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P06781

- RHO2_YEAST

UniProt

P06781 - RHO2_YEAST

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Protein
GTP-binding protein RHO2
Gene
RHO2, YNL090W, N2237
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 218GTP By similarity
Nucleotide bindingi61 – 655GTP By similarity
Nucleotide bindingi119 – 1224GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: SGD

GO - Biological processi

  1. GTP catabolic process Source: GOC
  2. actin filament organization Source: SGD
  3. establishment of cell polarity Source: SGD
  4. fungal-type cell wall organization Source: SGD
  5. microtubule-based process Source: SGD
  6. small GTPase mediated signal transduction Source: SGD
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33118-MONOMER.
ReactomeiREACT_188387. Axonal growth inhibition (RHOA activation).

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein RHO2
Gene namesi
Name:RHO2
Ordered Locus Names:YNL090W
ORF Names:N2237
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL090w.
SGDiS000005034. RHO2.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
  2. membrane Source: SGD
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189GTP-binding protein RHO2
PRO_0000198946Add
BLAST
Propeptidei190 – 1923Removed in mature form By similarity
PRO_0000281276

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi188 – 1881S-palmitoyl cysteine Inferred
Modified residuei189 – 1891Cysteine methyl ester By similarity
Lipidationi189 – 1891S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

MaxQBiP06781.
PaxDbiP06781.
PeptideAtlasiP06781.

Expressioni

Gene expression databases

GenevestigatoriP06781.

Interactioni

Protein-protein interaction databases

BioGridi35734. 120 interactions.
DIPiDIP-5750N.
IntActiP06781. 1 interaction.
MINTiMINT-582528.

Structurei

3D structure databases

ProteinModelPortaliP06781.
SMRiP06781. Positions 5-178.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 449Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00750000118005.
HOGENOMiHOG000233974.
KOiK07975.
OMAiNARTKWV.
OrthoDBiEOG7SN8QP.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06781-1 [UniParc]FASTAAdd to Basket

« Hide

MSEKAVRRKL VIIGDGACGK TSLLYVFTLG KFPEQYHPTV FENYVTDCRV    50
DGIKVSLTLW DTAGQEEYER LRPFSYSKAD IILIGFAVDN FESLINARTK 100
WADEALRYCP DAPIVLVGLK KDLRQEAHFK ENATDEMVPI EDAKQVARAI 150
GAKKYMECSA LTGEGVDDVF EVATRTSLLM KKEPGANCCI IL 192
Length:192
Mass (Da):21,479
Last modified:February 1, 1996 - v2
Checksum:i468AA876DF13F69C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481C → S in AAA34978. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M15190 Genomic DNA. Translation: AAA34978.1.
AF458969 Genomic DNA. Translation: AAM00517.1.
AF458970 Genomic DNA. Translation: AAM00523.1.
AF458971 Genomic DNA. Translation: AAM00529.1.
AF458972 Genomic DNA. Translation: AAM00535.1.
AF458973 Genomic DNA. Translation: AAM00541.1.
AF458974 Genomic DNA. Translation: AAM00547.1.
AF458976 Genomic DNA. Translation: AAM00559.1.
AF458978 Genomic DNA. Translation: AAM00571.1.
AF458981 Genomic DNA. Translation: AAM00589.1.
DQ115393 Genomic DNA. Translation: AAZ22518.1.
X89016 Genomic DNA. Translation: CAA61421.1.
Z71366 Genomic DNA. Translation: CAA95965.1.
BK006947 Genomic DNA. Translation: DAA10456.1.
PIRiS57533. TVBYH2.
RefSeqiNP_014309.3. NM_001182928.3.

Genome annotation databases

EnsemblFungiiYNL090W; YNL090W; YNL090W.
GeneIDi855634.
KEGGisce:YNL090W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M15190 Genomic DNA. Translation: AAA34978.1 .
AF458969 Genomic DNA. Translation: AAM00517.1 .
AF458970 Genomic DNA. Translation: AAM00523.1 .
AF458971 Genomic DNA. Translation: AAM00529.1 .
AF458972 Genomic DNA. Translation: AAM00535.1 .
AF458973 Genomic DNA. Translation: AAM00541.1 .
AF458974 Genomic DNA. Translation: AAM00547.1 .
AF458976 Genomic DNA. Translation: AAM00559.1 .
AF458978 Genomic DNA. Translation: AAM00571.1 .
AF458981 Genomic DNA. Translation: AAM00589.1 .
DQ115393 Genomic DNA. Translation: AAZ22518.1 .
X89016 Genomic DNA. Translation: CAA61421.1 .
Z71366 Genomic DNA. Translation: CAA95965.1 .
BK006947 Genomic DNA. Translation: DAA10456.1 .
PIRi S57533. TVBYH2.
RefSeqi NP_014309.3. NM_001182928.3.

3D structure databases

ProteinModelPortali P06781.
SMRi P06781. Positions 5-178.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35734. 120 interactions.
DIPi DIP-5750N.
IntActi P06781. 1 interaction.
MINTi MINT-582528.

Proteomic databases

MaxQBi P06781.
PaxDbi P06781.
PeptideAtlasi P06781.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL090W ; YNL090W ; YNL090W .
GeneIDi 855634.
KEGGi sce:YNL090W.

Organism-specific databases

CYGDi YNL090w.
SGDi S000005034. RHO2.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00750000118005.
HOGENOMi HOG000233974.
KOi K07975.
OMAi NARTKWV.
OrthoDBi EOG7SN8QP.

Enzyme and pathway databases

BioCyci YEAST:G3O-33118-MONOMER.
Reactomei REACT_188387. Axonal growth inhibition (RHOA activation).

Miscellaneous databases

NextBioi 979851.

Gene expression databases

Genevestigatori P06781.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00174. RHO. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51420. RHO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae."
    Madaule P., Axel R., Myers A.M.
    Proc. Natl. Acad. Sci. U.S.A. 84:779-783(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Dissecting the architecture of a quantitative trait locus in yeast."
    Steinmetz L.M., Sinha H., Richards D.R., Spiegelman J.I., Oefner P.J., McCusker J.H., Davis R.W.
    Nature 416:326-330(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S96, SK1, YJM 1129, YJM 280, YJM 320, YJM 326, YJM 339, YJM 421 and YJM 627.
  3. "Quantitative trait loci mapped to single-nucleotide resolution in yeast."
    Deutschbauer A.M., Davis R.W.
    Nat. Genet. 37:1333-1340(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SK1.
  4. "The sequence of a 17,933 bp segment of Saccharomyces cerevisiae chromosome XIV contains the RHO2, TOP2, MKT1 and END3 genes and five new open reading frames."
    Soler-Mira A., Saiz J.E., Ballesta J.P.G., Remacha M.A.
    Yeast 12:485-491(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  5. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. Cited for: PALMITOYLATION.

Entry informationi

Entry nameiRHO2_YEAST
AccessioniPrimary (citable) accession number: P06781
Secondary accession number(s): D6W190, Q45TZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3870 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3

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