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Protein

GTP-binding protein RHO2

Gene

RHO2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 3870 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 21GTPBy similarity8
Nucleotide bindingi61 – 65GTPBy similarity5
Nucleotide bindingi119 – 122GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • actin filament organization Source: SGD
  • establishment of cell polarity Source: SGD
  • fungal-type cell wall organization Source: SGD
  • microtubule-based process Source: SGD
  • small GTPase mediated signal transduction Source: SGD

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33118-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein RHO2
Gene namesi
Name:RHO2
Ordered Locus Names:YNL090W
ORF Names:N2237
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL090W
SGDiS000005034 RHO2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001989461 – 189GTP-binding protein RHO2Add BLAST189
PropeptideiPRO_0000281276190 – 192Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi188S-palmitoyl cysteine1 Publication1
Modified residuei189Cysteine methyl esterBy similarity1
Lipidationi189S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

MaxQBiP06781
PaxDbiP06781
PRIDEiP06781

PTM databases

SwissPalmiP06781

Interactioni

Protein-protein interaction databases

BioGridi35734, 158 interactors
DIPiDIP-5750N
IntActiP06781, 14 interactors
STRINGi4932.YNL090W

Structurei

3D structure databases

ProteinModelPortaliP06781
SMRiP06781
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 44Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

GeneTreeiENSGT00920000149167
HOGENOMiHOG000233974
InParanoidiP06781
KOiK07975
OMAiDNVKHKW
OrthoDBiEOG092C4TDG

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06781-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKAVRRKL VIIGDGACGK TSLLYVFTLG KFPEQYHPTV FENYVTDCRV
60 70 80 90 100
DGIKVSLTLW DTAGQEEYER LRPFSYSKAD IILIGFAVDN FESLINARTK
110 120 130 140 150
WADEALRYCP DAPIVLVGLK KDLRQEAHFK ENATDEMVPI EDAKQVARAI
160 170 180 190
GAKKYMECSA LTGEGVDDVF EVATRTSLLM KKEPGANCCI IL
Length:192
Mass (Da):21,479
Last modified:February 1, 1996 - v2
Checksum:i468AA876DF13F69C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48C → S in AAA34978 (PubMed:3543936).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15190 Genomic DNA Translation: AAA34978.1
AF458969 Genomic DNA Translation: AAM00517.1
AF458970 Genomic DNA Translation: AAM00523.1
AF458971 Genomic DNA Translation: AAM00529.1
AF458972 Genomic DNA Translation: AAM00535.1
AF458973 Genomic DNA Translation: AAM00541.1
AF458974 Genomic DNA Translation: AAM00547.1
AF458976 Genomic DNA Translation: AAM00559.1
AF458978 Genomic DNA Translation: AAM00571.1
AF458981 Genomic DNA Translation: AAM00589.1
DQ115393 Genomic DNA Translation: AAZ22518.1
X89016 Genomic DNA Translation: CAA61421.1
Z71366 Genomic DNA Translation: CAA95965.1
BK006947 Genomic DNA Translation: DAA10456.1
PIRiS57533 TVBYH2
RefSeqiNP_014309.3, NM_001182928.3

Genome annotation databases

EnsemblFungiiYNL090W; YNL090W; YNL090W
GeneIDi855634
KEGGisce:YNL090W

Similar proteinsi

Entry informationi

Entry nameiRHO2_YEAST
AccessioniPrimary (citable) accession number: P06781
Secondary accession number(s): D6W190, Q45TZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 1, 1996
Last modified: June 20, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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