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Protein

Kappa-casein

Gene

Csn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.

GO - Biological processi

  • lactation Source: MGI
  • protein stabilization Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-casein
Gene namesi
Name:Csn3
Synonyms:Csn10, Csnk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:107461. Csn3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 181160Kappa-caseinPRO_0000004499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei123 – 1231PhosphothreonineSequence analysis
Glycosylationi134 – 1341O-linked (GalNAc...)By similarity
Glycosylationi144 – 1441O-linked (GalNAc...)By similarity
Glycosylationi155 – 1551O-linked (GalNAc...)By similarity
Modified residuei162 – 1621Phosphoserine; alternateBy similarity
Glycosylationi162 – 1621O-linked (GalNAc...); alternateBy similarity
Modified residuei178 – 1781PhosphoserineBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei118 – 1192Cleavage; by chymosin/rennin

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP06796.
PRIDEiP06796.

PTM databases

PhosphoSiteiP06796.

Miscellaneous databases

PMAP-CutDBP06796.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

CleanExiMM_CSN3.
GenevisibleiP06796. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001667.

Structurei

3D structure databases

ProteinModelPortaliP06796.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the kappa-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCVG. Eukaryota.
ENOG4111E7Q. LUCA.
GeneTreeiENSGT00390000009184.
HOGENOMiHOG000111309.
HOVERGENiHBG005246.
InParanoidiP06796.
KOiK17282.
OMAiIPPKKIQ.
OrthoDBiEOG7MWH09.
TreeFamiTF338369.

Family and domain databases

InterProiIPR000117. Casein_kappa.
[Graphical view]
PANTHERiPTHR11470. PTHR11470. 1 hit.
PfamiPF00997. Casein_kappa. 1 hit.
[Graphical view]
PIRSFiPIRSF002374. Casein_kappa. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06796-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRNFIVVVN ILALTLPFLA AEIQNPDSNC RGEKNDIVYD EQRVLYTPVR
60 70 80 90 100
SVLNFNQYEP NYYHYRPSLP ATASPYMYYP LVVRLLLLRS PAPISKWQSM
110 120 130 140 150
PNFPQSAGVP YAIPNPSFLA MPTNENQDNT AIPTIDPITP IVSTPVPTME
160 170 180
SIVNTVANPE ASTVSINTPE TTTVPVSSTA A
Length:181
Mass (Da):20,030
Last modified:October 3, 2012 - v2
Checksum:i0EBEBF116A147F66
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91V → M in AAA37370 (PubMed:4042811).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10114 mRNA. Translation: AAA37370.1.
AK021350 mRNA. Translation: BAB32382.1.
AK085710 mRNA. Translation: BAC39516.1.
AK142607 mRNA. Translation: BAE25129.1.
AK142673 mRNA. Translation: BAE25155.1.
AK164788 mRNA. Translation: BAE37916.1.
AC022298 Genomic DNA. No translation available.
BC049949 mRNA. Translation: AAH49949.1.
BC050269 mRNA. Translation: AAH50269.1.
CCDSiCCDS19396.1.
PIRiA05080.
RefSeqiNP_031812.2. NM_007786.4.
XP_006534828.1. XM_006534765.2.
UniGeneiMm.296303.

Genome annotation databases

EnsembliENSMUST00000001667; ENSMUSP00000001667; ENSMUSG00000001622.
ENSMUST00000113267; ENSMUSP00000108892; ENSMUSG00000001622.
ENSMUST00000113271; ENSMUSP00000108896; ENSMUSG00000001622.
GeneIDi12994.
KEGGimmu:12994.
UCSCiuc008xzg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10114 mRNA. Translation: AAA37370.1.
AK021350 mRNA. Translation: BAB32382.1.
AK085710 mRNA. Translation: BAC39516.1.
AK142607 mRNA. Translation: BAE25129.1.
AK142673 mRNA. Translation: BAE25155.1.
AK164788 mRNA. Translation: BAE37916.1.
AC022298 Genomic DNA. No translation available.
BC049949 mRNA. Translation: AAH49949.1.
BC050269 mRNA. Translation: AAH50269.1.
CCDSiCCDS19396.1.
PIRiA05080.
RefSeqiNP_031812.2. NM_007786.4.
XP_006534828.1. XM_006534765.2.
UniGeneiMm.296303.

3D structure databases

ProteinModelPortaliP06796.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001667.

PTM databases

PhosphoSiteiP06796.

Proteomic databases

PaxDbiP06796.
PRIDEiP06796.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001667; ENSMUSP00000001667; ENSMUSG00000001622.
ENSMUST00000113267; ENSMUSP00000108892; ENSMUSG00000001622.
ENSMUST00000113271; ENSMUSP00000108896; ENSMUSG00000001622.
GeneIDi12994.
KEGGimmu:12994.
UCSCiuc008xzg.1. mouse.

Organism-specific databases

CTDi1448.
MGIiMGI:107461. Csn3.

Phylogenomic databases

eggNOGiENOG410JCVG. Eukaryota.
ENOG4111E7Q. LUCA.
GeneTreeiENSGT00390000009184.
HOGENOMiHOG000111309.
HOVERGENiHBG005246.
InParanoidiP06796.
KOiK17282.
OMAiIPPKKIQ.
OrthoDBiEOG7MWH09.
TreeFamiTF338369.

Miscellaneous databases

ChiTaRSiCsn3. mouse.
PMAP-CutDBP06796.
PROiP06796.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CSN3.
GenevisibleiP06796. MM.

Family and domain databases

InterProiIPR000117. Casein_kappa.
[Graphical view]
PANTHERiPTHR11470. PTHR11470. 1 hit.
PfamiPF00997. Casein_kappa. 1 hit.
[Graphical view]
PIRSFiPIRSF002374. Casein_kappa. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of mouse mammary gland kappa-casein: comparison with rat kappa-casein and rat and human gamma-fibrinogen."
    Thompson M.D., Dave J.R., Nakhasi H.L.
    DNA 4:263-271(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiCASK_MOUSE
AccessioniPrimary (citable) accession number: P06796
Secondary accession number(s): Q9D1U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.