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Protein

Multidrug resistance protein 1B

Gene

Abcb1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi426 – 433ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1068 – 1075ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-382556. ABC-family proteins mediated transport.
SABIO-RKP06795.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein 1B (EC:3.6.3.44)
Alternative name(s):
ATP-binding cassette sub-family B member 1B
P-glycoprotein 1
CD_antigen: CD243
Gene namesi
Name:Abcb1b
Synonyms:Abcb1, Mdr1, Mdr1b, Pgy1, Pgy1-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:97568. Abcb1b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43CytoplasmicBy similarityAdd BLAST43
Transmembranei44 – 66HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini67 – 115ExtracellularBy similarityAdd BLAST49
Transmembranei116 – 136HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini137 – 185CytoplasmicBy similarityAdd BLAST49
Transmembranei186 – 207HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini208 – 214ExtracellularBy similarity7
Transmembranei215 – 235HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini236 – 293CytoplasmicBy similarityAdd BLAST58
Transmembranei294 – 315HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini316 – 329ExtracellularBy similarityAdd BLAST14
Transmembranei330 – 351HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini352 – 709CytoplasmicBy similarityAdd BLAST358
Transmembranei710 – 730HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini731 – 754ExtracellularBy similarityAdd BLAST24
Transmembranei755 – 775HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini776 – 830CytoplasmicBy similarityAdd BLAST55
Transmembranei831 – 851HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini852ExtracellularBy similarity1
Transmembranei853 – 872HelicalPROSITE-ProRule annotationAdd BLAST20
Topological domaini873 – 932CytoplasmicBy similarityAdd BLAST60
Transmembranei933 – 955HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini956 – 971ExtracellularBy similarityAdd BLAST16
Transmembranei972 – 993HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini994 – 1276CytoplasmicBy similarityAdd BLAST283

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • intercellular canaliculus Source: MGI
  • mitochondrion Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3467.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933341 – 1276Multidrug resistance protein 1BAdd BLAST1276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineBy similarity1
Glycosylationi73N-linked (GlcNAc...)Sequence analysis1
Glycosylationi91N-linked (GlcNAc...)Sequence analysis1
Glycosylationi96N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Modified residuei641PhosphotyrosineCombined sources1
Modified residuei659PhosphoserineCombined sources1

Post-translational modificationi

Several phosphorylated serine residues are present in the linker domain.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP06795.
MaxQBiP06795.
PaxDbiP06795.
PRIDEiP06795.

PTM databases

iPTMnetiP06795.
PhosphoSitePlusiP06795.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028970.
ExpressionAtlasiP06795. baseline and differential.
GenevisibleiP06795. MM.

Interactioni

Subunit structurei

Interacts with PSMB5.By similarity

Protein-protein interaction databases

IntActiP06795. 1 interactor.
MINTiMINT-4101676.
STRINGi10090.ENSMUSP00000009058.

Chemistry databases

BindingDBiP06795.

Structurei

3D structure databases

ProteinModelPortaliP06795.
SMRiP06795.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 356ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST307
Domaini391 – 627ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini709 – 998ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST290
Domaini1033 – 1271ABC transporter 2PROSITE-ProRule annotationAdd BLAST239

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00530000062896.
HOVERGENiHBG080809.
InParanoidiP06795.
KOiK05658.
OMAiMFRYADW.
OrthoDBiEOG091G0HVA.
PhylomeDBiP06795.
TreeFamiTF105193.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFEENLKGR ADKNFSKMGK KSKKEKKEKK PAVGVFGMFR YADWLDKLCM
60 70 80 90 100
ILGTLAAIIH GTLLPLLMLV FGNMTDSFTK AEASILPSIT NQSGPNSTLI
110 120 130 140 150
ISNSSLEEEM AIYAYYYTGI GAGVLIVAYI QVSLWCLAAG RQIHKIRQKF
160 170 180 190 200
FHAIMNQEIG WFDVHDVGEL NTRLTDDVSK INDGIGDKIG MFFQSITTFL
210 220 230 240 250
AGFIIGFISG WKLTLVILAV SPLIGLSSAL WAKVLTSFTN KELQAYAKAG
260 270 280 290 300
AVAEEVLAAI RTVIAFGGQQ KELERYNKNL EEAKNVGIKK AITASISIGI
310 320 330 340 350
AYLLVYASYA LAFWYGTSLV LSNEYSIGEV LTVFFSILLG TFSIGHLAPN
360 370 380 390 400
IEAFANARGA AFEIFKIIDN EPSIDSFSTK GYKPDSIMGN LEFKNVHFNY
410 420 430 440 450
PSRSEVQILK GLNLKVKSGQ TVALVGNSGC GKSTTVQLMQ RLYDPLEGVV
460 470 480 490 500
SIDGQDIRTI NVRYLREIIG VVSQEPVLFA TTIAENIRYG REDVTMDEIE
510 520 530 540 550
KAVKEANAYD FIMKLPHQFD TLVGERGAQL SGGQKQRIAI ARALVRNPKI
560 570 580 590 600
LLLDEATSAL DTESEAVVQA ALDKAREGRT TIVIAHRLST VRNADVIAGF
610 620 630 640 650
DGGVIVEQGN HDELMREKGI YFKLVMTQTR GNEIEPGNNA YGSQSDTDAS
660 670 680 690 700
ELTSEESKSP LIRRSIYRSV HRKQDQERRL SMKEAVDEDV PLVSFWRILN
710 720 730 740 750
LNLSEWPYLL VGVLCAVING CIQPVFAIVF SRIVGVFSRD DDHETKRQNC
760 770 780 790 800
NLFSLFFLVM GLISFVTYFF QGFTFGKAGE ILTKRVRYMV FKSMLRQDIS
810 820 830 840 850
WFDDHKNSTG SLTTRLASDA SSVKGAMGAR LAVVTQNVAN LGTGVILSLV
860 870 880 890 900
YGWQLTLLLV VIIPLIVLGG IIEMKLLSGQ ALKDKKQLEI SGKIATEAIE
910 920 930 940 950
NFRTIVSLTR EQKFETMYAQ SLQVPYRNAM KKAHVFGITF SFTQAMMYFS
960 970 980 990 1000
YAACFRFGAY LVAQQLMTFE NVMLVFSAVV FGAMAAGNTS SFAPDYAKAK
1010 1020 1030 1040 1050
VSASHIIRII EKTPEIDSYS TEGLKPTLLE GNVKFNGVQF NYPTRPNIPV
1060 1070 1080 1090 1100
LQGLSLEVKK GQTLALVGSS GCGKSTVVQL LERFYDPMAG SVFLDGKEIK
1110 1120 1130 1140 1150
QLNVQWLRAH LGIVSQEPIL FDCSIAENIA YGDNSRAVSH EEIVRAAKEA
1160 1170 1180 1190 1200
NIHQFIDSLP DKYNTRVGDK GTQLSGGQKQ RIAIARALVR QPHILLLDEA
1210 1220 1230 1240 1250
TSALDTESEK VVQEALDKAR EGRTCIVIAH RLSTIQNADL IVVIENGKVK
1260 1270
EHGTHQQLLA QKGIYFSMVQ AGAKRS
Length:1,276
Mass (Da):140,994
Last modified:January 1, 1988 - v1
Checksum:i1804D0F011B0FF4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14757 mRNA. Translation: AAA79005.1.
M60348 Genomic DNA. Translation: AAA39513.1.
CCDSiCCDS19085.1.
PIRiA33719. DVMS1.
RefSeqiNP_035205.1. NM_011075.2.
UniGeneiMm.146649.
Mm.389059.

Genome annotation databases

EnsembliENSMUST00000009058; ENSMUSP00000009058; ENSMUSG00000028970.
GeneIDi18669.
KEGGimmu:18669.
UCSCiuc008wko.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14757 mRNA. Translation: AAA79005.1.
M60348 Genomic DNA. Translation: AAA39513.1.
CCDSiCCDS19085.1.
PIRiA33719. DVMS1.
RefSeqiNP_035205.1. NM_011075.2.
UniGeneiMm.146649.
Mm.389059.

3D structure databases

ProteinModelPortaliP06795.
SMRiP06795.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP06795. 1 interactor.
MINTiMINT-4101676.
STRINGi10090.ENSMUSP00000009058.

Chemistry databases

BindingDBiP06795.
ChEMBLiCHEMBL3467.

PTM databases

iPTMnetiP06795.
PhosphoSitePlusiP06795.

Proteomic databases

EPDiP06795.
MaxQBiP06795.
PaxDbiP06795.
PRIDEiP06795.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009058; ENSMUSP00000009058; ENSMUSG00000028970.
GeneIDi18669.
KEGGimmu:18669.
UCSCiuc008wko.2. mouse.

Organism-specific databases

CTDi18669.
MGIiMGI:97568. Abcb1b.

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00530000062896.
HOVERGENiHBG080809.
InParanoidiP06795.
KOiK05658.
OMAiMFRYADW.
OrthoDBiEOG091G0HVA.
PhylomeDBiP06795.
TreeFamiTF105193.

Enzyme and pathway databases

ReactomeiR-MMU-382556. ABC-family proteins mediated transport.
SABIO-RKP06795.

Miscellaneous databases

PROiP06795.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028970.
ExpressionAtlasiP06795. baseline and differential.
GenevisibleiP06795. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMDR1B_MOUSE
AccessioniPrimary (citable) accession number: P06795
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 2, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In mouse the MDR gene family includes three or more related but distinct cellular genes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.