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Protein

DNA repair protein RAD7

Gene

RAD7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the global genome repair (GGR) complex which promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA. This protein is one of 10 proteins (RAD1, 2,3,4,7,10,14, 16,23 and MMS19) involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.2 Publications

Miscellaneous

Present with 937 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • cellular protein localization Source: SGD
  • nucleotide-excision repair, DNA damage recognition Source: SGD
  • protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: SGD

Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciYEAST:G3O-31686-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein RAD7
Gene namesi
Name:RAD7
Ordered Locus Names:YJR052W
ORF Names:J1665
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJR052W.
SGDiS000003813. RAD7.

Subcellular locationi

GO - Cellular componenti

  • Cul3-RING ubiquitin ligase complex Source: SGD
  • nucleotide-excision repair factor 4 complex Source: SGD

Pathology & Biotechi

Disruption phenotypei

Mutants with mutations in the RAD7, RAD14, RAD16, and RAD23 genes show partial incision defectiveness.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000971551 – 565DNA repair protein RAD7Add BLAST565

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64PhosphoserineCombined sources1
Modified residuei85PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP06779.
PRIDEiP06779.

PTM databases

iPTMnetiP06779.

Interactioni

Subunit structurei

Component of the global genome repair (GGR) complex composed of at least ABF1, RAD7 and RAD16.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33806. 88 interactors.
DIPiDIP-2484N.
IntActiP06779. 9 interactors.
MINTiMINT-676974.
STRINGi4932.YJR052W.

Structurei

3D structure databases

ProteinModelPortaliP06779.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 200HydrophilicAdd BLAST200

Sequence similaritiesi

To S.pombe SpCC613.14.Curated

Phylogenomic databases

HOGENOMiHOG000066087.
InParanoidiP06779.
KOiK15082.
OMAiNVFGCMK.
OrthoDBiEOG092C234V.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiView protein in InterPro
IPR032675. L_dom-like.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
SMARTiView protein in SMART
SM00367. LRR_CC. 4 hits.

Sequencei

Sequence statusi: Complete.

P06779-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRSRNRPKR GGENEVKGPN SALTQFLREE GISAENIKQK WYQRQSKKQE
60 70 80 90 100
DATDEKKGKA EDDSFTAEIS RVVEDEEIDE IGTGSGTETE RAQVSYDARM
110 120 130 140 150
KLVPADSDEE EYETSHISDT PVSLSSANDR ESLTKKRQNT AKIIQNRRRK
160 170 180 190 200
RKRAADLLDR RVNKVSSLQS LCITKISENI SKWQKEADES SKLVFNKLRD
210 220 230 240 250
VLGGVSTANL NNLAKALSKN RALNDHTLQL FLKTDLKRLT FSDCSKISFD
260 270 280 290 300
GYKTLAIFSP HLTELSLQMC GQLNHESLLY IAEKLPNLKS LNLDGPFLIN
310 320 330 340 350
EDTWEKFFVI MKGRLEEFHI SNTHRFTDKS LSNLLINCGS TLVSLGLSRL
360 370 380 390 400
DSISNYALLP QYLVNDEFHS LCIEYPFNEE DVNDEIIINL LGQIGRTLRK
410 420 430 440 450
LVLNGCIDLT DSMIINGLTA FIPEKCPLEV LSLEESDQIT TDSLSYFFSK
460 470 480 490 500
VELNNLIECS FRRCLQLGDM AIIELLLNGA RDSLRSLNLN SLKELTKEAF
510 520 530 540 550
VALACPNLTY LDLGFVRCVD DSVIQMLGEQ NPNLTVIDVF GDNLVTEKAT
560
MRPGLTLIGR QSDSI
Length:565
Mass (Da):63,777
Last modified:February 1, 1995 - v3
Checksum:i85C77357DC99737A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti278 – 279LL → FV in AAB59347 (PubMed:2158927).Curated2
Sequence conflicti504 – 505AC → RP in AAB59347 (PubMed:2158927).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37696 Genomic DNA. Translation: AAB59347.1.
M13015 Genomic DNA. Translation: AAA34953.1.
L26347 Genomic DNA. Translation: AAA62860.1.
L36344 Genomic DNA. Translation: AAA88755.1.
Z49552 Genomic DNA. Translation: CAA89580.1.
BK006943 Genomic DNA. Translation: DAA08839.1.
PIRiA25226.
RefSeqiNP_012586.1. NM_001181710.1.

Genome annotation databases

EnsemblFungiiYJR052W; YJR052W; YJR052W.
GeneIDi853512.
KEGGisce:YJR052W.

Similar proteinsi

Entry informationi

Entry nameiRAD7_YEAST
AccessioniPrimary (citable) accession number: P06779
Secondary accession number(s): D6VWM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 1, 1995
Last modified: July 5, 2017
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names