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P06800

- PTPRC_MOUSE

UniProt

P06800 - PTPRC_MOUSE

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Protein
Receptor-type tyrosine-protein phosphatase C
Gene
Ptprc, Ly-5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN By similarity. Dephosphorylates LYN, and thereby modulates LYN activity.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei808 – 8081Substrate By similarity
Active sitei840 – 8401Phosphocysteine intermediate By similarity
Binding sitei884 – 8841Substrate By similarity
Active sitei1155 – 11551Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. heparan sulfate proteoglycan binding Source: MGI
  2. heparin binding Source: MGI
  3. protein binding Source: IntAct
  4. protein kinase binding Source: UniProtKB
  5. protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. B cell differentiation Source: MGI
  2. B cell proliferation Source: UniProtKB
  3. B cell receptor signaling pathway Source: UniProtKB
  4. T cell differentiation Source: UniProtKB
  5. T cell proliferation Source: MGI
  6. T cell receptor signaling pathway Source: UniProtKB
  7. activation of MAPK activity Source: MGI
  8. defense response to virus Source: UniProtKB
  9. dephosphorylation Source: UniProtKB
  10. heterotypic cell-cell adhesion Source: MGI
  11. leukocyte cell-cell adhesion Source: MGI
  12. negative regulation of T cell mediated cytotoxicity Source: UniProtKB
  13. negative regulation of cytokine-mediated signaling pathway Source: UniProtKB
  14. negative regulation of peptidyl-tyrosine phosphorylation Source: MGI
  15. negative regulation of protein autophosphorylation Source: MGI
  16. negative regulation of protein kinase activity Source: UniProtKB
  17. negative thymic T cell selection Source: MGI
  18. peptidyl-tyrosine dephosphorylation Source: GOC
  19. positive regulation of B cell proliferation Source: MGI
  20. positive regulation of MAPK cascade Source: MGI
  21. positive regulation of T cell differentiation Source: MGI
  22. positive regulation of T cell mediated cytotoxicity Source: MGI
  23. positive regulation of T cell mediated immunity Source: MGI
  24. positive regulation of T cell proliferation Source: UniProtKB
  25. positive regulation of alpha-beta T cell proliferation Source: MGI
  26. positive regulation of antigen receptor-mediated signaling pathway Source: UniProtKB
  27. positive regulation of extrinsic apoptotic signaling pathway Source: MGI
  28. positive regulation of gamma-delta T cell differentiation Source: MGI
  29. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: MGI
  30. positive regulation of isotype switching to IgG isotypes Source: MGI
  31. positive thymic T cell selection Source: MGI
  32. protein dephosphorylation Source: UniProtKB
  33. regulation of B cell differentiation Source: MGI
  34. regulation of B cell receptor signaling pathway Source: MGI
  35. regulation of cell cycle Source: UniProtKB
  36. regulation of extrinsic apoptotic signaling pathway Source: MGI
  37. regulation of humoral immune response mediated by circulating immunoglobulin Source: MGI
  38. release of sequestered calcium ion into cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

ReactomeiREACT_216080. Phosphorylation of CD3 and TCR zeta chains.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase C (EC:3.1.3.48)
Alternative name(s):
Leukocyte common antigen
Short name:
L-CA
Lymphocyte antigen 5
Short name:
Ly-5
T200
CD_antigen: CD45
Gene namesi
Name:Ptprc
Synonyms:Ly-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:97810. Ptprc.

Subcellular locationi

Membrane; Single-pass type I membrane protein. Membrane raft By similarity
Note: Colocalized with DPP4 in membrane rafts By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 564541Extracellular Reviewed prediction
Add
BLAST
Transmembranei565 – 58622Helical; Reviewed prediction
Add
BLAST
Topological domaini587 – 1291705Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell periphery Source: MGI
  2. external side of plasma membrane Source: MGI
  3. focal adhesion Source: UniProtKB
  4. integral component of plasma membrane Source: UniProtKB
  5. membrane raft Source: UniProtKB-SubCell
  6. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323
Add
BLAST
Chaini24 – 12911268Receptor-type tyrosine-protein phosphatase C
PRO_0000025471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi150 – 1501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi207 – 2071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi211 – 2111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi218 – 2181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi253 – 2531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi258 – 2581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi290 – 2901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi311 – 3111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi322 – 3221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi347 – 3471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi416 – 4161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi427 – 4271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi457 – 4571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi489 – 4891N-linked (GlcNAc...) Reviewed prediction
Modified residuei962 – 9621Phosphoserine1 Publication
Modified residuei1284 – 12841Phosphoserine By similarity

Post-translational modificationi

Heavily N- and O-glycosylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP06800.
PaxDbiP06800.
PRIDEiP06800.

PTM databases

PhosphoSiteiP06800.

Expressioni

Developmental stagei

Expression is restricted to the hematopoietic compartment of development.

Gene expression databases

ArrayExpressiP06800.
BgeeiP06800.
CleanExiMM_PTPRC.
GenevestigatoriP06800.

Interactioni

Subunit structurei

Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes By similarity. Binds GANAB and PRKCSH.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
LckP062403EBI-1672,EBI-1401

Protein-protein interaction databases

BioGridi202493. 3 interactions.
IntActiP06800. 8 interactions.
MINTiMINT-188397.
STRINGi10090.ENSMUSP00000074352.

Structurei

3D structure databases

ProteinModelPortaliP06800.
SMRiP06800. Positions 612-1216.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini374 – 47097Fibronectin type-III 1
Add
BLAST
Domaini471 – 56696Fibronectin type-III 2
Add
BLAST
Domaini640 – 899260Tyrosine-protein phosphatase 1
Add
BLAST
Domaini931 – 1214284Tyrosine-protein phosphatase 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni840 – 8467Substrate binding By similarity

Domaini

The first PTPase domain interacts with SKAP1 By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00680000099951.
HOVERGENiHBG000066.
OrthoDBiEOG7XSTCW.
TreeFamiTF351829.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR016335. Leukocyte_common_ag.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR024739. PTP_recept_N.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF12567. CD45. 1 hit.
PF12453. PTP_N. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF002004. Leukocyte_common_antigen. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 2 hits.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P06800-1) [UniParc]FASTAAdd to Basket

Also known as: B220

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGLWLKLLAF GFALLDTEVF VTGQTPTPSD ELSTTENALL LPQSDPLPAR     50
TTESTPPSIS ERGNGSSETT YHPGVLSTLL PHLSPQPDSQ TPSAGGADTQ 100
TFSSQADNPT LTPAPGGGTD PPGVPGERTV PGTIPADTAF PVDTPSLARN 150
SSAASPTHTS NVSTTDISSG ASLTTLTPST LGLASTDPPS TTIATTTKQT 200
CAAMFGNITV NYTYESSNQT FKADLKDVQN AKCGNEDCEN VLNNLEECSQ 250
IKNISVSNDS CAPATTIDLY VPPGTDKFSL HDCTPKEKAN TSICLEWKTK 300
NLDFRKCNSD NISYVLHCEP ENNTKCIRRN TFIPERCQLD NLRAQTNYTC 350
VAEILYRGVK LVKNVINVQT DLGIPETPKP SCGDPAARKT LVSWPEPVSK 400
PESASKPHGY VLCYKNNSEK CKSLPNNVTS FEVESLKPYK YYEVSLLAYV 450
NGKIQRNGTA EKCNFHTKAD RPDKVNGMKT SRPTDNSINV TCGPPYETNG 500
PKTFYILVVR SGGSFVTKYN KTNCQFYVDN LYYSTDYEFL VSFHNGVYEG 550
DSVIRNESTN FNAKALIIFL VFLIIVTSIA LLVVLYKIYD LRKKRSSNLD 600
EQQELVERDD EKQLMDVEPI HSDILLETYK RKIADEGRLF LAEFQSIPRV 650
FSKFPIKDAR KPHNQNKNRY VDILPYDYNR VELSEINGDA GSTYINASYI 700
DGFKEPRKYI AAQGPRDETV DDFWRMIWEQ KATVIVMVTR CEEGNRNKCA 750
EYWPSMEEGT RAFKDIVVTI NDHKRCPDYI IQKLNVAHKK EKATGREVTH 800
IQFTSWPDHG VPEDPHLLLK LRRRVNAFSN FFSGPIVVHC SAGVGRTGTY 850
IGIDAMLEGL EAEGKVDVYG YVVKLRRQRC LMVQVEAQYI LIHQALVEYN 900
QFGETEVNLS ELHSCLHNMK KRDPPSDPSP LEAEYQRLPS YRSWRTQHIG 950
NQEENKKKNR NSNVVPYDFN RVPLKHELEM SKESEPESDE SSDDDSDSEE 1000
TSKYINASFV MSYWKPEMMI AAQGPLKETI GDFWQMIFQR KVKVIVMLTE 1050
LVNGDQEVCA QYWGEGKQTY GDMEVEMKDT NRASAYTLRT FELRHSKRKE 1100
PRTVYQYQCT TWKGEELPAE PKDLVSMIQD LKQKLPKASP EGMKYHKHAS 1150
ILVHCRDGSQ QTGLFCALFN LLESAETEDV VDVFQVVKSL RKARPGVVCS 1200
YEQYQFLYDI IASIYPAQNG QVKKTNSQDK IEFHNEVDGG KQDANCVRPD 1250
GPLNKAQEDS RGVGTPEPTN SAEEPEHAAN GSASPAPTQS S 1291
Length:1,291
Mass (Da):144,604
Last modified:July 27, 2011 - v3
Checksum:iED752FD195BA9643
GO
Isoform 2 (identifier: P06800-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-73: Missing.

Show »
Length:1,248
Mass (Da):140,040
Checksum:iD08281C0463EA174
GO
Isoform 3 (identifier: P06800-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-169: Missing.

Show »
Length:1,152
Mass (Da):130,622
Checksum:iF1AA6650E654CAAB
GO

Sequence cautioni

The sequence AAA39462.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei31 – 169139Missing in isoform 3.
VSP_012442Add
BLAST
Alternative sequencei31 – 7343Missing in isoform 2.
VSP_012441Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti300 – 3001K → E in AAA39459. 1 Publication
Sequence conflicti398 – 3981V → A in AAA39459. 1 Publication
Sequence conflicti402 – 4032ES → DP in AAA39459. 1 Publication
Sequence conflicti476 – 4761N → T in AAA39459. 1 Publication
Sequence conflicti518 – 5203KYN → NTT in AAA39458. 1 Publication
Sequence conflicti528 – 5281V → G in AAA39458. 1 Publication
Sequence conflicti556 – 5561N → S in AAA39458. 1 Publication
Sequence conflicti588 – 5881I → S in AAA39458. 1 Publication
Sequence conflicti906 – 9061E → Q in AAA39458. 1 Publication
Sequence conflicti931 – 9311L → R in AAA39458. 1 Publication
Sequence conflicti953 – 9531E → G in AAA39458. 1 Publication
Sequence conflicti959 – 9591N → K in AAA39458. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14342 mRNA. Translation: AAA39458.1.
M92933 mRNA. Translation: AAA39459.1.
AC122903 Genomic DNA. No translation available.
AC159278 Genomic DNA. No translation available.
M17320 mRNA. Translation: AAA60449.1.
M23354 Genomic DNA. Translation: AAA39462.1. Different initiation.
M22456 Genomic DNA. Translation: AAB46374.1.
M11934 mRNA. Translation: AAA39461.1.
M23241 Genomic DNA. Translation: AAA39460.1.
M15174 mRNA. Translation: AAA40161.1.
PIRiA23329.
A28334.
A28335.
I57644.
UniGeneiMm.391573.

Genome annotation databases

EnsembliENSMUST00000027645; ENSMUSP00000027645; ENSMUSG00000026395. [P06800-1]
ENSMUST00000112036; ENSMUSP00000107667; ENSMUSG00000026395. [P06800-3]
UCSCiuc007cvf.2. mouse. [P06800-1]
uc007cvh.2. mouse. [P06800-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14342 mRNA. Translation: AAA39458.1 .
M92933 mRNA. Translation: AAA39459.1 .
AC122903 Genomic DNA. No translation available.
AC159278 Genomic DNA. No translation available.
M17320 mRNA. Translation: AAA60449.1 .
M23354 Genomic DNA. Translation: AAA39462.1 . Different initiation.
M22456 Genomic DNA. Translation: AAB46374.1 .
M11934 mRNA. Translation: AAA39461.1 .
M23241 Genomic DNA. Translation: AAA39460.1 .
M15174 mRNA. Translation: AAA40161.1 .
PIRi A23329.
A28334.
A28335.
I57644.
UniGenei Mm.391573.

3D structure databases

ProteinModelPortali P06800.
SMRi P06800. Positions 612-1216.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202493. 3 interactions.
IntActi P06800. 8 interactions.
MINTi MINT-188397.
STRINGi 10090.ENSMUSP00000074352.

Chemistry

GuidetoPHARMACOLOGYi 1852.

PTM databases

PhosphoSitei P06800.

Proteomic databases

MaxQBi P06800.
PaxDbi P06800.
PRIDEi P06800.

Protocols and materials databases

DNASUi 19264.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027645 ; ENSMUSP00000027645 ; ENSMUSG00000026395 . [P06800-1 ]
ENSMUST00000112036 ; ENSMUSP00000107667 ; ENSMUSG00000026395 . [P06800-3 ]
UCSCi uc007cvf.2. mouse. [P06800-1 ]
uc007cvh.2. mouse. [P06800-3 ]

Organism-specific databases

MGIi MGI:97810. Ptprc.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00680000099951.
HOVERGENi HBG000066.
OrthoDBi EOG7XSTCW.
TreeFami TF351829.

Enzyme and pathway databases

Reactomei REACT_216080. Phosphorylation of CD3 and TCR zeta chains.

Miscellaneous databases

NextBioi 296132.
PROi P06800.
SOURCEi Search...

Gene expression databases

ArrayExpressi P06800.
Bgeei P06800.
CleanExi MM_PTPRC.
Genevestigatori P06800.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
3.90.190.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR016335. Leukocyte_common_ag.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR024739. PTP_recept_N.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF12567. CD45. 1 hit.
PF12453. PTP_N. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PIRSFi PIRSF002004. Leukocyte_common_antigen. 1 hit.
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 2 hits.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 2 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequences of Ly-5 cDNA: isoform-related diversity of Ly-5 mRNA."
    Saga Y., Tung J.-S., Shen F.-W., Boyse E.A.
    Proc. Natl. Acad. Sci. U.S.A. 83:6940-6944(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  2. Erratum
    Saga Y., Tung J.-S., Shen F.-W., Boyse E.A.
    Proc. Natl. Acad. Sci. U.S.A. 84:1991-1991(1987)
    Cited for: SEQUENCE REVISION.
  3. "Comparison of mouse Ly5a and Ly5b leucocyte common antigen alleles."
    Zebedee S.L., Barritt D.S., Raschke W.C.
    Dev. Immunol. 1:243-254(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: BALB/c.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "Alternative use of 5' exons in the specification of Ly-5 isoforms distinguishing hematopoietic cell lineages."
    Saga Y., Tung J.-S., Shen F.-W.W., Boyse E.A.
    Proc. Natl. Acad. Sci. U.S.A. 84:5364-5368(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-226 (ISOFORM 2).
  6. "Organization of the Ly-5 gene."
    Saga Y., Tung J.-S., Shen F.-W.W., Pancoast T.C., Boyse E.A.
    Mol. Cell. Biol. 8:4889-4895(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
  7. "Sequence conservation in potential regulatory regions of the mouse and human leukocyte common antigen gene."
    Johnson N.A., Meyer C.M., Pingel J.T., Thomas M.L.
    J. Biol. Chem. 264:6220-6229(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
  8. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-263 (ISOFORM 3).
    Tissue: T-cell.
  9. "Structural features of Ly-5 glycoproteins of the mouse and counterparts in other mammals."
    Tung J.-S., Saga Y., Boyse E.A.
    Immunogenetics 28:271-277(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-73.
  10. "Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification."
    Yi T., Cleveland J.L., Ihle J.N.
    Blood 78:2222-2228(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 730-838.
  11. "Cloned murine T200 (Ly-5) cDNA reveals multiple transcripts within B- and T-lymphocyte lineages."
    Raschke W.C.
    Proc. Natl. Acad. Sci. U.S.A. 84:161-165(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 961-1291.
  12. "High sequence conservation between rat (T200) and mouse (Ly-5) leukocyte common antigens."
    Gonez L.J., Walker I.D., Sandrin M.S., McKenzie I.F.
    Immunogenetics 25:263-266(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
  13. "Identification of the CD45-associated 116-kDa and 80-kDa proteins as the alpha- and beta-subunits of alpha-glucosidase II."
    Arendt C.W., Ostergaard H.L.
    J. Biol. Chem. 272:13117-13125(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GANAB AND PRKCSH.
  14. "CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells."
    Katagiri T., Ogimoto M., Hasegawa K., Arimura Y., Mitomo K., Okada M., Clark M.R., Mizuno K., Yakura H.
    J. Immunol. 163:1321-1326(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-962, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPTPRC_MOUSE
AccessioniPrimary (citable) accession number: P06800
Secondary accession number(s): E9QLT5
, Q61812, Q61813, Q61814, Q61815, Q78EF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 154 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi