Reviewed, UniProtKB/Swiss-Prot P06800 (CD45_MOUSE)

Names and origin

Protein names

Recommended name:
    Leukocyte common antigen
      Short name=L-CA
    EC=3.1.3.48
Alternative name(s):
    Lymphocyte antigen 5
      Short name=Ly-5
    T200
    CD_antigen=CD45

Gene names

Name:	Ptprc
Synonyms:	Ly-5

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	1291 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Required for T-cell activation through the antigen receptor. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits an dephosphorylates SKAP1 and FYN.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subunit structure	Interacts with SKAP1 By similarity. Binds GANAB and PRKCSH.
Subcellular location	Membrane; Single-pass type I membrane protein.
Developmental stage	Expression is restricted to the hematopoietic compartment of development.
Domain	The first PTPase domain interacts with SKAP1 By similarity.
Post-translational modification	Heavily N- and O-glycosylated.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. Contains 2 fibronectin type-III domains. Contains 2 tyrosine-protein phosphatase domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal Transmembrane
Molecular function	Hydrolase Protein phosphatase
PTM	Glycoprotein Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	B cell differentiation Inferred from mutant phenotype. Source: MGI B cell proliferation Inferred from mutant phenotype. Source: UniProtKB B cell receptor signaling pathway Inferred from mutant phenotype. Source: UniProtKB T cell proliferation Inferred from mutant phenotype. Source: MGI T cell receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB activation of MAPK activity Inferred from mutant phenotype. Source: MGI defense response to virus Inferred from mutant phenotype. Source: UniProtKB heterotypic cell-cell adhesion Inferred from mutant phenotype. Source: MGI leukocyte adhesion Inferred from mutant phenotype. Source: MGI negative regulation of T cell mediated cytotoxicity Inferred from mutant phenotype. Source: UniProtKB negative regulation of cytokine-mediated signaling pathway Inferred from direct assay. Source: UniProtKB negative regulation of peptidyl-tyrosine phosphorylation Inferred from mutant phenotype. Source: MGI negative regulation of protein amino acid autophosphorylation Inferred from mutant phenotype. Source: MGI negative regulation of protein kinase activity Inferred from direct assay. Source: UniProtKB negative thymic T cell selection Inferred from mutant phenotype. Source: MGI positive regulation of B cell proliferation Inferred from mutant phenotype. Source: MGI positive regulation of MAPKKK cascade Inferred from mutant phenotype. Source: MGI positive regulation of T cell mediated cytotoxicity Inferred from mutant phenotype. Source: MGI positive regulation of alpha-beta T cell proliferation Inferred from mutant phenotype. Source: MGI positive regulation of antigen receptor-mediated signaling pathway Inferred from mutant phenotype. Source: UniProtKB positive regulation of apoptosis Inferred from mutant phenotype. Source: MGI positive regulation of gamma-delta T cell differentiation Inferred from mutant phenotype. Source: MGI positive regulation of humoral immune response mediated by circulating immunoglobulin Inferred from mutant phenotype. Source: MGI positive regulation of isotype switching to IgG isotypes Inferred from mutant phenotype. Source: MGI positive thymic T cell selection Inferred from mutant phenotype. Source: MGI protein amino acid dephosphorylation Inferred from direct assay. Source: UniProtKB regulation of B cell differentiation Inferred from mutant phenotype. Source: MGI regulation of B cell receptor signaling pathway Inferred from mutant phenotype. Source: MGI regulation of cell cycle Inferred from direct assay. Source: UniProtKB release of sequestered calcium ion into cytosol Inferred from direct assay. Source: UniProtKB
Cellular component	external side of plasma membrane Inferred from direct assay. Source: MGI focal adhesion Inferred from direct assay. Source: UniProtKB integral to plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	heparan sulfate proteoglycan binding Inferred from direct assay. Source: MGI heparin binding Inferred from direct assay. Source: MGI protein kinase binding Inferred from physical interaction. Source: UniProtKB protein tyrosine phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P06800-1)

Also known as: B220;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P06800-2)

The sequence of this isoform differs from the canonical sequence as follows:
     31-73: Missing.

Isoform 3 (identifier: P06800-3)

The sequence of this isoform differs from the canonical sequence as follows:
     31-169: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23
	Chain	24 – 1291	1268	Leukocyte common antigen		PRO_0000025471
Regions
	Topological domain	24 – 564	541	Extracellular Potential
	Transmembrane	565 – 586	22	Potential
	Topological domain	587 – 1291	705	Cytoplasmic Potential
	Domain	371 – 467	97	Fibronectin type-III 1
	Domain	472 – 559	88	Fibronectin type-III 2
	Domain	640 – 899	260	Tyrosine-protein phosphatase 1
	Domain	931 – 1214	284	Tyrosine-protein phosphatase 2
Sites
	Active site	840	1	Phosphocysteine intermediate By similarity
	Active site	1155	1	Phosphocysteine intermediate By similarity
Amino acid modifications
	Modified residue	940	1	Phosphoserine Ref.14
	Modified residue	962	1	Phosphoserine Ref.14 Ref.13
	Modified residue	984	1	Phosphoserine By similarity
	Modified residue	992	1	Phosphoserine By similarity
	Modified residue	996	1	Phosphoserine By similarity
	Glycosylation	64	1	N-linked (GlcNAc...) Potential
	Glycosylation	150	1	N-linked (GlcNAc...) Potential
	Glycosylation	161	1	N-linked (GlcNAc...) Potential
	Glycosylation	207	1	N-linked (GlcNAc...) Potential
	Glycosylation	211	1	N-linked (GlcNAc...) Potential
	Glycosylation	218	1	N-linked (GlcNAc...) Potential
	Glycosylation	253	1	N-linked (GlcNAc...) Potential
	Glycosylation	258	1	N-linked (GlcNAc...) Potential
	Glycosylation	290	1	N-linked (GlcNAc...) Potential
	Glycosylation	311	1	N-linked (GlcNAc...) Potential
	Glycosylation	322	1	N-linked (GlcNAc...) Potential
	Glycosylation	347	1	N-linked (GlcNAc...) Potential
	Glycosylation	416	1	N-linked (GlcNAc...) Potential
	Glycosylation	427	1	N-linked (GlcNAc...) Potential
	Glycosylation	457	1	N-linked (GlcNAc...) Potential
	Glycosylation	489	1	N-linked (GlcNAc...) Potential
	Glycosylation	518	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	31 – 169	139	Missing in isoform 3.		VSP_012442
	Alternative sequence	31 – 73	43	Missing in isoform 2.		VSP_012441
Experimental info
	Sequence conflict	300	1	K → E in AAA39459. Ref.3
	Sequence conflict	398	1	V → A in AAA39459. Ref.3
	Sequence conflict	402 – 403	2	ES → DP in AAA39459. Ref.3
	Sequence conflict	476	1	N → T in AAA39459. Ref.3
	Sequence conflict	518 – 520	3	NTT → KYN in AAA39459. Ref.3
	Sequence conflict	528	1	G → V in AAA39459. Ref.3
	Sequence conflict	556	1	S → N in AAA39459. Ref.3
	Sequence conflict	588	1	S → I in AAA39459. Ref.3
	Sequence conflict	906	1	Q → E in AAA39459. Ref.3
	Sequence conflict	931	1	R → L in AAA39459. Ref.3
	Sequence conflict	953	1	G → E in AAA39459. Ref.3
	Sequence conflict	959	1	K → N in AAA39459. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (B220) [UniParc]. Last modified January 4, 2005. Version 2. Checksum: A8061F3590C0F4FA	FASTA	1,291	144,404
	10 20 30 40 50 60 MGLWLKLLAF GFALLDTEVF VTGQTPTPSD ELSTTENALL LPQSDPLPAR TTESTPPSIS 70 80 90 100 110 120 ERGNGSSETT YHPGVLSTLL PHLSPQPDSQ TPSAGGADTQ TFSSQADNPT LTPAPGGGTD 130 140 150 160 170 180 PPGVPGERTV PGTIPADTAF PVDTPSLARN SSAASPTHTS NVSTTDISSG ASLTTLTPST 190 200 210 220 230 240 LGLASTDPPS TTIATTTKQT CAAMFGNITV NYTYESSNQT FKADLKDVQN AKCGNEDCEN 250 260 270 280 290 300 VLNNLEECSQ IKNISVSNDS CAPATTIDLY VPPGTDKFSL HDCTPKEKAN TSICLEWKTK 310 320 330 340 350 360 NLDFRKCNSD NISYVLHCEP ENNTKCIRRN TFIPERCQLD NLRAQTNYTC VAEILYRGVK 370 380 390 400 410 420 LVKNVINVQT DLGIPETPKP SCGDPAARKT LVSWPEPVSK PESASKPHGY VLCYKNNSEK 430 440 450 460 470 480 CKSLPNNVTS FEVESLKPYK YYEVSLLAYV NGKIQRNGTA EKCNFHTKAD RPDKVNGMKT 490 500 510 520 530 540 SRPTDNSINV TCGPPYETNG PKTFYILVVR SGGSFVTNTT KTNCQFYGDN LYYSTDYEFL 550 560 570 580 590 600 VSFHNGVYEG DSVIRSESTN FNAKALIIFL VFLIIVTSIA LLVVLYKSYD LRKKRSSNLD 610 620 630 640 650 660 EQQELVERDD EKQLMDVEPI HSDILLETYK RKIADEGRLF LAEFQSIPRV FSKFPIKDAR 670 680 690 700 710 720 KPHNQNKNRY VDILPYDYNR VELSEINGDA GSTYINASYI DGFKEPRKYI AAQGPRDETV 730 740 750 760 770 780 DDFWRMIWEQ KATVIVMVTR CEEGNRNKCA EYWPSMEEGT RAFKDIVVTI NDHKRCPDYI 790 800 810 820 830 840 IQKLNVAHKK EKATGREVTH IQFTSWPDHG VPEDPHLLLK LRRRVNAFSN FFSGPIVVHC 850 860 870 880 890 900 SAGVGRTGTY IGIDAMLEGL EAEGKVDVYG YVVKLRRQRC LMVQVEAQYI LIHQALVEYN 910 920 930 940 950 960 QFGETQVNLS ELHSCLHNMK KRDPPSDPSP REAEYQRLPS YRSWRTQHIG NQGENKKKKR 970 980 990 1000 1010 1020 NSNVVPYDFN RVPLKHELEM SKESEPESDE SSDDDSDSEE TSKYINASFV MSYWKPEMMI 1030 1040 1050 1060 1070 1080 AAQGPLKETI GDFWQMIFQR KVKVIVMLTE LVNGDQEVCA QYWGEGKQTY GDMEVEMKDT 1090 1100 1110 1120 1130 1140 NRASAYTLRT FELRHSKRKE PRTVYQYQCT TWKGEELPAE PKDLVSMIQD LKQKLPKASP 1150 1160 1170 1180 1190 1200 EGMKYHKHAS ILVHCRDGSQ QTGLFCALFN LLESAETEDV VDVFQVVKSL RKARPGVVCS 1210 1220 1230 1240 1250 1260 YEQYQFLYDI IASIYPAQNG QVKKTNSQDK IEFHNEVDGG KQDANCVRPD GPLNKAQEDS 1270 1280 1290 RGVGTPEPTN SAEEPEHAAN GSASPAPTQS S
	Isoform 2. Checksum: 95F1B1244344C3CD	FASTA	1,248	139,839
	10 20 30 40 50 60 MGLWLKLLAF GFALLDTEVF VTGQTPTPSD GVLSTLLPHL SPQPDSQTPS AGGADTQTFS 70 80 90 100 110 120 SQADNPTLTP APGGGTDPPG VPGERTVPGT IPADTAFPVD TPSLARNSSA ASPTHTSNVS 130 140 150 160 170 180 TTDISSGASL TTLTPSTLGL ASTDPPSTTI ATTTKQTCAA MFGNITVNYT YESSNQTFKA 190 200 210 220 230 240 DLKDVQNAKC GNEDCENVLN NLEECSQIKN ISVSNDSCAP ATTIDLYVPP GTDKFSLHDC 250 260 270 280 290 300 TPKEKANTSI CLEWKTKNLD FRKCNSDNIS YVLHCEPENN TKCIRRNTFI PERCQLDNLR 310 320 330 340 350 360 AQTNYTCVAE ILYRGVKLVK NVINVQTDLG IPETPKPSCG DPAARKTLVS WPEPVSKPES 370 380 390 400 410 420 ASKPHGYVLC YKNNSEKCKS LPNNVTSFEV ESLKPYKYYE VSLLAYVNGK IQRNGTAEKC 430 440 450 460 470 480 NFHTKADRPD KVNGMKTSRP TDNSINVTCG PPYETNGPKT FYILVVRSGG SFVTNTTKTN 490 500 510 520 530 540 CQFYGDNLYY STDYEFLVSF HNGVYEGDSV IRSESTNFNA KALIIFLVFL IIVTSIALLV 550 560 570 580 590 600 VLYKSYDLRK KRSSNLDEQQ ELVERDDEKQ LMDVEPIHSD ILLETYKRKI ADEGRLFLAE 610 620 630 640 650 660 FQSIPRVFSK FPIKDARKPH NQNKNRYVDI LPYDYNRVEL SEINGDAGST YINASYIDGF 670 680 690 700 710 720 KEPRKYIAAQ GPRDETVDDF WRMIWEQKAT VIVMVTRCEE GNRNKCAEYW PSMEEGTRAF 730 740 750 760 770 780 KDIVVTINDH KRCPDYIIQK LNVAHKKEKA TGREVTHIQF TSWPDHGVPE DPHLLLKLRR 790 800 810 820 830 840 RVNAFSNFFS GPIVVHCSAG VGRTGTYIGI DAMLEGLEAE GKVDVYGYVV KLRRQRCLMV 850 860 870 880 890 900 QVEAQYILIH QALVEYNQFG ETQVNLSELH SCLHNMKKRD PPSDPSPREA EYQRLPSYRS 910 920 930 940 950 960 WRTQHIGNQG ENKKKKRNSN VVPYDFNRVP LKHELEMSKE SEPESDESSD DDSDSEETSK 970 980 990 1000 1010 1020 YINASFVMSY WKPEMMIAAQ GPLKETIGDF WQMIFQRKVK VIVMLTELVN GDQEVCAQYW 1030 1040 1050 1060 1070 1080 GEGKQTYGDM EVEMKDTNRA SAYTLRTFEL RHSKRKEPRT VYQYQCTTWK GEELPAEPKD 1090 1100 1110 1120 1130 1140 LVSMIQDLKQ KLPKASPEGM KYHKHASILV HCRDGSQQTG LFCALFNLLE SAETEDVVDV 1150 1160 1170 1180 1190 1200 FQVVKSLRKA RPGVVCSYEQ YQFLYDIIAS IYPAQNGQVK KTNSQDKIEF HNEVDGGKQD 1210 1220 1230 1240 ANCVRPDGPL NKAQEDSRGV GTPEPTNSAE EPEHAANGSA SPAPTQSS
	Isoform 3. Checksum: B4D956B4E32EA812	FASTA	1,152	130,422
	10 20 30 40 50 60 MGLWLKLLAF GFALLDTEVF VTGQTPTPSD GASLTTLTPS TLGLASTDPP STTIATTTKQ 70 80 90 100 110 120 TCAAMFGNIT VNYTYESSNQ TFKADLKDVQ NAKCGNEDCE NVLNNLEECS QIKNISVSND 130 140 150 160 170 180 SCAPATTIDL YVPPGTDKFS LHDCTPKEKA NTSICLEWKT KNLDFRKCNS DNISYVLHCE 190 200 210 220 230 240 PENNTKCIRR NTFIPERCQL DNLRAQTNYT CVAEILYRGV KLVKNVINVQ TDLGIPETPK 250 260 270 280 290 300 PSCGDPAARK TLVSWPEPVS KPESASKPHG YVLCYKNNSE KCKSLPNNVT SFEVESLKPY 310 320 330 340 350 360 KYYEVSLLAY VNGKIQRNGT AEKCNFHTKA DRPDKVNGMK TSRPTDNSIN VTCGPPYETN 370 380 390 400 410 420 GPKTFYILVV RSGGSFVTNT TKTNCQFYGD NLYYSTDYEF LVSFHNGVYE GDSVIRSEST 430 440 450 460 470 480 NFNAKALIIF LVFLIIVTSI ALLVVLYKSY DLRKKRSSNL DEQQELVERD DEKQLMDVEP 490 500 510 520 530 540 IHSDILLETY KRKIADEGRL FLAEFQSIPR VFSKFPIKDA RKPHNQNKNR YVDILPYDYN 550 560 570 580 590 600 RVELSEINGD AGSTYINASY IDGFKEPRKY IAAQGPRDET VDDFWRMIWE QKATVIVMVT 610 620 630 640 650 660 RCEEGNRNKC AEYWPSMEEG TRAFKDIVVT INDHKRCPDY IIQKLNVAHK KEKATGREVT 670 680 690 700 710 720 HIQFTSWPDH GVPEDPHLLL KLRRRVNAFS NFFSGPIVVH CSAGVGRTGT YIGIDAMLEG 730 740 750 760 770 780 LEAEGKVDVY GYVVKLRRQR CLMVQVEAQY ILIHQALVEY NQFGETQVNL SELHSCLHNM 790 800 810 820 830 840 KKRDPPSDPS PREAEYQRLP SYRSWRTQHI GNQGENKKKK RNSNVVPYDF NRVPLKHELE 850 860 870 880 890 900 MSKESEPESD ESSDDDSDSE ETSKYINASF VMSYWKPEMM IAAQGPLKET IGDFWQMIFQ 910 920 930 940 950 960 RKVKVIVMLT ELVNGDQEVC AQYWGEGKQT YGDMEVEMKD TNRASAYTLR TFELRHSKRK 970 980 990 1000 1010 1020 EPRTVYQYQC TTWKGEELPA EPKDLVSMIQ DLKQKLPKAS PEGMKYHKHA SILVHCRDGS 1030 1040 1050 1060 1070 1080 QQTGLFCALF NLLESAETED VVDVFQVVKS LRKARPGVVC SYEQYQFLYD IIASIYPAQN 1090 1100 1110 1120 1130 1140 GQVKKTNSQD KIEFHNEVDG GKQDANCVRP DGPLNKAQED SRGVGTPEPT NSAEEPEHAA 1150 NGSASPAPTQ SS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequences of Ly-5 cDNA: isoform-related diversity of Ly-5 mRNA." Saga Y., Tung J.-S., Shen F.-W., Boyse E.A. Proc. Natl. Acad. Sci. U.S.A. 83:6940-6944(1986) [PubMed: 2944116] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[2]	Erratum Saga Y., Tung J.-S., Shen F.-W., Boyse E.A. Proc. Natl. Acad. Sci. U.S.A. 84:1991-1991(1987) Cited for: SEQUENCE REVISION.
[3]	"Comparison of mouse Ly5a and Ly5b leucocyte common antigen alleles." Zebedee S.L., Barritt D.S., Raschke W.C. Dev. Immunol. 1:243-254(1991) [PubMed: 1822988] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: BALB/c.
[4]	"Alternative use of 5' exons in the specification of Ly-5 isoforms distinguishing hematopoietic cell lineages." Saga Y., Tung J.-S., Shen F.-W.W., Boyse E.A. Proc. Natl. Acad. Sci. U.S.A. 84:5364-5368(1987) [PubMed: 3037546] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 1-226 (ISOFORM 2).
[5]	"Organization of the Ly-5 gene." Saga Y., Tung J.-S., Shen F.-W.W., Pancoast T.C., Boyse E.A. Mol. Cell. Biol. 8:4889-4895(1988) [PubMed: 3211131] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
[6]	"Sequence conservation in potential regulatory regions of the mouse and human leukocyte common antigen gene." Johnson N.A., Meyer C.M., Pingel J.T., Thomas M.L. J. Biol. Chem. 264:6220-6229(1989) [PubMed: 2522930] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
[7]	"Cloning of Ly-5 cDNA." Shen F.-W., Saga Y., Litman G., Freeman G., Tung J.-S., Cantor H., Boyse E.A. Proc. Natl. Acad. Sci. U.S.A. 82:7360-7363(1985) [PubMed: 3864163] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-263 (ISOFORM 3). Tissue: T-cell.
[8]	"Structural features of Ly-5 glycoproteins of the mouse and counterparts in other mammals." Tung J.-S., Saga Y., Boyse E.A. Immunogenetics 28:271-277(1988) [PubMed: 3417340] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-73.
[9]	"Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification." Yi T., Cleveland J.L., Ihle J.N. Blood 78:2222-2228(1991) [PubMed: 1932742] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 730-838.
[10]	"Cloned murine T200 (Ly-5) cDNA reveals multiple transcripts within B- and T-lymphocyte lineages." Raschke W.C. Proc. Natl. Acad. Sci. U.S.A. 84:161-165(1987) [PubMed: 2948186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 961-1291.
[11]	"High sequence conservation between rat (T200) and mouse (Ly-5) leukocyte common antigens." Gonez L.J., Walker I.D., Sandrin M.S., McKenzie I.F. Immunogenetics 25:263-266(1987) [PubMed: 3570377] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE.
[12]	"Identification of the CD45-associated 116-kDa and 80-kDa proteins as the alpha- and beta-subunits of alpha-glucosidase II." Arendt C.W., Ostergaard H.L. J. Biol. Chem. 272:13117-13125(1997) [PubMed: 9148925] [Abstract] Cited for: INTERACTION WITH GANAB AND PRKCSH.
[13]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed: 18973353] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-962, MASS SPECTROMETRY.
[14]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed: 19144319] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-940 AND SER-962, MASS SPECTROMETRY. Tissue: Macrophage.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M14342 mRNA. Translation: AAA39458.1. M92933 mRNA. Translation: AAA39459.1. M17320 mRNA. Translation: AAA60449.1. M22456 Genomic DNA. Translation: AAB46374.1. M11934 mRNA. Translation: AAA39461.1. M23241 Genomic DNA. Translation: AAA39460.1. Different initiation. M15174 mRNA. Translation: AAA40161.1. M23354 Genomic DNA. Translation: AAA39462.1. Different initiation.
IPI	IPI00126092. IPI00128856. IPI00461132.
PIR	A23329. A28334. A28335. I57644.
UniGene	Mm.391573
3D structure databases
HSSP	HSSP built from PDB template 1YFO based on UniProtKB P18052.
SMR	P06800. Positions 612-1219.
ModBase	Search...
Protein-protein interaction databases
STRING	P06800.
PTM databases
PhosphoSite	P06800.
Proteomic databases
PRIDE	P06800.
Genome annotation databases
Ensembl	ENSMUST00000027645; ENSMUSP00000027645; ENSMUSG00000026395; Mus musculus. [Genome view] ENSMUST00000074797; ENSMUSP00000074352; ENSMUSG00000026395; Mus musculus. [Genome view] ENSMUST00000081416; ENSMUSP00000080145; ENSMUSG00000026395; Mus musculus. [Genome view] ENSMUST00000112036; ENSMUSP00000107667; ENSMUSG00000026395; Mus musculus. [Genome view] ENSMUST00000112038; ENSMUSP00000107669; ENSMUSG00000026395; Mus musculus. [Genome view]
UCSC	uc007cvg.1. mouse. uc007cvh.1. mouse.
Organism-specific databases
MGI	MGI:97810. Ptprc.
Phylogenomic databases
HOVERGEN	P06800.
Enzyme and pathway databases
BRENDA	3.1.3.48. 244.
Gene expression databases
ArrayExpress	P06800.
Bgee	P06800.
CleanEx	MM_PTPRC.
Genevestigator	P06800.
GermOnline	ENSMUSG00000026395. Mus musculus.
Family and domain databases
InterPro	IPR000387. Dual-sp/Tyr_phosphatase. IPR008957. Fibronectin_typ-III-like_fold. IPR003961. FN_III. IPR016335. Leukocyte_common_Ag. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Gene3D	G3DSA:2.60.40.30. FN_III-like. 1 hit.
Pfam	PF00102. Y_phosphatase. 2 hits. [Graphical view]
PIRSF	PIRSF002004. Leukocyte_common_antigen. 1 hit.
PRINTS	PR00700. PRTYPHPHTASE.
SMART	SM00060. FN3. 2 hits. SM00194. PTPc. 2 hits. [Graphical view]
PROSITE	PS50853. FN3. 2 hits. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 2 hits. PS50055. TYR_PHOSPHATASE_PTP. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

CD45_MOUSE

Accession

Primary (citable) accession number: P06800
Secondary accession number(s): Q61812 , Q61813, Q61814, Q61815, Q78EF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 4, 2005
Last modified:	October 13, 2009
This is version 104 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)