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Protein

Protein E7

Gene

E7

Organism
Human papillomavirus type 18
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host inteferon alpha.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri65 – 10137By similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

G1/S host cell cycle checkpoint dysregulation by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Modulation of host cell cycle by virus, Transcription, Transcription regulation, Viral immunoevasion

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein E7UniRule annotation
Gene namesi
Name:E7UniRule annotation
OrganismiHuman papillomavirus type 18
Taxonomic identifieri333761 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009109 Componenti: Genome

Subcellular locationi

  • Host cytoplasm UniRule annotation
  • Host nucleus UniRule annotation

  • Note: Predominantly found in the host nucleus.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 105105Protein E7PRO_0000133416Add
BLAST

Post-translational modificationi

Highly phosphorylated.UniRule annotation

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Homodimer. Homooligomer. Interacts with host RB1; this interaction induces dissociation of RB1-E2F1 complex thereby disrupting RB1 activity. Interacts with host EP300; this interaction represses EP300 transcriptional activity. Interacts with protein E2; this interaction inhibits E7 oncogenic activity.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
MYCP011065EBI-1776887,EBI-447544From a different organism.
RB1P064003EBI-1776887,EBI-491274From a different organism.

Protein-protein interaction databases

DIPiDIP-45143N.
IntActiP06788. 27 interactions.
MINTiMINT-222077.

Structurei

3D structure databases

ProteinModelPortaliP06788.
SMRiP06788. Positions 54-105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 4949DisorderedUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi25 – 295LXCXE motif; interaction with host RB1UniRule annotation
Motifi83 – 919Nuclear export signalUniRule annotation

Sequence similaritiesi

Belongs to the papillomaviridae E7 protein family.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri65 – 10137By similarityAdd
BLAST

Keywords - Domaini

Zinc-finger

Family and domain databases

HAMAPiMF_04004. PPV_E7. 1 hit.
InterProiIPR000148. Papilloma_E7.
[Graphical view]
PfamiPF00527. E7. 1 hit.
[Graphical view]
PIRSFiPIRSF003407. Papvi_E7. 1 hit.

Sequencei

Sequence statusi: Complete.

P06788-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHGPKATLQD IVLHLEPQNE IPVDLLCHEQ LSDSEEENDE IDGVNHQHLP
60 70 80 90 100
ARRAEPQRHT MLCMCCKCEA RIKLVVESSA DDLRAFQQLF LNTLSFVCPW

CASQQ
Length:105
Mass (Da):11,995
Last modified:April 1, 1990 - v2
Checksum:i2CDB119534D0186A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731K → E (PubMed:3039146).Curated
Sequence conflicti73 – 731K → E (PubMed:3034571).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05015 Genomic DNA. Translation: CAA28665.1.
M20324 mRNA. Translation: AAA99513.1.
M20325 mRNA. Translation: AAA99515.1.
M26798 Genomic DNA. Translation: AAA46947.1.
X04773 Genomic DNA. Translation: CAA28467.1.
A06324 Unassigned DNA. Translation: CAA00540.1.
A06328 Unassigned RNA. Translation: CAA00543.1.
PIRiB26165. W7WL18.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05015 Genomic DNA. Translation: CAA28665.1.
M20324 mRNA. Translation: AAA99513.1.
M20325 mRNA. Translation: AAA99515.1.
M26798 Genomic DNA. Translation: AAA46947.1.
X04773 Genomic DNA. Translation: CAA28467.1.
A06324 Unassigned DNA. Translation: CAA00540.1.
A06328 Unassigned RNA. Translation: CAA00543.1.
PIRiB26165. W7WL18.

3D structure databases

ProteinModelPortaliP06788.
SMRiP06788. Positions 54-105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-45143N.
IntActiP06788. 27 interactions.
MINTiMINT-222077.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_04004. PPV_E7. 1 hit.
InterProiIPR000148. Papilloma_E7.
[Graphical view]
PfamiPF00527. E7. 1 hit.
[Graphical view]
PIRSFiPIRSF003407. Papvi_E7. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVE7_HPV18
AccessioniPrimary (citable) accession number: P06788
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: April 1, 1990
Last modified: September 7, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.