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Protein

GTP-binding protein RHO2

Gene

RHO2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 21GTPBy similarity8
Nucleotide bindingi61 – 65GTPBy similarity5
Nucleotide bindingi119 – 122GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • actin filament organization Source: SGD
  • establishment of cell polarity Source: SGD
  • fungal-type cell wall organization Source: SGD
  • microtubule-based process Source: SGD
  • small GTPase mediated signal transduction Source: SGD
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33118-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein RHO2
Gene namesi
Name:RHO2
Ordered Locus Names:YNL090W
ORF Names:N2237
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIV

Organism-specific databases

EuPathDBiFungiDB:YNL090W.
SGDiS000005034. RHO2.

Subcellular locationi

GO - Cellular componenti

  • intracellular Source: GOC
  • membrane Source: SGD
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001989461 – 189GTP-binding protein RHO2Add BLAST189
PropeptideiPRO_0000281276190 – 192Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi188S-palmitoyl cysteine1 Publication1
Modified residuei189Cysteine methyl esterBy similarity1
Lipidationi189S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

MaxQBiP06781.
PRIDEiP06781.

PTM databases

SwissPalmiP06781.

Interactioni

Protein-protein interaction databases

BioGridi35734. 124 interactors.
DIPiDIP-5750N.
IntActiP06781. 1 interactor.
MINTiMINT-582528.

Structurei

3D structure databases

ProteinModelPortaliP06781.
SMRiP06781.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 44Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

GeneTreeiENSGT00830000129187.
HOGENOMiHOG000233974.
InParanoidiP06781.
KOiK07975.
OMAiQNVIRRK.
OrthoDBiEOG092C4TDG.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06781-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKAVRRKL VIIGDGACGK TSLLYVFTLG KFPEQYHPTV FENYVTDCRV
60 70 80 90 100
DGIKVSLTLW DTAGQEEYER LRPFSYSKAD IILIGFAVDN FESLINARTK
110 120 130 140 150
WADEALRYCP DAPIVLVGLK KDLRQEAHFK ENATDEMVPI EDAKQVARAI
160 170 180 190
GAKKYMECSA LTGEGVDDVF EVATRTSLLM KKEPGANCCI IL
Length:192
Mass (Da):21,479
Last modified:February 1, 1996 - v2
Checksum:i468AA876DF13F69C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48C → S in AAA34978 (PubMed:3543936).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15190 Genomic DNA. Translation: AAA34978.1.
AF458969 Genomic DNA. Translation: AAM00517.1.
AF458970 Genomic DNA. Translation: AAM00523.1.
AF458971 Genomic DNA. Translation: AAM00529.1.
AF458972 Genomic DNA. Translation: AAM00535.1.
AF458973 Genomic DNA. Translation: AAM00541.1.
AF458974 Genomic DNA. Translation: AAM00547.1.
AF458976 Genomic DNA. Translation: AAM00559.1.
AF458978 Genomic DNA. Translation: AAM00571.1.
AF458981 Genomic DNA. Translation: AAM00589.1.
DQ115393 Genomic DNA. Translation: AAZ22518.1.
X89016 Genomic DNA. Translation: CAA61421.1.
Z71366 Genomic DNA. Translation: CAA95965.1.
BK006947 Genomic DNA. Translation: DAA10456.1.
PIRiS57533. TVBYH2.
RefSeqiNP_014309.3. NM_001182928.3.

Genome annotation databases

EnsemblFungiiYNL090W; YNL090W; YNL090W.
GeneIDi855634.
KEGGisce:YNL090W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15190 Genomic DNA. Translation: AAA34978.1.
AF458969 Genomic DNA. Translation: AAM00517.1.
AF458970 Genomic DNA. Translation: AAM00523.1.
AF458971 Genomic DNA. Translation: AAM00529.1.
AF458972 Genomic DNA. Translation: AAM00535.1.
AF458973 Genomic DNA. Translation: AAM00541.1.
AF458974 Genomic DNA. Translation: AAM00547.1.
AF458976 Genomic DNA. Translation: AAM00559.1.
AF458978 Genomic DNA. Translation: AAM00571.1.
AF458981 Genomic DNA. Translation: AAM00589.1.
DQ115393 Genomic DNA. Translation: AAZ22518.1.
X89016 Genomic DNA. Translation: CAA61421.1.
Z71366 Genomic DNA. Translation: CAA95965.1.
BK006947 Genomic DNA. Translation: DAA10456.1.
PIRiS57533. TVBYH2.
RefSeqiNP_014309.3. NM_001182928.3.

3D structure databases

ProteinModelPortaliP06781.
SMRiP06781.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35734. 124 interactors.
DIPiDIP-5750N.
IntActiP06781. 1 interactor.
MINTiMINT-582528.

PTM databases

SwissPalmiP06781.

Proteomic databases

MaxQBiP06781.
PRIDEiP06781.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYNL090W; YNL090W; YNL090W.
GeneIDi855634.
KEGGisce:YNL090W.

Organism-specific databases

EuPathDBiFungiDB:YNL090W.
SGDiS000005034. RHO2.

Phylogenomic databases

GeneTreeiENSGT00830000129187.
HOGENOMiHOG000233974.
InParanoidiP06781.
KOiK07975.
OMAiQNVIRRK.
OrthoDBiEOG092C4TDG.

Enzyme and pathway databases

BioCyciYEAST:G3O-33118-MONOMER.

Miscellaneous databases

PROiP06781.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHO2_YEAST
AccessioniPrimary (citable) accession number: P06781
Secondary accession number(s): D6W190, Q45TZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 162 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3870 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.