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P06798

- HXA4_MOUSE

UniProt

P06798 - HXA4_MOUSE

Protein

Homeobox protein Hox-A4

Gene

Hoxa4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 4 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi180 – 23960HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. embryonic skeletal system morphogenesis Source: MGI
    3. multicellular organismal development Source: MGI
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-A4
    Alternative name(s):
    Homeobox protein Hox-1.4
    Homeobox protein MH-3
    Gene namesi
    Name:Hoxa4
    Synonyms:Hox-1.4, Hoxa-4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:96176. Hoxa4.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Overexpression results in abnormal gut development (megacolon).

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 285285Homeobox protein Hox-A4PRO_0000200049Add
    BLAST

    Proteomic databases

    PaxDbiP06798.
    PRIDEiP06798.

    PTM databases

    PhosphoSiteiP06798.

    Expressioni

    Developmental stagei

    During development of the prepuberal testis high levels of HOXA4 transcripts were found at days 17, 24 and 30. The first day of HOXA4 expression was day 14. The activation of the HOXA4 gene in male germ cells seems to occur at the pachytene stage of meiotic prophase and its level of expression is stage-specific during embryogenesis.

    Gene expression databases

    BgeeiP06798.
    CleanExiMM_HOXA4.
    GenevestigatoriP06798.

    Interactioni

    Protein-protein interaction databases

    BioGridi200369. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP06798.
    SMRiP06798. Positions 153-240.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi159 – 1646Antp-type hexapeptide

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG257177.
    GeneTreeiENSGT00750000117269.
    HOGENOMiHOG000231179.
    HOVERGENiHBG016849.
    InParanoidiP06798.
    KOiK09304.
    OrthoDBiEOG780RP4.
    PhylomeDBiP06798.
    TreeFamiTF352857.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P06798-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMSSFLINS NYIEPKFPPF EEFAPHGGPG GGDGAVGGGP GYPRPQSAPH    50
    LPAPNPHAAR QPPAYYAPRA REPSYPGGLY PAPAAACPYA CRGASPGRPE 100
    QSPAPGAHPS PAPQPPVPLG HCAPGPTTPA VATGGSAPAC PLLLADQGPA 150
    GPKGKEPVVY PWMKKIHVSA VNSSYNGGEP KRSRTAYTRQ QVLELEKEFH 200
    FNRYLTRRRR IEIAHTLCLS ERQVKIWFQN RRMKWKKDHK LPNTKMRSSN 250
    TASAPAGPPG KAQTHSPHHH PHPLPGASTP IPSSI 285
    Length:285
    Mass (Da):30,468
    Last modified:July 15, 1999 - v4
    Checksum:i475D48D6C6302A26
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti97 – 971G → A in BAC36181. (PubMed:16141072)Curated
    Sequence conflicti97 – 971G → A in CAA47330. (PubMed:2576648)Curated
    Sequence conflicti117 – 1204VPLG → APPR in BAC36181. (PubMed:16141072)Curated
    Sequence conflicti181 – 1811K → E in CAA35228. (PubMed:1686835)Curated
    Sequence conflicti181 – 1811K → E in AAA37831. (PubMed:3726554)Curated
    Sequence conflicti210 – 2101Missing in AAA37831. (PubMed:3726554)Curated
    Sequence conflicti269 – 2691H → P(PubMed:7909702)Curated
    Sequence conflicti269 – 2691H → P(PubMed:7901228)Curated
    Sequence conflicti269 – 2691H → P in BAC36181. (PubMed:16141072)Curated
    Sequence conflicti272 – 2732HP → PE(PubMed:3726554)Curated
    Sequence conflicti279 – 2857TPIPSSI → HPFPPPYNLETWISFSHLCA LLISAPVLICSSLSKPETPK QNPTCWKP in CAA31889. (PubMed:1686835)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S70444 Genomic DNA. Translation: AAB30705.2.
    S67058 Genomic DNA. Translation: AAB28662.2.
    AK076098 mRNA. Translation: BAC36181.1.
    X66861 Genomic DNA. Translation: CAA47330.1.
    X13538 mRNA. Translation: CAA31889.1.
    X17346 Genomic DNA. Translation: CAA35228.1.
    M27432 mRNA. Translation: AAA16440.1.
    M13813 mRNA. Translation: AAA37831.1.
    CCDSiCCDS20142.1.
    PIRiA43556.
    RefSeqiNP_032291.1. NM_008265.3.
    UniGeneiMm.439647.

    Genome annotation databases

    EnsembliENSMUST00000101395; ENSMUSP00000098943; ENSMUSG00000000942.
    GeneIDi15401.
    KEGGimmu:15401.
    UCSCiuc009byf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S70444 Genomic DNA. Translation: AAB30705.2 .
    S67058 Genomic DNA. Translation: AAB28662.2 .
    AK076098 mRNA. Translation: BAC36181.1 .
    X66861 Genomic DNA. Translation: CAA47330.1 .
    X13538 mRNA. Translation: CAA31889.1 .
    X17346 Genomic DNA. Translation: CAA35228.1 .
    M27432 mRNA. Translation: AAA16440.1 .
    M13813 mRNA. Translation: AAA37831.1 .
    CCDSi CCDS20142.1.
    PIRi A43556.
    RefSeqi NP_032291.1. NM_008265.3.
    UniGenei Mm.439647.

    3D structure databases

    ProteinModelPortali P06798.
    SMRi P06798. Positions 153-240.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200369. 1 interaction.

    PTM databases

    PhosphoSitei P06798.

    Proteomic databases

    PaxDbi P06798.
    PRIDEi P06798.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000101395 ; ENSMUSP00000098943 ; ENSMUSG00000000942 .
    GeneIDi 15401.
    KEGGi mmu:15401.
    UCSCi uc009byf.1. mouse.

    Organism-specific databases

    CTDi 3201.
    MGIi MGI:96176. Hoxa4.

    Phylogenomic databases

    eggNOGi NOG257177.
    GeneTreei ENSGT00750000117269.
    HOGENOMi HOG000231179.
    HOVERGENi HBG016849.
    InParanoidi P06798.
    KOi K09304.
    OrthoDBi EOG780RP4.
    PhylomeDBi P06798.
    TreeFami TF352857.

    Miscellaneous databases

    NextBioi 288098.
    PROi P06798.
    SOURCEi Search...

    Gene expression databases

    Bgeei P06798.
    CleanExi MM_HOXA4.
    Genevestigatori P06798.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multiple levels of regulation exist for expression of the Hoxa-4 (Hox-1.4) gene in the mouse testis."
      Viviano C.M., Galliot B., Wolgemuth D.J.
      Cell. Mol. Biol. Res. 39:483-495(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Protein product of the somatic-type transcript of the Hoxa-4 (Hox-1.4) gene binds to homeobox consensus binding sites in its promoter and intron."
      Wu K., Wolgemuth D.J.
      J. Cell. Biochem. 52:449-462(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    4. "The mouse Hox-1.4 gene: primary structure, evidence for promoter activity and expression during development."
      Galliot B., Dolle P., Vigneron M., Featherstone M.S., Baron A., Duboule D.
      Development 107:343-359(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-170.
    5. "Murine embryonic spinal cord and adult testis Hox-1.4 cDNAs are identical 3' to the homeo box."
      Rubin M.R., Nguyen-Huu M.C.
      DNA Seq. 1:329-334(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 171-199, NUCLEOTIDE SEQUENCE [MRNA] OF 180-285.
      Strain: ICR.
      Tissue: Spinal cord and Testis.
    6. "Differential expression of the c-abl proto-oncogene and the homeo box-containing gene Hox 1.4 during mouse spermatogenesis."
      Duggal R.N., Zakeri Z.F., Ponzetto C., Wolgemuth D.J.
      Ann. N. Y. Acad. Sci. 513:112-127(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 180-285.
    7. "A mouse homeo box gene is expressed in spermatocytes and embryos."
      Rubin M.R., Toth L.E., Patel M.D., D'Eustachio P., Nguyen-Huu M.C.
      Science 233:663-667(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 180-273.
    8. "Isolation of a mouse cDNA coding for a developmentally regulated, testis-specific transcript containing homeo box homology."
      Wolgemuth D.J., Engelmyer E., Duggal R.N., Gizang-Ginsberg E., Mutter G.L., Ponzetto C., Viviano C., Zakeri Z.F.
      EMBO J. 5:1229-1235(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 198-271.
    9. "Transgenic mice overexpressing the mouse homoeobox-containing gene Hox-1.4 exhibit abnormal gut development."
      Wolgemuth D.J., Behringer R.R., Mostoller M.P., Brinster R.L., Palmiter R.D.
      Nature 337:464-467(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: RESULTS OF OVEREXPRESSION.

    Entry informationi

    Entry nameiHXA4_MOUSE
    AccessioniPrimary (citable) accession number: P06798
    Secondary accession number(s): Q61684, Q64388, Q8BPE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 150 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3