Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P06781

- RHO2_YEAST

UniProt

P06781 - RHO2_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

GTP-binding protein RHO2

Gene

RHO2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 218GTPBy similarity
Nucleotide bindingi61 – 655GTPBy similarity
Nucleotide bindingi119 – 1224GTPBy similarity

GO - Molecular functioni

  1. GTPase activity Source: SGD
  2. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. actin filament organization Source: SGD
  2. establishment of cell polarity Source: SGD
  3. fungal-type cell wall organization Source: SGD
  4. GTP catabolic process Source: GOC
  5. microtubule-based process Source: SGD
  6. small GTPase mediated signal transduction Source: SGD
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33118-MONOMER.
ReactomeiREACT_230996. VEGFA-VEGFR2 Pathway.
REACT_240239. Rho GTPase cycle.
REACT_246186. G beta:gamma signalling through PI3Kgamma.
REACT_248666. G alpha (12/13) signalling events.
REACT_254325. PI3K/AKT activation.
REACT_269225. EPHA-mediated growth cone collapse.
REACT_269379. Sema4D induced cell migration and growth-cone collapse.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein RHO2
Gene namesi
Name:RHO2
Ordered Locus Names:YNL090W
ORF Names:N2237
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIV

Organism-specific databases

CYGDiYNL090w.
SGDiS000005034. RHO2.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. intracellular Source: InterPro
  2. membrane Source: SGD
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189GTP-binding protein RHO2PRO_0000198946Add
BLAST
Propeptidei190 – 1923Removed in mature formBy similarityPRO_0000281276

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi188 – 1881S-palmitoyl cysteine1 Publication
Modified residuei189 – 1891Cysteine methyl esterBy similarity
Lipidationi189 – 1891S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

MaxQBiP06781.
PaxDbiP06781.
PeptideAtlasiP06781.

Expressioni

Gene expression databases

GenevestigatoriP06781.

Interactioni

Protein-protein interaction databases

BioGridi35734. 121 interactions.
DIPiDIP-5750N.
IntActiP06781. 1 interaction.
MINTiMINT-582528.

Structurei

3D structure databases

ProteinModelPortaliP06781.
SMRiP06781. Positions 5-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 449Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000119850.
HOGENOMiHOG000233974.
InParanoidiP06781.
KOiK07975.
OMAiNARTKWV.
OrthoDBiEOG7SN8QP.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06781-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEKAVRRKL VIIGDGACGK TSLLYVFTLG KFPEQYHPTV FENYVTDCRV
60 70 80 90 100
DGIKVSLTLW DTAGQEEYER LRPFSYSKAD IILIGFAVDN FESLINARTK
110 120 130 140 150
WADEALRYCP DAPIVLVGLK KDLRQEAHFK ENATDEMVPI EDAKQVARAI
160 170 180 190
GAKKYMECSA LTGEGVDDVF EVATRTSLLM KKEPGANCCI IL
Length:192
Mass (Da):21,479
Last modified:February 1, 1996 - v2
Checksum:i468AA876DF13F69C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481C → S in AAA34978. (PubMed:3543936)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15190 Genomic DNA. Translation: AAA34978.1.
AF458969 Genomic DNA. Translation: AAM00517.1.
AF458970 Genomic DNA. Translation: AAM00523.1.
AF458971 Genomic DNA. Translation: AAM00529.1.
AF458972 Genomic DNA. Translation: AAM00535.1.
AF458973 Genomic DNA. Translation: AAM00541.1.
AF458974 Genomic DNA. Translation: AAM00547.1.
AF458976 Genomic DNA. Translation: AAM00559.1.
AF458978 Genomic DNA. Translation: AAM00571.1.
AF458981 Genomic DNA. Translation: AAM00589.1.
DQ115393 Genomic DNA. Translation: AAZ22518.1.
X89016 Genomic DNA. Translation: CAA61421.1.
Z71366 Genomic DNA. Translation: CAA95965.1.
BK006947 Genomic DNA. Translation: DAA10456.1.
PIRiS57533. TVBYH2.
RefSeqiNP_014309.3. NM_001182928.3.

Genome annotation databases

EnsemblFungiiYNL090W; YNL090W; YNL090W.
GeneIDi855634.
KEGGisce:YNL090W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15190 Genomic DNA. Translation: AAA34978.1 .
AF458969 Genomic DNA. Translation: AAM00517.1 .
AF458970 Genomic DNA. Translation: AAM00523.1 .
AF458971 Genomic DNA. Translation: AAM00529.1 .
AF458972 Genomic DNA. Translation: AAM00535.1 .
AF458973 Genomic DNA. Translation: AAM00541.1 .
AF458974 Genomic DNA. Translation: AAM00547.1 .
AF458976 Genomic DNA. Translation: AAM00559.1 .
AF458978 Genomic DNA. Translation: AAM00571.1 .
AF458981 Genomic DNA. Translation: AAM00589.1 .
DQ115393 Genomic DNA. Translation: AAZ22518.1 .
X89016 Genomic DNA. Translation: CAA61421.1 .
Z71366 Genomic DNA. Translation: CAA95965.1 .
BK006947 Genomic DNA. Translation: DAA10456.1 .
PIRi S57533. TVBYH2.
RefSeqi NP_014309.3. NM_001182928.3.

3D structure databases

ProteinModelPortali P06781.
SMRi P06781. Positions 5-178.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35734. 121 interactions.
DIPi DIP-5750N.
IntActi P06781. 1 interaction.
MINTi MINT-582528.

Proteomic databases

MaxQBi P06781.
PaxDbi P06781.
PeptideAtlasi P06781.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YNL090W ; YNL090W ; YNL090W .
GeneIDi 855634.
KEGGi sce:YNL090W.

Organism-specific databases

CYGDi YNL090w.
SGDi S000005034. RHO2.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000119850.
HOGENOMi HOG000233974.
InParanoidi P06781.
KOi K07975.
OMAi NARTKWV.
OrthoDBi EOG7SN8QP.

Enzyme and pathway databases

BioCyci YEAST:G3O-33118-MONOMER.
Reactomei REACT_230996. VEGFA-VEGFR2 Pathway.
REACT_240239. Rho GTPase cycle.
REACT_246186. G beta:gamma signalling through PI3Kgamma.
REACT_248666. G alpha (12/13) signalling events.
REACT_254325. PI3K/AKT activation.
REACT_269225. EPHA-mediated growth cone collapse.
REACT_269379. Sema4D induced cell migration and growth-cone collapse.

Miscellaneous databases

NextBioi 979851.

Gene expression databases

Genevestigatori P06781.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00174. RHO. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51420. RHO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae."
    Madaule P., Axel R., Myers A.M.
    Proc. Natl. Acad. Sci. U.S.A. 84:779-783(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Dissecting the architecture of a quantitative trait locus in yeast."
    Steinmetz L.M., Sinha H., Richards D.R., Spiegelman J.I., Oefner P.J., McCusker J.H., Davis R.W.
    Nature 416:326-330(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S96, SK1, YJM 1129, YJM 280, YJM 320, YJM 326, YJM 339, YJM 421 and YJM 627.
  3. "Quantitative trait loci mapped to single-nucleotide resolution in yeast."
    Deutschbauer A.M., Davis R.W.
    Nat. Genet. 37:1333-1340(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SK1.
  4. "The sequence of a 17,933 bp segment of Saccharomyces cerevisiae chromosome XIV contains the RHO2, TOP2, MKT1 and END3 genes and five new open reading frames."
    Soler-Mira A., Saiz J.E., Ballesta J.P.G., Remacha M.A.
    Yeast 12:485-491(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  5. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications."
    Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K., Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K., Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M., Beinhauer J.D., Boskovic J., Buitrago M.J.
    , Bussereau F., Coster F., Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F., Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C., Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A., Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H., Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L., Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R., Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D., Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A., Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C., Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F., Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G., Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M., Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.
    Nature 387:93-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. Cited for: PALMITOYLATION.

Entry informationi

Entry nameiRHO2_YEAST
AccessioniPrimary (citable) accession number: P06781
Secondary accession number(s): D6W190, Q45TZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3870 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

External Data

Dasty 3