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Protein

Multidrug resistance protein 1B

Gene

Abcb1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi426 – 4338ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1068 – 10758ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-382556. ABC-family proteins mediated transport.
SABIO-RKP06795.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein 1B (EC:3.6.3.44)
Alternative name(s):
ATP-binding cassette sub-family B member 1B
P-glycoprotein 1
CD_antigen: CD243
Gene namesi
Name:Abcb1b
Synonyms:Abcb1, Mdr1, Mdr1b, Pgy1, Pgy1-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:97568. Abcb1b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343CytoplasmicBy similarityAdd
BLAST
Transmembranei44 – 6623HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini67 – 11549ExtracellularBy similarityAdd
BLAST
Transmembranei116 – 13621HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini137 – 18549CytoplasmicBy similarityAdd
BLAST
Transmembranei186 – 20722HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini208 – 2147ExtracellularBy similarity
Transmembranei215 – 23521HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini236 – 29358CytoplasmicBy similarityAdd
BLAST
Transmembranei294 – 31522HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini316 – 32914ExtracellularBy similarityAdd
BLAST
Transmembranei330 – 35122HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini352 – 709358CytoplasmicBy similarityAdd
BLAST
Transmembranei710 – 73021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini731 – 75424ExtracellularBy similarityAdd
BLAST
Transmembranei755 – 77521HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini776 – 83055CytoplasmicBy similarityAdd
BLAST
Transmembranei831 – 85121HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini852 – 8521ExtracellularBy similarity
Transmembranei853 – 87220HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini873 – 93260CytoplasmicBy similarityAdd
BLAST
Transmembranei933 – 95523HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini956 – 97116ExtracellularBy similarityAdd
BLAST
Transmembranei972 – 99322HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini994 – 1276283CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intercellular canaliculus Source: MGI
  • mitochondrion Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2111404.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12761276Multidrug resistance protein 1BPRO_0000093334Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221PhosphoserineBy similarity
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence analysis
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence analysis
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis
Modified residuei641 – 6411PhosphotyrosineCombined sources
Modified residuei659 – 6591PhosphoserineCombined sources

Post-translational modificationi

Several phosphorylated serine residues are present in the linker domain.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP06795.
MaxQBiP06795.
PaxDbiP06795.
PRIDEiP06795.

PTM databases

iPTMnetiP06795.
PhosphoSiteiP06795.

Expressioni

Gene expression databases

BgeeiP06795.
ExpressionAtlasiP06795. baseline and differential.
GenevisibleiP06795. MM.

Interactioni

Subunit structurei

Interacts with PSMB5.By similarity

Protein-protein interaction databases

IntActiP06795. 1 interaction.
MINTiMINT-4101676.
STRINGi10090.ENSMUSP00000009058.

Chemistry

BindingDBiP06795.

Structurei

3D structure databases

ProteinModelPortaliP06795.
SMRiP06795. Positions 30-629.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 356307ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini391 – 627237ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini709 – 998290ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1033 – 1271239ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00530000062896.
HOVERGENiHBG080809.
InParanoidiP06795.
KOiK05658.
OMAiCAVINGC.
OrthoDBiEOG7Z3F4H.
PhylomeDBiP06795.
TreeFamiTF105193.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P06795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFEENLKGR ADKNFSKMGK KSKKEKKEKK PAVGVFGMFR YADWLDKLCM
60 70 80 90 100
ILGTLAAIIH GTLLPLLMLV FGNMTDSFTK AEASILPSIT NQSGPNSTLI
110 120 130 140 150
ISNSSLEEEM AIYAYYYTGI GAGVLIVAYI QVSLWCLAAG RQIHKIRQKF
160 170 180 190 200
FHAIMNQEIG WFDVHDVGEL NTRLTDDVSK INDGIGDKIG MFFQSITTFL
210 220 230 240 250
AGFIIGFISG WKLTLVILAV SPLIGLSSAL WAKVLTSFTN KELQAYAKAG
260 270 280 290 300
AVAEEVLAAI RTVIAFGGQQ KELERYNKNL EEAKNVGIKK AITASISIGI
310 320 330 340 350
AYLLVYASYA LAFWYGTSLV LSNEYSIGEV LTVFFSILLG TFSIGHLAPN
360 370 380 390 400
IEAFANARGA AFEIFKIIDN EPSIDSFSTK GYKPDSIMGN LEFKNVHFNY
410 420 430 440 450
PSRSEVQILK GLNLKVKSGQ TVALVGNSGC GKSTTVQLMQ RLYDPLEGVV
460 470 480 490 500
SIDGQDIRTI NVRYLREIIG VVSQEPVLFA TTIAENIRYG REDVTMDEIE
510 520 530 540 550
KAVKEANAYD FIMKLPHQFD TLVGERGAQL SGGQKQRIAI ARALVRNPKI
560 570 580 590 600
LLLDEATSAL DTESEAVVQA ALDKAREGRT TIVIAHRLST VRNADVIAGF
610 620 630 640 650
DGGVIVEQGN HDELMREKGI YFKLVMTQTR GNEIEPGNNA YGSQSDTDAS
660 670 680 690 700
ELTSEESKSP LIRRSIYRSV HRKQDQERRL SMKEAVDEDV PLVSFWRILN
710 720 730 740 750
LNLSEWPYLL VGVLCAVING CIQPVFAIVF SRIVGVFSRD DDHETKRQNC
760 770 780 790 800
NLFSLFFLVM GLISFVTYFF QGFTFGKAGE ILTKRVRYMV FKSMLRQDIS
810 820 830 840 850
WFDDHKNSTG SLTTRLASDA SSVKGAMGAR LAVVTQNVAN LGTGVILSLV
860 870 880 890 900
YGWQLTLLLV VIIPLIVLGG IIEMKLLSGQ ALKDKKQLEI SGKIATEAIE
910 920 930 940 950
NFRTIVSLTR EQKFETMYAQ SLQVPYRNAM KKAHVFGITF SFTQAMMYFS
960 970 980 990 1000
YAACFRFGAY LVAQQLMTFE NVMLVFSAVV FGAMAAGNTS SFAPDYAKAK
1010 1020 1030 1040 1050
VSASHIIRII EKTPEIDSYS TEGLKPTLLE GNVKFNGVQF NYPTRPNIPV
1060 1070 1080 1090 1100
LQGLSLEVKK GQTLALVGSS GCGKSTVVQL LERFYDPMAG SVFLDGKEIK
1110 1120 1130 1140 1150
QLNVQWLRAH LGIVSQEPIL FDCSIAENIA YGDNSRAVSH EEIVRAAKEA
1160 1170 1180 1190 1200
NIHQFIDSLP DKYNTRVGDK GTQLSGGQKQ RIAIARALVR QPHILLLDEA
1210 1220 1230 1240 1250
TSALDTESEK VVQEALDKAR EGRTCIVIAH RLSTIQNADL IVVIENGKVK
1260 1270
EHGTHQQLLA QKGIYFSMVQ AGAKRS
Length:1,276
Mass (Da):140,994
Last modified:January 1, 1988 - v1
Checksum:i1804D0F011B0FF4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14757 mRNA. Translation: AAA79005.1.
M60348 Genomic DNA. Translation: AAA39513.1.
CCDSiCCDS19085.1.
PIRiA33719. DVMS1.
RefSeqiNP_035205.1. NM_011075.2.
UniGeneiMm.146649.
Mm.389059.

Genome annotation databases

EnsembliENSMUST00000009058; ENSMUSP00000009058; ENSMUSG00000028970.
GeneIDi18669.
KEGGimmu:18669.
UCSCiuc008wko.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14757 mRNA. Translation: AAA79005.1.
M60348 Genomic DNA. Translation: AAA39513.1.
CCDSiCCDS19085.1.
PIRiA33719. DVMS1.
RefSeqiNP_035205.1. NM_011075.2.
UniGeneiMm.146649.
Mm.389059.

3D structure databases

ProteinModelPortaliP06795.
SMRiP06795. Positions 30-629.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP06795. 1 interaction.
MINTiMINT-4101676.
STRINGi10090.ENSMUSP00000009058.

Chemistry

BindingDBiP06795.
ChEMBLiCHEMBL2111404.

PTM databases

iPTMnetiP06795.
PhosphoSiteiP06795.

Proteomic databases

EPDiP06795.
MaxQBiP06795.
PaxDbiP06795.
PRIDEiP06795.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009058; ENSMUSP00000009058; ENSMUSG00000028970.
GeneIDi18669.
KEGGimmu:18669.
UCSCiuc008wko.2. mouse.

Organism-specific databases

CTDi18669.
MGIiMGI:97568. Abcb1b.

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00530000062896.
HOVERGENiHBG080809.
InParanoidiP06795.
KOiK05658.
OMAiCAVINGC.
OrthoDBiEOG7Z3F4H.
PhylomeDBiP06795.
TreeFamiTF105193.

Enzyme and pathway databases

ReactomeiR-MMU-382556. ABC-family proteins mediated transport.
SABIO-RKP06795.

Miscellaneous databases

PROiP06795.
SOURCEiSearch...

Gene expression databases

BgeeiP06795.
ExpressionAtlasiP06795. baseline and differential.
GenevisibleiP06795. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins."
    Gros P., Croop J., Housman D.
    Cell 47:371-380(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Mammalian multidrug-resistance gene: correlation of exon organization with structural domains and duplication of an ancestral gene."
    Raymond M., Gros P.
    Proc. Natl. Acad. Sci. U.S.A. 86:6488-6492(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cell-specific activity of cis-acting regulatory elements in the promoter of the mouse multidrug resistance gene mdr1."
    Raymond M., Gros P.
    Mol. Cell. Biol. 10:6036-6040(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-641 AND SER-659, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMDR1B_MOUSE
AccessioniPrimary (citable) accession number: P06795
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: June 8, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In mouse the MDR gene family includes three or more related but distinct cellular genes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.