170 180 DLKDNQLVVP ADGLYLVYSQ VLFKGQGCPD YVLLTHTVSR FAISYQEKVN LLSAVKSPCP 190 200 210 220 230 KDTPEGAELK PWYEPIYLGG VFQLEKGDQL SAEVNLPKYL DFAESGQVYF GVIAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression in Escherichia coli of the gene for mouse tumor necrosis factor." Shirai T., Shimizu N., Shiojiri S., Horiguchi S., Ito H. DNA 7:193-201(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor." Pennica D., Hayflick J.S., Bringman T.S., Palladino M.A., Goeddel D.V. Proc. Natl. Acad. Sci. U.S.A. 82:6060-6064(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators." Caput D., Beutler B., Hartog K., Thayer R., Brown-Shimer S., Cerami A. Proc. Natl. Acad. Sci. U.S.A. 83:1670-1674(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression." Fransen L., Mueller R., Marmenout A., Tavernier J., van der Heyden J., Kawashima E., Chollet A., Tizard R., van Heuverswyn H., van Vliet A., Ruysschaert M.-R., Fiers W. Nucleic Acids Res. 13:4417-4429(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"Molecular cloning of genes coding for tumor necrosis factor. Complete nucleotide sequence of the genome copy of TNF-alpha in mice." Shakhov A.N., Nedospasov S.A. Bioorg. Khim. 13:701-705(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[6]	"Nucleotide sequence of the murine TNF locus, including the TNF-alpha (tumor necrosis factor) and TNF-beta (lymphotoxin) genes." Semon D., Kawashima E., Jongeneel C.V., Shakhov A.N., Nedospasov S.A. Nucleic Acids Res. 15:9083-9084(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]	"Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping." Ikegami H., Makino S., Yamato E., Kawaguchi Y., Ueda H., Sakamoto T., Takekawa K., Ogihara T. J. Clin. Invest. 96:1936-1942(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CTS and NOD.
[8]	"Cloning and sequencing of the Tnfa genes of three inbred mouse strains." Iraqi F., Teale A. Immunogenetics 45:459-461(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-7 AND ALA-77. Strain: A/J, BALB/c and C57BL/6.
[9]	"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse." Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L. Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 129.
[10]	"Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies." Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 1-96. Strain: BFM/2Msf, BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf, pgn2 and SWN/Msf.
[11]	"Alternative cleavage of the cachectin/tumor necrosis factor propeptide results in a larger, inactive form of secreted protein." Cseh K., Beutler B. J. Biol. Chem. 264:16256-16260(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 70-87.
[12]	"Characterization of high molecular weight glycosylated forms of murine tumor necrosis factor." Sherry B., Juc D.-M., Zentella A., Cerami A. Biochem. Biophys. Res. Commun. 173:1072-1078(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 80-99.
[13]	"A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF." Kriegler M., Perez X., Defay K., Albert I., Lu S.D. Cell 53:45-53(1988) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF MEMBRANE-BOUND FORM.
[14]	"The structure of mouse tumour-necrosis factor at 1.4 A resolution: towards modulation of its selectivity and trimerization." Baeyens K.J., De Bondt H.L., Raeymaekers A., Fiers W., De Ranter C.J. Acta Crystallogr. D 55:772-778(1999) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 80-235.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M20155 Genomic DNA. Translation: AAA40462.1. Sequence problems.
M11731 mRNA. Translation: AAA40458.1.
M13049 mRNA. Translation: AAA40457.1.
X02611 mRNA. Translation: CAA26457.1.
M38296 Genomic DNA. Translation: AAA40459.1.
Y00467 Genomic DNA. Translation: CAA68530.1.
U06950 Unassigned DNA. Translation: AAA18594.1.
D84196 Genomic DNA. Translation: BAA19512.1.
D84199 Genomic DNA. Translation: BAA19513.1.
U68414 Genomic DNA. Translation: AAB65593.1.
AF109719 Genomic DNA. Translation: AAC82484.1.
AB039224 Genomic DNA. Translation: BAB68748.1. Sequence problems.
AB039225 Genomic DNA. Translation: BAB68749.1. Sequence problems.
AB039226 Genomic DNA. Translation: BAB68750.1. Sequence problems.
AB039227 Genomic DNA. Translation: BAB68751.1. Sequence problems.
AB039228 Genomic DNA. Translation: BAB68752.1. Sequence problems.
AB039229 Genomic DNA. Translation: BAB68753.1. Sequence problems.
AB039230 Genomic DNA. Translation: BAB68754.1. Sequence problems.
AB039231 Genomic DNA. Translation: BAB68755.1. Sequence problems.
AB039232 Genomic DNA. Translation: BAB68756.1. Sequence problems.

IPI

IPI00128861.

PIR

QWMSN. A22908.

RefSeq

NP_038721.1. NM_013693.2.

UniGene

Mm.1293.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2TNF	X-ray	1.40	A/B/C	80-235	[»]

ProteinModelPortal

P06804.

SMR

P06804. Positions 88-235.

ModBase

Search...

Protein-protein interaction databases

IntAct

P06804. 1 interaction.

PTM databases

PhosphoSite

P06804.

Proteomic databases

PaxDb

P06804.

PRIDE

P06804.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000025263; ENSMUSP00000025263; ENSMUSG00000024401.
ENSMUST00000167924; ENSMUSP00000126122; ENSMUSG00000024401.

GeneID

21926.

KEGG

mmu:21926.

Organism-specific databases

CTD

7124.

MGI

MGI:104798. Tnf.

Phylogenomic databases

eggNOG

NOG40413.

GeneTree

ENSGT00530000062992.

HOGENOM

HOG000048729.

HOVERGEN

HBG012516.

InParanoid

P06804.

KO

K03156.

OMA

WYEPIYL.

OrthoDB

EOG4JWVFT.

Gene expression databases

ArrayExpress

P06804.

Bgee

P06804.

CleanEx

MM_TNF.

Genevestigator

P06804.

GermOnline

ENSMUSG00000024401. Mus musculus.

Family and domain databases

Gene3D

2.60.120.40. 1 hit.

InterPro

IPR006052. TNF.
IPR006053. TNF_a/b/c.
IPR002959. TNF_alpha.
IPR021184. TNF_CS.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]

Pfam

PF00229. TNF. 1 hit.
[Graphical view]

PRINTS

PR01234. TNECROSISFCT.
PR01235. TNFALPHA.

SMART

SM00207. TNF. 1 hit.
[Graphical view]

SUPFAM

SSF49842. TNF_like. 1 hit.

PROSITE

PS00251. TNF_1. 1 hit.
PS50049. TNF_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChEMBL

CHEMBL4984.

EvolutionaryTrace

P06804.

NextBio

301508.

PMAP-CutDB

P06804.

SOURCE

Search...

Entry information

Entry name

TNFA_MOUSE

Accession

Primary (citable) accession number: P06804
Secondary accession number(s): O35853, Q62326, Q91VF3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	July 1, 1989
Last modified:	May 1, 2013
This is version 147 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program