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P06781

- RHO2_YEAST

UniProt

P06781 - RHO2_YEAST

Protein

GTP-binding protein RHO2

Gene

RHO2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 218GTPBy similarity
    Nucleotide bindingi61 – 655GTPBy similarity
    Nucleotide bindingi119 – 1224GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: SGD
    2. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. actin filament organization Source: SGD
    2. establishment of cell polarity Source: SGD
    3. fungal-type cell wall organization Source: SGD
    4. GTP catabolic process Source: GOC
    5. microtubule-based process Source: SGD
    6. small GTPase mediated signal transduction Source: SGD

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33118-MONOMER.
    ReactomeiREACT_188387. Axonal growth inhibition (RHOA activation).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP-binding protein RHO2
    Gene namesi
    Name:RHO2
    Ordered Locus Names:YNL090W
    ORF Names:N2237
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIV

    Organism-specific databases

    CYGDiYNL090w.
    SGDiS000005034. RHO2.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. intracellular Source: InterPro
    2. membrane Source: SGD
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 189189GTP-binding protein RHO2PRO_0000198946Add
    BLAST
    Propeptidei190 – 1923Removed in mature formBy similarityPRO_0000281276

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi188 – 1881S-palmitoyl cysteine1 Publication
    Modified residuei189 – 1891Cysteine methyl esterBy similarity
    Lipidationi189 – 1891S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Palmitate, Prenylation

    Proteomic databases

    MaxQBiP06781.
    PaxDbiP06781.
    PeptideAtlasiP06781.

    Expressioni

    Gene expression databases

    GenevestigatoriP06781.

    Interactioni

    Protein-protein interaction databases

    BioGridi35734. 120 interactions.
    DIPiDIP-5750N.
    IntActiP06781. 1 interaction.
    MINTiMINT-582528.

    Structurei

    3D structure databases

    ProteinModelPortaliP06781.
    SMRiP06781. Positions 5-178.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi36 – 449Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rho family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00750000118005.
    HOGENOMiHOG000233974.
    KOiK07975.
    OMAiNARTKWV.
    OrthoDBiEOG7SN8QP.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00174. RHO. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51420. RHO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P06781-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEKAVRRKL VIIGDGACGK TSLLYVFTLG KFPEQYHPTV FENYVTDCRV    50
    DGIKVSLTLW DTAGQEEYER LRPFSYSKAD IILIGFAVDN FESLINARTK 100
    WADEALRYCP DAPIVLVGLK KDLRQEAHFK ENATDEMVPI EDAKQVARAI 150
    GAKKYMECSA LTGEGVDDVF EVATRTSLLM KKEPGANCCI IL 192
    Length:192
    Mass (Da):21,479
    Last modified:February 1, 1996 - v2
    Checksum:i468AA876DF13F69C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti48 – 481C → S in AAA34978. (PubMed:3543936)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15190 Genomic DNA. Translation: AAA34978.1.
    AF458969 Genomic DNA. Translation: AAM00517.1.
    AF458970 Genomic DNA. Translation: AAM00523.1.
    AF458971 Genomic DNA. Translation: AAM00529.1.
    AF458972 Genomic DNA. Translation: AAM00535.1.
    AF458973 Genomic DNA. Translation: AAM00541.1.
    AF458974 Genomic DNA. Translation: AAM00547.1.
    AF458976 Genomic DNA. Translation: AAM00559.1.
    AF458978 Genomic DNA. Translation: AAM00571.1.
    AF458981 Genomic DNA. Translation: AAM00589.1.
    DQ115393 Genomic DNA. Translation: AAZ22518.1.
    X89016 Genomic DNA. Translation: CAA61421.1.
    Z71366 Genomic DNA. Translation: CAA95965.1.
    BK006947 Genomic DNA. Translation: DAA10456.1.
    PIRiS57533. TVBYH2.
    RefSeqiNP_014309.3. NM_001182928.3.

    Genome annotation databases

    EnsemblFungiiYNL090W; YNL090W; YNL090W.
    GeneIDi855634.
    KEGGisce:YNL090W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15190 Genomic DNA. Translation: AAA34978.1 .
    AF458969 Genomic DNA. Translation: AAM00517.1 .
    AF458970 Genomic DNA. Translation: AAM00523.1 .
    AF458971 Genomic DNA. Translation: AAM00529.1 .
    AF458972 Genomic DNA. Translation: AAM00535.1 .
    AF458973 Genomic DNA. Translation: AAM00541.1 .
    AF458974 Genomic DNA. Translation: AAM00547.1 .
    AF458976 Genomic DNA. Translation: AAM00559.1 .
    AF458978 Genomic DNA. Translation: AAM00571.1 .
    AF458981 Genomic DNA. Translation: AAM00589.1 .
    DQ115393 Genomic DNA. Translation: AAZ22518.1 .
    X89016 Genomic DNA. Translation: CAA61421.1 .
    Z71366 Genomic DNA. Translation: CAA95965.1 .
    BK006947 Genomic DNA. Translation: DAA10456.1 .
    PIRi S57533. TVBYH2.
    RefSeqi NP_014309.3. NM_001182928.3.

    3D structure databases

    ProteinModelPortali P06781.
    SMRi P06781. Positions 5-178.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35734. 120 interactions.
    DIPi DIP-5750N.
    IntActi P06781. 1 interaction.
    MINTi MINT-582528.

    Proteomic databases

    MaxQBi P06781.
    PaxDbi P06781.
    PeptideAtlasi P06781.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YNL090W ; YNL090W ; YNL090W .
    GeneIDi 855634.
    KEGGi sce:YNL090W.

    Organism-specific databases

    CYGDi YNL090w.
    SGDi S000005034. RHO2.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00750000118005.
    HOGENOMi HOG000233974.
    KOi K07975.
    OMAi NARTKWV.
    OrthoDBi EOG7SN8QP.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33118-MONOMER.
    Reactomei REACT_188387. Axonal growth inhibition (RHOA activation).

    Miscellaneous databases

    NextBioi 979851.

    Gene expression databases

    Genevestigatori P06781.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00174. RHO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51420. RHO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae."
      Madaule P., Axel R., Myers A.M.
      Proc. Natl. Acad. Sci. U.S.A. 84:779-783(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Dissecting the architecture of a quantitative trait locus in yeast."
      Steinmetz L.M., Sinha H., Richards D.R., Spiegelman J.I., Oefner P.J., McCusker J.H., Davis R.W.
      Nature 416:326-330(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: S96, SK1, YJM 1129, YJM 280, YJM 320, YJM 326, YJM 339, YJM 421 and YJM 627.
    3. "Quantitative trait loci mapped to single-nucleotide resolution in yeast."
      Deutschbauer A.M., Davis R.W.
      Nat. Genet. 37:1333-1340(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: SK1.
    4. "The sequence of a 17,933 bp segment of Saccharomyces cerevisiae chromosome XIV contains the RHO2, TOP2, MKT1 and END3 genes and five new open reading frames."
      Soler-Mira A., Saiz J.E., Ballesta J.P.G., Remacha M.A.
      Yeast 12:485-491(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    5. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
      Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
      , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
      Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    6. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. Cited for: PALMITOYLATION.

    Entry informationi

    Entry nameiRHO2_YEAST
    AccessioniPrimary (citable) accession number: P06781
    Secondary accession number(s): D6W190, Q45TZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 140 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 3870 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIV
      Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

    External Data

    Dasty 3