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Protein

Homeobox protein Hox-A4

Gene

Hoxa4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi180 – 239HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • multicellular organism development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A4
Alternative name(s):
Homeobox protein Hox-1.4
Homeobox protein MH-3
Gene namesi
Name:Hoxa4
Synonyms:Hox-1.4, Hoxa-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96176. Hoxa4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Overexpression results in abnormal gut development (megacolon).

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000491 – 285Homeobox protein Hox-A4Add BLAST285

Proteomic databases

MaxQBiP06798.
PaxDbiP06798.
PeptideAtlasiP06798.
PRIDEiP06798.

PTM databases

PhosphoSitePlusiP06798.

Expressioni

Developmental stagei

During development of the prepuberal testis high levels of HOXA4 transcripts were found at days 17, 24 and 30. The first day of HOXA4 expression was day 14. The activation of the HOXA4 gene in male germ cells seems to occur at the pachytene stage of meiotic prophase and its level of expression is stage-specific during embryogenesis.

Gene expression databases

BgeeiENSMUSG00000000942.
CleanExiMM_HOXA4.

Interactioni

Protein-protein interaction databases

BioGridi200369. 1 interactor.
STRINGi10090.ENSMUSP00000098943.

Structurei

3D structure databases

ProteinModelPortaliP06798.
SMRiP06798.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi159 – 164Antp-type hexapeptide6

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiP06798.
KOiK09304.
PhylomeDBiP06798.
TreeFamiTF352857.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMSSFLINS NYIEPKFPPF EEFAPHGGPG GGDGAVGGGP GYPRPQSAPH
60 70 80 90 100
LPAPNPHAAR QPPAYYAPRA REPSYPGGLY PAPAAACPYA CRGASPGRPE
110 120 130 140 150
QSPAPGAHPS PAPQPPVPLG HCAPGPTTPA VATGGSAPAC PLLLADQGPA
160 170 180 190 200
GPKGKEPVVY PWMKKIHVSA VNSSYNGGEP KRSRTAYTRQ QVLELEKEFH
210 220 230 240 250
FNRYLTRRRR IEIAHTLCLS ERQVKIWFQN RRMKWKKDHK LPNTKMRSSN
260 270 280
TASAPAGPPG KAQTHSPHHH PHPLPGASTP IPSSI
Length:285
Mass (Da):30,468
Last modified:July 15, 1999 - v4
Checksum:i475D48D6C6302A26
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97G → A in BAC36181 (PubMed:16141072).Curated1
Sequence conflicti97G → A in CAA47330 (PubMed:2576648).Curated1
Sequence conflicti117 – 120VPLG → APPR in BAC36181 (PubMed:16141072).Curated4
Sequence conflicti181K → E in CAA35228 (PubMed:1686835).Curated1
Sequence conflicti181K → E in AAA37831 (PubMed:3726554).Curated1
Sequence conflicti210Missing in AAA37831 (PubMed:3726554).Curated1
Sequence conflicti269H → P (PubMed:7909702).Curated1
Sequence conflicti269H → P (PubMed:7901228).Curated1
Sequence conflicti269H → P in BAC36181 (PubMed:16141072).Curated1
Sequence conflicti272 – 273HP → PE (PubMed:3726554).Curated2
Sequence conflicti279 – 285TPIPSSI → HPFPPPYNLETWISFSHLCA LLISAPVLICSSLSKPETPK QNPTCWKP in CAA31889 (PubMed:1686835).Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S70444 Genomic DNA. Translation: AAB30705.2.
S67058 Genomic DNA. Translation: AAB28662.2.
AK076098 mRNA. Translation: BAC36181.1.
X66861 Genomic DNA. Translation: CAA47330.1.
X13538 mRNA. Translation: CAA31889.1.
X17346 Genomic DNA. Translation: CAA35228.1.
M27432 mRNA. Translation: AAA16440.1.
M13813 mRNA. Translation: AAA37831.1.
CCDSiCCDS20142.1.
PIRiA43556.
RefSeqiNP_032291.1. NM_008265.3.
UniGeneiMm.439647.

Genome annotation databases

GeneIDi15401.
KEGGimmu:15401.
UCSCiuc009byf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S70444 Genomic DNA. Translation: AAB30705.2.
S67058 Genomic DNA. Translation: AAB28662.2.
AK076098 mRNA. Translation: BAC36181.1.
X66861 Genomic DNA. Translation: CAA47330.1.
X13538 mRNA. Translation: CAA31889.1.
X17346 Genomic DNA. Translation: CAA35228.1.
M27432 mRNA. Translation: AAA16440.1.
M13813 mRNA. Translation: AAA37831.1.
CCDSiCCDS20142.1.
PIRiA43556.
RefSeqiNP_032291.1. NM_008265.3.
UniGeneiMm.439647.

3D structure databases

ProteinModelPortaliP06798.
SMRiP06798.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200369. 1 interactor.
STRINGi10090.ENSMUSP00000098943.

PTM databases

PhosphoSitePlusiP06798.

Proteomic databases

MaxQBiP06798.
PaxDbiP06798.
PeptideAtlasiP06798.
PRIDEiP06798.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15401.
KEGGimmu:15401.
UCSCiuc009byf.1. mouse.

Organism-specific databases

CTDi3201.
MGIiMGI:96176. Hoxa4.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiP06798.
KOiK09304.
PhylomeDBiP06798.
TreeFamiTF352857.

Enzyme and pathway databases

ReactomeiR-MMU-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.

Miscellaneous databases

PROiP06798.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000942.
CleanExiMM_HOXA4.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXA4_MOUSE
AccessioniPrimary (citable) accession number: P06798
Secondary accession number(s): Q61684, Q64388, Q8BPE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: July 15, 1999
Last modified: November 2, 2016
This is version 164 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.