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P06798

- HXA4_MOUSE

UniProt

P06798 - HXA4_MOUSE

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Protein

Homeobox protein Hox-A4

Gene
Hoxa4, Hox-1.4, Hoxa-4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi180 – 23960HomeoboxAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. embryonic skeletal system morphogenesis Source: MGI
  3. multicellular organismal development Source: MGI
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A4
Alternative name(s):
Homeobox protein Hox-1.4
Homeobox protein MH-3
Gene namesi
Name:Hoxa4
Synonyms:Hox-1.4, Hoxa-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:96176. Hoxa4.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Overexpression results in abnormal gut development (megacolon).

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Homeobox protein Hox-A4PRO_0000200049Add
BLAST

Proteomic databases

PaxDbiP06798.
PRIDEiP06798.

PTM databases

PhosphoSiteiP06798.

Expressioni

Developmental stagei

During development of the prepuberal testis high levels of HOXA4 transcripts were found at days 17, 24 and 30. The first day of HOXA4 expression was day 14. The activation of the HOXA4 gene in male germ cells seems to occur at the pachytene stage of meiotic prophase and its level of expression is stage-specific during embryogenesis.

Gene expression databases

BgeeiP06798.
CleanExiMM_HOXA4.
GenevestigatoriP06798.

Interactioni

Protein-protein interaction databases

BioGridi200369. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP06798.
SMRiP06798. Positions 153-240.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi159 – 1646Antp-type hexapeptide

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG257177.
GeneTreeiENSGT00750000117269.
HOGENOMiHOG000231179.
HOVERGENiHBG016849.
InParanoidiP06798.
KOiK09304.
OrthoDBiEOG780RP4.
PhylomeDBiP06798.
TreeFamiTF352857.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06798-1 [UniParc]FASTAAdd to Basket

« Hide

MTMSSFLINS NYIEPKFPPF EEFAPHGGPG GGDGAVGGGP GYPRPQSAPH    50
LPAPNPHAAR QPPAYYAPRA REPSYPGGLY PAPAAACPYA CRGASPGRPE 100
QSPAPGAHPS PAPQPPVPLG HCAPGPTTPA VATGGSAPAC PLLLADQGPA 150
GPKGKEPVVY PWMKKIHVSA VNSSYNGGEP KRSRTAYTRQ QVLELEKEFH 200
FNRYLTRRRR IEIAHTLCLS ERQVKIWFQN RRMKWKKDHK LPNTKMRSSN 250
TASAPAGPPG KAQTHSPHHH PHPLPGASTP IPSSI 285
Length:285
Mass (Da):30,468
Last modified:July 15, 1999 - v4
Checksum:i475D48D6C6302A26
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971G → A in BAC36181. 1 Publication
Sequence conflicti97 – 971G → A in CAA47330. 1 Publication
Sequence conflicti117 – 1204VPLG → APPR in BAC36181. 1 Publication
Sequence conflicti181 – 1811K → E in CAA35228. 1 Publication
Sequence conflicti181 – 1811K → E in AAA37831. 1 Publication
Sequence conflicti210 – 2101Missing in AAA37831. 1 Publication
Sequence conflicti269 – 2691H → P1 Publication
Sequence conflicti269 – 2691H → P1 Publication
Sequence conflicti269 – 2691H → P in BAC36181. 1 Publication
Sequence conflicti272 – 2732HP → PE1 Publication
Sequence conflicti279 – 2857TPIPSSI → HPFPPPYNLETWISFSHLCA LLISAPVLICSSLSKPETPK QNPTCWKP in CAA31889. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S70444 Genomic DNA. Translation: AAB30705.2.
S67058 Genomic DNA. Translation: AAB28662.2.
AK076098 mRNA. Translation: BAC36181.1.
X66861 Genomic DNA. Translation: CAA47330.1.
X13538 mRNA. Translation: CAA31889.1.
X17346 Genomic DNA. Translation: CAA35228.1.
M27432 mRNA. Translation: AAA16440.1.
M13813 mRNA. Translation: AAA37831.1.
CCDSiCCDS20142.1.
PIRiA43556.
RefSeqiNP_032291.1. NM_008265.3.
UniGeneiMm.439647.

Genome annotation databases

EnsembliENSMUST00000101395; ENSMUSP00000098943; ENSMUSG00000000942.
GeneIDi15401.
KEGGimmu:15401.
UCSCiuc009byf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S70444 Genomic DNA. Translation: AAB30705.2 .
S67058 Genomic DNA. Translation: AAB28662.2 .
AK076098 mRNA. Translation: BAC36181.1 .
X66861 Genomic DNA. Translation: CAA47330.1 .
X13538 mRNA. Translation: CAA31889.1 .
X17346 Genomic DNA. Translation: CAA35228.1 .
M27432 mRNA. Translation: AAA16440.1 .
M13813 mRNA. Translation: AAA37831.1 .
CCDSi CCDS20142.1.
PIRi A43556.
RefSeqi NP_032291.1. NM_008265.3.
UniGenei Mm.439647.

3D structure databases

ProteinModelPortali P06798.
SMRi P06798. Positions 153-240.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200369. 1 interaction.

PTM databases

PhosphoSitei P06798.

Proteomic databases

PaxDbi P06798.
PRIDEi P06798.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000101395 ; ENSMUSP00000098943 ; ENSMUSG00000000942 .
GeneIDi 15401.
KEGGi mmu:15401.
UCSCi uc009byf.1. mouse.

Organism-specific databases

CTDi 3201.
MGIi MGI:96176. Hoxa4.

Phylogenomic databases

eggNOGi NOG257177.
GeneTreei ENSGT00750000117269.
HOGENOMi HOG000231179.
HOVERGENi HBG016849.
InParanoidi P06798.
KOi K09304.
OrthoDBi EOG780RP4.
PhylomeDBi P06798.
TreeFami TF352857.

Miscellaneous databases

NextBioi 288098.
PROi P06798.
SOURCEi Search...

Gene expression databases

Bgeei P06798.
CleanExi MM_HOXA4.
Genevestigatori P06798.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Multiple levels of regulation exist for expression of the Hoxa-4 (Hox-1.4) gene in the mouse testis."
    Viviano C.M., Galliot B., Wolgemuth D.J.
    Cell. Mol. Biol. Res. 39:483-495(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Protein product of the somatic-type transcript of the Hoxa-4 (Hox-1.4) gene binds to homeobox consensus binding sites in its promoter and intron."
    Wu K., Wolgemuth D.J.
    J. Cell. Biochem. 52:449-462(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  4. "The mouse Hox-1.4 gene: primary structure, evidence for promoter activity and expression during development."
    Galliot B., Dolle P., Vigneron M., Featherstone M.S., Baron A., Duboule D.
    Development 107:343-359(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-170.
  5. "Murine embryonic spinal cord and adult testis Hox-1.4 cDNAs are identical 3' to the homeo box."
    Rubin M.R., Nguyen-Huu M.C.
    DNA Seq. 1:329-334(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 171-199, NUCLEOTIDE SEQUENCE [MRNA] OF 180-285.
    Strain: ICR.
    Tissue: Spinal cord and Testis.
  6. "Differential expression of the c-abl proto-oncogene and the homeo box-containing gene Hox 1.4 during mouse spermatogenesis."
    Duggal R.N., Zakeri Z.F., Ponzetto C., Wolgemuth D.J.
    Ann. N. Y. Acad. Sci. 513:112-127(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 180-285.
  7. "A mouse homeo box gene is expressed in spermatocytes and embryos."
    Rubin M.R., Toth L.E., Patel M.D., D'Eustachio P., Nguyen-Huu M.C.
    Science 233:663-667(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 180-273.
  8. "Isolation of a mouse cDNA coding for a developmentally regulated, testis-specific transcript containing homeo box homology."
    Wolgemuth D.J., Engelmyer E., Duggal R.N., Gizang-Ginsberg E., Mutter G.L., Ponzetto C., Viviano C., Zakeri Z.F.
    EMBO J. 5:1229-1235(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 198-271.
  9. "Transgenic mice overexpressing the mouse homoeobox-containing gene Hox-1.4 exhibit abnormal gut development."
    Wolgemuth D.J., Behringer R.R., Mostoller M.P., Brinster R.L., Palmiter R.D.
    Nature 337:464-467(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: RESULTS OF OVEREXPRESSION.

Entry informationi

Entry nameiHXA4_MOUSE
AccessioniPrimary (citable) accession number: P06798
Secondary accession number(s): Q61684, Q64388, Q8BPE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: July 15, 1999
Last modified: July 9, 2014
This is version 149 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi