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P06804

- TNFA_MOUSE

UniProt

P06804 - TNFA_MOUSE

Protein

Tumor necrosis factor

Gene

Tnf

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 162 (01 Oct 2014)
      Sequence version 2 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
    The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei34 – 352Cleavage; by SPPL2A or SPPL2BBy similarity
    Sitei39 – 402Cleavage; by SPPL2A or SPPL2BBy similarity
    Sitei49 – 502Cleavage; by SPPL2A or SPPL2BBy similarity
    Sitei51 – 522Cleavage; by SPPL2A or SPPL2BBy similarity
    Sitei79 – 802Cleavage; by ADAM17By similarity

    GO - Molecular functioni

    1. cytokine activity Source: MGI
    2. protease binding Source: BHF-UCL
    3. protein binding Source: UniProtKB
    4. transcription regulatory region DNA binding Source: Ensembl
    5. tumor necrosis factor receptor binding Source: MGI

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
    2. activation of MAPK activity Source: Ensembl
    3. activation of MAPKKK activity Source: Ensembl
    4. apoptotic signaling pathway Source: MGI
    5. calcium-mediated signaling Source: Ensembl
    6. cell activation Source: Ensembl
    7. cell proliferation Source: MGI
    8. cellular extravasation Source: MGI
    9. cellular response to amino acid stimulus Source: MGI
    10. cellular response to lipopolysaccharide Source: MGI
    11. cellular response to nicotine Source: Ensembl
    12. chronic inflammatory response to antigenic stimulus Source: Ensembl
    13. defense response Source: MGI
    14. defense response to bacterium Source: MGI
    15. defense response to Gram-positive bacterium Source: MGI
    16. embryonic digestive tract development Source: Ensembl
    17. epithelial cell proliferation involved in salivary gland morphogenesis Source: MGI
    18. extracellular matrix organization Source: MGI
    19. extrinsic apoptotic signaling pathway Source: MGI
    20. extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
    21. glucose metabolic process Source: MGI
    22. humoral immune response Source: MGI
    23. inflammatory response Source: MGI
    24. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
    25. JNK cascade Source: MGI
    26. leukocyte migration Source: MGI
    27. leukocyte tethering or rolling Source: Ensembl
    28. lipopolysaccharide-mediated signaling pathway Source: Ensembl
    29. multicellular organismal development Source: MGI
    30. necroptotic signaling pathway Source: UniProtKB
    31. negative regulation of alkaline phosphatase activity Source: BHF-UCL
    32. negative regulation of branching involved in lung morphogenesis Source: Ensembl
    33. negative regulation of cell proliferation Source: Ensembl
    34. negative regulation of cytokine secretion involved in immune response Source: Ensembl
    35. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    36. negative regulation of glucose import Source: MGI
    37. negative regulation of growth of symbiont in host Source: MGI
    38. negative regulation of interleukin-6 production Source: Ensembl
    39. negative regulation of L-glutamate transport Source: Ensembl
    40. negative regulation of lipid catabolic process Source: Ensembl
    41. negative regulation of osteoblast differentiation Source: BHF-UCL
    42. negative regulation of protein complex disassembly Source: UniProtKB
    43. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    44. negative regulation of viral genome replication Source: Ensembl
    45. organ morphogenesis Source: MGI
    46. osteoclast differentiation Source: MGI
    47. positive regulation of apoptotic process Source: UniProtKB
    48. positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
    49. positive regulation of cell proliferation Source: MGI
    50. positive regulation of chemokine (C-X-C motif) ligand 2 production Source: Ensembl
    51. positive regulation of chemokine biosynthetic process Source: Ensembl
    52. positive regulation of chronic inflammatory response to antigenic stimulus Source: MGI
    53. positive regulation of cytokine secretion Source: Ensembl
    54. positive regulation of fever generation Source: BHF-UCL
    55. positive regulation of hair follicle development Source: UniProtKB
    56. positive regulation of heterotypic cell-cell adhesion Source: Ensembl
    57. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: MGI
    58. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
    59. positive regulation of interferon-gamma production Source: MGI
    60. positive regulation of interleukin-18 production Source: Ensembl
    61. positive regulation of interleukin-6 production Source: MGI
    62. positive regulation of interleukin-8 biosynthetic process Source: Ensembl
    63. positive regulation of JNK cascade Source: MGI
    64. positive regulation of JUN kinase activity Source: UniProtKB
    65. positive regulation of MAP kinase activity Source: UniProtKB
    66. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
    67. positive regulation of mitosis Source: Ensembl
    68. positive regulation of neuron apoptotic process Source: Ensembl
    69. positive regulation of NFAT protein import into nucleus Source: Ensembl
    70. positive regulation of NF-kappaB import into nucleus Source: BHF-UCL
    71. positive regulation of NF-kappaB transcription factor activity Source: MGI
    72. positive regulation of nitric oxide biosynthetic process Source: Ensembl
    73. positive regulation of osteoclast differentiation Source: Ensembl
    74. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    75. positive regulation of podosome assembly Source: Ensembl
    76. positive regulation of protein complex disassembly Source: UniProtKB
    77. positive regulation of protein kinase B signaling Source: MGI
    78. positive regulation of protein localization to cell surface Source: Ensembl
    79. positive regulation of protein phosphorylation Source: UniProtKB
    80. positive regulation of smooth muscle cell proliferation Source: Ensembl
    81. positive regulation of synaptic transmission Source: Ensembl
    82. positive regulation of transcription, DNA-templated Source: MGI
    83. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    84. positive regulation of translational initiation by iron Source: MGI
    85. positive regulation of vitamin D biosynthetic process Source: Ensembl
    86. protein import into nucleus, translocation Source: Ensembl
    87. protein kinase B signaling Source: Ensembl
    88. receptor biosynthetic process Source: Ensembl
    89. regulation of branching involved in salivary gland morphogenesis Source: MGI
    90. regulation of cell proliferation Source: MGI
    91. regulation of immunoglobulin secretion Source: MGI
    92. regulation of insulin secretion Source: Ensembl
    93. regulation of osteoclast differentiation Source: MGI
    94. regulation of protein phosphorylation Source: MGI
    95. regulation of protein secretion Source: MGI
    96. regulation of reactive oxygen species metabolic process Source: MGI
    97. response to activity Source: Ensembl
    98. response to drug Source: Ensembl
    99. response to glucocorticoid Source: Ensembl
    100. response to hypoxia Source: Ensembl
    101. response to mechanical stimulus Source: Ensembl
    102. response to virus Source: Ensembl
    103. sequestering of triglyceride Source: Ensembl
    104. skeletal muscle contraction Source: Ensembl
    105. transformed cell apoptotic process Source: MGI
    106. tumor necrosis factor-mediated signaling pathway Source: MGI

    Keywords - Molecular functioni

    Cytokine

    Enzyme and pathway databases

    ReactomeiREACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor
    Alternative name(s):
    Cachectin
    TNF-alpha
    Tumor necrosis factor ligand superfamily member 2
    Short name:
    TNF-a
    Cleaved into the following 6 chains:
    Gene namesi
    Name:Tnf
    Synonyms:Tnfa, Tnfsf2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:104798. Tnf.

    Subcellular locationi

    Chain C-domain 1 : Secreted By similarity
    Chain C-domain 2 : Secreted By similarity

    GO - Cellular componenti

    1. external side of plasma membrane Source: BHF-UCL
    2. extracellular space Source: MGI
    3. integral component of plasma membrane Source: MGI
    4. intracellular Source: MGI
    5. membrane raft Source: BHF-UCL
    6. phagocytic cup Source: BHF-UCL
    7. plasma membrane Source: MGI
    8. recycling endosome Source: BHF-UCL
    9. secretory granule Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235Tumor necrosis factor, membrane formPRO_0000034435Add
    BLAST
    Chaini1 – 3939Intracellular domain 1By similarityPRO_0000417255Add
    BLAST
    Chaini1 – 3535Intracellular domain 2By similarityPRO_0000417256Add
    BLAST
    Chaini50 – ?C-domain 1By similarityPRO_0000417257
    Chaini52 – ?C-domain 2By similarityPRO_0000417258
    Chaini80 – 235156Tumor necrosis factor, soluble formPRO_0000034436Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21Phosphoserine; by CK1By similarity
    Lipidationi20 – 201N6-myristoyl lysineBy similarity
    Glycosylationi83 – 831O-linked (GalNAc...); in soluble formBy similarity
    Glycosylationi86 – 861N-linked (GlcNAc...)
    Disulfide bondi148 ↔ 179

    Post-translational modificationi

    The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space By similarity. The soluble form derives from the membrane form by proteolytic processing.By similarity
    The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 By similarity.By similarity
    O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Myristate, Phosphoprotein

    Proteomic databases

    PaxDbiP06804.
    PRIDEiP06804.

    PTM databases

    PhosphoSiteiP06804.

    Miscellaneous databases

    PMAP-CutDBP06804.

    Expressioni

    Gene expression databases

    ArrayExpressiP06804.
    BgeeiP06804.
    CleanExiMM_TNF.
    GenevestigatoriP06804.

    Interactioni

    Subunit structurei

    Interacts with SPPL2B By similarity. Homotrimer.By similarity

    Protein-protein interaction databases

    BioGridi204240. 12 interactions.
    IntActiP06804. 1 interaction.

    Structurei

    Secondary structure

    1
    235
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi92 – 976
    Beta strandi99 – 1013
    Beta strandi107 – 1093
    Beta strandi115 – 1173
    Beta strandi121 – 1233
    Beta strandi126 – 1283
    Beta strandi130 – 14718
    Beta strandi154 – 1618
    Turni163 – 1653
    Beta strandi168 – 1769
    Beta strandi191 – 20414
    Beta strandi209 – 2157
    Helixi217 – 2193
    Beta strandi227 – 2348

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2TNFX-ray1.40A/B/C80-234[»]
    ProteinModelPortaliP06804.
    SMRiP06804. Positions 88-235.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP06804.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini57 – 235179ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tumor necrosis factor family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40413.
    GeneTreeiENSGT00530000062992.
    HOGENOMiHOG000048729.
    HOVERGENiHBG012516.
    InParanoidiP06804.
    KOiK03156.
    OMAiPWYEPIY.
    OrthoDBiEOG7V4B0Q.
    PhylomeDBiP06804.
    TreeFamiTF332169.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR006053. TNF.
    IPR002959. TNF_alpha.
    IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    PRINTSiPR01234. TNECROSISFCT.
    PR01235. TNFALPHA.
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P06804-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTESMIRDV ELAEEALPQK MGGFQNSRRC LCLSLFSFLL VAGATTLFCL    50
    LNFGVIGPQR DEKFPNGLPL ISSMAQTLTL RSSSQNSSDK PVAHVVANHQ 100
    VEEQLEWLSQ RANALLANGM DLKDNQLVVP ADGLYLVYSQ VLFKGQGCPD 150
    YVLLTHTVSR FAISYQEKVN LLSAVKSPCP KDTPEGAELK PWYEPIYLGG 200
    VFQLEKGDQL SAEVNLPKYL DFAESGQVYF GVIAL 235
    Length:235
    Mass (Da):25,896
    Last modified:July 1, 1989 - v2
    Checksum:i16DD2A9676D68C5D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti79 – 813Missing in AAB65593. (PubMed:9089109)Curated
    Sequence conflicti231 – 2311G → R(PubMed:2419912)Curated
    Sequence conflicti231 – 2311G → R(PubMed:2989794)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti7 – 71I → T in strain: BALB/c and C57BL/6. 1 Publication
    Natural varianti77 – 771T → A in strain: BALB/c and C57BL/6. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M20155 Genomic DNA. Translation: AAA40462.1. Sequence problems.
    M11731 mRNA. Translation: AAA40458.1.
    M13049 mRNA. Translation: AAA40457.1.
    X02611 mRNA. Translation: CAA26457.1.
    M38296 Genomic DNA. Translation: AAA40459.1.
    Y00467 Genomic DNA. Translation: CAA68530.1.
    U06950 Unassigned DNA. Translation: AAA18594.1.
    D84196 Genomic DNA. Translation: BAA19512.1.
    D84199 Genomic DNA. Translation: BAA19513.1.
    U68414 Genomic DNA. Translation: AAB65593.1.
    AF109719 Genomic DNA. Translation: AAC82484.1.
    AB039224 Genomic DNA. Translation: BAB68748.1. Sequence problems.
    AB039225 Genomic DNA. Translation: BAB68749.1. Sequence problems.
    AB039226 Genomic DNA. Translation: BAB68750.1. Sequence problems.
    AB039227 Genomic DNA. Translation: BAB68751.1. Sequence problems.
    AB039228 Genomic DNA. Translation: BAB68752.1. Sequence problems.
    AB039229 Genomic DNA. Translation: BAB68753.1. Sequence problems.
    AB039230 Genomic DNA. Translation: BAB68754.1. Sequence problems.
    AB039231 Genomic DNA. Translation: BAB68755.1. Sequence problems.
    AB039232 Genomic DNA. Translation: BAB68756.1. Sequence problems.
    CCDSiCCDS28691.1.
    PIRiA22908. QWMSN.
    RefSeqiNP_001265530.1. NM_001278601.1.
    NP_038721.1. NM_013693.3.
    UniGeneiMm.1293.

    Genome annotation databases

    EnsembliENSMUST00000025263; ENSMUSP00000025263; ENSMUSG00000024401.
    ENSMUST00000167924; ENSMUSP00000126122; ENSMUSG00000024401.
    GeneIDi21926.
    KEGGimmu:21926.
    UCSCiuc008cgr.1. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M20155 Genomic DNA. Translation: AAA40462.1 . Sequence problems.
    M11731 mRNA. Translation: AAA40458.1 .
    M13049 mRNA. Translation: AAA40457.1 .
    X02611 mRNA. Translation: CAA26457.1 .
    M38296 Genomic DNA. Translation: AAA40459.1 .
    Y00467 Genomic DNA. Translation: CAA68530.1 .
    U06950 Unassigned DNA. Translation: AAA18594.1 .
    D84196 Genomic DNA. Translation: BAA19512.1 .
    D84199 Genomic DNA. Translation: BAA19513.1 .
    U68414 Genomic DNA. Translation: AAB65593.1 .
    AF109719 Genomic DNA. Translation: AAC82484.1 .
    AB039224 Genomic DNA. Translation: BAB68748.1 . Sequence problems.
    AB039225 Genomic DNA. Translation: BAB68749.1 . Sequence problems.
    AB039226 Genomic DNA. Translation: BAB68750.1 . Sequence problems.
    AB039227 Genomic DNA. Translation: BAB68751.1 . Sequence problems.
    AB039228 Genomic DNA. Translation: BAB68752.1 . Sequence problems.
    AB039229 Genomic DNA. Translation: BAB68753.1 . Sequence problems.
    AB039230 Genomic DNA. Translation: BAB68754.1 . Sequence problems.
    AB039231 Genomic DNA. Translation: BAB68755.1 . Sequence problems.
    AB039232 Genomic DNA. Translation: BAB68756.1 . Sequence problems.
    CCDSi CCDS28691.1.
    PIRi A22908. QWMSN.
    RefSeqi NP_001265530.1. NM_001278601.1.
    NP_038721.1. NM_013693.3.
    UniGenei Mm.1293.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2TNF X-ray 1.40 A/B/C 80-234 [» ]
    ProteinModelPortali P06804.
    SMRi P06804. Positions 88-235.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204240. 12 interactions.
    IntActi P06804. 1 interaction.

    Chemistry

    ChEMBLi CHEMBL4984.

    PTM databases

    PhosphoSitei P06804.

    Proteomic databases

    PaxDbi P06804.
    PRIDEi P06804.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025263 ; ENSMUSP00000025263 ; ENSMUSG00000024401 .
    ENSMUST00000167924 ; ENSMUSP00000126122 ; ENSMUSG00000024401 .
    GeneIDi 21926.
    KEGGi mmu:21926.
    UCSCi uc008cgr.1. mouse.

    Organism-specific databases

    CTDi 7124.
    MGIi MGI:104798. Tnf.

    Phylogenomic databases

    eggNOGi NOG40413.
    GeneTreei ENSGT00530000062992.
    HOGENOMi HOG000048729.
    HOVERGENi HBG012516.
    InParanoidi P06804.
    KOi K03156.
    OMAi PWYEPIY.
    OrthoDBi EOG7V4B0Q.
    PhylomeDBi P06804.
    TreeFami TF332169.

    Enzyme and pathway databases

    Reactomei REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

    Miscellaneous databases

    EvolutionaryTracei P06804.
    NextBioi 301508.
    PMAP-CutDB P06804.
    PROi P06804.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P06804.
    Bgeei P06804.
    CleanExi MM_TNF.
    Genevestigatori P06804.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR006053. TNF.
    IPR002959. TNF_alpha.
    IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    PRINTSi PR01234. TNECROSISFCT.
    PR01235. TNFALPHA.
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression in Escherichia coli of the gene for mouse tumor necrosis factor."
      Shirai T., Shimizu N., Shiojiri S., Horiguchi S., Ito H.
      DNA 7:193-201(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor."
      Pennica D., Hayflick J.S., Bringman T.S., Palladino M.A., Goeddel D.V.
      Proc. Natl. Acad. Sci. U.S.A. 82:6060-6064(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators."
      Caput D., Beutler B., Hartog K., Thayer R., Brown-Shimer S., Cerami A.
      Proc. Natl. Acad. Sci. U.S.A. 83:1670-1674(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Molecular cloning of genes coding for tumor necrosis factor. Complete nucleotide sequence of the genome copy of TNF-alpha in mice."
      Shakhov A.N., Nedospasov S.A.
      Bioorg. Khim. 13:701-705(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    6. "Nucleotide sequence of the murine TNF locus, including the TNF-alpha (tumor necrosis factor) and TNF-beta (lymphotoxin) genes."
      Semon D., Kawashima E., Jongeneel C.V., Shakhov A.N., Nedospasov S.A.
      Nucleic Acids Res. 15:9083-9084(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping."
      Ikegami H., Makino S., Yamato E., Kawaguchi Y., Ueda H., Sakamoto T., Takekawa K., Ogihara T.
      J. Clin. Invest. 96:1936-1942(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: CTS and NOD.
    8. "Cloning and sequencing of the Tnfa genes of three inbred mouse strains."
      Iraqi F., Teale A.
      Immunogenetics 45:459-461(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-7 AND ALA-77.
      Strain: A/J, BALB/c and C57BL/6.
    9. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 129.
    10. "Conspicuous differences among gene genealogies of 21 nuclear genes of five Mus musculus subspecies."
      Liu Y., Kitano T., Koide T., Shiroishi T., Moriwaki K., Saitou N.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 1-96.
      Strain: BFM/2Msf, BLG2/Msf, C57BL/10SnJ, CAST/Ei, HMI/Msf, MSM/Msf, NJL/Msf, pgn2 and SWN/Msf.
    11. "Alternative cleavage of the cachectin/tumor necrosis factor propeptide results in a larger, inactive form of secreted protein."
      Cseh K., Beutler B.
      J. Biol. Chem. 264:16256-16260(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 70-87.
    12. "Characterization of high molecular weight glycosylated forms of murine tumor necrosis factor."
      Sherry B., Juc D.-M., Zentella A., Cerami A.
      Biochem. Biophys. Res. Commun. 173:1072-1078(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 80-99.
    13. "A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF."
      Kriegler M., Perez X., Defay K., Albert I., Lu S.D.
      Cell 53:45-53(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF MEMBRANE-BOUND FORM.
    14. "The structure of mouse tumour-necrosis factor at 1.4 A resolution: towards modulation of its selectivity and trimerization."
      Baeyens K.J., De Bondt H.L., Raeymaekers A., Fiers W., De Ranter C.J.
      Acta Crystallogr. D 55:772-778(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 80-235.

    Entry informationi

    Entry nameiTNFA_MOUSE
    AccessioniPrimary (citable) accession number: P06804
    Secondary accession number(s): O35853, Q62326, Q91VF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 162 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3