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Protein

Serine/threonine-protein kinase STE7

Gene

STE7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase required for cell-type-specific transcription and signal transduction in yeast. It is thought that it is phosphorylated by the ste11 protein kinase and that it can phosphorylate the FUS3 and or KSS1 kinases.

Miscellaneous

Present with 672 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Phosphorylated at multiple sites in response to pheromone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei220ATPPROSITE-ProRule annotation1
Active sitei331Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi197 – 205ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase kinase activity Source: SGD
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • activation of MAPK activity Source: SGD
  • invasive growth in response to glucose limitation Source: SGD
  • MAPK cascade Source: SGD
  • MAPK cascade involved in cell wall organization or biogenesis Source: SGD
  • protein phosphorylation Source: SGD
  • pseudohyphal growth Source: SGD
  • regulation of apoptotic process Source: GO_Central
  • regulation of mitotic cell cycle Source: GO_Central
  • regulation of transposition, RNA-mediated Source: SGD
  • response to pheromone Source: UniProtKB-KW
  • signal transduction involved in filamentous growth Source: SGD
  • stress-activated protein kinase signaling cascade Source: GO_Central

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processPheromone response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29553-MONOMER
BRENDAi2.7.12.2 984

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase STE7 (EC:2.7.12.2)
Gene namesi
Name:STE7
Ordered Locus Names:YDL159W
ORF Names:D1525
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL159W
SGDiS000002318 STE7

Subcellular locationi

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi353S → A: No loss of activity. 1 Publication1
Mutagenesisi359S → A: Inactivation. 1 Publication1
Mutagenesisi363T → A: Inactivation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000866881 – 515Serine/threonine-protein kinase STE7Add BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei359Phosphoserine1 Publication1
Modified residuei363Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP06784
PaxDbiP06784
PRIDEiP06784

PTM databases

iPTMnetiP06784

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31905, 56 interactors
DIPiDIP-9N
ELMiP06784
IntActiP06784, 27 interactors
MINTiP06784
STRINGi4932.YDL159W

Structurei

3D structure databases

ProteinModelPortaliP06784
SMRiP06784
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini191 – 466Protein kinasePROSITE-ProRule annotationAdd BLAST276

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00900000141267
HOGENOMiHOG000234206
InParanoidiP06784
KOiK11226
OMAiGGHNDTP
OrthoDBiEOG092C3RSG

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P06784-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQRKTLQRR NLKGLNLNLH PDVGNNGQLQ EKTETHQGQS RIEGHVMSNI
60 70 80 90 100
NAIQNNSNLF LRRGIKKKLT LDAFGDDQAI SKPNTVVIQQ PQNEPVLVLS
110 120 130 140 150
SLSQSPCVSS SSSLSTPCII DAYSNNFGLS PSSTNSTPST IQGLSNIATP
160 170 180 190 200
VENEHSISLP PLEESLSPAA ADLKDTLSGT SNGNYIQLQD LVQLGKIGAG
210 220 230 240 250
NSGTVVKALH VPDSKIVAKK TIPVEQNNST IINQLVRELS IVKNVKPHEN
260 270 280 290 300
IITFYGAYYN QHINNEIIIL MEYSDCGSLD KILSVYKRFV QRGTVSSKKT
310 320 330 340 350
WFNELTISKI AYGVLNGLDH LYRQYKIIHR DIKPSNVLIN SKGQIKLCDF
360 370 380 390 400
GVSKKLINSI ADTFVGTSTY MSPERIQGNV YSIKGDVWSL GLMIIELVTG
410 420 430 440 450
EFPLGGHNDT PDGILDLLQR IVNEPSPRLP KDRIYSKEMT DFVNRCCIKN
460 470 480 490 500
ERERSSIHEL LHHDLIMKYV SPSKDDKFRH WCRKIKSKIK EDKRIKREAL
510
DRAKLEKKQS ERSTH
Length:515
Mass (Da):57,709
Last modified:January 1, 1988 - v1
Checksum:iC8A75899CFBE8BDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14097 Genomic DNA Translation: AAA35118.1
Z67750 Genomic DNA Translation: CAA91587.1
Z74207 Genomic DNA Translation: CAA98732.1
X97751 Genomic DNA Translation: CAA66332.1
BK006938 Genomic DNA Translation: DAA11702.1
PIRiA25048
RefSeqiNP_010122.1, NM_001180219.1

Genome annotation databases

EnsemblFungiiYDL159W; YDL159W; YDL159W
GeneIDi851396
KEGGisce:YDL159W

Similar proteinsi

Entry informationi

Entry nameiSTE7_YEAST
AccessioniPrimary (citable) accession number: P06784
Secondary accession number(s): D6VRJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 23, 2018
This is version 189 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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