P06783 (STE3_YEAST) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 108.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Pheromone a factor receptor | ||||
| Gene names |
| ||||
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome] | ||||
| Taxonomic identifier | 559292 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › ![]() |
Protein attributes
| Sequence length | 470 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Receptor for the peptide pheromone a factor. |
| Subcellular location | |
| Sequence similarities | Belongs to the G-protein coupled receptor 4 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pheromone response |
| Cellular component | Membrane |
| Domain | Transmembrane Transmembrane helix |
| Molecular function | G-protein coupled receptor Receptor Transducer |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | cytogamy Inferred from direct assay PubMed 17369365. Source: SGD pheromone-dependent signal transduction involved in conjugation with cellular fusionInferred from mutant phenotype Ref.1. Source: SGD |
| Cellular_component | integral to plasma membrane Inferred from direct assay Ref.1. Source: SGD |
| Molecular_function | mating-type a-factor pheromone receptor activity Inferred from mutant phenotype Ref.1. Source: SGD |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 470 | 470 | Pheromone a factor receptor | PRO_0000195079 | |||||
Regions | |||||||||
| Topological domain | 1 – 5 | 5 | Extracellular Potential | ||||||
| Transmembrane | 6 – 23 | 18 | Helical; Potential | ||||||
| Topological domain | 24 – 29 | 6 | Cytoplasmic Potential | ||||||
| Transmembrane | 30 – 53 | 24 | Helical; Potential | ||||||
| Topological domain | 54 – 70 | 17 | Extracellular Potential | ||||||
| Transmembrane | 71 – 98 | 28 | Helical; Potential | ||||||
| Topological domain | 99 – 116 | 18 | Cytoplasmic Potential | ||||||
| Transmembrane | 117 – 134 | 18 | Helical; Potential | ||||||
| Topological domain | 135 – 155 | 21 | Extracellular Potential | ||||||
| Transmembrane | 156 – 183 | 28 | Helical; Potential | ||||||
| Topological domain | 184 – 205 | 22 | Cytoplasmic Potential | ||||||
| Transmembrane | 206 – 228 | 23 | Helical; Potential | ||||||
| Topological domain | 229 – 266 | 38 | Extracellular Potential | ||||||
| Transmembrane | 267 – 285 | 19 | Helical; Potential | ||||||
| Topological domain | 286 – 470 | 185 | Cytoplasmic Potential | ||||||
| Region | 300 – 470 | 171 | Hydrophilic | ||||||
Amino acid modifications | |||||||||
| Modified residue | 430 | 1 | Phosphoserine Ref.8 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Evidence the yeast STE3 gene encodes a receptor for the peptide pheromone a factor: gene sequence and implications for the structure of the presumed receptor." Hagen D.C., McCaffrey G., Sprague G.F. Jr. Proc. Natl. Acad. Sci. U.S.A. 83:1418-1422(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Nucleotide sequences of STE2 and STE3, cell type-specific sterile genes from Saccharomyces cerevisiae." Nakayama N., Miyajima A., Arai K. EMBO J. 4:2643-2648(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene." Wiemann S., Voss H., Schwager C., Rupp T., Stegemann J., Zimmermann J., Grothues D., Sensen C., Erfle H., Hewitt N., Banrevi A., Ansorge W. Yeast 9:1343-1348(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [4] | "Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. Mewes H.-W.Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [5] | Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c. |
| [6] | "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. LaBaer J.Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [7] | "A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A. |
| [8] | "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M12239 Genomic DNA. Translation: AAA35113.1. X03011 Genomic DNA. Translation: CAA26795.1. X74151 Genomic DNA. Translation: CAA52261.1. Z28177 Genomic DNA. Translation: CAA82019.1. AY692742 Genomic DNA. Translation: AAT92761.1. BK006944 Genomic DNA. Translation: DAA08989.1. |
| PIR | B24670. |
| RefSeq | NP_012743.1. NM_001179744.1. |
3D structure databases | |
| ProteinModelPortal | P06783. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-1146N. |
| IntAct | P06783. 1 interaction. |
| MINT | MINT-4788722. |
| STRING | 4932.YKL178C. |
Protein family/group databases | |
| GPCRDB | Search... |
Protocols and materials databases | |
| DNASU | 853677. |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | YKL178C; YKL178C; YKL178C. |
| GeneID | 853677. |
| KEGG | sce:YKL178C. |
Organism-specific databases | |
| CYGD | YKL178c. |
| SGD | S000001661. STE3. |
Phylogenomic databases | |
| eggNOG | NOG71865. |
| HOGENOM | HOG000093298. |
| KO | K04627. |
| OMA | DILHCTN. |
| OrthoDB | EOG4CC79F. |
Gene expression databases | |
| Genevestigator | P06783. |
| GermOnline | YKL178C. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR001499. GPCR_STE3. [Graphical view] |
| Pfam | PF02076. STE3. 1 hit. [Graphical view] |
| PRINTS | PR00899. GPCRSTE3. |
| ProtoNet | Search... |
Other | |
| NextBio | 974631. |
Entry information
| Entry name | STE3_YEAST | ||||||||
| Accession | Primary (citable) accession number: P06783 Secondary accession number(s): D6VX23 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome XI Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names |
| 7-transmembrane G-linked receptors List of 7-transmembrane G-linked receptor entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with
