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P06781 (RHO2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 138. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP-binding protein RHO2
Gene names
Name:RHO2
Ordered Locus Names:YNL090W
ORF Names:N2237
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length192 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Miscellaneous

Present with 3870 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the small GTPase superfamily. Rho family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 189189GTP-binding protein RHO2
PRO_0000198946
Propeptide190 – 1923Removed in mature form By similarity
PRO_0000281276

Regions

Nucleotide binding14 – 218GTP By similarity
Nucleotide binding61 – 655GTP By similarity
Nucleotide binding119 – 1224GTP By similarity
Motif36 – 449Effector region By similarity

Amino acid modifications

Modified residue1891Cysteine methyl ester By similarity
Lipidation1881S-palmitoyl cysteine Probable
Lipidation1891S-geranylgeranyl cysteine By similarity

Experimental info

Sequence conflict481C → S in AAA34978. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P06781 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 468AA876DF13F69C

FASTA19221,479
        10         20         30         40         50         60 
MSEKAVRRKL VIIGDGACGK TSLLYVFTLG KFPEQYHPTV FENYVTDCRV DGIKVSLTLW 

        70         80         90        100        110        120 
DTAGQEEYER LRPFSYSKAD IILIGFAVDN FESLINARTK WADEALRYCP DAPIVLVGLK 

       130        140        150        160        170        180 
KDLRQEAHFK ENATDEMVPI EDAKQVARAI GAKKYMECSA LTGEGVDDVF EVATRTSLLM 

       190 
KKEPGANCCI IL 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae."
Madaule P., Axel R., Myers A.M.
Proc. Natl. Acad. Sci. U.S.A. 84:779-783(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Dissecting the architecture of a quantitative trait locus in yeast."
Steinmetz L.M., Sinha H., Richards D.R., Spiegelman J.I., Oefner P.J., McCusker J.H., Davis R.W.
Nature 416:326-330(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: S96, SK1, YJM 1129, YJM 280, YJM 320, YJM 326, YJM 339, YJM 421 and YJM 627.
[3]"Quantitative trait loci mapped to single-nucleotide resolution in yeast."
Deutschbauer A.M., Davis R.W.
Nat. Genet. 37:1333-1340(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: SK1.
[4]"The sequence of a 17,933 bp segment of Saccharomyces cerevisiae chromosome XIV contains the RHO2, TOP2, MKT1 and END3 genes and five new open reading frames."
Soler-Mira A., Saiz J.E., Ballesta J.P.G., Remacha M.A.
Yeast 12:485-491(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[5]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J. expand/collapse author list , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[6]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"Global analysis of protein palmitoylation in yeast."
Roth A.F., Wan J., Bailey A.O., Sun B., Kuchar J.A., Green W.N., Phinney B.S., Yates J.R. III, Davis N.G.
Cell 125:1003-1013(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PALMITOYLATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M15190 Genomic DNA. Translation: AAA34978.1.
AF458969 Genomic DNA. Translation: AAM00517.1.
AF458970 Genomic DNA. Translation: AAM00523.1.
AF458971 Genomic DNA. Translation: AAM00529.1.
AF458972 Genomic DNA. Translation: AAM00535.1.
AF458973 Genomic DNA. Translation: AAM00541.1.
AF458974 Genomic DNA. Translation: AAM00547.1.
AF458976 Genomic DNA. Translation: AAM00559.1.
AF458978 Genomic DNA. Translation: AAM00571.1.
AF458981 Genomic DNA. Translation: AAM00589.1.
DQ115393 Genomic DNA. Translation: AAZ22518.1.
X89016 Genomic DNA. Translation: CAA61421.1.
Z71366 Genomic DNA. Translation: CAA95965.1.
BK006947 Genomic DNA. Translation: DAA10456.1.
PIRTVBYH2. S57533.
RefSeqNP_014309.3. NM_001182928.3.

3D structure databases

ProteinModelPortalP06781.
SMRP06781. Positions 5-178.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35734. 120 interactions.
DIPDIP-5750N.
IntActP06781. 1 interaction.
MINTMINT-582528.

Proteomic databases

MaxQBP06781.
PaxDbP06781.
PeptideAtlasP06781.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYNL090W; YNL090W; YNL090W.
GeneID855634.
KEGGsce:YNL090W.

Organism-specific databases

CYGDYNL090w.
SGDS000005034. RHO2.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00750000118005.
HOGENOMHOG000233974.
KOK07975.
OMANARTKWV.
OrthoDBEOG7SN8QP.

Enzyme and pathway databases

BioCycYEAST:G3O-33118-MONOMER.

Gene expression databases

GenevestigatorP06781.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio979851.

Entry information

Entry nameRHO2_YEAST
AccessionPrimary (citable) accession number: P06781
Secondary accession number(s): D6W190, Q45TZ2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIV

Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families