P06800 (PTPRC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Receptor-type tyrosine-protein phosphatase C
EC=3.1.3.48

Alternative name(s):
Leukocyte common antigen
Short name=L-CA
Lymphocyte antigen 5
Short name=Ly-5
T200
CD_antigen=CD45

Gene names

Name:	Ptprc
Synonyms:	Ly-5

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1291 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN By similarity. Dephosphorylates LYN, and thereby modulates LYN activity. Ref.14
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subunit structure	Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes By similarity. Binds GANAB and PRKCSH. Ref.13
Subcellular location	Membrane; Single-pass type I membrane protein. Membrane raft By similarity. Note: Colocalized with DPP4 in membrane rafts By similarity.
Developmental stage	Expression is restricted to the hematopoietic compartment of development.
Domain	The first PTPase domain interacts with SKAP1 By similarity.
Post-translational modification	Heavily N- and O-glycosylated.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. Contains 2 fibronectin type-III domains. Contains 2 tyrosine-protein phosphatase domains.
Sequence caution	The sequence AAA39462.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Hydrolase Protein phosphatase
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	B cell differentiation Inferred from mutant phenotype PubMed 12902479. Source: MGI B cell proliferation Inferred from mutant phenotype PubMed 8334701. Source: UniProtKB B cell receptor signaling pathway Inferred from mutant phenotype PubMed 8692271. Source: UniProtKB T cell proliferation Inferred from mutant phenotype PubMed 12902479. Source: MGI T cell receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB activation of MAPK activity Inferred from mutant phenotype PubMed 9254656. Source: MGI bone marrow development Inferred from electronic annotation. Source: Compara defense response to virus Inferred from mutant phenotype PubMed 8334701. Source: UniProtKB hematopoietic progenitor cell differentiation Inferred from electronic annotation. Source: Compara heterotypic cell-cell adhesion Inferred from mutant phenotype PubMed 7743522. Source: MGI immunoglobulin biosynthetic process Inferred from electronic annotation. Source: Compara leukocyte cell-cell adhesion Inferred from mutant phenotype PubMed 7743522. Source: MGI negative regulation of T cell mediated cytotoxicity Inferred from mutant phenotype PubMed 9725213. Source: UniProtKB negative regulation of cell adhesion involved in substrate-bound cell migration Inferred from electronic annotation. Source: Compara negative regulation of cytokine-mediated signaling pathway Inferred from direct assay PubMed 11201744. Source: UniProtKB negative regulation of peptidyl-tyrosine phosphorylation Inferred from mutant phenotype PubMed 7499277PubMed 8175795. Source: MGI negative regulation of protein autophosphorylation Inferred from mutant phenotype PubMed 7499277PubMed 8175795. Source: MGI negative regulation of protein kinase activity Inferred from direct assay PubMed 10970857. Source: UniProtKB negative thymic T cell selection Inferred from mutant phenotype PubMed 8666928. Source: MGI positive regulation of B cell proliferation Inferred from mutant phenotype PubMed 8566034PubMed 8666928PubMed 9015183PubMed 9254656. Source: MGI positive regulation of T cell mediated cytotoxicity Inferred from mutant phenotype PubMed 6233370. Source: MGI positive regulation of alpha-beta T cell proliferation Inferred from mutant phenotype PubMed 7751624. Source: MGI positive regulation of antigen receptor-mediated signaling pathway Inferred from mutant phenotype PubMed 8692271. Source: UniProtKB positive regulation of apoptotic process Inferred from mutant phenotype PubMed 8666928. Source: MGI positive regulation of gamma-delta T cell differentiation Inferred from mutant phenotype PubMed 7807014. Source: MGI positive regulation of hematopoietic stem cell migration Inferred from electronic annotation. Source: Compara positive regulation of humoral immune response mediated by circulating immunoglobulin Inferred from mutant phenotype PubMed 8566034. Source: MGI positive regulation of isotype switching to IgG isotypes Inferred from mutant phenotype PubMed 9015183. Source: MGI positive regulation of stem cell proliferation Inferred from electronic annotation. Source: Compara positive thymic T cell selection Inferred from mutant phenotype PubMed 8666928. Source: MGI regulation of B cell differentiation Inferred from mutant phenotype PubMed 8666928PubMed 9254656. Source: MGI regulation of B cell receptor signaling pathway Inferred from mutant phenotype PubMed 7499277. Source: MGI regulation of S phase Inferred from electronic annotation. Source: Compara regulation of cell cycle Inferred from direct assay PubMed 10970857. Source: UniProtKB release of sequestered calcium ion into cytosol Inferred from direct assay PubMed 10508267. Source: UniProtKB response to gamma radiation Inferred from electronic annotation. Source: Compara stem cell development Inferred from electronic annotation. Source: Compara
Cellular_component	external side of plasma membrane Inferred from direct assay PubMed 10848813PubMed 10943842PubMed 11466198PubMed 12714519PubMed 12900455PubMed 14609575PubMed 14990792PubMed 15240667PubMed 15795238PubMed 15845452PubMed 15909309PubMed 16287714PubMed 16455951PubMed 16493007PubMed 17277142PubMed 17941951PubMed 18628982PubMed 18762567PubMed 19015308PubMed 19838199PubMed 19934022PubMed 20660734PubMed 20709950PubMed 21460847PubMed 21606356PubMed 61878PubMed 6610701PubMed 7477352PubMed 7477353PubMed 7589135PubMed 7630421PubMed 7688139PubMed 7751624PubMed 8041705PubMed 8043862PubMed 8552190PubMed 8566025PubMed 8666928PubMed 8788039PubMed 9208839. Source: MGI focal adhesion Inferred from direct assay PubMed 9197241. Source: UniProtKB integral to plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB membrane raft Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	heparan sulfate proteoglycan binding Inferred from direct assay PubMed 8043862. Source: MGI heparin binding Inferred from direct assay PubMed 8043862. Source: MGI protein kinase binding Inferred from sequence or structural similarity. Source: UniProtKB protein tyrosine phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P06800-1)

Also known as: B220;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P06800-2)

The sequence of this isoform differs from the canonical sequence as follows:
     31-73: Missing.

Isoform 3 (identifier: P06800-3)

The sequence of this isoform differs from the canonical sequence as follows:
     31-169: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23
	Chain	24 – 1291	1268	Receptor-type tyrosine-protein phosphatase C		PRO_0000025471
Regions
	Topological domain	24 – 564	541	Extracellular Potential
	Transmembrane	565 – 586	22	Helical; Potential
	Topological domain	587 – 1291	705	Cytoplasmic Potential
	Domain	371 – 467	97	Fibronectin type-III 1
	Domain	472 – 559	88	Fibronectin type-III 2
	Domain	640 – 899	260	Tyrosine-protein phosphatase 1
	Domain	931 – 1214	284	Tyrosine-protein phosphatase 2
	Region	840 – 846	7	Substrate binding By similarity
Sites
	Active site	840	1	Phosphocysteine intermediate By similarity
	Active site	1155	1	Phosphocysteine intermediate By similarity
	Binding site	808	1	Substrate By similarity
	Binding site	884	1	Substrate By similarity
Amino acid modifications
	Modified residue	940	1	Phosphoserine Ref.16
	Modified residue	962	1	Phosphoserine Ref.15 Ref.16
	Modified residue	1284	1	Phosphoserine By similarity
	Glycosylation	64	1	N-linked (GlcNAc...) Potential
	Glycosylation	150	1	N-linked (GlcNAc...) Potential
	Glycosylation	161	1	N-linked (GlcNAc...) Potential
	Glycosylation	207	1	N-linked (GlcNAc...) Potential
	Glycosylation	211	1	N-linked (GlcNAc...) Potential
	Glycosylation	218	1	N-linked (GlcNAc...) Potential
	Glycosylation	253	1	N-linked (GlcNAc...) Potential
	Glycosylation	258	1	N-linked (GlcNAc...) Potential
	Glycosylation	290	1	N-linked (GlcNAc...) Potential
	Glycosylation	311	1	N-linked (GlcNAc...) Potential
	Glycosylation	322	1	N-linked (GlcNAc...) Potential
	Glycosylation	347	1	N-linked (GlcNAc...) Potential
	Glycosylation	416	1	N-linked (GlcNAc...) Potential
	Glycosylation	427	1	N-linked (GlcNAc...) Potential
	Glycosylation	457	1	N-linked (GlcNAc...) Potential
	Glycosylation	489	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	31 – 169	139	Missing in isoform 3.		VSP_012442
	Alternative sequence	31 – 73	43	Missing in isoform 2.		VSP_012441
Experimental info
	Sequence conflict	300	1	K → E in AAA39459. Ref.3
	Sequence conflict	398	1	V → A in AAA39459. Ref.3
	Sequence conflict	402 – 403	2	ES → DP in AAA39459. Ref.3
	Sequence conflict	476	1	N → T in AAA39459. Ref.3
	Sequence conflict	518 – 520	3	KYN → NTT in AAA39458. Ref.1
	Sequence conflict	528	1	V → G in AAA39458. Ref.1
	Sequence conflict	556	1	N → S in AAA39458. Ref.1
	Sequence conflict	588	1	I → S in AAA39458. Ref.1
	Sequence conflict	906	1	E → Q in AAA39458. Ref.1
	Sequence conflict	931	1	L → R in AAA39458. Ref.1
	Sequence conflict	953	1	E → G in AAA39458. Ref.1
	Sequence conflict	959	1	N → K in AAA39458. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (B220) [UniParc]. Last modified July 27, 2011. Version 3. Checksum: ED752FD195BA9643	FASTA	1,291	144,604
	10 20 30 40 50 60 MGLWLKLLAF GFALLDTEVF VTGQTPTPSD ELSTTENALL LPQSDPLPAR TTESTPPSIS 70 80 90 100 110 120 ERGNGSSETT YHPGVLSTLL PHLSPQPDSQ TPSAGGADTQ TFSSQADNPT LTPAPGGGTD 130 140 150 160 170 180 PPGVPGERTV PGTIPADTAF PVDTPSLARN SSAASPTHTS NVSTTDISSG ASLTTLTPST 190 200 210 220 230 240 LGLASTDPPS TTIATTTKQT CAAMFGNITV NYTYESSNQT FKADLKDVQN AKCGNEDCEN 250 260 270 280 290 300 VLNNLEECSQ IKNISVSNDS CAPATTIDLY VPPGTDKFSL HDCTPKEKAN TSICLEWKTK 310 320 330 340 350 360 NLDFRKCNSD NISYVLHCEP ENNTKCIRRN TFIPERCQLD NLRAQTNYTC VAEILYRGVK 370 380 390 400 410 420 LVKNVINVQT DLGIPETPKP SCGDPAARKT LVSWPEPVSK PESASKPHGY VLCYKNNSEK 430 440 450 460 470 480 CKSLPNNVTS FEVESLKPYK YYEVSLLAYV NGKIQRNGTA EKCNFHTKAD RPDKVNGMKT 490 500 510 520 530 540 SRPTDNSINV TCGPPYETNG PKTFYILVVR SGGSFVTKYN KTNCQFYVDN LYYSTDYEFL 550 560 570 580 590 600 VSFHNGVYEG DSVIRNESTN FNAKALIIFL VFLIIVTSIA LLVVLYKIYD LRKKRSSNLD 610 620 630 640 650 660 EQQELVERDD EKQLMDVEPI HSDILLETYK RKIADEGRLF LAEFQSIPRV FSKFPIKDAR 670 680 690 700 710 720 KPHNQNKNRY VDILPYDYNR VELSEINGDA GSTYINASYI DGFKEPRKYI AAQGPRDETV 730 740 750 760 770 780 DDFWRMIWEQ KATVIVMVTR CEEGNRNKCA EYWPSMEEGT RAFKDIVVTI NDHKRCPDYI 790 800 810 820 830 840 IQKLNVAHKK EKATGREVTH IQFTSWPDHG VPEDPHLLLK LRRRVNAFSN FFSGPIVVHC 850 860 870 880 890 900 SAGVGRTGTY IGIDAMLEGL EAEGKVDVYG YVVKLRRQRC LMVQVEAQYI LIHQALVEYN 910 920 930 940 950 960 QFGETEVNLS ELHSCLHNMK KRDPPSDPSP LEAEYQRLPS YRSWRTQHIG NQEENKKKNR 970 980 990 1000 1010 1020 NSNVVPYDFN RVPLKHELEM SKESEPESDE SSDDDSDSEE TSKYINASFV MSYWKPEMMI 1030 1040 1050 1060 1070 1080 AAQGPLKETI GDFWQMIFQR KVKVIVMLTE LVNGDQEVCA QYWGEGKQTY GDMEVEMKDT 1090 1100 1110 1120 1130 1140 NRASAYTLRT FELRHSKRKE PRTVYQYQCT TWKGEELPAE PKDLVSMIQD LKQKLPKASP 1150 1160 1170 1180 1190 1200 EGMKYHKHAS ILVHCRDGSQ QTGLFCALFN LLESAETEDV VDVFQVVKSL RKARPGVVCS 1210 1220 1230 1240 1250 1260 YEQYQFLYDI IASIYPAQNG QVKKTNSQDK IEFHNEVDGG KQDANCVRPD GPLNKAQEDS 1270 1280 1290 RGVGTPEPTN SAEEPEHAAN GSASPAPTQS S
	Isoform 2 [UniParc]. Checksum: D08281C0463EA174	FASTA	1,248	140,040
	10 20 30 40 50 60 MGLWLKLLAF GFALLDTEVF VTGQTPTPSD GVLSTLLPHL SPQPDSQTPS AGGADTQTFS 70 80 90 100 110 120 SQADNPTLTP APGGGTDPPG VPGERTVPGT IPADTAFPVD TPSLARNSSA ASPTHTSNVS 130 140 150 160 170 180 TTDISSGASL TTLTPSTLGL ASTDPPSTTI ATTTKQTCAA MFGNITVNYT YESSNQTFKA 190 200 210 220 230 240 DLKDVQNAKC GNEDCENVLN NLEECSQIKN ISVSNDSCAP ATTIDLYVPP GTDKFSLHDC 250 260 270 280 290 300 TPKEKANTSI CLEWKTKNLD FRKCNSDNIS YVLHCEPENN TKCIRRNTFI PERCQLDNLR 310 320 330 340 350 360 AQTNYTCVAE ILYRGVKLVK NVINVQTDLG IPETPKPSCG DPAARKTLVS WPEPVSKPES 370 380 390 400 410 420 ASKPHGYVLC YKNNSEKCKS LPNNVTSFEV ESLKPYKYYE VSLLAYVNGK IQRNGTAEKC 430 440 450 460 470 480 NFHTKADRPD KVNGMKTSRP TDNSINVTCG PPYETNGPKT FYILVVRSGG SFVTKYNKTN 490 500 510 520 530 540 CQFYVDNLYY STDYEFLVSF HNGVYEGDSV IRNESTNFNA KALIIFLVFL IIVTSIALLV 550 560 570 580 590 600 VLYKIYDLRK KRSSNLDEQQ ELVERDDEKQ LMDVEPIHSD ILLETYKRKI ADEGRLFLAE 610 620 630 640 650 660 FQSIPRVFSK FPIKDARKPH NQNKNRYVDI LPYDYNRVEL SEINGDAGST YINASYIDGF 670 680 690 700 710 720 KEPRKYIAAQ GPRDETVDDF WRMIWEQKAT VIVMVTRCEE GNRNKCAEYW PSMEEGTRAF 730 740 750 760 770 780 KDIVVTINDH KRCPDYIIQK LNVAHKKEKA TGREVTHIQF TSWPDHGVPE DPHLLLKLRR 790 800 810 820 830 840 RVNAFSNFFS GPIVVHCSAG VGRTGTYIGI DAMLEGLEAE GKVDVYGYVV KLRRQRCLMV 850 860 870 880 890 900 QVEAQYILIH QALVEYNQFG ETEVNLSELH SCLHNMKKRD PPSDPSPLEA EYQRLPSYRS 910 920 930 940 950 960 WRTQHIGNQE ENKKKNRNSN VVPYDFNRVP LKHELEMSKE SEPESDESSD DDSDSEETSK 970 980 990 1000 1010 1020 YINASFVMSY WKPEMMIAAQ GPLKETIGDF WQMIFQRKVK VIVMLTELVN GDQEVCAQYW 1030 1040 1050 1060 1070 1080 GEGKQTYGDM EVEMKDTNRA SAYTLRTFEL RHSKRKEPRT VYQYQCTTWK GEELPAEPKD 1090 1100 1110 1120 1130 1140 LVSMIQDLKQ KLPKASPEGM KYHKHASILV HCRDGSQQTG LFCALFNLLE SAETEDVVDV 1150 1160 1170 1180 1190 1200 FQVVKSLRKA RPGVVCSYEQ YQFLYDIIAS IYPAQNGQVK KTNSQDKIEF HNEVDGGKQD 1210 1220 1230 1240 ANCVRPDGPL NKAQEDSRGV GTPEPTNSAE EPEHAANGSA SPAPTQSS
	Isoform 3 [UniParc]. Checksum: F1AA6650E654CAAB	FASTA	1,152	130,622
	10 20 30 40 50 60 MGLWLKLLAF GFALLDTEVF VTGQTPTPSD GASLTTLTPS TLGLASTDPP STTIATTTKQ 70 80 90 100 110 120 TCAAMFGNIT VNYTYESSNQ TFKADLKDVQ NAKCGNEDCE NVLNNLEECS QIKNISVSND 130 140 150 160 170 180 SCAPATTIDL YVPPGTDKFS LHDCTPKEKA NTSICLEWKT KNLDFRKCNS DNISYVLHCE 190 200 210 220 230 240 PENNTKCIRR NTFIPERCQL DNLRAQTNYT CVAEILYRGV KLVKNVINVQ TDLGIPETPK 250 260 270 280 290 300 PSCGDPAARK TLVSWPEPVS KPESASKPHG YVLCYKNNSE KCKSLPNNVT SFEVESLKPY 310 320 330 340 350 360 KYYEVSLLAY VNGKIQRNGT AEKCNFHTKA DRPDKVNGMK TSRPTDNSIN VTCGPPYETN 370 380 390 400 410 420 GPKTFYILVV RSGGSFVTKY NKTNCQFYVD NLYYSTDYEF LVSFHNGVYE GDSVIRNEST 430 440 450 460 470 480 NFNAKALIIF LVFLIIVTSI ALLVVLYKIY DLRKKRSSNL DEQQELVERD DEKQLMDVEP 490 500 510 520 530 540 IHSDILLETY KRKIADEGRL FLAEFQSIPR VFSKFPIKDA RKPHNQNKNR YVDILPYDYN 550 560 570 580 590 600 RVELSEINGD AGSTYINASY IDGFKEPRKY IAAQGPRDET VDDFWRMIWE QKATVIVMVT 610 620 630 640 650 660 RCEEGNRNKC AEYWPSMEEG TRAFKDIVVT INDHKRCPDY IIQKLNVAHK KEKATGREVT 670 680 690 700 710 720 HIQFTSWPDH GVPEDPHLLL KLRRRVNAFS NFFSGPIVVH CSAGVGRTGT YIGIDAMLEG 730 740 750 760 770 780 LEAEGKVDVY GYVVKLRRQR CLMVQVEAQY ILIHQALVEY NQFGETEVNL SELHSCLHNM 790 800 810 820 830 840 KKRDPPSDPS PLEAEYQRLP SYRSWRTQHI GNQEENKKKN RNSNVVPYDF NRVPLKHELE 850 860 870 880 890 900 MSKESEPESD ESSDDDSDSE ETSKYINASF VMSYWKPEMM IAAQGPLKET IGDFWQMIFQ 910 920 930 940 950 960 RKVKVIVMLT ELVNGDQEVC AQYWGEGKQT YGDMEVEMKD TNRASAYTLR TFELRHSKRK 970 980 990 1000 1010 1020 EPRTVYQYQC TTWKGEELPA EPKDLVSMIQ DLKQKLPKAS PEGMKYHKHA SILVHCRDGS 1030 1040 1050 1060 1070 1080 QQTGLFCALF NLLESAETED VVDVFQVVKS LRKARPGVVC SYEQYQFLYD IIASIYPAQN 1090 1100 1110 1120 1130 1140 GQVKKTNSQD KIEFHNEVDG GKQDANCVRP DGPLNKAQED SRGVGTPEPT NSAEEPEHAA 1150 NGSASPAPTQ SS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequences of Ly-5 cDNA: isoform-related diversity of Ly-5 mRNA." Saga Y., Tung J.-S., Shen F.-W., Boyse E.A. Proc. Natl. Acad. Sci. U.S.A. 83:6940-6944(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[2]	Erratum Saga Y., Tung J.-S., Shen F.-W., Boyse E.A. Proc. Natl. Acad. Sci. U.S.A. 84:1991-1991(1987) Cited for: SEQUENCE REVISION.
[3]	"Comparison of mouse Ly5a and Ly5b leucocyte common antigen alleles." Zebedee S.L., Barritt D.S., Raschke W.C. Dev. Immunol. 1:243-254(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: BALB/c.
[4]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[5]	"Alternative use of 5' exons in the specification of Ly-5 isoforms distinguishing hematopoietic cell lineages." Saga Y., Tung J.-S., Shen F.-W.W., Boyse E.A. Proc. Natl. Acad. Sci. U.S.A. 84:5364-5368(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-226 (ISOFORM 2).
[6]	"Organization of the Ly-5 gene." Saga Y., Tung J.-S., Shen F.-W.W., Pancoast T.C., Boyse E.A. Mol. Cell. Biol. 8:4889-4895(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
[7]	"Sequence conservation in potential regulatory regions of the mouse and human leukocyte common antigen gene." Johnson N.A., Meyer C.M., Pingel J.T., Thomas M.L. J. Biol. Chem. 264:6220-6229(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
[8]	"Cloning of Ly-5 cDNA." Shen F.-W., Saga Y., Litman G., Freeman G., Tung J.-S., Cantor H., Boyse E.A. Proc. Natl. Acad. Sci. U.S.A. 82:7360-7363(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-263 (ISOFORM 3). Tissue: T-cell.
[9]	"Structural features of Ly-5 glycoproteins of the mouse and counterparts in other mammals." Tung J.-S., Saga Y., Boyse E.A. Immunogenetics 28:271-277(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-73.
[10]	"Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification." Yi T., Cleveland J.L., Ihle J.N. Blood 78:2222-2228(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 730-838.
[11]	"Cloned murine T200 (Ly-5) cDNA reveals multiple transcripts within B- and T-lymphocyte lineages." Raschke W.C. Proc. Natl. Acad. Sci. U.S.A. 84:161-165(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 961-1291.
[12]	"High sequence conservation between rat (T200) and mouse (Ly-5) leukocyte common antigens." Gonez L.J., Walker I.D., Sandrin M.S., McKenzie I.F. Immunogenetics 25:263-266(1987) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE.
[13]	"Identification of the CD45-associated 116-kDa and 80-kDa proteins as the alpha- and beta-subunits of alpha-glucosidase II." Arendt C.W., Ostergaard H.L. J. Biol. Chem. 272:13117-13125(1997) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH GANAB AND PRKCSH.
[14]	"CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells." Katagiri T., Ogimoto M., Hasegawa K., Arimura Y., Mitomo K., Okada M., Clark M.R., Mizuno K., Yakura H. J. Immunol. 163:1321-1326(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[15]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-962, MASS SPECTROMETRY. Tissue: Melanoma.
[16]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-940 AND SER-962, MASS SPECTROMETRY. Tissue: Macrophage.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M14342 mRNA. Translation: AAA39458.1. M92933 mRNA. Translation: AAA39459.1. AC122903 Genomic DNA. No translation available. AC159278 Genomic DNA. No translation available. M17320 mRNA. Translation: AAA60449.1. M23354 Genomic DNA. Translation: AAA39462.1. Different initiation. M22456 Genomic DNA. Translation: AAB46374.1. M11934 mRNA. Translation: AAA39461.1. M23241 Genomic DNA. Translation: AAA39460.1. M15174 mRNA. Translation: AAA40161.1.
IPI	IPI00126092. IPI00128856. IPI00461132.
PIR	A23329. A28334. A28335. I57644.
UniGene	Mm.391573.
3D structure databases
ProteinModelPortal	P06800.
SMR	P06800. Positions 471-550, 612-1216.
ModBase	Search...
Protein-protein interaction databases
IntAct	P06800. 6 interactions.
MINT	MINT-188397.
STRING	10090.ENSMUSP00000074352.
PTM databases
PhosphoSite	P06800.
Proteomic databases
PaxDb	P06800.
PRIDE	P06800.
Protocols and materials databases
DNASU	19264.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000027645; ENSMUSP00000027645; ENSMUSG00000026395. ENSMUST00000112036; ENSMUSP00000107667; ENSMUSG00000026395.
UCSC	uc007cvg.2. mouse.
Organism-specific databases
MGI	MGI:97810. Ptprc.
Phylogenomic databases
eggNOG	COG5599.
GeneTree	ENSGT00640000091300.
HOVERGEN	HBG000066.
OMA	KHELEMS.
OrthoDB	EOG4MPHPN.
Gene expression databases
ArrayExpress	P06800.
Bgee	P06800.
CleanEx	MM_PTPRC.
Genevestigator	P06800.
GermOnline	ENSMUSG00000026395. Mus musculus.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. IPR016335. Leukocyte_common_ag. IPR024739. PTP_recept_N. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Pfam	PF12567. CD45. 1 hit. PF12453. PTP_N. 1 hit. PF00102. Y_phosphatase. 2 hits. [Graphical view]
PIRSF	PIRSF002004. Leukocyte_common_antigen. 1 hit.
PRINTS	PR00700. PRTYPHPHTASE.
SMART	SM00060. FN3. 2 hits. SM00194. PTPc. 2 hits. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 2 hits.
PROSITE	PS50853. FN3. 2 hits. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 2 hits. PS50055. TYR_PHOSPHATASE_PTP. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	296132.
SOURCE	Search...

Entry information

Entry name

PTPRC_MOUSE

Accession

Primary (citable) accession number: P06800
Secondary accession number(s): E9QLT5 , Q61812, Q61813, Q61814, Q61815, Q78EF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 140 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program